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Protein

Iron-sulfur cluster assembly enzyme ISCU, mitochondrial

Gene

ISCU

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins (PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 2 iron, 2 sulfur cluster binding Source: GO_Central
  • 4 iron, 4 sulfur cluster binding Source: GO_Central
  • ferrous iron binding Source: GO_Central
  • iron ion binding Source: UniProtKB
  • iron-sulfur transferase activity Source: GO_Central
  • protein-containing complex scaffold activity Source: HGNC

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandIron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis

SIGNOR Signaling Network Open Resource

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SIGNORi
Q9H1K1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iron-sulfur cluster assembly enzyme ISCU, mitochondrial
Alternative name(s):
NifU-like N-terminal domain-containing protein
NifU-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ISCU
Synonyms:NIFUN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136003.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:29882 ISCU

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611911 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1K1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Myopathy with exercise intolerance Swedish type (MEIS)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAutosomal recessive metabolic disease characterized by lifelong severe exercise intolerance, in which minor exertion causes fatigue of active muscles, shortness of breath, and cardiac palpitations in association with lactic acidosis. The biochemical phenotype is characterized by a deficiency in mitochondrial iron-sulfur proteins and impaired muscle oxidative metabolism.
See also OMIM:255125

Organism-specific databases

DisGeNET

More...
DisGeNETi
23479

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
ISCU

MalaCards human disease database

More...
MalaCardsi
ISCU
MIMi255125 phenotype

Open Targets

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OpenTargetsi
ENSG00000136003

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
43115 Hereditary myopathy with lactic acidosis due to ISCU deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA162392328

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
ISCU

Domain mapping of disease mutations (DMDM)

More...
DMDMi
313104118

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 34MitochondrionSequence analysisAdd BLAST34
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001969235 – 167Iron-sulfur cluster assembly enzyme ISCU, mitochondrialAdd BLAST133

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q9H1K1

MaxQB - The MaxQuant DataBase

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MaxQBi
Q9H1K1

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q9H1K1

PeptideAtlas

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PeptideAtlasi
Q9H1K1

PRoteomics IDEntifications database

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PRIDEi
Q9H1K1

ProteomicsDB human proteome resource

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ProteomicsDBi
80422
80423 [Q9H1K1-2]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q9H1K1-1 [Q9H1K1-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H1K1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H1K1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in heart, liver, skeletal muscle, brain, pancreas, kidney, lung and placenta.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000136003 Expressed in 239 organ(s), highest expression level in heart

CleanEx database of gene expression profiles

More...
CleanExi
HS_ISCU

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H1K1 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H1K1 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB006329
HPA038602
HPA057592

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds NFS1 (PubMed:11060020). Interacts with HSCB (PubMed:20668094). Interacts with GLRX5 (PubMed:26100117). Interacts with HSPA9 (PubMed:26702583).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
117038, 20 interactors

Database of interacting proteins

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DIPi
DIP-39616N

Protein interaction database and analysis system

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IntActi
Q9H1K1, 27 interactors

Molecular INTeraction database

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MINTi
Q9H1K1

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000310623

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1167
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H1K1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H1K1

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NifU family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3361 Eukaryota
COG0822 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000015813

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000069228

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG052621

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H1K1

KEGG Orthology (KO)

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KOi
K22068

Identification of Orthologs from Complete Genome Data

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OMAi
VGAPECG

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0RA2

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H1K1

TreeFam database of animal gene trees

More...
TreeFami
TF105422

Family and domain databases

Conserved Domains Database

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CDDi
cd06664 IscU_like, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011339 ISC_FeS_clus_asmbl_IscU
IPR002871 NIF_FeS_clus_asmbl_NifU_N

The PANTHER Classification System

More...
PANTHERi
PTHR10093 PTHR10093, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01592 NifU_N, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01999 iscU, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H1K1-1) [UniParc]FASTAAdd to basket
Also known as: ISCU2

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAGAFRLR RAASALLLRS PRLPARELSA PARLYHKKVV DHYENPRNVG
60 70 80 90 100
SLDKTSKNVG TGLVGAPACG DVMKLQIQVD EKGKIVDARF KTFGCGSAIA
110 120 130 140 150
SSSLATEWVK GKTVEEALTI KNTDIAKELC LPPVKLHCSM LAEDAIKAAL
160
ADYKLKQEPK KGEAEKK
Length:167
Mass (Da):17,999
Last modified:November 30, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0166D3EC9F1EEB47
GO
Isoform 2 (identifier: Q9H1K1-2) [UniParc]FASTAAdd to basket
Also known as: ISCU1

