Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9H1D9 (RPC6_HUMAN)

Entry version 177 (02 Dec 2020)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Add a publicationFeedback
Protein

DNA-directed RNA polymerase III subunit RPC6

Gene

POLR3F

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. Preferentially binds double-stranded DNA (dsDNA) (PubMed:21358628).3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processAntiviral defense, Immunity, Innate immunity, Transcription

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H1D9

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1834949, Cytosolic sensors of pathogen-associated DNA
R-HSA-73780, RNA Polymerase III Chain Elongation
R-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC6
Short name:
RNA polymerase III subunit C6
Alternative name(s):
DNA-directed RNA polymerase III subunit F
RNA polymerase III 39 kDa subunit
Short name:
RPC39
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:POLR3F
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000132664.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:15763, POLR3F

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617455, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H1D9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi137 – 140KAVK → EAVE: Strongly impaired dsDNA-binding. No effect on interaction with POLR3C. 1 Publication4
Mutagenesisi173 – 175ESE → KSK: Strongly impaired dsDNA-binding. No effect on interaction with POLR3C. 1 Publication3

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000132664

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA33520

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H1D9, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		POLR3F

Domain mapping of disease mutations (DMDM)

More...DMDMi		20139728

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000739722 – 316DNA-directed RNA polymerase III subunit RPC6Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki7Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H1D9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H1D9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H1D9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H1D9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H1D9

PeptideAtlas

More...PeptideAtlasi		Q9H1D9

PRoteomics IDEntifications database

More...PRIDEi		Q9H1D9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80402

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H1D9

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q9H1D9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H1D9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000132664, Expressed in cerebellar hemisphere and 189 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H1D9, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000132664, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits. RPC3/POLR3C, RPC6/POLR3F and RPC7/POLR3G form a Pol III subcomplex (By similarity). Directly interacts with POLR3C (PubMed:21358628).

Interacts with TBP and TFIIIB90 and GTF3C4 (By similarity) (PubMed:10523658).

Interacts with MAF1 (PubMed:18377933).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115866, 42 interactors

Database of interacting proteins

More...DIPi		DIP-34646N

Protein interaction database and analysis system

More...IntActi		Q9H1D9, 38 interactors

Molecular INTeraction database

More...MINTi		Q9H1D9

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H1D9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1316
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H1D9

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9H1D9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3233, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000009679

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_033661_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H1D9

Identification of Orthologs from Complete Genome Data

More...OMAi		CEYMRDW

Database of Orthologous Groups

More...OrthoDBi		1287786at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H1D9

TreeFam database of animal gene trees

More...TreeFami		TF103051

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007832, RNA_pol_Rpc34
IPR016049, RNA_pol_Rpc34-like
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR12780, PTHR12780, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05158, RNA_pol_Rpc34, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF028763, RNA_pol_Rpc34, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46785, SSF46785, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H1D9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEVKVKVQP PDADPVEIEN RIIELCHQFP HGITDQVIQN EMPHIEAQQR 
        60         70         80         90        100
AVAINRLLSM GQLDLLRSNT GLLYRIKDSQ NAGKMKGSDN QEKLVYQIIE 
       110        120        130        140        150
DAGNKGIWSR DIRYKSNLPL TEINKILKNL ESKKLIKAVK SVAASKKKVY 
       160        170        180        190        200
MLYNLQPDRS VTGGAWYSDQ DFESEFVEVL NQQCFKFLQS KAETARESKQ 
       210        220        230        240        250
NPMIQRNSSF ASSHEVWKYI CELGISKVEL SMEDIETILN TLIYDGKVEM 
       260        270        280        290        300
TIIAAKEGTV GSVDGHMKLY RAVNPIIPPT GLVRAPCGLC PVFDDCHEGG 
       310 
EISPSNCIYM TEWLEF
Length:316
Mass (Da):35,684
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i49B1360AF8B365ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → G in AAB63677 (PubMed:9171375).Curated1
Sequence conflicti44 – 53HIEAQQRAVA → QYRSPAAGSS in AAB63677 (PubMed:9171375).Curated10
Sequence conflicti255 – 290AKEGT…PCGLC → CKRRHSWQCRWTHETVQGSQ SNHPSHRFGPGHPVDSA in AAB63677 (PubMed:9171375).CuratedAdd BLAST36

