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Entry version 152 (17 Jun 2020)
Sequence version 3 (07 Mar 2006)
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Protein

Activating signal cointegrator 1 complex subunit 2

Gene

ASCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ubiquitin binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-112126 ALKBH3 mediated reversal of alkylation damage

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Activating signal cointegrator 1 complex subunit 2
Alternative name(s):
ASC-1 complex subunit p1001 Publication
Trip4 complex subunit p1001 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ASCC2
Synonyms:ASC1P100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 22

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000100325.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24103 ASCC2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614216 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1I8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi478 – 479LL → AA: Loss of ubiquitin binding. 1 Publication2
Mutagenesisi506L → A: Loss of ubiquitin binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84164

Open Targets

More...
OpenTargetsi
ENSG00000100325

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134916940

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H1I8 Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ASCC2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
92090990

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646891 – 757Activating signal cointegrator 1 complex subunit 2Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei233PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei713PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H1I8

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H1I8

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H1I8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H1I8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H1I8

PeptideAtlas

More...
PeptideAtlasi
Q9H1I8

PRoteomics IDEntifications database

More...
PRIDEi
Q9H1I8

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
27212
80413 [Q9H1I8-1]
80414 [Q9H1I8-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H1I8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H1I8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000100325 Expressed in testis and 210 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H1I8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H1I8 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000100325 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:29144457, PubMed:29997253).

Interacts directly with ASCC3 (PubMed:29997253). The ASCC complex interacts with ALKBH3 (PubMed:29144457, PubMed:22055184).

Interacts (via CUE domain) with 'Lys-63'-linked polyubiquitin chains, but not with 'Lys-48'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347).

Interacts with CSRP1 (PubMed:26924529).

Interacts with PRPF8, a component of the spliceosome (PubMed:29144457).

Interacts with ZCCHC4 (PubMed:31799605).

6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123921, 68 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H1I8

Protein interaction database and analysis system

More...
IntActi
Q9H1I8, 60 interactors

Molecular INTeraction database

More...
MINTi
Q9H1I8

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000380877

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H1I8 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1757
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H1I8

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H1I8

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini467 – 510CUEPROSITE-ProRule annotationAdd BLAST44

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ASCC2 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4501 Eukaryota
ENOG410XSUE LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018806

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_012749_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H1I8

KEGG Orthology (KO)

More...
KOi
K18667

Identification of Orthologs from Complete Genome Data

More...
OMAi
ERCFVPY

Database of Orthologous Groups

More...
OrthoDBi
311659at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H1I8

TreeFam database of animal gene trees

More...
TreeFami
TF323459

Family and domain databases

Conserved Domains Database

More...
CDDi
cd14364 CUE_ASCC2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR041800 ASCC2_CUE
IPR003892 CUE
IPR009060 UBA-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02845 CUE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00546 CUE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934 SSF46934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51140 CUE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H1I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPALPLDQLQ ITHKDPKTGK LRTSPALHPE QKADRYFVLY KPPPKDNIPA
60 70 80 90 100
LVEEYLERAT FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLRYVPR
110 120 130 140 150
KFDEGVASAP EVVDMQKRLH RSVFLTFLRM STHKESKDHF ISPSAFGEIL
160 170 180 190 200
YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI GNIFTQQPSY YSDLDETLPT
210 220 230 240 250
ILQVFSNILQ HCGLQGDGAN TTPQKLEERG RLTPSDMPLL ELKDIVLYLC
260 270 280 290 300
DTCTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEAAIPEM ESAIKKRRLE
310 320 330 340 350
DSKLLGDLWQ RLSHSRKKLM EIFHIILNQI CLLPILESSC DNIQGFIEEF
360 370 380 390 400
LQIFSSLLQE KRFLRDYDAL FPVAEDISLL QQASSVLDET RTAYILQAVE
410 420 430 440 450
SAWEGVDRRK ATDAKDPSVI EEPNGEPNGV TVTAEAVSQA SSHPENSEEE
460 470 480 490 500
ECMGAAAAVG PAMCGVELDS LISQVKDLLP DLGEGFILAC LEYYHYDPEQ
510 520 530 540 550
VINNILEERL APTLSQLDRN LDREMKPDPT PLLTSRHNVF QNDEFDVFSR
560 570 580 590 600
DSVDLSRVHK GKSTRKEENT RSLLNDKRAV AAQRQRYEQY SVVVEEVPLQ
610 620 630 640 650
PGESLPYHSV YYEDEYDDTY DGNQVGANDA DSDDELISRR PFTIPQVLRT
660 670 680 690 700
KVPREGQEED DDDEEDDADE EAPKPDHFVQ DPAVLREKAE ARRMAFLAKK
710 720 730 740 750
GYRHDSSTAV AGSPRGHGQS RETTQERRKK EANKATRANH NRRTMADRKR