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MAAAGAFRLRRAASALLLRSPRLPARELSAPARLYHKK → MVLIDMSVDLSTQ

Show »
Length:142
Mass (Da):15,263
Checksum:iEE72CEDC86CD6FF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KQ30B3KQ30_HUMAN
Iron-sulfur cluster assembly enzyme...
ISCU
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DNC9B4DNC9_HUMAN
Iron-sulfur cluster assembly enzyme...
ISCU
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H5N2F5H5N2_HUMAN
Iron-sulfur cluster assembly enzyme...
ISCU
154Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H672F5H672_HUMAN
Iron-sulfur cluster assembly enzyme...
ISCU
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7F → G in AAG37428 (PubMed:11060020).Curated1
Sequence conflicti7F → G in AAH11906 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06072812A → VCombined sources2 PublicationsCorresponds to variant dbSNP:rs2287555EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0134921 – 38MAAAG…LYHKK → MVLIDMSVDLSTQ in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY009127 mRNA Translation: AAG37427.1
AY009128 mRNA Translation: AAG37428.1
AC008119 Genomic DNA No translation available.
BC011906 mRNA Translation: AAH11906.1
BC061903 mRNA Translation: AAH61903.1
U47101 mRNA Translation: AAC50885.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS44966.1 [Q9H1K1-1]
CCDS9118.1 [Q9H1K1-2]

NCBI Reference Sequences

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RefSeqi
NP_001306971.1, NM_001320042.1
NP_055116.1, NM_014301.4 [Q9H1K1-2]
NP_998760.1, NM_213595.3 [Q9H1K1-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.615131

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000311893; ENSP00000310623; ENSG00000136003 [Q9H1K1-1]
ENST00000392807; ENSP00000376554; ENSG00000136003 [Q9H1K1-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
23479

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:23479

UCSC genome browser

More...
UCSCi
uc001tnc.5 human [Q9H1K1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY009127 mRNA Translation: AAG37427.1
AY009128 mRNA Translation: AAG37428.1
AC008119 Genomic DNA No translation available.
BC011906 mRNA Translation: AAH11906.1
BC061903 mRNA Translation: AAH61903.1
U47101 mRNA Translation: AAC50885.1
CCDSiCCDS44966.1 [Q9H1K1-1]
CCDS9118.1 [Q9H1K1-2]
RefSeqiNP_001306971.1, NM_001320042.1
NP_055116.1, NM_014301.4 [Q9H1K1-2]
NP_998760.1, NM_213595.3 [Q9H1K1-1]
UniGeneiHs.615131

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5KZ5electron microscopy14.30a/b/c/d/e/f/g/h/i/j/k/l50-167[»]
5WKPX-ray3.15D/H38-167[»]
5WLWX-ray3.32D/H38-167[»]
ProteinModelPortaliQ9H1K1
SMRiQ9H1K1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117038, 20 interactors
DIPiDIP-39616N
IntActiQ9H1K1, 27 interactors
MINTiQ9H1K1
STRINGi9606.ENSP00000310623

PTM databases

iPTMnetiQ9H1K1
PhosphoSitePlusiQ9H1K1

Polymorphism and mutation databases

BioMutaiISCU
DMDMi313104118

Proteomic databases

EPDiQ9H1K1
MaxQBiQ9H1K1
PaxDbiQ9H1K1
PeptideAtlasiQ9H1K1
PRIDEiQ9H1K1
ProteomicsDBi80422
80423 [Q9H1K1-2]
TopDownProteomicsiQ9H1K1-1 [Q9H1K1-1]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
23479
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311893; ENSP00000310623; ENSG00000136003 [Q9H1K1-1]
ENST00000392807; ENSP00000376554; ENSG00000136003 [Q9H1K1-2]
GeneIDi23479
KEGGihsa:23479
UCSCiuc001tnc.5 human [Q9H1K1-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
23479
DisGeNETi23479
EuPathDBiHostDB:ENSG00000136003.15

GeneCards: human genes, protein and diseases

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GeneCardsi
ISCU
GeneReviewsiISCU
HGNCiHGNC:29882 ISCU
HPAiCAB006329
HPA038602
HPA057592
MalaCardsiISCU
MIMi255125 phenotype
611911 gene
neXtProtiNX_Q9H1K1
OpenTargetsiENSG00000136003
Orphaneti43115 Hereditary myopathy with lactic acidosis due to ISCU deficiency
PharmGKBiPA162392328

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3361 Eukaryota
COG0822 LUCA
GeneTreeiENSGT00390000015813
HOGENOMiHOG000069228
HOVERGENiHBG052621
InParanoidiQ9H1K1
KOiK22068
OMAiVGAPECG
OrthoDBiEOG091G0RA2
PhylomeDBiQ9H1K1
TreeFamiTF105422

Enzyme and pathway databases

ReactomeiR-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis
SIGNORiQ9H1K1

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ISCU human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ISCU

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
23479

Protein Ontology

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PROi
PR:Q9H1K1

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000136003 Expressed in 239 organ(s), highest expression level in heart
CleanExiHS_ISCU
ExpressionAtlasiQ9H1K1 baseline and differential
GenevisibleiQ9H1K1 HS

Family and domain databases

CDDicd06664 IscU_like, 1 hit
InterProiView protein in InterPro
IPR011339 ISC_FeS_clus_asmbl_IscU
IPR002871 NIF_FeS_clus_asmbl_NifU_N
PANTHERiPTHR10093 PTHR10093, 1 hit
PfamiView protein in Pfam
PF01592 NifU_N, 1 hit
TIGRFAMsiTIGR01999 iscU, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiISCU_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1K1
Secondary accession number(s): Q6P713, Q99617, Q9H1K2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: November 30, 2010
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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