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Protein

Activating signal cointegrator 1 complex subunit 2

Gene

ASCC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347).2 Publications

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-112126 ALKBH3 mediated reversal of alkylation damage

Names & Taxonomyi

Protein namesi
Recommended name:
Activating signal cointegrator 1 complex subunit 2
Alternative name(s):
ASC-1 complex subunit p1001 Publication
Trip4 complex subunit p1001 Publication
Gene namesi
Name:ASCC2
Synonyms:ASC1P100
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100325.14
HGNCiHGNC:24103 ASCC2
MIMi614216 gene
neXtProtiNX_Q9H1I8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi478 – 479LL → AA: Loss of ubiquitin binding. 1 Publication2
Mutagenesisi506L → A: Loss of ubiquitin binding. 1 Publication1

Organism-specific databases

DisGeNETi84164
OpenTargetsiENSG00000100325
PharmGKBiPA134916940

Polymorphism and mutation databases

BioMutaiASCC2
DMDMi92090990

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000646891 – 757Activating signal cointegrator 1 complex subunit 2Add BLAST757

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei233PhosphothreonineCombined sources1
Modified residuei447PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei713PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H1I8
MaxQBiQ9H1I8
PaxDbiQ9H1I8
PeptideAtlasiQ9H1I8
PRIDEiQ9H1I8
ProteomicsDBi80413
80414 [Q9H1I8-2]

PTM databases

iPTMnetiQ9H1I8
PhosphoSitePlusiQ9H1I8

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000100325 Expressed in 211 organ(s), highest expression level in testis
CleanExiHS_ASCC2
ExpressionAtlasiQ9H1I8 baseline and differential
GenevisibleiQ9H1I8 HS

Organism-specific databases

HPAiHPA001439
HPA052879

Interactioni

Subunit structurei

Identified in the ASCC complex that contains ASCC1, ASCC2 and ASCC3 (PubMed:29144457, PubMed:29997253). Interacts directly with ASCC3 (PubMed:29997253). The ASCC complex interacts with ALKBH3 (PubMed:29144457, PubMed:22055184). Interacts (via CUE domain) with 'Lys-63'-linked polyubiquitin chains, but not with 'Lys-48'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex, that contains TRIP4, ASCC1, ASCC2 and ASCC3 (PubMed:12077347). Interacts with CSRP1 (PubMed:26924529). Interacts with PRPF8, a component of the spliceosome (PubMed:29144457).5 Publications

Protein-protein interaction databases

BioGridi123921, 62 interactors
CORUMiQ9H1I8
IntActiQ9H1I8, 53 interactors
MINTiQ9H1I8
STRINGi9606.ENSP00000305502

Structurei

Secondary structure

1757
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H1I8
SMRiQ9H1I8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H1I8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini467 – 510CUEPROSITE-ProRule annotationAdd BLAST44

Sequence similaritiesi

Belongs to the ASCC2 family.Curated

Phylogenomic databases

eggNOGiKOG4501 Eukaryota
ENOG410XSUE LUCA
GeneTreeiENSGT00390000018806
HOGENOMiHOG000234347
HOVERGENiHBG050589
InParanoidiQ9H1I8
KOiK18667
OMAiHMQGLTG
OrthoDBiEOG091G06RW
PhylomeDBiQ9H1I8
TreeFamiTF323459

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H1I8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPALPLDQLQ ITHKDPKTGK LRTSPALHPE QKADRYFVLY KPPPKDNIPA
60 70 80 90 100
LVEEYLERAT FVANDLDWLL ALPHDKFWCQ VIFDETLQKC LDSYLRYVPR
110 120 130 140 150
KFDEGVASAP EVVDMQKRLH RSVFLTFLRM STHKESKDHF ISPSAFGEIL
160 170 180 190 200
YNNFLFDIPK ILDLCVLFGK GNSPLLQKMI GNIFTQQPSY YSDLDETLPT
210 220 230 240 250
ILQVFSNILQ HCGLQGDGAN TTPQKLEERG RLTPSDMPLL ELKDIVLYLC
260 270 280 290 300
DTCTTLWAFL DIFPLACQTF QKHDFCYRLA SFYEAAIPEM ESAIKKRRLE
310 320 330 340 350
DSKLLGDLWQ RLSHSRKKLM EIFHIILNQI CLLPILESSC DNIQGFIEEF
360 370 380 390 400
LQIFSSLLQE KRFLRDYDAL FPVAEDISLL QQASSVLDET RTAYILQAVE
410 420 430 440 450
SAWEGVDRRK ATDAKDPSVI EEPNGEPNGV TVTAEAVSQA SSHPENSEEE
460 470 480 490 500
ECMGAAAAVG PAMCGVELDS LISQVKDLLP DLGEGFILAC LEYYHYDPEQ
510 520 530 540 550
VINNILEERL APTLSQLDRN LDREMKPDPT PLLTSRHNVF QNDEFDVFSR
560 570 580 590 600
DSVDLSRVHK GKSTRKEENT RSLLNDKRAV AAQRQRYEQY SVVVEEVPLQ
610 620 630 640 650
PGESLPYHSV YYEDEYDDTY DGNQVGANDA DSDDELISRR PFTIPQVLRT
660 670 680 690 700
KVPREGQEED DDDEEDDADE EAPKPDHFVQ DPAVLREKAE ARRMAFLAKK
710 720 730 740 750
GYRHDSSTAV AGSPRGHGQS RETTQERRKK EANKATRANH NRRTMADRKR

