ALX4

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
DNA bindingⁱ	214 – 273	HomeoboxPROSITE-ProRule annotationAdd BLAST		60

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Non-traceable author statementⁱ
- 11137991
HMG box domain binding Source: Ensembl
protein heterodimerization activity Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding Source: Ensembl
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification Source: Ensembl
digestive tract development Source: Ensembl
embryonic digit morphogenesis Source: Ensembl
embryonic forelimb morphogenesis Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
embryonic skeletal system morphogenesis Source: Ensembl
hair follicle development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 19692347
muscle organ development Source: Ensembl
post-embryonic development Source: Ensembl
regulation of apoptotic process Source: Ensembl
roof of mouth development Source: Ensembl
skeletal system development
Source: UniProtKB
Non-traceable author statementⁱ
- 11106354

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	Q9H161

SIGNORⁱ

Q9H161

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Homeobox protein aristaless-like 4
Gene namesⁱ	Name:ALX4 Synonyms:KIAA1788
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000052850.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:450 ALX4
MIMⁱ	605420 gene
neXtProtⁱ	NX_Q9H161

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Parietal foramina 2 (PFM2)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAutosomal dominant disease characterized by oval defects of the parietal bones caused by deficient ossification around the parietal notch, which is normally obliterated during the fifth fetal month. PFM2 is also a clinical feature of Potocki-Shaffer syndrome.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_010785	218	R → Q in PFM2. 1 PublicationCorresponds to variant dbSNP:rs104894193EnsemblClinVar.		1
Natural variantⁱVAR_010897	272	R → P in PFM2. 1 PublicationCorresponds to variant dbSNP:rs104894196EnsemblClinVar.		1

Frontonasal dysplasia 2 (FND2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionThe term frontonasal dysplasia describes an array of abnormalities affecting the eyes, forehead and nose and linked to midfacial dysraphia. The clinical picture is highly variable. Major findings include true ocular hypertelorism; broadening of the nasal root; median facial cleft affecting the nose and/or upper lip and palate; unilateral or bilateral clefting of the alae nasi; lack of formation of the nasal tip; anterior cranium bifidum occultum; a V-shaped or widow's peak frontal hairline.

Potocki-Shaffer syndrome (POSHS)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA syndrome characterized by foramina parietalia permagna, multiple exostoses, and craniofacial dysostosis and mental retardation in some cases.

Craniosynostosis 5 (CRS5)1 Publication

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.

Keywords - Diseaseⁱ

Craniosynostosis, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	60529
GeneReviewsⁱ	ALX4
MalaCards human disease database More...MalaCardsⁱ	ALX4
MIMⁱ	601224 phenotype 609597 phenotype 613451 phenotype 615529 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000052850
Orphanetⁱ	228390 Frontonasal dysplasia with alopecia and genital anomaly 35093 Isolated scaphocephaly 60015 Parietal foramina 52022 Potocki-Shaffer syndrome
PharmGKBⁱ	PA24755

Polymorphism and mutation databases

BioMutaⁱ	ALX4
DMDMⁱ	254763249

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000048814	1 – 411	Homeobox protein aristaless-like 4Add BLAST		411

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	200	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q9H161
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H161
PaxDbⁱ	Q9H161
PeptideAtlas More...PeptideAtlasⁱ	Q9H161
PRIDEⁱ	Q9H161
ProteomicsDBⁱ	80361

PTM databases

iPTMnetⁱ	Q9H161
PhosphoSitePlusⁱ	Q9H161

Expressionⁱ

Tissue specificityⁱ

Expression is likely to be restricted to bone. Found in parietal bone.

Gene expression databases

Bgeeⁱ	ENSG00000052850
CleanExⁱ	HS_ALX4
Genevisibleⁱ	Q9H161 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA001903

HPAⁱ

HPA001903

Interactionⁱ

Subunit structureⁱ

Binds DNA.By similarity

GO - Molecular functionⁱ

HMG box domain binding Source: Ensembl
protein heterodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	121938, 14 interactors
IntActⁱ	Q9H161, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q9H161
STRINGⁱ	9606.ENSP00000332744

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	223 – 235	Combined sources	13
Helixⁱ	241 – 251	Combined sources	11
Helixⁱ	255 – 269	Combined sources	15

3D structure databases

ProteinModelPortalⁱ	Q9H161
SMRⁱ	Q9H161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	391 – 404	OARPROSITE-ProRule annotationAdd BLAST		14

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	104 – 115	Poly-GlnAdd BLAST		12

