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Protein

Lysophosphatidic acid receptor 5

Gene

LPAR5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors

Chemistry databases

SwissLipidsiSLP:000001578

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 5
Short name:
LPA receptor 5
Short name:
LPA-5
Alternative name(s):
G-protein coupled receptor 92
G-protein coupled receptor 93
Gene namesi
Name:LPAR5
Synonyms:GPR92, GPR93
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000184574.9
HGNCiHGNC:13307 LPAR5
MIMi606926 gene
neXtProtiNX_Q9H1C0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26ExtracellularSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini48 – 55CytoplasmicSequence analysis8
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 96ExtracellularSequence analysisAdd BLAST20
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 136CytoplasmicSequence analysisAdd BLAST19
Transmembranei137 – 157Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini158 – 187ExtracellularSequence analysisAdd BLAST30
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 239CytoplasmicSequence analysisAdd BLAST31
Transmembranei240 – 260Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini261 – 276ExtracellularSequence analysisAdd BLAST16
Transmembranei277 – 297Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini298 – 372CytoplasmicSequence analysisAdd BLAST75

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57121
OpenTargetsiENSG00000184574
PharmGKBiPA28935

Chemistry databases

ChEMBLiCHEMBL5700
GuidetoPHARMACOLOGYi124

Polymorphism and mutation databases

BioMutaiLPAR5
DMDMi48474954

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696001 – 372Lysophosphatidic acid receptor 5Add BLAST372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi9N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi94 ↔ 175PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H1C0
PeptideAtlasiQ9H1C0
PRIDEiQ9H1C0
ProteomicsDBi80396

PTM databases

iPTMnetiQ9H1C0
PhosphoSitePlusiQ9H1C0

Expressioni

Tissue specificityi

Not expressed in frontal cortex, basal forebrain, caudate putamen, thalamus, or hippocampus.

Gene expression databases

BgeeiENSG00000184574
CleanExiHS_LPAR5
ExpressionAtlasiQ9H1C0 baseline and differential
GenevisibleiQ9H1C0 HS

Organism-specific databases

HPAiHPA013170

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000327875

Chemistry databases

BindingDBiQ9H1C0

Structurei

3D structure databases

ProteinModelPortaliQ9H1C0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF9D Eukaryota
ENOG410XTCM LUCA
GeneTreeiENSGT00920000148939
HOGENOMiHOG000231307
HOVERGENiHBG103813
InParanoidiQ9H1C0
KOiK08390
OMAiPFPDLLC
OrthoDBiEOG091G091Z
PhylomeDBiQ9H1C0
TreeFamiTF350009

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H1C0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLANSSSTNS SVLPCPDYRP THRLHLVVYS LVLAAGLPLN ALALWVFLRA
60 70 80 90 100
LRVHSVVSVY MCNLAASDLL FTLSLPVRLS YYALHHWPFP DLLCQTTGAI
110 120 130 140 150
FQMNMYGSCI FLMLINVDRY AAIVHPLRLR HLRRPRVARL LCLGVWALIL
160 170 180 190 200
VFAVPAARVH RPSRCRYRDL EVRLCFESFS DELWKGRLLP LVLLAEALGF
210 220 230 240 250
LLPLAAVVYS SGRVFWTLAR PDATQSQRRR KTVRLLLANL VIFLLCFVPY
260 270 280 290 300
NSTLAVYGLL RSKLVAASVP ARDRVRGVLM VMVLLAGANC VLDPLVYYFS
310 320 330 340 350
AEGFRNTLRG LGTPHRARTS ATNGTRAALA QSERSAVTTD ATRPDAASQG
360 370
LLRPSDSHSL SSFTQCPQDS AL
Length:372
Mass (Da):41,347
Last modified:March 1, 2001 - v1
Checksum:iBA35709084BB6D84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ272207 mRNA Translation: CAC03715.1
AF411112 Genomic DNA Translation: AAL26483.1
AB083600 Genomic DNA Translation: BAB89313.1
BC033571 mRNA Translation: AAH33571.1
BC072394 mRNA Translation: AAH72394.1
CCDSiCCDS8553.1
RefSeqiNP_001136433.1, NM_001142961.1
NP_065133.1, NM_020400.5
UniGeneiHs.155538

Genome annotation databases

EnsembliENST00000329858; ENSP00000327875; ENSG00000184574
ENST00000431922; ENSP00000393098; ENSG00000184574
GeneIDi57121
KEGGihsa:57121
UCSCiuc001qps.3 human

Similar proteinsi

Entry informationi

Entry nameiLPAR5_HUMAN
AccessioniPrimary (citable) accession number: Q9H1C0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: March 1, 2001
Last modified: June 20, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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