Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 166 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Nuclear RNA export factor 5

Gene

NXF5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H1B4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNA export factor 5
Alternative name(s):
TAP-like protein 1
Short name:
TAPL-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NXF5
Synonyms:TAPL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000126952.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8075, NXF5

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300319, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1B4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of mental retardation and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5.1 Publication

Organism-specific databases

DisGeNET

More...
DisGeNETi
55998

Open Targets

More...
OpenTargetsi
ENSG00000126952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA31862

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H1B4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
NXF5

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20978537

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205351 – 397Nuclear RNA export factor 5Add BLAST397

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H1B4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H1B4

PeptideAtlas

More...
PeptideAtlasi
Q9H1B4

PRoteomics IDEntifications database

More...
PRIDEi
Q9H1B4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80387 [Q9H1B4-1]
80388 [Q9H1B4-2]
80389 [Q9H1B4-3]
80390 [Q9H1B4-4]
80391 [Q9H1B4-5]
80392 [Q9H1B4-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H1B4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H1B4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000126952, Expressed in adult mammalian kidney and 44 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H1B4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000126952, Tissue enhanced (epididymis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NXT1 and NXT2.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
121023, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H1B4, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000426978

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H1B4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H1B4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini13 – 92RRMAdd BLAST80
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati160 – 185LRR 1Add BLAST26
Repeati186 – 209LRR 2Add BLAST24
Repeati210 – 237LRR 3Add BLAST28
Repeati238 – 265LRR 4Add BLAST28
Domaini280 – 367NTF2; truncatedAdd BLAST88

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NTF2 domain heterodimerizes with NXT1 and NXT2.By similarity
The RNA-binding domain is a non-canonical RNP-type domain.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3763, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1585916_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H1B4

KEGG Orthology (KO)

More...
KOi
K14284

Identification of Orthologs from Complete Genome Data

More...
OMAi
DSRNIKM

Database of Orthologous Groups

More...
OrthoDBi
1051093at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H1B4

TreeFam database of animal gene trees

More...
TreeFami
TF314566

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR032710, NTF2-like_dom_sf
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR015245, Tap_RNA-bd

The PANTHER Classification System

More...
PANTHERi
PTHR10662, PTHR10662, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09162, Tap-RNA_bind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (6)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 6 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform A (identifier: Q9H1B4-1) [UniParc]FASTAAdd to basket
Also known as: TAPL-1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRNTQDENM RKWFKVTIPY GIKYDKAWLM NSIQSNCSVP FTPVDFHYIR
60 70 80 90 100
NRACFFVQVA SAASALKDVS YKIYDDENQK ICIFVSHFTA PYSVKNKLKP
110 120 130 140 150
GQMEMLKLTM NKRYNVSQQA LDLQNLRFDP DLMGRDIDII LNRRNCMAAT
160 170 180 190 200
LKITERNFPE LLSLNLCNNK LYQLDGLSDI TEKAPKVKTL NLSKNKLESA
210 220 230 240 250
WELGKVKGLK LEELWLEGNP LCSTFSDQSA YVSAIRDCFP KLLRLDGREL
260 270 280 290 300
SAPVIVDIDS SETMKPCKEN FTGSETLKHL VLQFLQQSNL CKYFKDSRNI
310 320 330 340 350
KILKDPYLQR KLLKHTKCPR NVDSLSALPE TQHDFTSILV DMWYQTVNTC
360 370 380 390
FLPRAGPESQ RWWCLLSLKW KDGLRVLILP SCGPSSLPLA AIPVCAS
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Length:397
Mass (Da):45,628
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0D5E5EDCA850E3A6
GO
Isoform B (identifier: Q9H1B4-2) [UniParc]FASTAAdd to basket
Also known as: TAPL-1b

The sequence of this isoform differs from the canonical sequence as follows:
     361-368: RWWCLLSL → SGRMVSGF
     369-397: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:368
Mass (Da):42,417
Checksum:i19C121BB5CCAFD98
GO
Isoform C (identifier: Q9H1B4-3) [UniParc]FASTAAdd to basket
Also known as: TAPL-1c

The sequence of this isoform differs from the canonical sequence as follows:
     161-168: LLSLNLCN → RRLPKSRP
     169-397: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:168
Mass (Da):19,824
Checksum:i2E79418A641AE3FA
GO
Isoform D (identifier: Q9H1B4-4) [UniParc]FASTAAdd to basket
Also known as: TAPL-1d

The sequence of this isoform differs from the canonical sequence as follows:
     18-80: Missing.
     361-368: RWWCLLSL → SGRMVSGF
     369-397: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:305
Mass (Da):35,167
Checksum:i55160EF749700797
GO
Isoform E (identifier: Q9H1B4-5) [UniParc]FASTAAdd to basket
Also known as: TAPL-1e

The sequence of this isoform differs from the canonical sequence as follows:
     18-80: Missing.
     363-365: WCL → VGG
     366-397: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:302
Mass (Da):34,901
Checksum:i7DF796DC969D320C
GO
Isoform F (identifier: Q9H1B4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     361-397: RWWCLLSLKWKDGLRVLILPSCGPSSLPLAAIPVCAS → SLRPL

