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Entry version 164 (12 Aug 2020)
Sequence version 2 (19 Jul 2005)
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Protein

Z-DNA-binding protein 1

Gene

ZBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis (By similarity). Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity).By similarity1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

ZBP1-dependent necroptosis is normally inhibited by RIPK1: RIPK1 inhibits the ZBP1-induced activation of RIPK3 via FADD-mediated recruitment of CASP8, which cleaves RIPK1 and limits TNF-induced necroptosis.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, RNA-binding
Biological processAntiviral defense, Apoptosis, Host-virus interaction, Immunity, Innate immunity, Necrosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H171

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1606322, ZBP1(DAI) mediated induction of type I IFNs
R-HSA-1606341, IRF3 mediated activation of type 1 IFN
R-HSA-1810476, RIP-mediated NFkB activation via ZBP1
R-HSA-3134975, Regulation of innate immune responses to cytosolic DNA

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Z-DNA-binding protein 1Curated
Alternative name(s):
DNA-dependent activator of IFN-regulatory factors1 Publication
Short name:
DAI1 Publication
Tumor stroma and activated macrophage protein DLM-11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZBP1Imported
Synonyms:C20orf183Imported, DLM11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000124256.14

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16176, ZBP1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606750, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H171

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
81030

Open Targets

More...
OpenTargetsi
ENSG00000124256

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38094

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H171, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZBP1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
71153189

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000665641 – 429Z-DNA-binding protein 1Add BLAST429

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated.By similarity

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H171

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H171

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H171

PeptideAtlas

More...
PeptideAtlasi
Q9H171

PRoteomics IDEntifications database

More...
PRIDEi
Q9H171

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
199
24833
80370 [Q9H171-1]
80371 [Q9H171-2]
80372 [Q9H171-3]
80373 [Q9H171-4]
80374 [Q9H171-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H171

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H171

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen (PubMed:11842111). Expressed to a lesser extent in thymus, lung and liver (PubMed:11842111).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000124256, Expressed in granulocyte and 167 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H171, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H171, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000124256, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Interacts (via RIP homotypic interaction motif) with RIPK3; leading to RIPK3 activation and necroptosis (By similarity).

Interacts (via RIP homotypic interaction motif) with RIPK1 (By similarity).

By similarity

(Microbial infection) Interacts with human herpesvirus 1 protein ICP0.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123349, 18 interactors

Database of interacting proteins

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DIPi
DIP-44121N

Protein interaction database and analysis system

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IntActi
Q9H171, 12 interactors

Molecular INTeraction database

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MINTi
Q9H171

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000360215

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H171, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1429
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H171

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H171

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini8 – 70Z-binding 1PROSITE-ProRule annotationAdd BLAST63
Domaini103 – 166Z-binding 2PROSITE-ProRule annotationAdd BLAST64

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi195 – 219RIP homotypic interaction motif (RHIM) 1By similarityAdd BLAST25
Motifi253 – 277RIP homotypic interaction motif (RHIM) 2By similarityAdd BLAST25

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Z-binding domains recognize and bind left-handed double-stranded Z-RNA structures, but not A-RNA, the right-handed double-stranded RNAs that are structurally very different from Z-RNAs. The second Z-binding domain is essential for sensing influenza A virus (IAV) Z-RNAs.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502SRWE, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000002234

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_053260_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H171

KEGG Orthology (KO)

More...
KOi
K12965

Identification of Orthologs from Complete Genome Data

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OMAi
QQNPINM

Database of Orthologous Groups

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OrthoDBi
1138811at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H171

TreeFam database of animal gene trees

More...
TreeFami
TF337658

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR042371, Zalpha_dom
IPR042361, ZBP1

The PANTHER Classification System

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PANTHERi
PTHR14966, PTHR14966, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF02295, z-alpha, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00550, Zalpha, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785, SSF46785, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50139, Z_BINDING, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (7+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 7 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H171-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQAPADPGR EGHLEQRILQ VLTEAGSPVK LAQLVKECQA PKRELNQVLY
60 70 80 90 100
RMKKELKVSL TSPATWCLGG TDPEGEGPAE LALSSPAERP QQHAATIPET
110 120 130 140 150
PGPQFSQQRE EDIYRFLKDN GPQRALVIAQ ALGMRTAKDV NRDLYRMKSR
160 170 180 190 200
HLLDMDEQSK AWTIYRPEDS GRRAKSASII YQHNPINMIC QNGPNSWISI
210 220 230 240 250
ANSEAIQIGH GNIITRQTVS REDGSAGPRH LPSMAPGDSS TWGTLVDPWG
260 270 280 290 300
PQDIHMEQSI LRRVQLGHSN EMRLHGVPSE GPAHIPPGSP PVSATAAGPE
310 320 330 340 350
ASFEARIPSP GTHPEGEAAQ RIHMKSCFLE DATIGNSNKM SISPGVAGPG
360 370 380 390 400
GVAGSGEGEP GEDAGRRPAD TQSRSHFPRD IGQPITPSHS KLTPKLETMT
410 420
LGNRSHKAAE GSHYVDEASH EGSWWGGGI
Length:429
Mass (Da):46,343
Last modified:July 19, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2C9B195112822991
GO
Isoform 2 (identifier: Q9H171-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-429: GRRPADTQSR...HEGSWWGGGI → VAAFTEVLNP...HKIYLLKNKK

