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UniProtKB - Q9H190 (SDCB2_HUMAN)
Protein
Syntenin-2
Gene
SDCBP2
Organism
Homo sapiens (Human)
Status
Functioni
Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival (PubMed:15961997).
1 PublicationCaution
The nuclear speckles location of SDCBP2 is under debate. One study shows that in paraformaldehyde fixed cells, SDCBP2 is highly enriched in nuclear speckles (PubMed:15961997). The same authors investigate subcellular location in living cells and fail to detect SDCBP2 in nuclear speckles, and propose that enrichment in nuclear speckles is fixation-dependent (PubMed:23300061).2 Publications
GO - Molecular functioni
- identical protein binding Source: IntAct
- phosphatidylinositol-4,5-bisphosphate binding Source: UniProtKB
- protein C-terminus binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
GO - Biological processi
- cell population proliferation Source: UniProtKB
- intracellular signal transduction Source: UniProtKB
- intracellular transport Source: UniProtKB
- nervous system development Source: UniProtKB
Keywordsi
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9H190 |
SignaLinki | Q9H190 |
Protein family/group databases
MoonDBi | Q9H190, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Syntenin-2Alternative name(s): Similar to TACIP181 Publication Short name: SITAC1 Publication Syndecan-binding protein 2 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15756, SDCBP2 |
MIMi | 617358, gene |
neXtProti | NX_Q9H190 |
VEuPathDBi | HostDB:ENSG00000125775 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm 1 Publication
Nucleus
- nucleolus 2 Publications
- nucleoplasm 1 Publication
- Nucleus speckle 1 Publication
Plasma membrane
- Cell membrane 1 Publication
Note: Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments (PubMed:11102519). Colocalizes with TM4SF1 in the apical region of the cell (PubMed:11102519). Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments (PubMed:15961997). PIP2 plays an important role in the distribution of SDCBP2 (PubMed:23300061).3 Publications
Cytosol
- cytosol Source: HPA
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: HPA
Nucleus
- nuclear speck Source: UniProtKB
- nucleolus Source: UniProtKB
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 113 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-167; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-167. 1 Publication | 1 | |
Mutagenesisi | 167 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-197 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-113. 1 Publication | 1 | |
Mutagenesisi | 197 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-244. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-244. 1 Publication | 1 | |
Mutagenesisi | 244 | K → A: Abolishes phosphatidylinositol 4,5-bisphosphate binding and targeting to plasma membrane, speckles and nucleoli; when associated with A-113; A-167 and A-197. Reduces phosphatidylinositol 4,5-bisphosphate binding and does not change subcellular localization; when associated with A-197. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 27111 |
OpenTargetsi | ENSG00000125775 |
PharmGKBi | PA38033 |
Miscellaneous databases
Pharosi | Q9H190, Tbio |
Genetic variation databases
BioMutai | SDCBP2 |
DMDMi | 20455288 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000184004 | 1 – 292 | Syntenin-2Add BLAST | 292 |
Proteomic databases
EPDi | Q9H190 |
jPOSTi | Q9H190 |
MassIVEi | Q9H190 |
MaxQBi | Q9H190 |
PaxDbi | Q9H190 |
PeptideAtlasi | Q9H190 |
PRIDEi | Q9H190 |
ProteomicsDBi | 80379 [Q9H190-1] 80380 [Q9H190-3] |
PTM databases