Sequence similaritiesⁱ

Belongs to the paired homeobox family.Curated

Keywords - Domainⁱ

Homeobox

Phylogenomic databases

eggNOGⁱ	KOG0490 Eukaryota ENOG410YIJ3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140809
HOGENOMⁱ	HOG000231518
HOVERGENⁱ	HBG004214
InParanoidⁱ	Q9H161
KEGG Orthology (KO) More...KOⁱ	K09451
OMAⁱ	HMGQTHM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B1L
PhylomeDBⁱ	Q9H161
TreeFamⁱ	TF350743

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR033203 ALX4 IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom
PANTHERⁱ	PTHR24329:SF322 PTHR24329:SF322, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03826 OAR, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9H161-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNAETCVSYC ESPAAAMDAY YSPVSQSREG SSPFRAFPGG DKFGTTFLSA 
        60         70         80         90        100
AAKAQGFGDA KSRARYGAGQ QDLATPLESG AGARGSFNKF QPQPSTPQPQ 
       110        120        130        140        150
PPPQPQPQQQ QPQPQPPAQP HLYLQRGACK TPPDGSLKLQ EGSSGHSAAL 
       160        170        180        190        200
QVPCYAKESS LGEPELPPDS DTVGMDSSYL SVKEAGVKGP QDRASSDLPS 
       210        220        230        240        250
PLEKADSESN KGKKRRNRTT FTSYQLEELE KVFQKTHYPD VYAREQLAMR 
       260        270        280        290        300
TDLTEARVQV WFQNRRAKWR KRERFGQMQQ VRTHFSTAYE LPLLTRAENY 
       310        320        330        340        350
AQIQNPSWLG NNGAASPVPA CVVPCDPVPA CMSPHAHPPG SGASSVTDFL 
       360        370        380        390        400
SVSGAGSHVG QTHMGSLFGA ASLSPGLNGY ELNGEPDRKT SSIAALRMKA 
       410 
KEHSAAISWA T

Length:411

Mass (Da):44,241

Last modified:July 28, 2009 - v2

Checksum:ⁱD41780B230C7E55C

GO

Sequence cautionⁱ

The sequence AAG23961 differs from that shown. Reason: Frameshift at positions 314, 323 and 340.Curated

The sequence BAB47417 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	134	D → N in AAG23961 (PubMed:11017806).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_069279	7	V → F in CRS5; low-penetrance mutation associated with disease susceptibility; results in gain-of-function. 1 PublicationCorresponds to variant dbSNP:rs281865153EnsemblClinVar.	1
Natural variantⁱVAR_010783	35	R → T2 PublicationsCorresponds to variant dbSNP:rs3824915EnsemblClinVar.	1
Natural variantⁱVAR_010784	102	P → S1 PublicationCorresponds to variant dbSNP:rs12421995EnsemblClinVar.	1
Natural variantⁱVAR_069280	211	K → E in CRS5; low-penetrance mutation associated with disease susceptibility; results in gain-of-function. 1 PublicationCorresponds to variant dbSNP:rs281865154EnsemblClinVar.	1
Natural variantⁱVAR_010785	218	R → Q in PFM2. 1 PublicationCorresponds to variant dbSNP:rs104894193EnsemblClinVar.	1
Natural variantⁱVAR_058413	257	R → T. Corresponds to variant dbSNP:rs3824915EnsemblClinVar.	1
Natural variantⁱVAR_010897	272	R → P in PFM2. 1 PublicationCorresponds to variant dbSNP:rs104894196EnsemblClinVar.	1
Natural variantⁱVAR_069281	306	P → L1 PublicationCorresponds to variant dbSNP:rs149897209Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF294629 mRNA Translation: AAG23961.1 Frameshift. AF308822 , AF308823, AF308824, AF308825 Genomic DNA Translation: AAK38835.1 AJ404888 mRNA Translation: CAC15060.1 AJ279074 , AJ279075, AJ279076, AJ279077 Genomic DNA Translation: CAC15120.1 AB058691 mRNA Translation: BAB47417.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31468.1
NCBI Reference Sequences More...RefSeqⁱ	NP_068745.2, NM_021926.3
UniGeneⁱ	Hs.436055

Genome annotation databases

Ensemblⁱ	ENST00000329255; ENSP00000332744; ENSG00000052850
GeneIDⁱ	60529
KEGGⁱ	hsa:60529
UCSC genome browser More...UCSCⁱ	uc001myb.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q9H161	ALX4 (Fragment)		HYLKL		84
ALX4 (Fragment)		PANTR		255
ALX4 (Fragment)		PANPA		146
ALX4 (Fragment)		western gorilla		103
ALX4 (Fragment)		HYLKL		144
+1

