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Entry version 153 (18 Sep 2019)
Sequence version 2 (18 May 2010)
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Protein

Ribonuclease 7

Gene

RNASE7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966). Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966). Causes loss of bacterial membrane integrity (PubMed:17150966). Probably contributes to urinary tract sterility (PubMed:25075772). Bactericidal activity is independent of RNase activity (PubMed:17150966).4 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.2 µM for tRNA1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei43Proton acceptor1 Publication1
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei66Critical for catalytic activity1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei91SubstrateBy similarity1
    Active sitei151Proton donor1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionAntibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-6803157 Antimicrobial peptides

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Ribonuclease 7 (EC:3.1.27.-3 Publications)
    Short name:
    RNase 7
    Alternative name(s):
    Skin-derived antimicrobial protein 2
    Short name:
    SAP-2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:RNASE7
    ORF Names:UNQ2516/PRO6006
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:19278 RNASE7

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    612484 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_Q9H1E1

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Keywords - Cellular componenti

    Secreted

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29 – 32Missing : Significant loss of bactericidal activity. No effect on catalytic activity. 1 Publication4
    Mutagenesisi29K → A: Slight loss of bactericidal activity. No effect on catalytic activity. 1 Publication1
    Mutagenesisi31K → A: Significant loss of bactericidal activity. No effect on catalytic activity. 1 Publication1
    Mutagenesisi43H → A: Loss of catalytic activity. No effect on bactericidal activity. 1 Publication1
    Mutagenesisi60 – 63KHTK → NHTQ: No significant effect on bactericidal activity or catalytic activity. 1 Publication4
    Mutagenesisi66K → A: Loss of catalytic activity. No effect on bactericidal activity. 1 Publication1
    Mutagenesisi124 – 128KRQNK → AAQNT: No significant effect on bactericidal activity or catalytic activity. 1 Publication5
    Mutagenesisi139 – 140KK → QQ: Moderate loss of bactericidal activity. No effect on catalytic activity. 1 Publication2
    Mutagenesisi151H → A: Loss of catalytic activity. No effect on bactericidal activity. 1 Publication1

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    84659

    Open Targets

    More...
    OpenTargetsi
    ENSG00000165799

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA134939592

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    Q9H1E1

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    RNASE7

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    296452879

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 281 PublicationAdd BLAST28
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003090129 – 156Ribonuclease 7Add BLAST128

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 109Combined sources1 Publication
    Disulfide bondi65 ↔ 119Combined sources1 Publication
    Disulfide bondi83 ↔ 134Combined sources1 Publication
    Disulfide bondi90 ↔ 97Combined sources1 Publication
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    Q9H1E1

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q9H1E1

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q9H1E1

    PeptideAtlas

    More...
    PeptideAtlasi
    Q9H1E1

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q9H1E1

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    80403

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q9H1E1

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q9H1E1

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) (PubMed:25075772). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut (PubMed:12244054). Expressed in liver, kidney, skeletal muscle and heart (PubMed:12527768).3 Publications

    <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

    Up-regulated in response to the cytokines IL1B, IFNG and TNF (PubMed:12244054). Strongly up-regulated in response to the bacterium P.aeruginosa (PubMed:12244054). Moderately up-regulated in response to S.aureus, E.coli and S.pyogenes (PubMed:12244054). Up-regulated in kidney in response to infection (PubMed:25075772).2 Publications

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000165799 Expressed in 53 organ(s), highest expression level in amniotic fluid

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q9H1E1 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB062560
    CAB068225
    HPA005690

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    124179, 23 interactors

    Protein interaction database and analysis system

    More...
    IntActi
    Q9H1E1, 21 interactors

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000298690

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    Secondary structure

    1156
    Legend: HelixTurnBeta strandPDB Structure known for this area
    Show more details

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q9H1E1

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    Protein Data Bank in Europe - Knowledge Base

    More...
    PDBe-KBi
    Search...

    Miscellaneous databases

    Relative evolutionary importance of amino acids within a protein sequence

    More...
    EvolutionaryTracei
    Q9H1E1

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 32Important for antibacterial activity1 Publication4
    Regioni66 – 70Substrate bindingBy similarity5
    Regioni139 – 140Important for antibacterial activity1 Publication2

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the pancreatic ribonuclease family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IXRT Eukaryota
    ENOG4111AZ3 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000164606

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000276882

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q9H1E1

    KEGG Orthology (KO)

    More...
    KOi
    K01172

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    IVACKPP

    Database of Orthologous Groups

    More...
    OrthoDBi
    1549558at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q9H1E1

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF333393

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.10.130.10, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001427 RNaseA
    IPR036816 RNaseA-like_dom_sf
    IPR023411 RNaseA_AS
    IPR023412 RNaseA_domain

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR11437 PTHR11437, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00074 RnaseA, 1 hit

    Protein Motif fingerprint database; a protein domain database

    More...
    PRINTSi
    PR00794 RIBONUCLEASE

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00092 RNAse_Pc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF54076 SSF54076, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00127 RNASE_PANCREATIC, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9H1E1-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MAPARAGFCP LLLLLLLGLW VAEIPVSAKP KGMTSSQWFK IQHMQPSPQA
    60 70 80 90 100
    CNSAMKNINK HTKRCKDLNT FLHEPFSSVA ATCQTPKIAC KNGDKNCHQS
    110 120 130 140 150
    HGAVSLTMCK LTSGKHPNCR YKEKRQNKSY VVACKPPQKK DSQQFHLVPV

    HLDRVL
    Length:156
    Mass (Da):17,419
    Last modified:May 18, 2010 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8659D3EECEF4054
    GO

    <p>This subsection of the ‘Sequence’ section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

    Molecular mass is 14546.06 Da from positions 29 - 156. Determined by ESI. 1 Publication

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024619103A → P4 PublicationsCorresponds to variant dbSNP:rs1263872Ensembl.1
    Natural variantiVAR_024620116H → Y4 PublicationsCorresponds to variant dbSNP:rs1243469Ensembl.1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AJ131212 mRNA Translation: CAC20410.1
    AJ306608 mRNA Translation: CAC84462.1
    AJ306609 mRNA Translation: CAC84457.1
    AJ306610 mRNA Translation: CAC84458.1
    AY170392 mRNA Translation: AAO12510.1
    AY359097 mRNA Translation: AAQ89455.1
    AL161668 Genomic DNA No translation available.
    BC074960 mRNA Translation: AAH74960.1
    BC112334 mRNA Translation: AAI12335.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS41914.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_115961.2, NM_032572.3

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000298690; ENSP00000298690; ENSG00000165799
    ENST00000481538; ENSP00000431382; ENSG00000165799

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    84659

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:84659

    UCSC genome browser

    More...
    UCSCi
    uc001vzk.4 human

    Keywords - Coding sequence diversityi

    Polymorphism

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AJ131212 mRNA Translation: CAC20410.1
    AJ306608 mRNA Translation: CAC84462.1
    AJ306609 mRNA Translation: CAC84457.1
    AJ306610 mRNA Translation: CAC84458.1
    AY170392 mRNA Translation: AAO12510.1
    AY359097 mRNA Translation: AAQ89455.1
    AL161668 Genomic DNA No translation available.
    BC074960 mRNA Translation: AAH74960.1
    BC112334 mRNA Translation: AAI12335.1
    CCDSiCCDS41914.1
    RefSeqiNP_115961.2, NM_032572.3

    3D structure databases

    Select the link destinations:

    Protein Data Bank Europe

    More...
    PDBei

    Protein Data Bank RCSB

    More...
    RCSB PDBi

    Protein Data Bank Japan

    More...
    PDBji
    Links Updated
    PDB entryMethodResolution (Å)ChainPositionsPDBsum
    2HKYNMR-A29-156[»]
    SMRiQ9H1E1
    ModBaseiSearch...
    PDBe-KBiSearch...

    Protein-protein interaction databases

    BioGridi124179, 23 interactors
    IntActiQ9H1E1, 21 interactors
    STRINGi9606.ENSP00000298690

    PTM databases

    iPTMnetiQ9H1E1
    PhosphoSitePlusiQ9H1E1

    Polymorphism and mutation databases

    BioMutaiRNASE7
    DMDMi296452879

    Proteomic databases

    MassIVEiQ9H1E1
    MaxQBiQ9H1E1
    PaxDbiQ9H1E1
    PeptideAtlasiQ9H1E1
    PRIDEiQ9H1E1
    ProteomicsDBi80403

    Genome annotation databases

    EnsembliENST00000298690; ENSP00000298690; ENSG00000165799
    ENST00000481538; ENSP00000431382; ENSG00000165799
    GeneIDi84659
    KEGGihsa:84659
    UCSCiuc001vzk.4 human

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    84659
    DisGeNETi84659

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    RNASE7
    HGNCiHGNC:19278 RNASE7
    HPAiCAB062560
    CAB068225
    HPA005690
    MIMi612484 gene
    neXtProtiNX_Q9H1E1
    OpenTargetsiENSG00000165799
    PharmGKBiPA134939592

    GenAtlas: human gene database

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    GenAtlasi
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    Phylogenomic databases

    eggNOGiENOG410IXRT Eukaryota
    ENOG4111AZ3 LUCA
    GeneTreeiENSGT00940000164606
    HOGENOMiHOG000276882
    InParanoidiQ9H1E1
    KOiK01172
    OMAiIVACKPP
    OrthoDBi1549558at2759
    PhylomeDBiQ9H1E1
    TreeFamiTF333393

    Enzyme and pathway databases

    ReactomeiR-HSA-6803157 Antimicrobial peptides

    Miscellaneous databases

    EvolutionaryTraceiQ9H1E1

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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    GenomeRNAii
    84659
    PharosiQ9H1E1

    Protein Ontology

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    PROi
    PR:Q9H1E1

    The Stanford Online Universal Resource for Clones and ESTs

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    SOURCEi
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    Gene expression databases

    BgeeiENSG00000165799 Expressed in 53 organ(s), highest expression level in amniotic fluid
    GenevisibleiQ9H1E1 HS

    Family and domain databases

    Gene3Di3.10.130.10, 1 hit
    InterProiView protein in InterPro
    IPR001427 RNaseA
    IPR036816 RNaseA-like_dom_sf
    IPR023411 RNaseA_AS
    IPR023412 RNaseA_domain
    PANTHERiPTHR11437 PTHR11437, 1 hit
    PfamiView protein in Pfam
    PF00074 RnaseA, 1 hit
    PRINTSiPR00794 RIBONUCLEASE
    SMARTiView protein in SMART
    SM00092 RNAse_Pc, 1 hit
    SUPFAMiSSF54076 SSF54076, 1 hit
    PROSITEiView protein in PROSITE
    PS00127 RNASE_PANCREATIC, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

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    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNAS7_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1E1
    Secondary accession number(s): P80927, P83685, Q546N3
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 19, 2001
    Last sequence update: May 18, 2010
    Last modified: September 18, 2019
    This is version 153 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    UniProt is an ELIXIR core data resource
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