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Protein

Thioredoxin-related transmembrane protein 4

Gene

TMX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin-related transmembrane protein 4
Alternative name(s):
Thioredoxin domain-containing protein 13
Gene namesi
Name:TMX4
Synonyms:KIAA1162, TXNDC13
ORF Names:PSEC0095, UNQ475/PRO938
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125827.8
HGNCiHGNC:25237 TMX4
neXtProtiNX_Q9H1E5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125827
PharmGKBiPA164726669

Polymorphism and mutation databases

BioMutaiTMX4
DMDMi30173124

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003419124 – 349Thioredoxin-related transmembrane protein 4Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi64 ↔ 67Redox-activePROSITE-ProRule annotation
Modified residuei251PhosphoserineCombined sources1
Modified residuei259PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

EPDiQ9H1E5
MaxQBiQ9H1E5
PaxDbiQ9H1E5
PeptideAtlasiQ9H1E5
PRIDEiQ9H1E5
ProteomicsDBi80406

PTM databases

GlyConnecti1802
iPTMnetiQ9H1E5
PhosphoSitePlusiQ9H1E5
SwissPalmiQ9H1E5

Expressioni

Gene expression databases

BgeeiENSG00000125827 Expressed in 236 organ(s), highest expression level in pituitary gland
CleanExiHS_TXNDC13
ExpressionAtlasiQ9H1E5 baseline and differential
GenevisibleiQ9H1E5 HS

Organism-specific databases

HPAiHPA000399
HPA015752

Interactioni

Protein-protein interaction databases

BioGridi121120, 31 interactors
IntActiQ9H1E5, 3 interactors
MINTiQ9H1E5
STRINGi9606.ENSP00000246024

Structurei

3D structure databases

ProteinModelPortaliQ9H1E5
SMRiQ9H1E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 137ThioredoxinPROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi224 – 334Glu-richAdd BLAST111

Keywords - Domaini

Redox-active center, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0913 Eukaryota
ENOG4111H66 LUCA
GeneTreeiENSGT00390000011580
HOGENOMiHOG000045750
InParanoidiQ9H1E5
OMAiQHADKGP
OrthoDBiEOG091G0MRE
PhylomeDBiQ9H1E5
TreeFamiTF106376

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H1E5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGGRCGPQL TALLAAWIAA VAATAGPEEA ALPPEQSRVQ PMTASNWTLV
60 70 80 90 100
MEGEWMLKFY APWCPSCQQT DSEWEAFAKN GEILQISVGK VDVIQEPGLS
110 120 130 140 150
GRFFVTTLPA FFHAKDGIFR RYRGPGIFED LQNYILEKKW QSVEPLTGWK
160 170 180 190 200
SPASLTMSGM AGLFSISGKI WHLHNYFTVT LGIPAWCSYV FFVIATLVFG
210 220 230 240 250
LFMGLVLVVI SECFYVPLPR HLSERSEQNR RSEEAHRAEQ LQDAEEEKDD
260 270 280 290 300
SNEEENKDSL VDDEEEKEDL GDEDEAEEEE EEDNLAAGVD EERSEANDQG
310 320 330 340
PPGEDGVTRE EVEPEEAEEG ISEQPCPADT EVVEDSLRQR KSQHADKGL
Length:349
Mass (Da):38,952
Last modified:March 1, 2001 - v1
Checksum:iFE944AA2F44131F1
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PIN7E9PIN7_HUMAN
Thioredoxin-related transmembrane p...
TMX4
198Annotation score:
E9PIU6E9PIU6_HUMAN
Thioredoxin-related transmembrane p...
TMX4
79Annotation score:

Sequence cautioni

The sequence CAB56344 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti289V → E in BAC11237 (PubMed:16303743).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052578215Y → C. Corresponds to variant dbSNP:rs1135711Ensembl.1
Natural variantiVAR_052579303G → R1 PublicationCorresponds to variant dbSNP:rs2076015Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359004 mRNA Translation: AAQ89363.1
AK074838 mRNA Translation: BAC11237.1
AK075404 mRNA Translation: BAC11599.1
AL021396 Genomic DNA No translation available.
BC033787 mRNA Translation: AAH33787.1
AL118494 mRNA Translation: CAB56344.1 Different initiation.
AB032988 mRNA Translation: BAA86476.1
CCDSiCCDS13101.1
RefSeqiNP_066979.2, NM_021156.3
UniGeneiHs.169358

Genome annotation databases

EnsembliENST00000246024; ENSP00000246024; ENSG00000125827
GeneIDi56255
KEGGihsa:56255
UCSCiuc002wmx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY359004 mRNA Translation: AAQ89363.1
AK074838 mRNA Translation: BAC11237.1
AK075404 mRNA Translation: BAC11599.1
AL021396 Genomic DNA No translation available.
BC033787 mRNA Translation: AAH33787.1
AL118494 mRNA Translation: CAB56344.1 Different initiation.
AB032988 mRNA Translation: BAA86476.1
CCDSiCCDS13101.1
RefSeqiNP_066979.2, NM_021156.3
UniGeneiHs.169358

3D structure databases

ProteinModelPortaliQ9H1E5
SMRiQ9H1E5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121120, 31 interactors
IntActiQ9H1E5, 3 interactors
MINTiQ9H1E5
STRINGi9606.ENSP00000246024

PTM databases

GlyConnecti1802
iPTMnetiQ9H1E5
PhosphoSitePlusiQ9H1E5
SwissPalmiQ9H1E5

Polymorphism and mutation databases

BioMutaiTMX4
DMDMi30173124

Proteomic databases

EPDiQ9H1E5
MaxQBiQ9H1E5
PaxDbiQ9H1E5
PeptideAtlasiQ9H1E5
PRIDEiQ9H1E5
ProteomicsDBi80406

Protocols and materials databases

DNASUi56255
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246024; ENSP00000246024; ENSG00000125827
GeneIDi56255
KEGGihsa:56255
UCSCiuc002wmx.2 human

Organism-specific databases

CTDi56255
EuPathDBiHostDB:ENSG00000125827.8
GeneCardsiTMX4
H-InvDBiHIX0174699
HGNCiHGNC:25237 TMX4
HPAiHPA000399
HPA015752
neXtProtiNX_Q9H1E5
OpenTargetsiENSG00000125827
PharmGKBiPA164726669
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0913 Eukaryota
ENOG4111H66 LUCA
GeneTreeiENSGT00390000011580
HOGENOMiHOG000045750
InParanoidiQ9H1E5
OMAiQHADKGP
OrthoDBiEOG091G0MRE
PhylomeDBiQ9H1E5
TreeFamiTF106376

Miscellaneous databases

ChiTaRSiTMX4 human
GeneWikiiTMX4
GenomeRNAii56255
PROiPR:Q9H1E5

Gene expression databases

BgeeiENSG00000125827 Expressed in 236 organ(s), highest expression level in pituitary gland
CleanExiHS_TXNDC13
ExpressionAtlasiQ9H1E5 baseline and differential
GenevisibleiQ9H1E5 HS

Family and domain databases

InterProiView protein in InterPro
IPR036249 Thioredoxin-like_sf
IPR017937 Thioredoxin_CS
IPR013766 Thioredoxin_domain
PfamiView protein in Pfam
PF00085 Thioredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS00194 THIOREDOXIN_1, 1 hit
PS51352 THIOREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTMX4_HUMAN
AccessioniPrimary (citable) accession number: Q9H1E5
Secondary accession number(s): Q8N4P7
, Q8NCC1, Q9UJA1, Q9ULQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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