Protein	Similar proteins		Species	Score	Length
Q9H161	Homeobox protein aristaless-like 4		MOUSE		399
UPI0003342F82		CONCR		416
ALX homeobox 4		CANLF		414
UPI00032B03DB		OCHPR		413
UPI000905AA5B		PANPR		412
+83

Protein	Similar proteins		Species	Score	Length
Q9H161	Homeobox protein aristaless-like 4		MOUSE		399
UPI0003342F82		CONCR		416
ALX homeobox 4		CANLF		414
UPI00032B03DB		OCHPR		413
UPI000905AA5B		PANPR		412
+88

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF294629 mRNA Translation: AAG23961.1 Frameshift. AF308822 , AF308823, AF308824, AF308825 Genomic DNA Translation: AAK38835.1 AJ404888 mRNA Translation: CAC15060.1 AJ279074 , AJ279075, AJ279076, AJ279077 Genomic DNA Translation: CAC15120.1 AB058691 mRNA Translation: BAB47417.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31468.1
NCBI Reference Sequences More...RefSeqⁱ	NP_068745.2, NM_021926.3
UniGeneⁱ	Hs.436055

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2M0C	NMR	-	A	209-280	[»]
ProteinModelPortalⁱ	Q9H161
SMRⁱ	Q9H161
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	121938, 14 interactors
IntActⁱ	Q9H161, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q9H161
STRINGⁱ	9606.ENSP00000332744

PTM databases

iPTMnetⁱ	Q9H161
PhosphoSitePlusⁱ	Q9H161

Polymorphism and mutation databases

BioMutaⁱ	ALX4
DMDMⁱ	254763249

Proteomic databases

EPDⁱ	Q9H161
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H161
PaxDbⁱ	Q9H161
PeptideAtlas More...PeptideAtlasⁱ	Q9H161
PRIDEⁱ	Q9H161
ProteomicsDBⁱ	80361

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	60529
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000329255; ENSP00000332744; ENSG00000052850
GeneIDⁱ	60529
KEGGⁱ	hsa:60529
UCSC genome browser More...UCSCⁱ	uc001myb.4 human

Organism-specific databases

CTDⁱ	60529
DisGeNET More...DisGeNETⁱ	60529
EuPathDBⁱ	HostDB:ENSG00000052850.5
GeneCardsⁱ	ALX4
GeneReviewsⁱ	ALX4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:450 ALX4
Human Protein Atlas More...HPAⁱ	HPA001903
MalaCards human disease database More...MalaCardsⁱ	ALX4
MIMⁱ	601224 phenotype 605420 gene 609597 phenotype 613451 phenotype 615529 phenotype
neXtProtⁱ	NX_Q9H161
Open Targets More...OpenTargetsⁱ	ENSG00000052850
Orphanetⁱ	228390 Frontonasal dysplasia with alopecia and genital anomaly 35093 Isolated scaphocephaly 60015 Parietal foramina 52022 Potocki-Shaffer syndrome
PharmGKBⁱ	PA24755
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0490 Eukaryota ENOG410YIJ3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140809
HOGENOMⁱ	HOG000231518
HOVERGENⁱ	HBG004214
InParanoidⁱ	Q9H161
KEGG Orthology (KO) More...KOⁱ	K09451
OMAⁱ	HMGQTHM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B1L
PhylomeDBⁱ	Q9H161
TreeFamⁱ	TF350743

Enzyme and pathway databases

SIGNORⁱ	Q9H161

SIGNORⁱ

Q9H161

Miscellaneous databases

ChiTaRSⁱ	ALX4 human
GeneWikiⁱ	ALX4
GenomeRNAiⁱ	60529
Protein Ontology More...PROⁱ	PR:Q9H161
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000052850
CleanExⁱ	HS_ALX4
Genevisibleⁱ	Q9H161 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR033203 ALX4 IPR009057 Homeobox-like_sf IPR017970 Homeobox_CS IPR001356 Homeobox_dom IPR003654 OAR_dom
PANTHERⁱ	PTHR24329:SF322 PTHR24329:SF322, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF03826 OAR, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit
SUPFAMⁱ	SSF46689 SSF46689, 1 hit
PROSITEⁱ	View protein in PROSITE PS00027 HOMEOBOX_1, 1 hit PS50071 HOMEOBOX_2, 1 hit PS50803 OAR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ALX4_HUMAN
Accessionⁱ	Q9H161Primary (citable) accession number: Q9H161 Secondary accession number(s): Q96JN7, Q9H198, Q9HAY9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
	Last sequence update:	July 28, 2009
	Last modified:	July 18, 2018
	This is version 164 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

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Supporting data

UniProtKB - Q9H161 (ALX4_HUMAN)

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Homeobox protein aristaless-like 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