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Protein

Anaphase-promoting complex subunit 1

Gene

ANAPC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, Cell division, Mitosis, Ubl conjugation pathway

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H1A4

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anaphase-promoting complex subunit 1
Short name:
APC1
Alternative name(s):
Cyclosome subunit 1
Mitotic checkpoint regulator
Testis-specific gene 24 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ANAPC1
Synonyms:TSG24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000153107.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19988 ANAPC1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608473 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H1A4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
64682

Open Targets

More...
OpenTargetsi
ENSG00000153107

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134907013

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ANAPC1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37537845

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002158711 – 1944Anaphase-promoting complex subunit 1Add BLAST1944

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei51PhosphoserineCombined sources1
Modified residuei60PhosphoserineCombined sources1
Modified residuei202Phosphoserine1 Publication1
Modified residuei286Phosphoserine1 Publication1
Modified residuei291PhosphothreonineCombined sources1 Publication1
Modified residuei313PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei343PhosphoserineCombined sources1
Modified residuei355PhosphoserineCombined sources1 Publication1
Modified residuei362PhosphoserineCombined sources1
Modified residuei373Phosphoserine1 Publication1
Modified residuei377PhosphoserineCombined sources1 Publication1
Modified residuei537Phosphothreonine1 Publication1
Modified residuei547PhosphoserineCombined sources1
Modified residuei555PhosphoserineCombined sources1
Modified residuei571Phosphotyrosine1 Publication1
Modified residuei686PhosphoserineCombined sources1
Modified residuei688PhosphoserineCombined sources1 Publication1
Modified residuei916PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation on Ser-355 occurs specifically during mitosis.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H1A4

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H1A4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H1A4

PeptideAtlas

More...
PeptideAtlasi
Q9H1A4

PRoteomics IDEntifications database

More...
PRIDEi
Q9H1A4

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80384

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H1A4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H1A4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000153107 Expressed in 150 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_ANAPC1

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H1A4 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H1A4 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA036329
HPA036330
HPA042998

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The mammalian APC/C is composed at least of 14 distinct subunits ANAPC1, ANAPC2, CDC27/APC3, ANAPC4, ANAPC5, CDC16/APC6, ANAPC7, CDC23/APC8, ANAPC10, ANAPC11, CDC26/APC12, ANAPC13, ANAPC15 and ANAPC16 that assemble into a complex of at least 19 chains with a combined molecular mass of around 1.2 MDa; APC/C interacts with FZR1 and FBXO5.2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
122229, 86 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H1A4

Database of interacting proteins

More...
DIPi
DIP-32940N

Protein interaction database and analysis system

More...
IntActi
Q9H1A4, 49 interactors

Molecular INTeraction database

More...
MINTi
Q9H1A4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000339109

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11944
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q9H1A4

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H1A4

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati1297 – 1325PC 1Add BLAST29
Repeati1366 – 1404PC 2Add BLAST39
Repeati1467 – 1501PC 3Add BLAST35
Repeati1520 – 1552PC 4Add BLAST33

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the APC1 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1858 Eukaryota
ENOG410XQ83 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016757

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231934

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG045326

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H1A4

KEGG Orthology (KO)

More...
KOi
K03348

Identification of Orthologs from Complete Genome Data

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OMAi
AIAEWMQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00RP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H1A4

