SDCBP2

Functionⁱ

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).1 Publication

Caution

The nuclear speckles location of SDCBP2 is under debate. One study shows that in paraformaldehyde fixed cells, SDCBP2 is highly enriched in nuclear speckles (PubMed:15961997). The same authors investigate subcellular location in living cells and fail to detect SDCBP2 in nuclear speckles, and propose that enrichment in nuclear speckles is fixation-dependent (PubMed:23300061).2 Publications

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
- 27107012
phosphatidylinositol-4,5-bisphosphate binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15961997
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11152476
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 11152476
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11152476

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell proliferation
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15961997
intracellular signal transduction
Source: UniProtKB
Non-traceable author statementⁱ
- 11152476
intracellular transport
Source: UniProtKB
Non-traceable author statementⁱ
- 11152476
nervous system development
Source: UniProtKB
Non-traceable author statementⁱ
- 11152476

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Lipid-binding

Ligand

Lipid-binding

Protein family/group databases

MoonDBⁱ	Q9H190 Predicted

MoonDBⁱ

Q9H190 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Syntenin-2 Alternative name(s): Similar to TACIP181 Publication Short name: SITAC1 Publication Syndecan-binding protein 2
Gene namesⁱ	Name:SDCBP2Imported Synonyms:SITAC18
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000125775.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:15756 SDCBP2
MIMⁱ	617358 gene
neXtProtⁱ	NX_Q9H190

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	113	K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-167; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-167. 1 Publication	1
Mutagenesisⁱ	167	K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-113. 1 Publication	1
Mutagenesisⁱ	197	K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-244. 1 Publication	1
Mutagenesisⁱ	244	K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-197. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-197. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	27111
Open Targets More...OpenTargetsⁱ	ENSG00000125775
PharmGKBⁱ	PA38033

Polymorphism and mutation databases

BioMutaⁱ	SDCBP2
DMDMⁱ	20455288

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000184004	1 – 292	Syntenin-2Add BLAST		292

Proteomic databases

EPDⁱ	Q9H190
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H190
PaxDbⁱ	Q9H190
PeptideAtlas More...PeptideAtlasⁱ	Q9H190
PRIDEⁱ	Q9H190
ProteomicsDBⁱ	80379 80380 [Q9H190-3]

PTM databases

iPTMnetⁱ	Q9H190
PhosphoSitePlusⁱ	Q9H190
SwissPalmⁱ	Q9H190

Expressionⁱ

Tissue specificityⁱ

Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).2 Publications

Inductionⁱ

Down-regulated by HPV8 E6 papillomavirus (HPV) oncoprotein (at protein level).1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000125775 Expressed in 141 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_SDCBP2
Genevisibleⁱ	Q9H190 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054554 HPA064490

HPAⁱ

HPA054554
HPA064490

Interactionⁱ

Subunit structureⁱ

Monomer and homodimer (PubMed:11152476, PubMed:23300061). Interacts with SDCBP (PubMed:11152476). Interacts with TM4SF1 (PubMed:11102519).3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
itself		3	EBI-742426,EBI-742426
ADAP1	O75689	3	EBI-742426,EBI-714732
ARF4	P18085	3	EBI-742426,EBI-1237085
CT45A3	Q8NHU0	6	EBI-742426,EBI-8643558
CT45A5	Q6NSH3	4	EBI-742426,EBI-8635816
EIF1AD	Q8N9N8	6	EBI-742426,EBI-750700
FAM133A	Q8N9E0	7	EBI-742426,EBI-10268158
FAM13C	Q8NE31	3	EBI-742426,EBI-751248
FAM9B	Q8IZU0	3	EBI-742426,EBI-10175124
FBXO28	Q9NVF7	5	EBI-742426,EBI-740282
LGALS14	Q8TCE9	3	EBI-742426,EBI-10274069
LGALS2	P05162	5	EBI-742426,EBI-7181544
LYAR	Q9NX58	5	EBI-742426,EBI-713507
MMTAG2	Q9BU76	3	EBI-742426,EBI-742459
NKAPD1	Q6ZUT1	5	EBI-742426,EBI-3920396
NKAPD1	Q6ZUT1-2	3	EBI-742426,EBI-10180231
NPM2	Q86SE8	3	EBI-742426,EBI-6658150
PAFAH1B3	Q15102	3	EBI-742426,EBI-711522
PRPF38A	Q8NAV1	5	EBI-742426,EBI-715374
PRPF40A	O75400-2	5	EBI-742426,EBI-5280197
PRR13	Q9NZ81	6	EBI-742426,EBI-740924
RNPS1	D3DU92	3	EBI-742426,EBI-10176640
RPL22	P35268	4	EBI-742426,EBI-354533
SREK1IP1	Q8N9Q2	5	EBI-742426,EBI-10268630
TDO2	P48775	3	EBI-742426,EBI-743494
Tgfa	P01134	6	EBI-742426,EBI-16418721	From Rattus norvegicus.
TIFA	Q96CG3	6	EBI-742426,EBI-740711
TM4SF1	P30408	3	EBI-742426,EBI-714256
TNP1	P09430	3	EBI-742426,EBI-10196343
YTHDC1	Q96MU7	5	EBI-742426,EBI-2849854
ZCCHC10	Q8TBK6	3	EBI-742426,EBI-597063
ZCCHC17	Q9NP64	7	EBI-742426,EBI-746345
ZNF581	Q9P0T4	3	EBI-742426,EBI-745520
ZRSR2	Q15696	5	EBI-742426,EBI-6657923

GO - Molecular functionⁱ

identical protein binding
Source: IntAct
Inferred from physical interactionⁱ
- 25416956
- 27107012
protein C-terminus binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11152476
protein heterodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 11152476
protein homodimerization activity
Source: UniProtKB
Inferred from direct assayⁱ
- 11152476

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	118007, 47 interactors
IntActⁱ	Q9H190, 69 interactors
Molecular INTeraction database More...MINTⁱ	Q9H190

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H190
SMRⁱ	Q9H190
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	108 – 187	PDZ 1PROSITE-ProRule annotationAdd BLAST		80
Domainⁱ	192 – 267	PDZ 2PROSITE-ProRule annotationAdd BLAST		76

Domainⁱ

Binds phosphatidylinositol 4,5-bisphosphate (PIP2) via its two PDZ domains. These domains target SDCBP2 to the plasma membranes and nucleoli, two PIP2-rich regions.1 Publication

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IK98 Eukaryota ENOG410YNPQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014465
HOGENOMⁱ	HOG000231604
HOVERGENⁱ	HBG053211
InParanoidⁱ	Q9H190
OMAⁱ	TLLHHTM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0HJI
PhylomeDBⁱ	Q9H190
TreeFamⁱ	TF327131

Family and domain databases

InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 2 hits
SUPFAMⁱ	SSF50156 SSF50156, 2 hits
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 2 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9H190-1) [UniParc]FASTA Add to basket

Also known as: Alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL 
        60         70         80         90        100
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA 
       110        120        130        140        150
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD 
       160        170        180        190        200
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM 
       210        220        230        240        250
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME 
       260        270        280        290 
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA

Length:292

Mass (Da):31,594

Last modified:May 2, 2002 - v2

Checksum:ⁱE12536839E1CD91C

GO

Isoform 3 (identifier: Q9H190-3) [UniParc]FASTA Add to basket

Also known as: Beta

The sequence of this isoform differs from the canonical sequence as follows:
1-85: Missing.

« Hide

        10         20         30         40         50
MVAPVTGYSL GVRRAEIKPG VREIHLCKDE RGKTGLRLRK VDQGLFVQLV 
        60         70         80         90        100
QANTPASLVG LRFGDQLLQI DGRDCAGWSS HKAHQVVKKA SGDKIVVVVR 
       110        120        130        140        150
DRPFQRTVTM HKDSMGHVGF VIKKGKIVSL VKGSSAARNG LLTNHYVCEV 
       160        170        180        190        200
DGQNVIGLKD KKIMEILATA GNVVTLTIIP SVIYEHMVKK LPPVLLHHTM 

DHSIPDA

Show »

Length:207

Mass (Da):22,664

Checksum:ⁱ16913A0148BF691A

GO

Sequence cautionⁱ

The sequence AAH02727 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	69	Q → H in CAC21716 (PubMed:11152476).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_053700	182	V → M2 PublicationsCorresponds to variant dbSNP:rs2273959Ensembl.	1
Natural variantⁱVAR_036544	191	R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs35367003Ensembl.	1
Natural variantⁱVAR_053701	223	R → C. Corresponds to variant dbSNP:rs1048621Ensembl.	1
Natural variantⁱVAR_053702	242	G → R. Corresponds to variant dbSNP:rs4814111Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006352	1 – 85	Missing in isoform 3. 2 PublicationsAdd BLAST		85

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159228 mRNA Translation: AAF80369.1 AJ292245 mRNA Translation: CAC21573.1 AJ292244 mRNA Translation: CAC21716.1 AF131809 mRNA Translation: AAD20049.1 AL136531 Genomic DNA No translation available. BC002727 mRNA Translation: AAH02727.2 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13013.1 [Q9H190-3] CCDS42848.1 [Q9H190-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001186713.1, NM_001199784.1 [Q9H190-1] NP_056500.2, NM_015685.5 [Q9H190-3] NP_536737.3, NM_080489.4 [Q9H190-1]
UniGeneⁱ	Hs.657015

Genome annotation databases

Ensemblⁱ	ENST00000339987; ENSP00000342935; ENSG00000125775 [Q9H190-1] ENST00000360779; ENSP00000354013; ENSG00000125775 [Q9H190-1] ENST00000381808; ENSP00000371229; ENSG00000125775 [Q9H190-3] ENST00000381812; ENSP00000371233; ENSG00000125775 [Q9H190-1]
GeneIDⁱ	27111
KEGGⁱ	hsa:27111
UCSC genome browser More...UCSCⁱ	uc002weu.5 human [Q9H190-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H190	Isoform 3 of Syntenin-2		HUMAN		207	UniRef90_Q9H190
Uncharacterized protein		MACMU		328
Uncharacterized protein		MACFA		292
Uncharacterized protein		CHLSB		292
Uncharacterized protein		PAPAN		292
+13

Protein	Similar proteins		Species	Score	Length	Source
Q9H190	Syntenin-2		RAT		296	UniRef50_Q9H190
Syntenin-2		MOUSE		292
Isoform 3 of Syntenin-2		HUMAN		207
Uncharacterized protein		MACMU		328
Uncharacterized protein		MACFA		292
+173

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF159228 mRNA Translation: AAF80369.1 AJ292245 mRNA Translation: CAC21573.1 AJ292244 mRNA Translation: CAC21716.1 AF131809 mRNA Translation: AAD20049.1 AL136531 Genomic DNA No translation available. BC002727 mRNA Translation: AAH02727.2 Different initiation.
CCDSⁱ	CCDS13013.1 [Q9H190-3] CCDS42848.1 [Q9H190-1]
RefSeqⁱ	NP_001186713.1, NM_001199784.1 [Q9H190-1] NP_056500.2, NM_015685.5 [Q9H190-3] NP_536737.3, NM_080489.4 [Q9H190-1]
UniGeneⁱ	Hs.657015

3D structure databases

ProteinModelPortalⁱ	Q9H190
SMRⁱ	Q9H190
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	118007, 47 interactors
IntActⁱ	Q9H190, 69 interactors
MINTⁱ	Q9H190

Protein family/group databases

MoonDBⁱ	Q9H190 Predicted

MoonDBⁱ

Q9H190 Predicted

PTM databases

iPTMnetⁱ	Q9H190
PhosphoSitePlusⁱ	Q9H190
SwissPalmⁱ	Q9H190

Polymorphism and mutation databases

BioMutaⁱ	SDCBP2
DMDMⁱ	20455288

Proteomic databases

EPDⁱ	Q9H190
MaxQBⁱ	Q9H190
PaxDbⁱ	Q9H190
PeptideAtlasⁱ	Q9H190
PRIDEⁱ	Q9H190
ProteomicsDBⁱ	80379 80380 [Q9H190-3]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000339987; ENSP00000342935; ENSG00000125775 [Q9H190-1] ENST00000360779; ENSP00000354013; ENSG00000125775 [Q9H190-1] ENST00000381808; ENSP00000371229; ENSG00000125775 [Q9H190-3] ENST00000381812; ENSP00000371233; ENSG00000125775 [Q9H190-1]
GeneIDⁱ	27111
KEGGⁱ	hsa:27111
UCSCⁱ	uc002weu.5 human [Q9H190-1]

Organism-specific databases

CTDⁱ	27111
DisGeNETⁱ	27111
EuPathDBⁱ	HostDB:ENSG00000125775.14
GeneCardsⁱ	SDCBP2
H-InvDBⁱ	HIX0158663
HGNCⁱ	HGNC:15756 SDCBP2
HPAⁱ	HPA054554 HPA064490
MIMⁱ	617358 gene
neXtProtⁱ	NX_Q9H190
OpenTargetsⁱ	ENSG00000125775
PharmGKBⁱ	PA38033
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK98 Eukaryota ENOG410YNPQ LUCA
GeneTreeⁱ	ENSGT00390000014465
HOGENOMⁱ	HOG000231604
HOVERGENⁱ	HBG053211
InParanoidⁱ	Q9H190
OMAⁱ	TLLHHTM
OrthoDBⁱ	EOG091G0HJI
PhylomeDBⁱ	Q9H190
TreeFamⁱ	TF327131

Miscellaneous databases

ChiTaRSⁱ	SDCBP2 human
GeneWikiⁱ	SDCBP2
GenomeRNAiⁱ	27111
Protein Ontology More...PROⁱ	PR:Q9H190
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000125775 Expressed in 141 organ(s), highest expression level in lower esophagus mucosa
CleanExⁱ	HS_SDCBP2
Genevisibleⁱ	Q9H190 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001478 PDZ IPR036034 PDZ_sf
Pfamⁱ	View protein in Pfam PF00595 PDZ, 1 hit
SMARTⁱ	View protein in SMART SM00228 PDZ, 2 hits
SUPFAMⁱ	SSF50156 SSF50156, 2 hits
PROSITEⁱ	View protein in PROSITE PS50106 PDZ, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SDCB2_HUMAN
Accessionⁱ	Q9H190Primary (citable) accession number: Q9H190 Secondary accession number(s): O95892 , Q5W0X1, Q9BZ42, Q9H567, Q9NRY8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
	Last sequence update:	May 2, 2002
	Last modified:	November 7, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM

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UniProtKB - Q9H190 (SDCB2_HUMAN)

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Syntenin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Nucleus

Other locations

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

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Organism-specific databases

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Gene expression databases

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