SKGMIPS
Length:757
Mass (Da):86,360
Last modified:March 7, 2006 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB1DCE21E3068E64
GO
Isoform 2 (identifier: Q9H1I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     483-484: GE → EK
     485-757: Missing.

Show »
Length:370
Mass (Da):41,794
Checksum:iA89920B986C9E9B7
GO
Isoform 3 (identifier: Q9H1I8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.
     137-159: Missing.

Show »
Length:681
Mass (Da):77,369
Checksum:iB2D69EB5D82C311E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AH59B1AH59_HUMAN
Activating signal cointegrator 1 co...
ASCC2
240Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAQ6F8WAQ6_HUMAN
Activating signal cointegrator 1 co...
ASCC2
78Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3Y4H7C3Y4_HUMAN
Activating signal cointegrator 1 co...
ASCC2
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C395H7C395_HUMAN
Activating signal cointegrator 1 co...
ASCC2
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2W4F2Z2W4_HUMAN
Activating signal cointegrator 1 co...
ASCC2
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB15089 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti344Q → H in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti526K → N in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti586R → C in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti639R → G in BAH13926 (PubMed:14702039).Curated1
Sequence conflicti645P → L in AAG45475 (PubMed:12077347).Curated1
Sequence conflicti653P → L in AAG45475 (PubMed:12077347).Curated1
Sequence conflicti661D → G in BAH13926 (PubMed:14702039).Curated1
Sequence conflicti744T → I in BAH13926 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05067596R → C. Corresponds to variant dbSNP:rs1894473Ensembl.1
Natural variantiVAR_050676123V → I. Corresponds to variant dbSNP:rs11549795Ensembl.1
Natural variantiVAR_025512407D → H. Corresponds to variant dbSNP:rs28265Ensembl.1
Natural variantiVAR_025513423P → S. Corresponds to variant dbSNP:rs36571Ensembl.1
Natural variantiVAR_019464509R → Q1 PublicationCorresponds to variant dbSNP:rs4823054Ensembl.1
Natural variantiVAR_050677546D → G. Corresponds to variant dbSNP:rs34833047Ensembl.1
Natural variantiVAR_050678588E → K. Corresponds to variant dbSNP:rs34062345Ensembl.1
Natural variantiVAR_025514639R → L. Corresponds to variant dbSNP:rs6006259Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0110091 – 114Missing in isoform 2. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_04587828 – 80Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_045879137 – 159Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_011010483 – 484GE → EK in isoform 2. 1 Publication2
Alternative sequenceiVSP_011011485 – 757Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY013289 mRNA Translation: AAG45475.1
AK022886 mRNA Translation: BAB14293.1
AK025241 mRNA Translation: BAB15089.1 Different initiation.
AK303257 mRNA Translation: BAH13926.1
AC004882 Genomic DNA No translation available.
Z82171 Genomic DNA No translation available.
BC025368 mRNA Translation: AAH25368.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13869.1 [Q9H1I8-1]
CCDS56226.1 [Q9H1I8-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001229835.1, NM_001242906.1 [Q9H1I8-3]
NP_115580.2, NM_032204.4 [Q9H1I8-1]
XP_005261832.1, XM_005261775.2
XP_016884487.1, XM_017028998.1 [Q9H1I8-1]
XP_016884488.1, XM_017028999.1
XP_016884489.1, XM_017029000.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000307790; ENSP00000305502; ENSG00000100325 [Q9H1I8-1]
ENST00000397771; ENSP00000380877; ENSG00000100325 [Q9H1I8-1]
ENST00000542393; ENSP00000437570; ENSG00000100325 [Q9H1I8-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84164