TreeFam database of animal gene trees

More...
TreeFami
TF105441

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR024990 Apc1

The PANTHER Classification System

More...
PANTHERi
PTHR12827 PTHR12827, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12859 ANAPC1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H1A4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNFYEERTT MIAARDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS
60 70 80 90 100
SDGAAGLVGS LQEVTIHEKQ KESWQLRKGV SEIGEDVDYD EELYVAGNMV
110 120 130 140 150
IWSKGSKSQA LAVYKAFTVD SPVQQALWCD FIISQDKSEK AYSSNEVEKC
160 170 180 190 200
ICILQSSCIN MHSIEGKDYI ASLPFQVANV WPTKYGLLFE RSASSHEVPP
210 220 230 240 250
GSPREPLPTM FSMLHPLDEI TPLVCKSGSL FGSSRVQYVV DHAMKIVFLN
260 270 280 290 300
TDPSIVMTYD AVQNVHSVWT LRRVKSEEEN VVLKFSEQGG TPQNVATSSS
310 320 330 340 350
LTAHLRSLSK GDSPVTSPFQ NYSSIHSQSR STSSPSLHSR SPSISNMAAL
360 370 380 390 400
SRAHSPALGV HSFSGVQRFN ISSHNQSPKR HSISHSPNSN SNGSFLAPET
410 420 430 440 450
EPIVPELCID HLWTETITNI REKNSQASKV FITSDLCGQK FLCFLVESQL
460 470 480 490 500
QLRCVKFQES NDKTQLIFGS VTNIPAKDAA PVEKIDTMLV LEGSGNLVLY
510 520 530 540 550
TGVVRVGKVF IPGLPAPSLT MSNTMPRPST PLDGVSTPKP LSKLLGSLDE
560 570 580 590 600
VVLLSPVPEL RDSSKLHDSL YNEDCTFQQL GTYIHSIRDP VHNRVTLELS
610 620 630 640 650
NGSMVRITIP EIATSELVQT CLQAIKFILP KEIAVQMLVK WYNVHSAPGG
660 670 680 690 700
PSYHSEWNLF VTCLMNMMGY NTDRLAWTRN FDFEGSLSPV IAPKKARPSE
710 720 730 740 750
TGSDDDWEYL LNSDYHQNVE SHLLNRSLCL SPSEASQMKD EDFSQNLSLD
760 770 780 790 800
SSTLLFTHIP AIFFVLHLVY EELKLNTLMG EGICSLVELL VQLARDLKLG
810 820 830 840 850
PYVDHYYRDY PTLVRTTGQV CTIDPGQTGF MHHPSFFTSE PPSIYQWVSS
860 870 880 890 900
CLKGEGMPPY PYLPGICERS RLVVLSIALY ILGDESLVSD ESSQYLTRIT
910 920 930 940 950
IAPQKLQVEQ EENRFSFRHS TSVSSLAERL VVWMTNVGFT LRDLETLPFG
960 970 980 990 1000
IALPIRDAIY HCREQPASDW PEAVCLLIGR QDLSKQACEG NLPKGKSVLS
1010 1020 1030 1040 1050
SDVPSGTETE EEDDGMNDMN HEVMSLIWSE DLRVQDVRRL LQSAHPVRVN
1060 1070 1080 1090 1100
VVQYPELSDH EFIEEKENRL LQLCQRTMAL PVGRGMFTLF SYHPVPTEPL
1110 1120 1130 1140 1150
PIPKLNLTGR APPRNTTVDL NSGNIDVPPN MTSWASFHNG VAAGLKIAPA
1160 1170 1180 1190 1200
SQIDSAWIVY NKPKHAELAN EYAGFLMALG LNGHLTKLAT LNIHDYLTKG
1210 1220 1230 1240 1250
HEMTSIGLLL GVSAAKLGTM DMSITRLLSI HIPALLPPTS TELDVPHNVQ
1260 1270 1280 1290 1300
VAAVVGIGLV YQGTAHRHTA EVLLAEIGRP PGPEMEYCTD RESYSLAAGL
1310 1320 1330 1340 1350
ALGMVCLGHG SNLIGMSDLN VPEQLYQYMV GGHRRFQTGM HREKHKSPSY
1360 1370 1380 1390 1400
QIKEGDTINV DVTCPGATLA LAMIYLKTNN RSIADWLRAP DTMYLLDFVK
1410 1420 1430 1440 1450
PEFLLLRTLA RCLILWDDIL PNSKWVDSNV PQIIRENSIS LSEIELPCSE
1460 1470 1480 1490 1500
DLNLETLSQA HVYIIAGACL SLGFRFAGSE NLSAFNCLHK FAKDFMTYLS
1510 1520 1530 1540 1550
APNASVTGPH NLETCLSVVL LSLAMVMAGS GNLKVLQLCR FLHMKTGGEM
1560 1570 1580 1590 1600
NYGFHLAHHM ALGLLFLGGG RYSLSTSNSS IAALLCALYP HFPAHSTDNR
1610 1620 1630 1640 1650
YHLQALRHLY VLAAEPRLLV PVDVDTNTPC YALLEVTYKG TQWYEQTKEE
1660 1670 1680 1690 1700
LMAPTLLPEL HLLKQIKVKG PRYWELLIDL SKGTQHLKSI LSKDGVLYVK
1710 1720 1730 1740 1750
LRAGQLSYKE DPMGWQSLLA QTVANRNSEA RAFKPETISA FTSDPALLSF
1760 1770 1780 1790 1800
AEYFCKPTVN MGQKQEILDL FSSVLYECVT QETPEMLPAY IAMDQAIRRL
1810 1820 1830 1840 1850
GRREMSETSE LWQIKLVLEF FSSRSHQERL QNHPKRGLFM NSEFLPVVKC
1860 1870 1880 1890 1900
TIDNTLDQWL QVGGDMCVHA YLSGQPLEES QLSMLACFLV YHSVPAPQHL
1910 1920 1930 1940
PPIGLEGSTS FAELLFKFKQ LKMPVRALLR LAPLLLGNPQ PMVM
Length:1,944
Mass (Da):216,500
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE08B1FE3FC28917E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y564H0Y564_HUMAN
Anaphase-promoting complex subunit ...
ANAPC1
1,452Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAS1F8WAS1_HUMAN
Anaphase-promoting complex subunit ...
ANAPC1
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF63A0A2R8YF63_HUMAN
Anaphase-promoting complex subunit ...
ANAPC1
259Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti604M → V in BAB14687 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ278357 mRNA Translation: CAC19484.1
BC005089 mRNA Translation: AAH05089.1
BC104902 mRNA Translation: AAI04903.1
BC104904 mRNA Translation: AAI04905.1
AK023807 mRNA Translation: BAB14687.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2093.1

NCBI Reference Sequences

More...
RefSeqi
NP_073153.1, NM_022662.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.436527

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000341068; ENSP00000339109; ENSG00000153107

Database of genes from NCBI RefSeq genomes

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GeneIDi
64682

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:64682

UCSC genome browser

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UCSCi
uc002thi.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ278357 mRNA Translation: CAC19484.1
BC005089 mRNA Translation: AAH05089.1
BC104902 mRNA Translation: AAI04903.1
BC104904 mRNA Translation: AAI04905.1
AK023807 mRNA Translation: BAB14687.1
CCDSiCCDS2093.1
RefSeqiNP_073153.1, NM_022662.3
UniGeneiHs.436527

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4UI9electron microscopy3.60A1-1944[»]
5A31electron microscopy4.30A11-1897[»]
5G04electron microscopy4.00A1-1943[»]
5G05electron microscopy3.40A1-1944[»]
5KHRelectron microscopy6.10A1-1944[»]
5KHUelectron microscopy4.80A1-1944[»]
5L9Telectron microscopy6.40A1-1944[»]
5L9Uelectron microscopy6.40A1-1944[»]
5LCWelectron microscopy4.00A1-1944[»]
5LGGX-ray2.15A1-33[»]
A70-306[»]
A403-613[»]
ProteinModelPortaliQ9H1A4
SMRiQ9H1A4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122229, 86 interactors
CORUMiQ9H1A4
DIPiDIP-32940N
IntActiQ9H1A4, 49 interactors
MINTiQ9H1A4
STRINGi9606.ENSP00000339109

PTM databases

iPTMnetiQ9H1A4
PhosphoSitePlusiQ9H1A4

Polymorphism and mutation databases

BioMutaiANAPC1
DMDMi37537845

Proteomic databases

EPDiQ9H1A4
MaxQBiQ9H1A4
PaxDbiQ9H1A4
PeptideAtlasiQ9H1A4
PRIDEiQ9H1A4
ProteomicsDBi80384

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341068; ENSP00000339109; ENSG00000153107
GeneIDi64682
KEGGihsa:64682
UCSCiuc002thi.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
64682
DisGeNETi64682
EuPathDBiHostDB:ENSG00000153107.11

GeneCards: human genes, protein and diseases

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GeneCardsi
ANAPC1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0002242
HIX0161603
HGNCiHGNC:19988 ANAPC1
HPAiHPA036329
HPA036330
HPA042998
MIMi608473 gene
neXtProtiNX_Q9H1A4
OpenTargetsiENSG00000153107
PharmGKBiPA134907013

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1858 Eukaryota
ENOG410XQ83 LUCA
GeneTreeiENSGT00390000016757
HOGENOMiHOG000231934
HOVERGENiHBG045326
InParanoidiQ9H1A4
KOiK03348
OMAiAIAEWMQ
OrthoDBiEOG091G00RP
PhylomeDBiQ9H1A4
TreeFamiTF105441

Enzyme and pathway databases

UniPathwayi
UPA00143

ReactomeiR-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex
R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B
R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C
R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin
R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase
R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins
R-HSA-176412 Phosphorylation of the APC/C
R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ9H1A4

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ANAPC1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ANAPC1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
64682

Protein Ontology

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PROi
PR:Q9H1A4

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000153107 Expressed in 150 organ(s), highest expression level in kidney
CleanExiHS_ANAPC1
ExpressionAtlasiQ9H1A4 baseline and differential
GenevisibleiQ9H1A4 HS

Family and domain databases

InterProiView protein in InterPro
IPR024990 Apc1
PANTHERiPTHR12827 PTHR12827, 1 hit
PfamiView protein in Pfam
PF12859 ANAPC1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAPC1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H1A4
Secondary accession number(s): Q2M3H8, Q9BSE6, Q9H8D0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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