SKGMIPS
Length:757
Mass (Da):86,360
Last modified:March 7, 2006 - v3
Checksum:iBB1DCE21E3068E64
GO
Isoform 2 (identifier: Q9H1I8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-114: Missing.
     483-484: GE → EK
     485-757: Missing.

Note: No experimental confirmation available.
Show »
Length:370
Mass (Da):41,794
Checksum:iA89920B986C9E9B7
GO
Isoform 3 (identifier: Q9H1I8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-80: Missing.
     137-159: Missing.

Note: No experimental confirmation available.
Show »
Length:681
Mass (Da):77,369
Checksum:iB2D69EB5D82C311E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AH59B1AH59_HUMAN
Activating signal cointegrator 1 co...
ASCC2
240Annotation score:
F8WAQ6F8WAQ6_HUMAN
Activating signal cointegrator 1 co...
ASCC2
78Annotation score:
H7C3Y4H7C3Y4_HUMAN
Activating signal cointegrator 1 co...
ASCC2
87Annotation score:
F2Z2W4F2Z2W4_HUMAN
Activating signal cointegrator 1 co...
ASCC2
37Annotation score:
H7C395H7C395_HUMAN
Activating signal cointegrator 1 co...
ASCC2
54Annotation score:

Sequence cautioni

The sequence BAB15089 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti344Q → H in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti526K → N in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti586R → C in BAB15089 (PubMed:14702039).Curated1
Sequence conflicti639R → G in BAH13926 (PubMed:14702039).Curated1
Sequence conflicti645P → L in AAG45475 (PubMed:12077347).Curated1
Sequence conflicti653P → L in AAG45475 (PubMed:12077347).Curated1
Sequence conflicti661D → G in BAH13926 (PubMed:14702039).Curated1
Sequence conflicti744T → I in BAH13926 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05067596R → C. Corresponds to variant dbSNP:rs1894473Ensembl.1
Natural variantiVAR_050676123V → I. Corresponds to variant dbSNP:rs11549795Ensembl.1
Natural variantiVAR_025512407D → H. Corresponds to variant dbSNP:rs28265Ensembl.1
Natural variantiVAR_025513423P → S. Corresponds to variant dbSNP:rs36571Ensembl.1
Natural variantiVAR_019464509R → Q1 PublicationCorresponds to variant dbSNP:rs4823054Ensembl.1
Natural variantiVAR_050677546D → G. Corresponds to variant dbSNP:rs34833047Ensembl.1
Natural variantiVAR_050678588E → K. Corresponds to variant dbSNP:rs34062345Ensembl.1
Natural variantiVAR_025514639R → L. Corresponds to variant dbSNP:rs6006259Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0110091 – 114Missing in isoform 2. 1 PublicationAdd BLAST114
Alternative sequenceiVSP_04587828 – 80Missing in isoform 3. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_045879137 – 159Missing in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_011010483 – 484GE → EK in isoform 2. 1 Publication2
Alternative sequenceiVSP_011011485 – 757Missing in isoform 2. 1 PublicationAdd BLAST273

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013289 mRNA Translation: AAG45475.1
AK022886 mRNA Translation: BAB14293.1
AK025241 mRNA Translation: BAB15089.1 Different initiation.
AK303257 mRNA Translation: BAH13926.1
AC004882 Genomic DNA No translation available.
Z82171 Genomic DNA No translation available.
BC025368 mRNA Translation: AAH25368.1
CCDSiCCDS13869.1 [Q9H1I8-1]
CCDS56226.1 [Q9H1I8-3]
RefSeqiNP_001229835.1, NM_001242906.1 [Q9H1I8-3]
NP_115580.2, NM_032204.4 [Q9H1I8-1]
XP_005261832.1, XM_005261775.2 [Q9H1I8-1]
XP_016884487.1, XM_017028998.1 [Q9H1I8-1]
XP_016884488.1, XM_017028999.1 [Q9H1I8-1]
XP_016884489.1, XM_017029000.1 [Q9H1I8-1]
UniGeneiHs.731754

