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UniProtKB - Q9H190 (SDCB2_HUMAN)

Entry version 171 (23 Feb 2022)
Sequence version 2 (02 May 2002)
Previous versions | rss
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Protein

Syntenin-2

Gene

SDCBP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).

1 Publication

Caution

The nuclear speckles location of SDCBP2 is under debate. One study shows that in paraformaldehyde fixed cells, SDCBP2 is highly enriched in nuclear speckles (PubMed:15961997). The same authors investigate subcellular location in living cells and fail to detect SDCBP2 in nuclear speckles, and propose that enrichment in nuclear speckles is fixation-dependent (PubMed:23300061).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandLipid-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H190

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H190

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...MoonDBi		Q9H190, Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Syntenin-2
Alternative name(s):
Similar to TACIP181 Publication
Short name:
SITAC1 Publication
Syndecan-binding protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SDCBP2Imported
Synonyms:SITAC18
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:15756, SDCBP2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		617358, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H190

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000125775

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi113K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-167; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-167. 1 Publication1
Mutagenesisi167K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-113. 1 Publication1
Mutagenesisi197K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-244. 1 Publication1
Mutagenesisi244K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-197. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-197. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		27111

Open Targets

More...OpenTargetsi		ENSG00000125775

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38033

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H190, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SDCBP2

Domain mapping of disease mutations (DMDM)

More...DMDMi		20455288

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001840041 – 292Syntenin-2Add BLAST292

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H190

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H190

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H190

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H190

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H190

PeptideAtlas

More...PeptideAtlasi		Q9H190

PRoteomics IDEntifications database

More...PRIDEi		Q9H190

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80379 [Q9H190-1]
80380 [Q9H190-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H190

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H190

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q9H190

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by HPV8 E6 papillomavirus (HPV) oncoprotein (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000125775, Expressed in lower esophagus mucosa and 160 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H190, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000125775, Tissue enhanced (esophagus, intestine, stomach)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer (PubMed:11152476, PubMed:23300061).

Interacts with SDCBP (PubMed:11152476).

Interacts with TM4SF1 (PubMed:11102519).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q9H190
With#Exp.IntAct
ADAP1 [O75689]3EBI-742426,EBI-714732
AKAP17A [Q02040]3EBI-742426,EBI-1042725
AP1M1 [Q9BXS5]3EBI-742426,EBI-541426
ARF4 [P18085]3EBI-742426,EBI-1237085
CHCHD1 [Q96BP2]3EBI-742426,EBI-5454898
CRCT1 [Q9UGL9]3EBI-742426,EBI-713677
CRY2 [Q49AN0]3EBI-742426,EBI-2212355
CT45A1 [Q5HYN5]3EBI-742426,EBI-12051833
CT45A10 [P0DMU9]3EBI-742426,EBI-12153495
CT45A3 [Q8NHU0]8EBI-742426,EBI-8643558
CT45A5 [Q6NSH3]4EBI-742426,EBI-8635816
DMC1 [Q14565]3EBI-742426,EBI-930865
EIF1AD [Q8N9N8]7EBI-742426,EBI-750700
FAM133A [Q8N9E0]9EBI-742426,EBI-10268158
FAM13C [Q8NE31]3EBI-742426,EBI-751248
FAM9B [Q8IZU0]3EBI-742426,EBI-10175124
FBXO28 [Q9NVF7]6EBI-742426,EBI-740282
HSBP1 [O75506]3EBI-742426,EBI-748664
LGALS14 [Q8TCE9]3EBI-742426,EBI-10274069
LGALS2 [P05162]7EBI-742426,EBI-7181544
LYAR [Q9NX58]8EBI-742426,EBI-713507
MMTAG2 [Q9BU76]4EBI-742426,EBI-742459
NFU1 [Q9UMS0]3EBI-742426,EBI-725252
NKAPD1 [Q6ZUT1]6EBI-742426,EBI-3920396
NKAPD1 - isoform 2 [Q6ZUT1-2]3EBI-742426,EBI-10180231
NOP56 [O00567]3EBI-742426,EBI-396034
NPM2 [Q86SE8]4EBI-742426,EBI-6658150
PAFAH1B3 [Q15102]5EBI-742426,EBI-711522
PHC1 [P78364]3EBI-742426,EBI-725403
PRM2 [P04554]3EBI-742426,EBI-9681663
PRPF38A [Q8NAV1]7EBI-742426,EBI-715374
PRPF40A - isoform 2 [O75400-2]6EBI-742426,EBI-5280197
PRR13 [Q9NZ81]7EBI-742426,EBI-740924
RNPS1 [D3DU92]3EBI-742426,EBI-10176640
RNPS1 [Q15287]4EBI-742426,EBI-395959
RPL22 [P35268]5EBI-742426,EBI-354533
RPL22L1 [Q6P5R6]3EBI-742426,EBI-2512545
RPL41 [P62945]3EBI-742426,EBI-2116899
itself3EBI-742426,EBI-742426
SREK1IP1 [Q8N9Q2]6EBI-742426,EBI-10268630
SYT17 [Q9BSW7]3EBI-742426,EBI-745392
TCP11L1 [Q9NUJ3]3EBI-742426,EBI-2555179
TDO2 [P48775]4EBI-742426,EBI-743494
TIFA [Q96CG3]6EBI-742426,EBI-740711
TM4SF1 [P30408]3EBI-742426,EBI-714256
TNNT1 - isoform 3 [P13805-3]3EBI-742426,EBI-12151635
TNP1 [P09430]4EBI-742426,EBI-10196343
VAX1 - isoform 2 [Q5SQQ9-2]3EBI-742426,EBI-12227803
VPS25 [Q9BRG1]3EBI-742426,EBI-741945
YTHDC1 [Q96MU7]7EBI-742426,EBI-2849854
ZCCHC10 [Q8TBK6]4EBI-742426,EBI-597063
ZCCHC17 [Q9NP64]8EBI-742426,EBI-746345
ZNF581 [Q9P0T4]3EBI-742426,EBI-745520
ZRSR2 [Q15696]7EBI-742426,EBI-6657923
Tgfa [P01134] from Rattus norvegicus.6EBI-742426,EBI-16418721