iPTMneti | Q9H190 |
PhosphoSitePlusi | Q9H190 |
SwissPalmi | Q9H190 |
Expressioni
Tissue specificityi
Preferentially expressed in cells of the digestive tract (PubMed:11102519). Low expression in skeletal muscle and kidney (PubMed:11102519). Detected in differentiated keratinocytes of normal and malignant epithelium (PubMed:22623796). In healthy skin, expression is localized in suprabasal epidermal layers (PubMed:22623796).2 Publications
Inductioni
Down-regulated by HPV8 E6 papillomavirus (HPV) oncoprotein (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000125775, Expressed in lower esophagus mucosa and 160 other tissues |
Genevisiblei | Q9H190, HS |
Organism-specific databases
HPAi | ENSG00000125775, Tissue enhanced (esophagus, intestine, stomach) |
Interactioni
Subunit structurei
Binary interactionsi
Q9H190
GO - Molecular functioni
- identical protein binding Source: IntAct
- protein C-terminus binding Source: UniProtKB
- protein heterodimerization activity Source: UniProtKB
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 118007, 74 interactors |
IntActi | Q9H190, 70 interactors |
MINTi | Q9H190 |
STRINGi | 9606.ENSP00000371233 |
Miscellaneous databases
RNActi | Q9H190, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 108 – 187 | PDZ 1PROSITE-ProRule annotationAdd BLAST | 80 | |
Domaini | 192 – 267 | PDZ 2PROSITE-ProRule annotationAdd BLAST | 76 |
Domaini
Binds phosphatidylinositol 4,5-bisphosphate (PIP2) via its two PDZ domains. These domains target SDCBP2 to the plasma membranes and nucleoli, two PIP2-rich regions.1 Publication
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | ENOG502S0HE, Eukaryota |
GeneTreei | ENSGT00940000161179 |
HOGENOMi | CLU_059870_0_0_1 |
InParanoidi | Q9H190 |
OMAi | DGCDCAG |
OrthoDBi | 1035679at2759 |
PhylomeDBi | Q9H190 |
TreeFami | TF327131 |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q9H190-1) [UniParc]FASTAAdd to basket
Also known as: Alpha
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSLYPSLED LKVDQAIQAQ VRASPKMPAL PVQATAISPP PVLYPNLAEL
60 70 80 90 100
ENYMGLSLSS QEVQESLLQI PEGDSTAVSG PGPGQMVAPV TGYSLGVRRA
110 120 130 140 150
EIKPGVREIH LCKDERGKTG LRLRKVDQGL FVQLVQANTP ASLVGLRFGD
160 170 180 190 200
QLLQIDGRDC AGWSSHKAHQ VVKKASGDKI VVVVRDRPFQ RTVTMHKDSM
210 220 230 240 250
GHVGFVIKKG KIVSLVKGSS AARNGLLTNH YVCEVDGQNV IGLKDKKIME
260 270 280 290
ILATAGNVVT LTIIPSVIYE HMVKKLPPVL LHHTMDHSIP DA
Sequence cautioni
The sequence AAH02727 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 69 | Q → H in CAC21716 (PubMed:11152476).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053700 | 182 | V → M2 PublicationsCorresponds to variant dbSNP:rs2273959Ensembl. | 1 | |
Natural variantiVAR_036544 | 191 | R → Q in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs35367003Ensembl. | 1 | |
Natural variantiVAR_053701 | 223 | R → C. Corresponds to variant dbSNP:rs1048621Ensembl. | 1 | |
Natural variantiVAR_053702 | 242 | G → R. Corresponds to variant dbSNP:rs4814111Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_006352 | 1 – 85 | Missing in isoform 3. 2 PublicationsAdd BLAST | 85 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159228 mRNA Translation: AAF80369.1 AJ292245 mRNA Translation: CAC21573.1 AJ292244 mRNA Translation: CAC21716.1 AF131809 mRNA Translation: AAD20049.1 AL136531 Genomic DNA No translation available. BC002727 mRNA Translation: AAH02727.2 Different initiation. |
CCDSi | CCDS13013.1 [Q9H190-3] CCDS42848.1 [Q9H190-1] |
RefSeqi | NP_001186713.1, NM_001199784.1 [Q9H190-1] NP_056500.2, NM_015685.5 [Q9H190-3] NP_536737.3, NM_080489.4 [Q9H190-1] |
Genome annotation databases