Genome annotation databases

EnsembliENST00000307790; ENSP00000305502; ENSG00000100325 [Q9H1I8-1]
ENST00000397771; ENSP00000380877; ENSG00000100325 [Q9H1I8-1]
ENST00000542393; ENSP00000437570; ENSG00000100325 [Q9H1I8-3]
GeneIDi84164
KEGGihsa:84164
UCSCiuc003agr.4 human [Q9H1I8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY013289 mRNA Translation: AAG45475.1
AK022886 mRNA Translation: BAB14293.1
AK025241 mRNA Translation: BAB15089.1 Different initiation.
AK303257 mRNA Translation: BAH13926.1
AC004882 Genomic DNA No translation available.
Z82171 Genomic DNA No translation available.
BC025368 mRNA Translation: AAH25368.1
CCDSiCCDS13869.1 [Q9H1I8-1]
CCDS56226.1 [Q9H1I8-3]
RefSeqiNP_001229835.1, NM_001242906.1 [Q9H1I8-3]
NP_115580.2, NM_032204.4 [Q9H1I8-1]
XP_005261832.1, XM_005261775.2 [Q9H1I8-1]
XP_016884487.1, XM_017028998.1 [Q9H1I8-1]
XP_016884488.1, XM_017028999.1 [Q9H1I8-1]
XP_016884489.1, XM_017029000.1 [Q9H1I8-1]
UniGeneiHs.731754

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DI0NMR-A463-526[»]
ProteinModelPortaliQ9H1I8
SMRiQ9H1I8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123921, 62 interactors
CORUMiQ9H1I8
IntActiQ9H1I8, 53 interactors
MINTiQ9H1I8
STRINGi9606.ENSP00000305502

PTM databases

iPTMnetiQ9H1I8
PhosphoSitePlusiQ9H1I8

Polymorphism and mutation databases

BioMutaiASCC2
DMDMi92090990

Proteomic databases

EPDiQ9H1I8
MaxQBiQ9H1I8
PaxDbiQ9H1I8
PeptideAtlasiQ9H1I8
PRIDEiQ9H1I8
ProteomicsDBi80413
80414 [Q9H1I8-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307790; ENSP00000305502; ENSG00000100325 [Q9H1I8-1]
ENST00000397771; ENSP00000380877; ENSG00000100325 [Q9H1I8-1]
ENST00000542393; ENSP00000437570; ENSG00000100325 [Q9H1I8-3]
GeneIDi84164
KEGGihsa:84164
UCSCiuc003agr.4 human [Q9H1I8-1]

Organism-specific databases

CTDi84164
DisGeNETi84164
EuPathDBiHostDB:ENSG00000100325.14
GeneCardsiASCC2
HGNCiHGNC:24103 ASCC2
HPAiHPA001439
HPA052879
MIMi614216 gene
neXtProtiNX_Q9H1I8
OpenTargetsiENSG00000100325
PharmGKBiPA134916940
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4501 Eukaryota
ENOG410XSUE LUCA
GeneTreeiENSGT00390000018806
HOGENOMiHOG000234347
HOVERGENiHBG050589
InParanoidiQ9H1I8
KOiK18667
OMAiHMQGLTG
OrthoDBiEOG091G06RW
PhylomeDBiQ9H1I8
TreeFamiTF323459

Enzyme and pathway databases

ReactomeiR-HSA-112126 ALKBH3 mediated reversal of alkylation damage

Miscellaneous databases

ChiTaRSiASCC2 human
EvolutionaryTraceiQ9H1I8
GeneWikiiASCC2
GenomeRNAii84164
PROiPR:Q9H1I8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100325 Expressed in 211 organ(s), highest expression level in testis
CleanExiHS_ASCC2
ExpressionAtlasiQ9H1I8 baseline and differential
GenevisibleiQ9H1I8 HS

Family and domain databases

InterProiView protein in InterPro
IPR003892 CUE
IPR009060 UBA-like_sf
PfamiView protein in Pfam
PF02845 CUE, 1 hit
SMARTiView protein in SMART
SM00546 CUE, 1 hit
SUPFAMiSSF46934 SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS51140 CUE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiASCC2_HUMAN
AccessioniPrimary (citable) accession number: Q9H1I8
Secondary accession number(s): B7Z8E0
, F5H6J9, Q4TT54, Q8TAZ0, Q9H711, Q9H9D6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: March 7, 2006
Last modified: November 7, 2018
This is version 140 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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