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84164

UCSC genome browser

More...
UCSCi
uc003agr.4 human [Q9H1I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013289 mRNA Translation: AAG45475.1
AK022886 mRNA Translation: BAB14293.1
AK025241 mRNA Translation: BAB15089.1 Different initiation.
AK303257 mRNA Translation: BAH13926.1
AC004882 Genomic DNA No translation available.
Z82171 Genomic DNA No translation available.
BC025368 mRNA Translation: AAH25368.1
CCDSiCCDS13869.1 [Q9H1I8-1]
CCDS56226.1 [Q9H1I8-3]
RefSeqiNP_001229835.1, NM_001242906.1 [Q9H1I8-3]
NP_115580.2, NM_032204.4 [Q9H1I8-1]
XP_005261832.1, XM_005261775.2
XP_016884487.1, XM_017028998.1 [Q9H1I8-1]
XP_016884488.1, XM_017028999.1
XP_016884489.1, XM_017029000.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DI0NMR-A463-526[»]
SMRiQ9H1I8
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123921, 68 interactors
CORUMiQ9H1I8
IntActiQ9H1I8, 60 interactors
MINTiQ9H1I8
STRINGi9606.ENSP00000380877

PTM databases

iPTMnetiQ9H1I8
PhosphoSitePlusiQ9H1I8

Polymorphism and mutation databases

BioMutaiASCC2
DMDMi92090990

Proteomic databases

EPDiQ9H1I8
jPOSTiQ9H1I8
MassIVEiQ9H1I8
MaxQBiQ9H1I8
PaxDbiQ9H1I8
PeptideAtlasiQ9H1I8
PRIDEiQ9H1I8
ProteomicsDBi27212
80413 [Q9H1I8-1]
80414 [Q9H1I8-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
224 160 antibodies

Genome annotation databases

EnsembliENST00000307790; ENSP00000305502; ENSG00000100325 [Q9H1I8-1]
ENST00000397771; ENSP00000380877; ENSG00000100325 [Q9H1I8-1]
ENST00000542393; ENSP00000437570; ENSG00000100325 [Q9H1I8-3]
GeneIDi84164
KEGGihsa:84164
UCSCiuc003agr.4 human [Q9H1I8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84164
DisGeNETi84164
EuPathDBiHostDB:ENSG00000100325.14

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ASCC2
HGNCiHGNC:24103 ASCC2
HPAiENSG00000100325 Low tissue specificity
MIMi614216 gene
neXtProtiNX_Q9H1I8
OpenTargetsiENSG00000100325
PharmGKBiPA134916940

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4501 Eukaryota
ENOG410XSUE LUCA
GeneTreeiENSGT00390000018806
HOGENOMiCLU_012749_0_0_1
InParanoidiQ9H1I8
KOiK18667
OMAiERCFVPY
OrthoDBi311659at2759
PhylomeDBiQ9H1I8
TreeFamiTF323459

Enzyme and pathway databases

ReactomeiR-HSA-112126 ALKBH3 mediated reversal of alkylation damage

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84164 6 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ASCC2 human
EvolutionaryTraceiQ9H1I8

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
ASCC2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84164
PharosiQ9H1I8 Tdark

Protein Ontology

More...
PROi
PR:Q9H1I8
RNActiQ9H1I8 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000100325 Expressed in testis and 210 other tissues
ExpressionAtlasiQ9H1I8 baseline and differential
GenevisibleiQ9H1I8 HS

Family and domain databases

CDDicd14364 CUE_ASCC2, 1 hit
InterProiView protein in InterPro
IPR041800 ASCC2_CUE
IPR003892 CUE
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiASCC2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1I8
Secondary accession number(s): B7Z8E0
, F5H6J9, Q4TT54, Q8TAZ0, Q9H711, Q9H9D6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 7, 2006
Last modified: June 17, 2020
This is version 152 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
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