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UniProtKB - Q9H1H9 (KI13A_HUMAN)

Entry version 160 (11 Dec 2019)
Sequence version 2 (28 Nov 2006)
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Protein

Kinesin-like protein KIF13A

Gene

KIF13A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi102 – 109ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Protein transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Kinesin-like protein KIF13A
Alternative name(s):
Kinesin-like protein RBKIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KIF13A
Synonyms:RBKIN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000137177.18

Human Gene Nomenclature Database

More...HGNCi		HGNC:14566 KIF13A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		605433 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H1H9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane, Microtubule

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		63971

Open Targets

More...OpenTargetsi		ENSG00000137177

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30098

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H1H9 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		KIF13A

Domain mapping of disease mutations (DMDM)

More...DMDMi		118572662

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001254461 – 1805Kinesin-like protein KIF13AAdd BLAST1805

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei636PhosphoserineCombined sources1
Modified residuei1287PhosphoserineCombined sources1
Modified residuei1454PhosphoserineCombined sources1
Modified residuei1490PhosphoserineBy similarity1
Modified residuei1529PhosphoserineCombined sources1
Modified residuei1572PhosphoserineCombined sources1
Modified residuei1648PhosphoserineBy similarity1
Modified residuei1698PhosphoserineCombined sources1
Isoform 3 (identifier: Q9H1H9-3)
Modified residuei1481PhosphoserineCombined sources1
Isoform 4 (identifier: Q9H1H9-4)
Modified residuei1481PhosphoserineCombined sources1
Isoform 2 (identifier: Q9H1H9-2)
Modified residuei1494PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H1H9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H1H9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H1H9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H1H9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H1H9

PeptideAtlas

More...PeptideAtlasi		Q9H1H9

PRoteomics IDEntifications database

More...PRIDEi		Q9H1H9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		23911
80409 [Q9H1H9-1]
80410 [Q9H1H9-2]
80411 [Q9H1H9-3]
80412 [Q9H1H9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H1H9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H1H9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest levels in heart, brain and skeletal muscle.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed at very low level in most fetal tissues, but at higher levels in skeletal muscle and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137177 Expressed in 214 organ(s), highest expression level in tendon

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H1H9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H1H9 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA029253
HPA029254

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with AP2B1 (By similarity).

Interacts with ZFYVE26.

Interacts with AP1G1 and AP1G2.

By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
Q9NQM43EBI-1759129,EBI-10239299

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		122019, 15 interactors

Database of interacting proteins

More...DIPi		DIP-52276N

Protein interaction database and analysis system

More...IntActi		Q9H1H9, 12 interactors

Molecular INTeraction database

More...MINTi		Q9H1H9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000259711

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H1H9 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H1H9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 352Kinesin motorPROSITE-ProRule annotationAdd BLAST348
Domaini469 – 519FHAAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili359 – 436Sequence analysisAdd BLAST78
Coiled coili602 – 775Sequence analysisAdd BLAST174
Coiled coili1100 – 1138Sequence analysisAdd BLAST39
Coiled coili1518 – 1547Sequence analysisAdd BLAST30

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0245 Eukaryota
COG5059 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157508

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H1H9

KEGG Orthology (KO)

More...KOi		K17914

Database of Orthologous Groups

More...OrthoDBi		76316at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H1H9

TreeFam database of animal gene trees

More...TreeFami		TF105221

Family and domain databases

Conserved Domains Database

More...CDDi		cd00060 FHA, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.850.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000253 FHA_dom
IPR032923 KIF13A
IPR022164 Kinesin-like
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR24115 PTHR24115, 1 hit
PTHR24115:SF458 PTHR24115:SF458, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF12473 DUF3694, 1 hit
PF00498 FHA, 1 hit
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00380 KINESINHEAVY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00129 KISc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H1H9-1) [UniParc]FASTAAdd to basket
Also known as: RBKIN1

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDTKVKVAV RVRPMNRREL ELNTKCVVEM EGNQTVLHPP PSNTKQGERK 
        60         70         80         90        100
PPKVFAFDYC FWSMDESNTT KYAGQEVVFK CLGEGILEKA FQGYNACIFA 
       110        120        130        140        150
YGQTGSGKSF SMMGHAEQLG LIPRLCCALF KRISLEQNES QTFKVEVSYM 
       160        170        180        190        200
EIYNEKVRDL LDPKGSRQSL KVREHKVLGP YVDGLSQLAV TSFEDIESLM 
       210        220        230        240        250
SEGNKSRTVA ATNMNEESSR SHAVFNIIIT QTLYDLQSGN SGEKVSKVSL 
       260        270        280        290        300
VDLAGSERVS KTGAAGERLK EGSNINKSLT TLGLVISSLA DQAAGKGKSK 
       310        320        330        340        350
FVPYRDSVLT WLLKDNLGGN SQTSMIATIS PAADNYEETL STLRYADRAK 
       360        370        380        390        400
RIVNHAVVNE DPNAKVIREL REEVEKLREQ LSQAEAMKAP ELKEKLEESE 
       410        420        430        440        450
KLIKELTVTW EEKLRKTEEI AQERQRQLES MGISLEMSGI KVGDDKCYLV 
       460        470        480        490        500
NLNADPALNE LLVYYLKDHT RVGADTSQDI QLFGIGIQPQ HCEIDIASDG 
       510        520        530        540        550
DVTLTPKENA RSCVNGTLVC STTQLWHGDR ILWGNNHFFR INLPKRKRRD 
       560        570        580        590        600
WLKDFEKETG PPEHDLDAAS EASSEPDYNY EFAQMEVIMK TLNSNDPVQN 
       610        620        630        640        650
VVQVLEKQYL EEKRSALEEQ RLMYERELEQ LRQQLSPDRQ PQSSGPDRLA 
       660        670        680        690        700
YSSQTAQQKV TQWAEERDEL FRQSLAKLRE QLVKANTLVR EANFLAEEMS 
       710        720        730        740        750
KLTDYQVTLQ IPAANLSANR KRGAIVSEPA IQVRRKGKST QVWTIEKLEN 
       760        770        780        790        800
KLIDMRDLYQ EWKEKVPEAK RLYGKRGDPF YEAQENHNLI GVANVFLECL 
       810        820        830        840        850
FCDVKLQYAV PIISQQGEVA GRLHVEVMRV TGAVPERVVE DDSSENSSES 
       860        870        880        890        900
GSLEVVDSSG EIIHRVKKLT CRVKIKEATG LPLNLSNFVF CQYTFWDQCE 
       910        920        930        940        950
STVAAPVVDP EVPSPQSKDA QYTVTFSHCK DYVVNVTEEF LEFISDGALA 
       960        970        980        990       1000
IEVWGHRCAG NGSSIWEVDS LHAKTRTLHD RWNEVTRRIE MWISILELNE 
      1010       1020       1030       1040       1050
LGEYAAVELH QAKDVNTGGI FQLRQGHSRR VQVTVKPVQH SGTLPLMVEA 
      1060       1070       1080       1090       1100
ILSVSIGCVT ARSTKLQRGL DSYQRDDEDG DDMDSYQEED LNCVRERWSD 
      1110       1120       1130       1140       1150
ALIKRREYLD EQIKKVSNKT EKTEDDVERE AQLVEQWVGL TEERNAVLVP 
      1160       1170       1180       1190       1200
APGSGIPGAP ADWIPPPGME THIPVLFLDL NADDLSANEQ LVGPHASGVN 
      1210       1220       1230       1240       1250
SILPKEHGSQ FFYLPIIKHS DDEVSATASW DSSVHDSVHL NRVTPQNERI 
      1260       1270       1280       1290       1300
YLIVKTTVQL SHPAAMELVL RKRIAANIYN KQSFTQSLKR RISLKNIFYS 
      1310       1320       1330       1340       1350
CGVTYEIVSN IPKATEEIED RETLALLAAR SENEGTSDGE TYIEKYTRGV 
      1360       1370       1380       1390       1400
LQVENILSLE RLRQAVTVKE ALSTKARHIR RSLSTPNVHN VSSSRPDLSG 
      1410       1420       1430       1440       1450
FDEDDKGWPE NQLDMSDYSS SYQDVACYGT LPRDSPRRNK EGCTSETPHA 
      1460       1470       1480       1490       1500
LTVSPFKAFS PQPPKFFKPL MPVKEEHKKR IALEARPLLS QESMPPPQAH 
      1510       1520       1530       1540       1550
NPGCIVPSGS NGSSMPVEHN SKREKKIDSE EEENELEAIN RKLISSQPYV 
      1560       1570       1580       1590       1600
PVEFADFSVY NASLENREWF SSKVDLSNSR VLEKEVSRSP TTSSITSGYF 
      1610       1620       1630       1640       1650
SHSASNATLS DMVVPSSDSS DQLAIQTKDA DSTEHSTPSL VHDFRPSSNK 
      1660       1670       1680       1690       1700
ELTEVEKGLV KDKIIVVPLK ENSALAKGSP SSQSIPEKNS KSLCRTGSCS 
      1710       1720       1730       1740       1750
ELDACPSKIS QPARGFCPRE VTVEHTTNIL EDHSFTEFMG VSEGKDFDGL 
      1760       1770       1780       1790       1800
TDSSAGELSS RRSLPNKTGG KTVSDGLHHP SQLHSKLEND QVIIPEAAFW 

VLCCQ
Length:1,805
Mass (Da):202,308
Last modified:November 28, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E5A6C6941DC67CC
GO
Isoform 2 (identifier: Q9H1H9-2) [UniParc]FASTAAdd to basket
Also known as: RBKIN2

The sequence of this isoform differs from the canonical sequence as follows:
     1493-1527: Missing.

Show »
Length:1,770
Mass (Da):198,627
Checksum:i8117B6828ABF7193
GO
Isoform 3 (identifier: Q9H1H9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1083: Missing.
     1493-1527: Missing.
     1792-1797: VIIPEA → GGTTSR
     1798-1805: Missing.

Show »
Length:1,749
Mass (Da):196,070
Checksum:iF4C1C2E8435D578D
GO
Isoform 4 (identifier: Q9H1H9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1071-1083: Missing.
     1493-1527: Missing.

Show »
Length:1,757
Mass (Da):197,085
Checksum:i92277256F8DDEF0F
GO
Isoform 5 (identifier: Q9H1H9-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     50-70: KPPKVFAFDYCFWSMDESNTT → LVTVAHISNSSTLGGQGKRIT
     71-1805: Missing.

Show »
Length:70
Mass (Da):7,726
Checksum:iA5457B8ACF8B75EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GUA8A0A1B0GUA8_HUMAN
Kinesin-like protein KIF13A
KIF13A
1,845Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y307H0Y307_HUMAN
Kinesin-like protein KIF13A
KIF13A
889Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y9Z7H0Y9Z7_HUMAN
Kinesin-like protein KIF13A
KIF13A
801Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y925H0Y925_HUMAN
Kinesin-like protein KIF13A
KIF13A
270Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti674S → G in AAG38890 (PubMed:11861365).Curated1
Sequence conflicti674S → G in AAG38891 (PubMed:11861365).Curated1
Sequence conflicti925T → A in AAG38890 (PubMed:11861365).Curated1
Sequence conflicti925T → A in AAG38891 (PubMed:11861365).Curated1
Sequence conflicti1185L → P in AAG38890 (PubMed:11861365).Curated1
Sequence conflicti1185L → P in AAG38891 (PubMed:11861365).Curated1
Sequence conflicti1521S → N in AAG38890 (PubMed:11861365).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0293891415M → V. Corresponds to variant dbSNP:rs17689215Ensembl.1
Natural variantiVAR_0496991600F → S. Corresponds to variant dbSNP:rs12211658Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04558450 – 70KPPKV…ESNTT → LVTVAHISNSSTLGGQGKRI T in isoform 5. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_04558571 – 1805Missing in isoform 5. 1 PublicationAdd BLAST1735
Alternative sequenceiVSP_0217241071 – 1083Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST13
Alternative sequenceiVSP_0028701493 – 1527Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST35
Alternative sequenceiVSP_0217251792 – 1797VIIPEA → GGTTSR in isoform 3. 1 Publication6
Alternative sequenceiVSP_0217261798 – 1805Missing in isoform 3. 1 Publication8

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AJ291578 mRNA Translation: CAC20442.1
AJ291579 mRNA Translation: CAC20443.1
AY014403 mRNA Translation: AAG38890.1
AY014404 mRNA Translation: AAG38891.1
AL023807 Genomic DNA No translation available.
AL138724 Genomic DNA No translation available.
BC062673 mRNA No translation available.
BC127115 mRNA Translation: AAI27116.1
BC127116 mRNA Translation: AAI27117.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS47380.1 [Q9H1H9-3]
CCDS47381.1 [Q9H1H9-1]
CCDS54967.1 [Q9H1H9-4]
CCDS54968.1 [Q9H1H9-2]
CCDS58998.1 [Q9H1H9-5]

NCBI Reference Sequences

More...RefSeqi		NP_001099036.1, NM_001105566.2 [Q9H1H9-2]
NP_001099037.1, NM_001105567.2 [Q9H1H9-4]
NP_001099038.1, NM_001105568.2 [Q9H1H9-3]
NP_001230352.1, NM_001243423.1 [Q9H1H9-5]
NP_071396.4, NM_022113.5 [Q9H1H9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259711; ENSP00000259711; ENSG00000137177 [Q9H1H9-1]
ENST00000378814; ENSP00000368091; ENSG00000137177 [Q9H1H9-3]
ENST00000378826; ENSP00000368103; ENSG00000137177 [Q9H1H9-2]
ENST00000378843; ENSP00000368120; ENSG00000137177 [Q9H1H9-4]
ENST00000502704; ENSP00000425453; ENSG00000137177 [Q9H1H9-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		63971

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:63971

UCSC genome browser

More...UCSCi		uc003ncf.4 human [Q9H1H9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ291578 mRNA Translation: CAC20442.1
AJ291579 mRNA Translation: CAC20443.1
AY014403 mRNA Translation: AAG38890.1
AY014404 mRNA Translation: AAG38891.1
AL023807 Genomic DNA No translation available.
AL138724 Genomic DNA No translation available.
BC062673 mRNA No translation available.
BC127115 mRNA Translation: AAI27116.1
BC127116 mRNA Translation: AAI27117.1
CCDSiCCDS47380.1 [Q9H1H9-3]
CCDS47381.1 [Q9H1H9-1]
CCDS54967.1 [Q9H1H9-4]
CCDS54968.1 [Q9H1H9-2]
CCDS58998.1 [Q9H1H9-5]
RefSeqiNP_001099036.1, NM_001105566.2 [Q9H1H9-2]
NP_001099037.1, NM_001105567.2 [Q9H1H9-4]
NP_001099038.1, NM_001105568.2 [Q9H1H9-3]
NP_001230352.1, NM_001243423.1 [Q9H1H9-5]
NP_071396.4, NM_022113.5 [Q9H1H9-1]

3D structure databases

SMRiQ9H1H9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi122019, 15 interactors
DIPiDIP-52276N
IntActiQ9H1H9, 12 interactors
MINTiQ9H1H9
STRINGi9606.ENSP00000259711

PTM databases

iPTMnetiQ9H1H9
PhosphoSitePlusiQ9H1H9

Polymorphism and mutation databases

BioMutaiKIF13A
DMDMi118572662

Proteomic databases

EPDiQ9H1H9
jPOSTiQ9H1H9
MassIVEiQ9H1H9
MaxQBiQ9H1H9
PaxDbiQ9H1H9
PeptideAtlasiQ9H1H9
PRIDEiQ9H1H9
ProteomicsDBi23911
80409 [Q9H1H9-1]
80410 [Q9H1H9-2]
80411 [Q9H1H9-3]
80412 [Q9H1H9-4]

Genome annotation databases

EnsembliENST00000259711; ENSP00000259711; ENSG00000137177 [Q9H1H9-1]
ENST00000378814; ENSP00000368091; ENSG00000137177 [Q9H1H9-3]
ENST00000378826; ENSP00000368103; ENSG00000137177 [Q9H1H9-2]
ENST00000378843; ENSP00000368120; ENSG00000137177 [Q9H1H9-4]
ENST00000502704; ENSP00000425453; ENSG00000137177 [Q9H1H9-5]
GeneIDi63971
KEGGihsa:63971
UCSCiuc003ncf.4 human [Q9H1H9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		63971
DisGeNETi63971
EuPathDBiHostDB:ENSG00000137177.18

GeneCards: human genes, protein and diseases

More...GeneCardsi		KIF13A
HGNCiHGNC:14566 KIF13A
HPAiHPA029253
HPA029254
MIMi605433 gene
neXtProtiNX_Q9H1H9
OpenTargetsiENSG00000137177
PharmGKBiPA30098

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0245 Eukaryota
COG5059 LUCA
GeneTreeiENSGT00940000157508
InParanoidiQ9H1H9
KOiK17914
OrthoDBi76316at2759
PhylomeDBiQ9H1H9
TreeFamiTF105221

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		KIF13A human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		KIF13A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		63971
PharosiQ9H1H9 Tbio

Protein Ontology

More...PROi		PR:Q9H1H9
RNActiQ9H1H9 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137177 Expressed in 214 organ(s), highest expression level in tendon
ExpressionAtlasiQ9H1H9 baseline and differential
GenevisibleiQ9H1H9 HS

Family and domain databases

CDDicd00060 FHA, 1 hit
Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR000253 FHA_dom
IPR032923 KIF13A
IPR022164 Kinesin-like
IPR027640 Kinesin-like_fam
IPR022140 Kinesin-like_KIF1-typ
IPR032405 Kinesin_assoc
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
IPR008984 SMAD_FHA_dom_sf
PANTHERiPTHR24115 PTHR24115, 1 hit
PTHR24115:SF458 PTHR24115:SF458, 1 hit
PfamiView protein in Pfam
PF12473 DUF3694, 1 hit
PF00498 FHA, 1 hit
PF12423 KIF1B, 1 hit
PF00225 Kinesin, 1 hit
PF16183 Kinesin_assoc, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF49879 SSF49879, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiKI13A_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1H9
Secondary accession number(s): A0JP21
, A0JP22, F2Z382, Q5THQ2, Q5THQ3, Q9H193, Q9H194, Q9H1H8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2002
Last sequence update: November 28, 2006
Last modified: December 11, 2019
This is version 160 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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