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		118007, 74 interactors

Protein interaction database and analysis system

More...IntActi		Q9H190, 70 interactors

Molecular INTeraction database

More...MINTi		Q9H190

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000371233

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H190, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H190

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 187PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini192 – 267PDZ 2PROSITE-ProRule annotationAdd BLAST76

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Binds phosphatidylinositol 4,5-bisphosphate (PIP2) via its two PDZ domains. These domains target SDCBP2 to the plasma membranes and nucleoli, two PIP2-rich regions.1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S0HE, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161179

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_059870_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H190

Identification of Orthologs from Complete Genome Data

More...OMAi		DGCDCAG

Database of Orthologous Groups

More...OrthoDBi		1035679at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H190

TreeFam database of animal gene trees

More...TreeFami		TF327131

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.42.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00595, PDZ, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00228, PDZ, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF50156, SSF50156, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50106, PDZ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to basket
Also known as: Alpha

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL 
        60         70         80         90        100
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA 
       110        120        130        140        150
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD 
       160        170        180        190        200
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM 
       210        220        230        240        250
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME 
       260        270        280        290 
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA
Length:292
Mass (Da):31,594
Last modified:May 2, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE12536839E1CD91C
GO
Isoform 3 (identifier: Q9H190-3) [UniParc]FASTAAdd to basket
Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: Missing.

Show »
Length:207
Mass (Da):22,664
Checksum:i16913A0148BF691A
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH02727 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti69Q → H in CAC21716 (PubMed:11152476).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_053700182V → M2 PublicationsCorresponds to variant dbSNP:rs2273959Ensembl.1
Natural variantiVAR_036544191R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs35367003Ensembl.1
Natural variantiVAR_053701223R → C. Corresponds to variant dbSNP:rs1048621Ensembl.1
Natural variantiVAR_053702242G → R. Corresponds to variant dbSNP:rs4814111Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0063521 – 85Missing in isoform 3. 2 PublicationsAdd BLAST85

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF159228 mRNA Translation: AAF80369.1
AJ292245 mRNA Translation: CAC21573.1
AJ292244 mRNA Translation: CAC21716.1
AF131809 mRNA Translation: AAD20049.1
AL136531 Genomic DNA No translation available.
BC002727 mRNA Translation: AAH02727.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS13013.1 [Q9H190-3]
CCDS42848.1 [Q9H190-1]

NCBI Reference Sequences

More...RefSeqi		NP_001186713.1, NM_001199784.1 [Q9H190-1]
NP_056500.2, NM_015685.5 [Q9H190-3]
NP_536737.3, NM_080489.4 [Q9H190-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000339987; ENSP00000342935; ENSG00000125775
ENST00000360779; ENSP00000354013; ENSG00000125775
ENST00000381808; ENSP00000371229; ENSG00000125775 [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775

Database of genes from NCBI RefSeq genomes

More...GeneIDi		27111

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:27111

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000360779.4; ENSP00000354013.3; NM_080489.5; NP_536737.3

UCSC genome browser

More...UCSCi		uc002weu.5, human [Q9H190-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159228 mRNA Translation: AAF80369.1
AJ292245 mRNA Translation: CAC21573.1
AJ292244 mRNA Translation: CAC21716.1
AF131809 mRNA Translation: AAD20049.1
AL136531 Genomic DNA No translation available.
BC002727 mRNA Translation: AAH02727.2 Different initiation.
CCDSiCCDS13013.1 [Q9H190-3]
CCDS42848.1 [Q9H190-1]
RefSeqiNP_001186713.1, NM_001199784.1 [Q9H190-1]
NP_056500.2, NM_015685.5 [Q9H190-3]
NP_536737.3, NM_080489.4 [Q9H190-1]

3D structure databases

SMRiQ9H190
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi118007, 74 interactors
IntActiQ9H190, 70 interactors
MINTiQ9H190
STRINGi9606.ENSP00000371233

Protein family/group databases

MoonDBiQ9H190, Predicted

PTM databases

iPTMnetiQ9H190
PhosphoSitePlusiQ9H190
SwissPalmiQ9H190

Genetic variation databases

BioMutaiSDCBP2
DMDMi20455288

Proteomic databases

EPDiQ9H190
jPOSTiQ9H190
MassIVEiQ9H190
MaxQBiQ9H190
PaxDbiQ9H190
PeptideAtlasiQ9H190
PRIDEiQ9H190
ProteomicsDBi80379 [Q9H190-1]
80380 [Q9H190-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		23059, 243 antibodies from 30 providers

The DNASU plasmid repository

More...DNASUi		27111

Genome annotation databases

EnsembliENST00000339987; ENSP00000342935; ENSG00000125775
ENST00000360779; ENSP00000354013; ENSG00000125775
ENST00000381808; ENSP00000371229; ENSG00000125775 [Q9H190-3]
ENST00000381812; ENSP00000371233; ENSG00000125775
GeneIDi27111
KEGGihsa:27111
MANE-SelectiENST00000360779.4; ENSP00000354013.3; NM_080489.5; NP_536737.3
UCSCiuc002weu.5, human [Q9H190-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		27111
DisGeNETi27111

GeneCards: human genes, protein and diseases

More...GeneCardsi		SDCBP2
HGNCiHGNC:15756, SDCBP2
HPAiENSG00000125775, Tissue enhanced (esophagus, intestine, stomach)
MIMi617358, gene
neXtProtiNX_Q9H190
OpenTargetsiENSG00000125775
PharmGKBiPA38033
VEuPathDBiHostDB:ENSG00000125775

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S0HE, Eukaryota
GeneTreeiENSGT00940000161179
HOGENOMiCLU_059870_0_0_1
InParanoidiQ9H190
OMAiDGCDCAG
OrthoDBi1035679at2759
PhylomeDBiQ9H190
TreeFamiTF327131

Enzyme and pathway databases

PathwayCommonsiQ9H190
SignaLinkiQ9H190

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		27111, 12 hits in 1042 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		SDCBP2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		27111
PharosiQ9H190, Tbio

Protein Ontology

More...PROi		PR:Q9H190
RNActiQ9H190, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000125775, Expressed in lower esophagus mucosa and 160 other tissues
GenevisibleiQ9H190, HS

Family and domain databases

Gene3Di2.30.42.10, 2 hits
InterProiView protein in InterPro
IPR001478, PDZ
IPR036034, PDZ_sf
PfamiView protein in Pfam
PF00595, PDZ, 1 hit
SMARTiView protein in SMART
SM00228, PDZ, 2 hits
SUPFAMiSSF50156, SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106, PDZ, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSDCB2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H190
Secondary accession number(s): O95892
, Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: May 2, 2002
Last modified: February 23, 2022
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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