Show »
Length:446
Mass (Da):48,754
Checksum:iAB6807A7F1397076
GO
Isoform 3 (identifier: Q9H171-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     365-429: GRRPADTQSR...HEGSWWGGGI → GRRPADTQSRSFDGQE

Show »
Length:380
Mass (Da):41,028
Checksum:i247472C6F85CEB36
GO
Isoform 4 (identifier: Q9H171-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-109: Missing.

Show »
Length:406
Mass (Da):43,786
Checksum:i709506D06777E8F2
GO
Isoform 5 (identifier: Q9H171-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     87-149: AERPQQHAAT...VNRDLYRMKS → GNCHPGEAGL...LTAGLLGRGC
     150-429: Missing.

Show »
Length:149
Mass (Da):15,985
Checksum:i1D948BB00599314B
GO
Isoform 6 (identifier: Q9H171-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     225-248: SAGPRHLPSMAPGDSSTWGTLVDP → KSPKRAQGGDLGGEPPDPLGGGKG
     249-429: Missing.

Show »
Length:248
Mass (Da):27,218
Checksum:iE79D75F5D4FE665C
GO
Isoform 7 (identifier: Q9H171-7) [UniParc]FASTAAdd to basket
Also known as: Delta-exon-21 Publication, Deltaexon-21 Publication, Delta-Z-alpha1 Publication, DeltaZalpha1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     12-86: Missing.

Show »
Length:354
Mass (Da):38,220
Checksum:i162A79FBD15B1B0F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y6D1H0Y6D1_HUMAN
Z-DNA-binding protein 1
ZBP1
119Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05703017R → I. Corresponds to variant dbSNP:rs35813125Ensembl.1
Natural variantiVAR_06172853K → R. Corresponds to variant dbSNP:rs35895307Ensembl.1
Natural variantiVAR_05703170G → R. Corresponds to variant dbSNP:rs34964609Ensembl.1
Natural variantiVAR_01431688E → K2 PublicationsCorresponds to variant dbSNP:rs2073145Ensembl.1
Natural variantiVAR_057032154D → H. Corresponds to variant dbSNP:rs16981187Ensembl.1
Natural variantiVAR_057033166R → H. Corresponds to variant dbSNP:rs34478944Ensembl.1
Natural variantiVAR_069138258Q → R3 PublicationsCorresponds to variant dbSNP:rs2865394Ensembl.1
Natural variantiVAR_061729332A → V. Corresponds to variant dbSNP:rs41275648Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04608112 – 86Missing in isoform 7. 1 PublicationAdd BLAST75
Alternative sequenceiVSP_00407987 – 149AERPQ…YRMKS → GNCHPGEAGLTLQGASWQWT STDLSLGSNLNSATWELTGF LSLCLGFFFWLMELTAGLLG RGC in isoform 5. 1 PublicationAdd BLAST63
Alternative sequenceiVSP_00407887 – 109Missing in isoform 4. CuratedAdd BLAST23
Alternative sequenceiVSP_004080150 – 429Missing in isoform 5. 1 PublicationAdd BLAST280
Alternative sequenceiVSP_045405225 – 248SAGPR…TLVDP → KSPKRAQGGDLGGEPPDPLG GGKG in isoform 6. 1 PublicationAdd BLAST24
Alternative sequenceiVSP_045406249 – 429Missing in isoform 6. 1 PublicationAdd BLAST181
Alternative sequenceiVSP_004081365 – 429GRRPA…WGGGI → VAAFTEVLNPSKSFMKFGIN FFQTPVNVDSLTSSHESQMF LTACRLVIFSRRFSTYFAQI HLRNHSVLHLCPHKIYLLKN KK in isoform 2. CuratedAdd BLAST65
Alternative sequenceiVSP_004082365 – 429GRRPA…WGGGI → GRRPADTQSRSFDGQE in isoform 3. CuratedAdd BLAST65

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AJ300575 mRNA Translation: CAC18810.1
CT002036 mRNA No translation available.
AK122761 mRNA Translation: BAG53713.1
AL035541 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75511.1
BC028218 mRNA Translation: AAH28218.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS13461.1 [Q9H171-1]
CCDS54477.1 [Q9H171-7]
CCDS54478.1 [Q9H171-6]

NCBI Reference Sequences

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RefSeqi
NP_001153889.1, NM_001160417.1
NP_001153890.1, NM_001160418.1 [Q9H171-7]
NP_001153891.1, NM_001160419.2 [Q9H171-6]
NP_001310895.1, NM_001323966.1
NP_110403.2, NM_030776.2 [Q9H171-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000371173; ENSP00000360215; ENSG00000124256 [Q9H171-1]
ENST00000395822; ENSP00000379167; ENSG00000124256 [Q9H171-7]
ENST00000541799; ENSP00000440552; ENSG00000124256 [Q9H171-6]

Database of genes from NCBI RefSeq genomes

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GeneIDi
81030

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:81030

UCSC genome browser

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UCSCi
uc002xyo.4, human [Q9H171-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ300575 mRNA Translation: CAC18810.1
CT002036 mRNA No translation available.
AK122761 mRNA Translation: BAG53713.1
AL035541 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75511.1
BC028218 mRNA Translation: AAH28218.1
CCDSiCCDS13461.1 [Q9H171-1]
CCDS54477.1 [Q9H171-7]
CCDS54478.1 [Q9H171-6]
RefSeqiNP_001153889.1, NM_001160417.1
NP_001153890.1, NM_001160418.1 [Q9H171-7]
NP_001153891.1, NM_001160419.2 [Q9H171-6]
NP_001310895.1, NM_001323966.1
NP_110403.2, NM_030776.2 [Q9H171-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2L4MNMR-A103-166[»]
2LNBNMR-A6-74[»]
3EYIX-ray1.45A/B103-166[»]
4KA4X-ray2.60A/B/D/E96-165[»]
SMRiQ9H171
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123349, 18 interactors
DIPiDIP-44121N
IntActiQ9H171, 12 interactors
MINTiQ9H171
STRINGi9606.ENSP00000360215

PTM databases

iPTMnetiQ9H171
PhosphoSitePlusiQ9H171

Polymorphism and mutation databases

BioMutaiZBP1
DMDMi71153189

Proteomic databases

jPOSTiQ9H171
MassIVEiQ9H171
PaxDbiQ9H171
PeptideAtlasiQ9H171
PRIDEiQ9H171
ProteomicsDBi199
24833
80370 [Q9H171-1]
80371 [Q9H171-2]
80372 [Q9H171-3]
80373 [Q9H171-4]
80374 [Q9H171-5]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
14231, 201 antibodies

The DNASU plasmid repository

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DNASUi
81030

Genome annotation databases

EnsembliENST00000371173; ENSP00000360215; ENSG00000124256 [Q9H171-1]
ENST00000395822; ENSP00000379167; ENSG00000124256 [Q9H171-7]
ENST00000541799; ENSP00000440552; ENSG00000124256 [Q9H171-6]
GeneIDi81030
KEGGihsa:81030
UCSCiuc002xyo.4, human [Q9H171-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
81030
DisGeNETi81030
EuPathDBiHostDB:ENSG00000124256.14

GeneCards: human genes, protein and diseases

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GeneCardsi
ZBP1
HGNCiHGNC:16176, ZBP1
HPAiENSG00000124256, Tissue enhanced (blood, lymphoid tissue)
MIMi606750, gene
neXtProtiNX_Q9H171
OpenTargetsiENSG00000124256
PharmGKBiPA38094

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502SRWE, Eukaryota
GeneTreeiENSGT00390000002234
HOGENOMiCLU_053260_0_0_1
InParanoidiQ9H171
KOiK12965
OMAiQQNPINM
OrthoDBi1138811at2759
PhylomeDBiQ9H171
TreeFamiTF337658

Enzyme and pathway databases

PathwayCommonsiQ9H171
ReactomeiR-HSA-1606322, ZBP1(DAI) mediated induction of type I IFNs
R-HSA-1606341, IRF3 mediated activation of type 1 IFN
R-HSA-1810476, RIP-mediated NFkB activation via ZBP1
R-HSA-3134975, Regulation of innate immune responses to cytosolic DNA

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
81030, 5 hits in 873 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZBP1, human
EvolutionaryTraceiQ9H171

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ZBP1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
81030
PharosiQ9H171, Tbio

Protein Ontology

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PROi
PR:Q9H171
RNActiQ9H171, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000124256, Expressed in granulocyte and 167 other tissues
ExpressionAtlasiQ9H171, baseline and differential
GenevisibleiQ9H171, HS

Family and domain databases

Gene3Di1.10.10.10, 2 hits
InterProiView protein in InterPro
IPR036388, WH-like_DNA-bd_sf
IPR036390, WH_DNA-bd_sf
IPR042371, Zalpha_dom
IPR042361, ZBP1
PANTHERiPTHR14966, PTHR14966, 1 hit
PfamiView protein in Pfam
PF02295, z-alpha, 1 hit
SMARTiView protein in SMART
SM00550, Zalpha, 2 hits
SUPFAMiSSF46785, SSF46785, 2 hits
PROSITEiView protein in PROSITE
PS50139, Z_BINDING, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZBP1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H171
Secondary accession number(s): A2A2F7
, B3KVA1, F5GYT1, Q5JY39, Q9BYW4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: July 19, 2005
Last modified: August 12, 2020
This is version 164 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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