Show »
Length:365
Mass (Da):42,162
Checksum:i3EAD3AF2C8555ADC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00373118 – 80Missing in isoform D and isoform E. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_003732161 – 168LLSLNLCN → RRLPKSRP in isoform C. 1 Publication8
Alternative sequenceiVSP_003733169 – 397Missing in isoform C. 1 PublicationAdd BLAST229
Alternative sequenceiVSP_043896361 – 397RWWCL…PVCAS → SLRPL in isoform F. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_003734361 – 368RWWCLLSL → SGRMVSGF in isoform B and isoform D. 1 Publication8
Alternative sequenceiVSP_003735363 – 365WCL → VGG in isoform E. 1 Publication3
Alternative sequenceiVSP_003736366 – 397Missing in isoform E. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_003737369 – 397Missing in isoform D and isoform B. 1 PublicationAdd BLAST29

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ277654 mRNA Translation: CAC20428.1
AJ277655 mRNA Translation: CAC20429.1
AJ277656 mRNA Translation: CAC20430.1
AJ277657 mRNA Translation: CAC20431.1
AJ277658 mRNA Translation: CAC20432.1
AL672207, Z70228 Genomic DNA Translation: CAI42476.1
AL672207, Z70228 Genomic DNA Translation: CAI42478.1
AL672207, Z70228 Genomic DNA Translation: CAI42475.1
AL672207, Z70228 Genomic DNA Translation: CAI42477.1
BC131708 mRNA Translation: AAI31709.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14491.2 [Q9H1B4-6]

NCBI Reference Sequences

More...
RefSeqi
NP_116564.2, NM_032946.2 [Q9H1B4-6]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000473265; ENSP00000426978; ENSG00000126952 [Q9H1B4-6]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55998

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55998

UCSC genome browser

More...
UCSCi
uc004eih.2, human [Q9H1B4-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ277654 mRNA Translation: CAC20428.1
AJ277655 mRNA Translation: CAC20429.1
AJ277656 mRNA Translation: CAC20430.1
AJ277657 mRNA Translation: CAC20431.1
AJ277658 mRNA Translation: CAC20432.1
AL672207, Z70228 Genomic DNA Translation: CAI42476.1
AL672207, Z70228 Genomic DNA Translation: CAI42478.1
AL672207, Z70228 Genomic DNA Translation: CAI42475.1
AL672207, Z70228 Genomic DNA Translation: CAI42477.1
BC131708 mRNA Translation: AAI31709.1
CCDSiCCDS14491.2 [Q9H1B4-6]
RefSeqiNP_116564.2, NM_032946.2 [Q9H1B4-6]

3D structure databases

SMRiQ9H1B4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi121023, 9 interactors
IntActiQ9H1B4, 3 interactors
STRINGi9606.ENSP00000426978

PTM databases

iPTMnetiQ9H1B4
PhosphoSitePlusiQ9H1B4

Polymorphism and mutation databases

BioMutaiNXF5
DMDMi20978537

Proteomic databases

MassIVEiQ9H1B4
PaxDbiQ9H1B4
PeptideAtlasiQ9H1B4
PRIDEiQ9H1B4
ProteomicsDBi80387 [Q9H1B4-1]
80388 [Q9H1B4-2]
80389 [Q9H1B4-3]
80390 [Q9H1B4-4]
80391 [Q9H1B4-5]
80392 [Q9H1B4-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
467, 119 antibodies

Genome annotation databases

EnsembliENST00000473265; ENSP00000426978; ENSG00000126952 [Q9H1B4-6]
GeneIDi55998
KEGGihsa:55998
UCSCiuc004eih.2, human [Q9H1B4-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55998
DisGeNETi55998
EuPathDBiHostDB:ENSG00000126952.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
NXF5
HGNCiHGNC:8075, NXF5
HPAiENSG00000126952, Tissue enhanced (epididymis)
MIMi300319, gene
neXtProtiNX_Q9H1B4
OpenTargetsiENSG00000126952
PharmGKBiPA31862

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3763, Eukaryota
GeneTreeiENSGT00390000007539
HOGENOMiCLU_1585916_0_0_1
InParanoidiQ9H1B4
KOiK14284
OMAiDSRNIKM
OrthoDBi1051093at2759
PhylomeDBiQ9H1B4
TreeFamiTF314566

Enzyme and pathway databases

PathwayCommonsiQ9H1B4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
55998, 3 hits in 511 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
55998
PharosiQ9H1B4, Tdark

Protein Ontology

More...
PROi
PR:Q9H1B4
RNActiQ9H1B4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000126952, Expressed in adult mammalian kidney and 44 other tissues
GenevisibleiQ9H1B4, HS

Family and domain databases

Gene3Di3.30.70.330, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR032710, NTF2-like_dom_sf
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR015245, Tap_RNA-bd
PANTHERiPTHR10662, PTHR10662, 1 hit
PfamiView protein in Pfam
PF09162, Tap-RNA_bind, 1 hit
SUPFAMiSSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXF5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1B4
Secondary accession number(s): A2RRM0
, B1AV82, B1AV83, B1AV84, B1AV85, Q9H1B0, Q9H1B1, Q9H1B2, Q9H1B3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2002
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 166 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again