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Protein

Interferon regulatory factor 2-binding protein-like

Gene

IRF2BPL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May contribute to the control of female reproductive function (By similarity). May play a role in gene transcription by transactivating GNRH1 promoter and repressing PENK promoter.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri715 – 762RING-type; degenerateAdd BLAST48

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Interferon regulatory factor 2-binding protein-like
Alternative name(s):
Enhanced at puberty protein 1
Gene namesi
Name:IRF2BPL
Synonyms:C14orf4, EAP1, KIAA1865
ORF Names:My039
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000119669.4
HGNCiHGNC:14282 IRF2BPL
MIMi611720 gene
neXtProtiNX_Q9H1B7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi715C → A: Loss of transcription activity. 1 Publication1

Organism-specific databases

DisGeNETi64207
OpenTargetsiENSG00000119669
PharmGKBiPA25516

Polymorphism and mutation databases

BioMutaiIRF2BPL
DMDMi34395562

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000564111 – 796Interferon regulatory factor 2-binding protein-likeAdd BLAST796

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei69PhosphoserineCombined sources1
Cross-linki79Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei215PhosphoserineCombined sources1
Modified residuei519PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei657PhosphoserineCombined sources1
Modified residuei658PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei662PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H1B7
MaxQBiQ9H1B7
PaxDbiQ9H1B7
PeptideAtlasiQ9H1B7
PRIDEiQ9H1B7
ProteomicsDBi80395

PTM databases

iPTMnetiQ9H1B7
PhosphoSitePlusiQ9H1B7

Miscellaneous databases

PMAP-CutDBiQ9H1B7

Expressioni

Tissue specificityi

Highly expressed in the heart, moderately in skeletal muscle and pancreas, and weakly in brain, kidney, liver, testis, thyroid gland and lymphocytes.1 Publication

Gene expression databases

BgeeiENSG00000119669 Expressed in 209 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_C14orf4
GenevisibleiQ9H1B7 HS

Organism-specific databases

HPAiHPA050862
HPA061333

Interactioni

Protein-protein interaction databases

BioGridi122101, 17 interactors
CORUMiQ9H1B7
IntActiQ9H1B7, 3 interactors
MINTiQ9H1B7
STRINGi9606.ENSP00000238647

Structurei

Secondary structure

1796
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H1B7
SMRiQ9H1B7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H1B7

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili85 – 132Sequence analysisAdd BLAST48
Coiled coili335 – 371Sequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi88 – 102Poly-AlaAdd BLAST15
Compositional biasi103 – 127Poly-GlnAdd BLAST25
Compositional biasi153 – 164Poly-AlaAdd BLAST12
Compositional biasi174 – 296Gly/Pro-richAdd BLAST123
Compositional biasi596 – 623Pro-richAdd BLAST28

Sequence similaritiesi

Belongs to the IRF2BP family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri715 – 762RING-type; degenerateAdd BLAST48

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG3579 Eukaryota
ENOG410Z1AW LUCA
GeneTreeiENSGT00390000005089
HOVERGENiHBG108364
InParanoidiQ9H1B7
KOiK22383
OMAiQNGPSPM
OrthoDBiEOG091G040R
PhylomeDBiQ9H1B7
TreeFamiTF317075

Family and domain databases

InterProiView protein in InterPro
IPR022750 Interferon_reg_fac2-bd1_2_Znf
PfamiView protein in Pfam
PF11261 IRF-2BP1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H1B7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAQVSSSR RQSCYLCDLP RMPWAMIWDF SEPVCRGCVN YEGADRIEFV
60 70 80 90 100
IETARQLKRA HGCFQDGRSP GPPPPVGVKT VALSAKEAAA AAAAAAAAAA
110 120 130 140 150
AAQQQQQQQQ QQQQQQQQQQ QQQQQQQLNH VDGSSKPAVL AAPSGLERYG
160 170 180 190 200
LSAAAAAAAA AAAAVEQRSR FEYPPPPVSL GSSSHTARLP NGLGGPNGFP
210 220 230 240 250
KPTPEEGPPE LNRQSPNSSS AAASVASRRG THGGLVTGLP NPGGGGGPQL
260 270 280 290 300
TVPPNLLPQT LLNGPASAAV LPPPPPHALG SRGPPTPAPP GAPGGPACLG
310 320 330 340 350
GTPGVSATSS SASSSTSSSV AEVGVGAGGK RPGSVSSTDQ ERELKEKQRN
360 370 380 390 400
AEALAELSES LRNRAEEWAS KPKMVRDTLL TLAGCTPYEV RFKKDHSLLG
410 420 430 440 450
RVFAFDAVSK PGMDYELKLF IEYPTGSGNV YSSASGVAKQ MYQDCMKDFG
460 470 480 490 500
RGLSSGFKYL EYEKKHGSGD WRLLGDLLPE AVRFFKEGVP GADMLPQPYL
510 520 530 540 550
DASCPMLPTA LVSLSRAPSA PPGTGALPPA APSGRGAAAS LRKRKASPEP
560 570 580 590 600
PDSAEGALKL GEEQQRQQWM ANQSEALKLT MSAGGFAAPG HAAGGPPPPP
610 620 630 640 650
PPLGPHSNRT TPPESAPQNG PSPMAALMSV ADTLGTAHSP KDGSSVHSTT
660 670 680 690 700
ASARRNSSSP VSPASVPGQR RLASRNGDLN LQVAPPPPSA HPGMDQVHPQ
710 720 730 740 750
NIPDSPMANS GPLCCTICHE RLEDTHFVQC PSVPSHKFCF PCSRESIKAQ
760 770 780 790
GATGEVYCPS GEKCPLVGSN VPWAFMQGEI ATILAGDVKV KKERDP
Length:796
Mass (Da):82,659
Last modified:March 1, 2001 - v1
Checksum:iDCF7898F15AD6A37
GO

Sequence cautioni

The sequence BAB47494 differs from that shown. Aberrant splicing.Curated

Polymorphismi

The poly-Gln region is polymorphic; the most frequent allele contained 24 Gln. Stretches of 20-31 Gln are observed in healthy individuals.1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277365 Genomic DNA Translation: CAC10539.1
AC007686 Genomic DNA No translation available.
AB058768 mRNA Translation: BAB47494.1 Sequence problems.
AL832320 mRNA Translation: CAD38615.1
AF063597 mRNA Translation: AAG43156.1
CCDSiCCDS9854.1
PIRiJC7555
RefSeqiNP_078772.1, NM_024496.3
UniGeneiHs.179260
Hs.745194

Genome annotation databases

EnsembliENST00000238647; ENSP00000238647; ENSG00000119669
GeneIDi64207
KEGGihsa:64207
UCSCiuc001xsy.4 human

Keywords - Coding sequence diversityi

Polymorphism, Triplet repeat expansion

Similar proteinsi

Entry informationi

Entry nameiI2BPL_HUMAN
AccessioniPrimary (citable) accession number: Q9H1B7
Secondary accession number(s): Q8NDQ2, Q96JG2, Q9H3I7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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