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U93869 mRNA Translation: AAB63677.1
AK290892 mRNA Translation: BAF83581.1
AL121893 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10240.1
BC012588 mRNA Translation: AAH12588.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13135.1

NCBI Reference Sequences

More...RefSeqi		NP_001269455.1, NM_001282526.1
NP_006457.2, NM_006466.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377603; ENSP00000366828; ENSG00000132664

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10621

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10621

UCSC genome browser

More...UCSCi		uc002wqv.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U93869 mRNA Translation: AAB63677.1
AK290892 mRNA Translation: BAF83581.1
AL121893 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10240.1
BC012588 mRNA Translation: AAH12588.1
CCDSiCCDS13135.1
RefSeqiNP_001269455.1, NM_001282526.1
NP_006457.2, NM_006466.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DK5NMR-A78-155[»]
2YU3NMR-A61-142[»]
SMRiQ9H1D9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115866, 42 interactors
DIPiDIP-34646N
IntActiQ9H1D9, 38 interactors
MINTiQ9H1D9
STRINGi9606.ENSP00000366828

PTM databases

iPTMnetiQ9H1D9
MetOSiteiQ9H1D9
PhosphoSitePlusiQ9H1D9

Polymorphism and mutation databases

BioMutaiPOLR3F
DMDMi20139728

Proteomic databases

EPDiQ9H1D9
jPOSTiQ9H1D9
MassIVEiQ9H1D9
MaxQBiQ9H1D9
PaxDbiQ9H1D9
PeptideAtlasiQ9H1D9
PRIDEiQ9H1D9
ProteomicsDBi80402

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24572, 188 antibodies

The DNASU plasmid repository

More...DNASUi		10621

Genome annotation databases

EnsembliENST00000377603; ENSP00000366828; ENSG00000132664
GeneIDi10621
KEGGihsa:10621
UCSCiuc002wqv.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10621
EuPathDBiHostDB:ENSG00000132664.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		POLR3F
HGNCiHGNC:15763, POLR3F
HPAiENSG00000132664, Low tissue specificity
MIMi617455, gene
neXtProtiNX_Q9H1D9
OpenTargetsiENSG00000132664
PharmGKBiPA33520

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3233, Eukaryota
GeneTreeiENSGT00390000009679
HOGENOMiCLU_033661_1_0_1
InParanoidiQ9H1D9
OMAiCEYMRDW
OrthoDBi1287786at2759
PhylomeDBiQ9H1D9
TreeFamiTF103051

Enzyme and pathway databases

PathwayCommonsiQ9H1D9
ReactomeiR-HSA-1834949, Cytosolic sensors of pathogen-associated DNA
R-HSA-73780, RNA Polymerase III Chain Elongation
R-HSA-73980, RNA Polymerase III Transcription Termination
R-HSA-749476, RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061, RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066, RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071, RNA Polymerase III Transcription Initiation From Type 3 Promoter

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10621, 688 hits in 859 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		POLR3F, human
EvolutionaryTraceiQ9H1D9

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		POLR3F

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10621
PharosiQ9H1D9, Tbio

Protein Ontology

More...PROi		PR:Q9H1D9
RNActiQ9H1D9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000132664, Expressed in cerebellar hemisphere and 189 other tissues
GenevisibleiQ9H1D9, HS

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR007832, RNA_pol_Rpc34
IPR016049, RNA_pol_Rpc34-like
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
PANTHERiPTHR12780, PTHR12780, 1 hit
PfamiView protein in Pfam
PF05158, RNA_pol_Rpc34, 1 hit
PIRSFiPIRSF028763, RNA_pol_Rpc34, 1 hit
SUPFAMiSSF46785, SSF46785, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRPC6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1D9
Secondary accession number(s): A8K4C7, O15319
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: December 2, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again