Ensembli | ENST00000339987; ENSP00000342935; ENSG00000125775 ENST00000360779; ENSP00000354013; ENSG00000125775 ENST00000381808; ENSP00000371229; ENSG00000125775 [Q9H190-3] ENST00000381812; ENSP00000371233; ENSG00000125775 |
GeneIDi | 27111 |
KEGGi | hsa:27111 |
MANE-Selecti | ENST00000360779.4; ENSP00000354013.3; NM_080489.5; NP_536737.3 |
UCSCi | uc002weu.5, human [Q9H190-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159228 mRNA Translation: AAF80369.1 AJ292245 mRNA Translation: CAC21573.1 AJ292244 mRNA Translation: CAC21716.1 AF131809 mRNA Translation: AAD20049.1 AL136531 Genomic DNA No translation available. BC002727 mRNA Translation: AAH02727.2 Different initiation. |
CCDSi | CCDS13013.1 [Q9H190-3] CCDS42848.1 [Q9H190-1] |
RefSeqi | NP_001186713.1, NM_001199784.1 [Q9H190-1] NP_056500.2, NM_015685.5 [Q9H190-3] NP_536737.3, NM_080489.4 [Q9H190-1] |
3D structure databases
SMRi | Q9H190 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 118007, 74 interactors |
IntActi | Q9H190, 70 interactors |
MINTi | Q9H190 |
STRINGi | 9606.ENSP00000371233 |
Protein family/group databases
MoonDBi | Q9H190, Predicted |
PTM databases
iPTMneti | Q9H190 |
PhosphoSitePlusi | Q9H190 |
SwissPalmi | Q9H190 |
Genetic variation databases
BioMutai | SDCBP2 |
DMDMi | 20455288 |
Proteomic databases
EPDi | Q9H190 |
jPOSTi | Q9H190 |
MassIVEi | Q9H190 |
MaxQBi | Q9H190 |
PaxDbi | Q9H190 |
PeptideAtlasi | Q9H190 |
PRIDEi | Q9H190 |
ProteomicsDBi | 80379 [Q9H190-1] 80380 [Q9H190-3] |
Protocols and materials databases
Antibodypediai | 23059, 243 antibodies from 30 providers |
DNASUi | 27111 |
Genome annotation databases
Ensembli | ENST00000339987; ENSP00000342935; ENSG00000125775 ENST00000360779; ENSP00000354013; ENSG00000125775 ENST00000381808; ENSP00000371229; ENSG00000125775 [Q9H190-3] ENST00000381812; ENSP00000371233; ENSG00000125775 |
GeneIDi | 27111 |
KEGGi | hsa:27111 |
MANE-Selecti | ENST00000360779.4; ENSP00000354013.3; NM_080489.5; NP_536737.3 |
UCSCi | uc002weu.5, human [Q9H190-1] |
Organism-specific databases
CTDi | 27111 |
DisGeNETi | 27111 |
GeneCardsi | SDCBP2 |
HGNCi | HGNC:15756, SDCBP2 |
HPAi | ENSG00000125775, Tissue enhanced (esophagus, intestine, stomach) |
MIMi | 617358, gene |
neXtProti | NX_Q9H190 |
OpenTargetsi | ENSG00000125775 |
PharmGKBi | PA38033 |
VEuPathDBi | HostDB:ENSG00000125775 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S0HE, Eukaryota |
GeneTreei | ENSGT00940000161179 |
HOGENOMi | CLU_059870_0_0_1 |
InParanoidi | Q9H190 |
OMAi | DGCDCAG |
OrthoDBi | 1035679at2759 |
PhylomeDBi | Q9H190 |
TreeFami | TF327131 |
Enzyme and pathway databases
PathwayCommonsi | Q9H190 |
SignaLinki | Q9H190 |
Miscellaneous databases
BioGRID-ORCSi | 27111, 12 hits in 1042 CRISPR screens |
GeneWikii | SDCBP2 |
GenomeRNAii | 27111 |
Pharosi | Q9H190, Tbio |
PROi | PR:Q9H190 |
RNActi | Q9H190, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125775, Expressed in lower esophagus mucosa and 160 other tissues |
Genevisiblei | Q9H190, HS |
Family and domain databases
Gene3Di | 2.30.42.10, 2 hits |
InterProi | View protein in InterPro IPR001478, PDZ IPR036034, PDZ_sf |
Pfami | View protein in Pfam PF00595, PDZ, 1 hit |
SMARTi | View protein in SMART SM00228, PDZ, 2 hits |
SUPFAMi | SSF50156, SSF50156, 2 hits |
PROSITEi | View protein in PROSITE PS50106, PDZ, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | SDCB2_HUMAN | |
Accessioni | Q9H190Primary (citable) accession number: Q9H190 Secondary accession number(s): O95892 Q9NRY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2002 |
Last sequence update: | May 2, 2002 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot