UniProtKB - Q9H169 (STMN4_HUMAN)
Protein
Stathmin-4
Gene
STMN4
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits microtubule-destabilizing activity.By similarity
GO - Molecular functioni
- tubulin binding Source: GO_Central
GO - Biological processi
- microtubule depolymerization Source: GO_Central
- neuron projection development Source: GO_Central
- regulation of cytoskeleton organization Source: GO_Central
- regulation of microtubule polymerization or depolymerization Source: GO_Central
Enzyme and pathway databases
PathwayCommonsi | Q9H169 |
Names & Taxonomyi
Protein namesi | Recommended name: Stathmin-4Alternative name(s): Stathmin-like protein B3 Short name: RB3 |
Gene namesi | Name:STMN4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000015592.16 |
HGNCi | HGNC:16078, STMN4 |
neXtProti | NX_Q9H169 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus By similarity
Other locations
- growth cone By similarity
- axon By similarity
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- growth cone Source: UniProtKB-SubCell
- neuron projection Source: GO_Central
Keywords - Cellular componenti
Cell projection, Golgi apparatusPathology & Biotechi
Organism-specific databases
DisGeNETi | 81551 |
OpenTargetsi | ENSG00000015592 |
PharmGKBi | PA38089 |
Miscellaneous databases
Pharosi | Q9H169, Tbio |
Chemistry databases
DrugBanki | DB07574, 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE DB01206, Lomustine |
Polymorphism and mutation databases
BioMutai | STMN4 |
DMDMi | 17368936 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000182406 | 1 – 189 | Stathmin-4Add BLAST | 189 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 20 | S-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 22 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 90 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, Palmitate, PhosphoproteinProteomic databases
jPOSTi | Q9H169 |
MassIVEi | Q9H169 |
MaxQBi | Q9H169 |
PeptideAtlasi | Q9H169 |
PRIDEi | Q9H169 |
ProteomicsDBi | 34108 6479 80368 [Q9H169-1] 80369 [Q9H169-2] |
PTM databases
iPTMneti | Q9H169 |
PhosphoSitePlusi | Q9H169 |
Expressioni
Gene expression databases
Bgeei | ENSG00000015592, Expressed in C1 segment of cervical spinal cord and 155 other tissues |
ExpressionAtlasi | Q9H169, baseline and differential |
Genevisiblei | Q9H169, HS |
Organism-specific databases
HPAi | ENSG00000015592, Tissue enriched (brain) |
Interactioni
Binary interactionsi
Hide detailsIsoform 2 [Q9H169-2]
GO - Molecular functioni
- tubulin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 123515, 29 interactors |
IntActi | Q9H169, 27 interactors |
Miscellaneous databases
RNActi | Q9H169, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9H169 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 189 | SLDPROSITE-ProRule annotationAdd BLAST | 142 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 90 – 188 | Sequence analysisAdd BLAST | 99 |
Sequence similaritiesi
Belongs to the stathmin family.Curated
Keywords - Domaini
Coiled coilPhylogenomic databases
GeneTreei | ENSGT00950000182794 |
HOGENOMi | CLU_102026_0_1_1 |
InParanoidi | Q9H169 |
OMAi | GWCVIKD |
PhylomeDBi | Q9H169 |
TreeFami | TF326935 |
Family and domain databases
InterProi | View protein in InterPro IPR028834, Stathmin-4 IPR030514, Stathmin_CS IPR000956, Stathmin_fam IPR036002, Stathmin_sf |
PANTHERi | PTHR10104, PTHR10104, 1 hit PTHR10104:SF6, PTHR10104:SF6, 1 hit |
Pfami | View protein in Pfam PF00836, Stathmin, 1 hit |
PIRSFi | PIRSF002285, Stathmin, 1 hit |
PRINTSi | PR00345, STATHMIN |
SUPFAMi | SSF101494, SSF101494, 1 hit |
PROSITEi | View protein in PROSITE PS00563, STATHMIN_1, 1 hit PS01041, STATHMIN_2, 1 hit PS51663, STATHMIN_3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H169-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MTLAAYKEKM KELPLVSLFC SCFLADPLNK SSYKYEADTV DLNWCVISDM
60 70 80 90 100
EVIELNKCTS GQSFEVILKP PSFDGVPEFN ASLPRRRDPS LEEIQKKLEA
110 120 130 140 150
AEERRKYQEA ELLKHLAEKR EHEREVIQKA IEENNNFIKM AKEKLAQKME
160 170 180
SNKENREAHL AAMLERLQEK DKHAEEVRKN KELKEEASR
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EVN3 | E7EVN3_HUMAN | Stathmin-4 | STMN4 | 258 | Annotation score: | ||
E5RIR6 | E5RIR6_HUMAN | Stathmin-4 | STMN4 | 231 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 11 | K → M in BAH12575 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055279 | 1 – 9 | Missing in isoform 3. 1 Publication | 9 | |
Alternative sequenceiVSP_006279 | 36 | E → EGWCGRQCRRKDESQRKDSA DWRERRAQ in isoform 2 and isoform 4. 2 Publications | 1 | |
Alternative sequenceiVSP_055280 | 171 – 188 | DKHAE…KEEAS → EPPAA in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 18 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ303455 mRNA Translation: CAC22254.1 AL136568 mRNA Translation: CAB66503.1 AK295329 mRNA Translation: BAH12033.1 AK297415 mRNA Translation: BAH12575.1 AC090150 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63562.1 CH471080 Genomic DNA Translation: EAW63563.1 CH471080 Genomic DNA Translation: EAW63565.1 CH471080 Genomic DNA Translation: EAW63567.1 BC011520 mRNA Translation: AAH11520.1 BC111001 mRNA Translation: AAI11002.1 |
CCDSi | CCDS6055.1 [Q9H169-2] CCDS64851.1 [Q9H169-3] CCDS64852.1 [Q9H169-1] CCDS64854.1 [Q9H169-4] |
RefSeqi | NP_001269982.1, NM_001283053.1 [Q9H169-4] NP_001269983.1, NM_001283054.1 [Q9H169-1] NP_001269984.1, NM_001283055.1 [Q9H169-3] NP_110422.2, NM_030795.3 [Q9H169-2] |
Genome annotation databases
Ensembli | ENST00000265770; ENSP00000265770; ENSG00000015592 [Q9H169-1] ENST00000350889; ENSP00000342538; ENSG00000015592 [Q9H169-2] ENST00000519997; ENSP00000428474; ENSG00000015592 [Q9H169-3] ENST00000523048; ENSP00000428428; ENSG00000015592 [Q9H169-4] |
GeneIDi | 81551 |
KEGGi | hsa:81551 |
UCSCi | uc003xfj.5, human [Q9H169-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ303455 mRNA Translation: CAC22254.1 AL136568 mRNA Translation: CAB66503.1 AK295329 mRNA Translation: BAH12033.1 AK297415 mRNA Translation: BAH12575.1 AC090150 Genomic DNA No translation available. CH471080 Genomic DNA Translation: EAW63562.1 CH471080 Genomic DNA Translation: EAW63563.1 CH471080 Genomic DNA Translation: EAW63565.1 CH471080 Genomic DNA Translation: EAW63567.1 BC011520 mRNA Translation: AAH11520.1 BC111001 mRNA Translation: AAI11002.1 |
CCDSi | CCDS6055.1 [Q9H169-2] CCDS64851.1 [Q9H169-3] CCDS64852.1 [Q9H169-1] CCDS64854.1 [Q9H169-4] |
RefSeqi | NP_001269982.1, NM_001283053.1 [Q9H169-4] NP_001269983.1, NM_001283054.1 [Q9H169-1] NP_001269984.1, NM_001283055.1 [Q9H169-3] NP_110422.2, NM_030795.3 [Q9H169-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6BR1 | X-ray | 2.30 | E | 49-189 | [»] | |
6BRF | X-ray | 2.50 | E | 49-189 | [»] | |
6BRY | X-ray | 2.70 | E | 49-189 | [»] | |
6NNG | X-ray | 2.40 | E | 49-189 | [»] | |
6O5M | X-ray | 2.30 | E | 49-189 | [»] | |
6O5N | X-ray | 3.00 | E | 49-189 | [»] | |
6O61 | X-ray | 2.60 | E | 49-189 | [»] | |
6PC4 | X-ray | 2.60 | E | 49-189 | [»] | |
SMRi | Q9H169 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123515, 29 interactors |
IntActi | Q9H169, 27 interactors |
Chemistry databases
DrugBanki | DB07574, 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE DB01206, Lomustine |
PTM databases
iPTMneti | Q9H169 |
PhosphoSitePlusi | Q9H169 |
Polymorphism and mutation databases
BioMutai | STMN4 |
DMDMi | 17368936 |
Proteomic databases
jPOSTi | Q9H169 |
MassIVEi | Q9H169 |
MaxQBi | Q9H169 |
PeptideAtlasi | Q9H169 |
PRIDEi | Q9H169 |
ProteomicsDBi | 34108 6479 80368 [Q9H169-1] 80369 [Q9H169-2] |
Protocols and materials databases
Antibodypediai | 10084, 149 antibodies |
DNASUi | 81551 |
Genome annotation databases
Ensembli | ENST00000265770; ENSP00000265770; ENSG00000015592 [Q9H169-1] ENST00000350889; ENSP00000342538; ENSG00000015592 [Q9H169-2] ENST00000519997; ENSP00000428474; ENSG00000015592 [Q9H169-3] ENST00000523048; ENSP00000428428; ENSG00000015592 [Q9H169-4] |
GeneIDi | 81551 |
KEGGi | hsa:81551 |
UCSCi | uc003xfj.5, human [Q9H169-1] |
Organism-specific databases
CTDi | 81551 |
DisGeNETi | 81551 |
EuPathDBi | HostDB:ENSG00000015592.16 |
GeneCardsi | STMN4 |
HGNCi | HGNC:16078, STMN4 |
HPAi | ENSG00000015592, Tissue enriched (brain) |
neXtProti | NX_Q9H169 |
OpenTargetsi | ENSG00000015592 |
PharmGKBi | PA38089 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182794 |
HOGENOMi | CLU_102026_0_1_1 |
InParanoidi | Q9H169 |
OMAi | GWCVIKD |
PhylomeDBi | Q9H169 |
TreeFami | TF326935 |
Enzyme and pathway databases
PathwayCommonsi | Q9H169 |
Miscellaneous databases
BioGRID-ORCSi | 81551, 1 hit in 842 CRISPR screens |
GenomeRNAii | 81551 |
Pharosi | Q9H169, Tbio |
PROi | PR:Q9H169 |
RNActi | Q9H169, protein |
Gene expression databases
Bgeei | ENSG00000015592, Expressed in C1 segment of cervical spinal cord and 155 other tissues |
ExpressionAtlasi | Q9H169, baseline and differential |
Genevisiblei | Q9H169, HS |
Family and domain databases
InterProi | View protein in InterPro IPR028834, Stathmin-4 IPR030514, Stathmin_CS IPR000956, Stathmin_fam IPR036002, Stathmin_sf |
PANTHERi | PTHR10104, PTHR10104, 1 hit PTHR10104:SF6, PTHR10104:SF6, 1 hit |
Pfami | View protein in Pfam PF00836, Stathmin, 1 hit |
PIRSFi | PIRSF002285, Stathmin, 1 hit |
PRINTSi | PR00345, STATHMIN |
SUPFAMi | SSF101494, SSF101494, 1 hit |
PROSITEi | View protein in PROSITE PS00563, STATHMIN_1, 1 hit PS01041, STATHMIN_2, 1 hit PS51663, STATHMIN_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | STMN4_HUMAN | |
Accessioni | Q9H169Primary (citable) accession number: Q9H169 Secondary accession number(s): B7Z2Z7 Q2TAB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 16, 2001 |
Last sequence update: | March 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 150 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM