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Entry version 164 (29 Sep 2021)
Sequence version 2 (18 May 2010)
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Protein

Ribonuclease 7

Gene

RNASE7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits a potent RNase activity (PubMed:12244054, PubMed:12527768, PubMed:17150966).

Has broad-spectrum antimicrobial activity against many pathogenic microorganisms and remarkably potent activity (lethal dose of 90% < 30 nM) against a vancomycin resistant Enterococcus faecium (PubMed:12244054, PubMed:12527768, PubMed:25075772, PubMed:17150966).

Causes loss of bacterial membrane integrity (PubMed:17150966).

Probably contributes to urinary tract sterility (PubMed:25075772).

Bactericidal activity is independent of RNase activity (PubMed:17150966).

4 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=2.2 µM for tRNA1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei43Proton acceptor1 Publication1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei66Critical for catalytic activity1 Publication1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei91SubstrateBy similarity1
Active sitei151Proton donor1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntibiotic, Antimicrobial, Endonuclease, Hydrolase, Nuclease

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H1E1

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6803157, Antimicrobial peptides

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ribonuclease 7 (EC:3.1.27.-3 Publications)
Short name:
RNase 7
Alternative name(s):
Skin-derived antimicrobial protein 2
Short name:
SAP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNASE7
ORF Names:UNQ2516/PRO6006
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19278, RNASE7

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612484, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1E1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000165799

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi29 – 32Missing : Significant loss of bactericidal activity. No effect on catalytic activity. 1 Publication4
Mutagenesisi29K → A: Slight loss of bactericidal activity. No effect on catalytic activity. 1 Publication1
Mutagenesisi31K → A: Significant loss of bactericidal activity. No effect on catalytic activity. 1 Publication1
Mutagenesisi43H → A: Loss of catalytic activity. No effect on bactericidal activity. 1 Publication1
Mutagenesisi60 – 63KHTK → NHTQ: No significant effect on bactericidal activity or catalytic activity. 1 Publication4
Mutagenesisi66K → A: Loss of catalytic activity. No effect on bactericidal activity. 1 Publication1
Mutagenesisi124 – 128KRQNK → AAQNT: No significant effect on bactericidal activity or catalytic activity. 1 Publication5
Mutagenesisi139 – 140KK → QQ: Moderate loss of bactericidal activity. No effect on catalytic activity. 1 Publication2
Mutagenesisi151H → A: Loss of catalytic activity. No effect on bactericidal activity. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84659

Open Targets

More...
OpenTargetsi
ENSG00000165799

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134939592

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H1E1, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
RNASE7

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296452879

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 281 PublicationAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003090129 – 156Ribonuclease 7Add BLAST128

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi51 ↔ 109Combined sources1 Publication
Disulfide bondi65 ↔ 119Combined sources1 Publication
Disulfide bondi83 ↔ 134Combined sources1 Publication
Disulfide bondi90 ↔ 97Combined sources1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H1E1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H1E1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H1E1

PeptideAtlas

More...
PeptideAtlasi
Q9H1E1

PRoteomics IDEntifications database

More...
PRIDEi
Q9H1E1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80403

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9H1E1, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H1E1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H1E1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in collecting ducts in kidney, and in apical uroepithelium in bladder (at protein level) (PubMed:25075772). Expressed in various epithelial tissues including skin, respiratory tract, genito-urinary tract and, at a low level, in the gut (PubMed:12244054). Expressed in liver, kidney, skeletal muscle and heart (PubMed:12527768).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated in response to the cytokines IL1B, IFNG and TNF (PubMed:12244054). Strongly up-regulated in response to the bacterium P.aeruginosa (PubMed:12244054). Moderately up-regulated in response to S.aureus, E.coli and S.pyogenes (PubMed:12244054). Up-regulated in kidney in response to infection (PubMed:25075772).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000165799, Expressed in amniotic fluid and 75 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H1E1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000165799, Tissue enhanced (esophagus, lymphoid tissue, tongue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
124179, 23 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H1E1, 21 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000298690

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H1E1, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1156
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q9H1E1

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H1E1

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H1E1

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 32Important for antibacterial activity1 Publication4
Regioni66 – 70Substrate bindingBy similarity5
Regioni139 – 140Important for antibacterial activity1 Publication2

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the pancreatic ribonuclease family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502TDZ3, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000164606

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_117006_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H1E1

Identification of Orthologs from Complete Genome Data

More...
OMAi
IVACKPP

Database of Orthologous Groups

More...
OrthoDBi
1549558at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H1E1

TreeFam database of animal gene trees

More...
TreeFami
TF333393

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.10.130.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001427, RNaseA
IPR036816, RNaseA-like_dom_sf
IPR023411, RNaseA_AS
IPR023412, RNaseA_domain

The PANTHER Classification System

More...
PANTHERi
PTHR11437, PTHR11437, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00074, RnaseA, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00794, RIBONUCLEASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00092, RNAse_Pc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54076, SSF54076, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00127, RNASE_PANCREATIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1E1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPARAGFCP LLLLLLLGLW VAEIPVSAKP KGMTSSQWFK IQHMQPSPQA
60 70 80 90 100
CNSAMKNINK HTKRCKDLNT FLHEPFSSVA ATCQTPKIAC KNGDKNCHQS
110 120 130 140 150
HGAVSLTMCK LTSGKHPNCR YKEKRQNKSY VVACKPPQKK DSQQFHLVPV

HLDRVL
Length:156
Mass (Da):17,419
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8659D3EECEF4054
GO

<p>This subsection of the 'Sequence' section reports information derived from mass spectrometry experiments done on the entire protein or on biologically active derived peptide(s).<p><a href='/help/mass_spectrometry' target='_top'>More...</a></p>Mass spectrometryi

Molecular mass is 14546.06 Da. Determined by ESI. 1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_024619103A → P4 PublicationsCorresponds to variant dbSNP:rs1263872Ensembl.1
Natural variantiVAR_024620116H → Y4 PublicationsCorresponds to variant dbSNP:rs1243469Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ131212 mRNA Translation: CAC20410.1
AJ306608 mRNA Translation: CAC84462.1
AJ306609 mRNA Translation: CAC84457.1
AJ306610 mRNA Translation: CAC84458.1
AY170392 mRNA Translation: AAO12510.1
AY359097 mRNA Translation: AAQ89455.1
AL161668 Genomic DNA No translation available.
BC074960 mRNA Translation: AAH74960.1
BC112334 mRNA Translation: AAI12335.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS41914.1

NCBI Reference Sequences

More...
RefSeqi
NP_115961.2, NM_032572.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000298690; ENSP00000298690; ENSG00000165799
ENST00000481538; ENSP00000431382; ENSG00000165799

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84659

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84659

UCSC genome browser

More...
UCSCi
uc001vzk.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131212 mRNA Translation: CAC20410.1
AJ306608 mRNA Translation: CAC84462.1
AJ306609 mRNA Translation: CAC84457.1
AJ306610 mRNA Translation: CAC84458.1
AY170392 mRNA Translation: AAO12510.1
AY359097 mRNA Translation: AAQ89455.1
AL161668 Genomic DNA No translation available.
BC074960 mRNA Translation: AAH74960.1
BC112334 mRNA Translation: AAI12335.1
CCDSiCCDS41914.1
RefSeqiNP_115961.2, NM_032572.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HKYNMR-A29-156[»]
BMRBiQ9H1E1
SMRiQ9H1E1
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi124179, 23 interactors
IntActiQ9H1E1, 21 interactors
STRINGi9606.ENSP00000298690

PTM databases

GlyGeniQ9H1E1, 1 site
iPTMnetiQ9H1E1
PhosphoSitePlusiQ9H1E1

Genetic variation databases

BioMutaiRNASE7
DMDMi296452879

Proteomic databases

MassIVEiQ9H1E1
MaxQBiQ9H1E1
PaxDbiQ9H1E1
PeptideAtlasiQ9H1E1
PRIDEiQ9H1E1
ProteomicsDBi80403

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
69, 68 antibodies

The DNASU plasmid repository

More...
DNASUi
84659

Genome annotation databases

EnsembliENST00000298690; ENSP00000298690; ENSG00000165799
ENST00000481538; ENSP00000431382; ENSG00000165799
GeneIDi84659
KEGGihsa:84659
UCSCiuc001vzk.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84659
DisGeNETi84659

GeneCards: human genes, protein and diseases

More...
GeneCardsi
RNASE7
HGNCiHGNC:19278, RNASE7
HPAiENSG00000165799, Tissue enhanced (esophagus, lymphoid tissue, tongue)
MIMi612484, gene
neXtProtiNX_Q9H1E1
OpenTargetsiENSG00000165799
PharmGKBiPA134939592
VEuPathDBiHostDB:ENSG00000165799

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502TDZ3, Eukaryota
GeneTreeiENSGT00940000164606
HOGENOMiCLU_117006_0_1_1
InParanoidiQ9H1E1
OMAiIVACKPP
OrthoDBi1549558at2759
PhylomeDBiQ9H1E1
TreeFamiTF333393

Enzyme and pathway databases

PathwayCommonsiQ9H1E1
ReactomeiR-HSA-6803157, Antimicrobial peptides

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84659, 5 hits in 1004 CRISPR screens
EvolutionaryTraceiQ9H1E1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84659
PharosiQ9H1E1, Tbio

Protein Ontology

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PROi
PR:Q9H1E1
RNActiQ9H1E1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000165799, Expressed in amniotic fluid and 75 other tissues
GenevisibleiQ9H1E1, HS

Family and domain databases

Gene3Di3.10.130.10, 1 hit
InterProiView protein in InterPro
IPR001427, RNaseA
IPR036816, RNaseA-like_dom_sf
IPR023411, RNaseA_AS
IPR023412, RNaseA_domain
PANTHERiPTHR11437, PTHR11437, 1 hit
PfamiView protein in Pfam
PF00074, RnaseA, 1 hit
PRINTSiPR00794, RIBONUCLEASE
SMARTiView protein in SMART
SM00092, RNAse_Pc, 1 hit
SUPFAMiSSF54076, SSF54076, 1 hit
PROSITEiView protein in PROSITE
PS00127, RNASE_PANCREATIC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNAS7_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1E1
Secondary accession number(s): P80927, P83685, Q546N3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 19, 2001
Last sequence update: May 18, 2010
Last modified: September 29, 2021
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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