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Protein

Inhibitor of growth protein 2

Gene

ING2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei214Histone H3K4me3By similarity1
Metal bindingi215Zinc 1By similarity1
Metal bindingi217Zinc 1By similarity1
Binding sitei225Histone H3K4me3By similarity1
Metal bindingi228Zinc 2By similarity1
Binding sitei229Histone H3K4me3By similarity1
Metal bindingi233Zinc 2By similarity1
Binding sitei237Histone H3K4me3By similarity1
Metal bindingi239Zinc 1; via pros nitrogenBy similarity1
Metal bindingi242Zinc 1By similarity1
Metal bindingi255Zinc 2By similarity1
Metal bindingi258Zinc 2By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 261PHD-typePROSITE-ProRule annotationAdd BLAST50

GO - Molecular functioni

  • chromatin binding Source: ProtInc
  • DNA binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • methylated histone binding Source: UniProtKB
  • phosphatidylinositol binding Source: UniProtKB
  • protein-containing complex binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator
Biological processGrowth regulation, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-6811555 PI5P Regulates TP53 Acetylation
SIGNORiQ9H160

Names & Taxonomyi

Protein namesi
Recommended name:
Inhibitor of growth protein 2
Alternative name(s):
Inhibitor of growth 1-like protein
Short name:
ING1Lp
p32
p33ING2
Gene namesi
Name:ING2
Synonyms:ING1L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168556.6
HGNCiHGNC:6063 ING2
MIMi604215 gene
neXtProtiNX_Q9H160

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3622
OpenTargetsiENSG00000168556
PharmGKBiPA29873

Chemistry databases

ChEMBLiCHEMBL3784904

Polymorphism and mutation databases

BioMutaiING2
DMDMi59798471

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002126631 – 280Inhibitor of growth protein 2Add BLAST280

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki195Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication

Post-translational modificationi

Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiQ9H160
MaxQBiQ9H160
PaxDbiQ9H160
PeptideAtlasiQ9H160
PRIDEiQ9H160
ProteomicsDBi80360

PTM databases

iPTMnetiQ9H160
PhosphoSitePlusiQ9H160

Expressioni

Tissue specificityi

Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.1 Publication

Inductioni

Induced by the DNA-damaging agents etoposide and neocarzinostatin.1 Publication

Gene expression databases

BgeeiENSG00000168556 Expressed in 224 organ(s), highest expression level in left adrenal gland
CleanExiHS_ING2
ExpressionAtlasiQ9H160 baseline and differential
GenevisibleiQ9H160 HS

Organism-specific databases

HPAiHPA019486
HPA021517

Interactioni

Subunit structurei

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109834, 47 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ9H160
IntActiQ9H160, 12 interactors
MINTiQ9H160
STRINGi9606.ENSP00000307183

Chemistry databases

BindingDBiQ9H160

Structurei

3D structure databases

ProteinModelPortaliQ9H160
SMRiQ9H160
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni264 – 280PBR1 PublicationAdd BLAST17

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili48 – 120Sequence analysisAdd BLAST73

Domaini

The PHD-type zinc finger mediates the binding to H3K4me3.1 Publication
The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns5P).1 Publication

Sequence similaritiesi

Belongs to the ING family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri212 – 261PHD-typePROSITE-ProRule annotationAdd BLAST50

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG1973 Eukaryota
COG5034 LUCA
GeneTreeiENSGT00550000074538
HOGENOMiHOG000239724
HOVERGENiHBG006607
InParanoidiQ9H160
KOiK19198
OMAiLCHMTNG
OrthoDBiEOG091G0J8Y
PhylomeDBiQ9H160
TreeFamiTF352014

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028639 ING2
IPR024610 ING_N_histone_binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333:SF37 PTHR10333:SF37, 1 hit
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform ING2a (identifier: Q9H160-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR
60 70 80 90 100
ELDNKYQETL KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK
110 120 130 140 150
IQIVTQMLEL VENRARQMEL HSQCFQDPAE SERASDKAKM DSSQPERSSR
160 170 180 190 200
RPRRQRTSES RDLCHMANGI EDCDDQPPKE KKSKSAKKKK RSKAKQEREA
210 220 230 240 250
SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF SCVSLTYKPK
260 270 280
GKWYCPKCRG DNEKTMDKST EKTKKDRRSR
Length:280
Mass (Da):32,808
Last modified:February 15, 2005 - v2
Checksum:iDC85A6ECAF7A5D81
GO
Isoform ING2b (identifier: Q9H160-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-58: MLGQQQQQLY...LRELDNKYQE → MDQDGDQQLGPSRILAPQ

Note: Low expression except in testis, where it reaches half of ING2a levels.
Show »
Length:240
Mass (Da):27,984
Checksum:iA445AEC5BBFA3B35
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4X5C9J4X5_HUMAN
Inhibitor of growth protein 2
ING2
138Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → T in CAC20567 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0478211 – 58MLGQQ…NKYQE → MDQDGDQQLGPSRILAPQ in isoform ING2b. 2 PublicationsAdd BLAST58

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012853 mRNA Translation: BAA36419.1
AF053537 mRNA Translation: AAG11395.1
AF062748, AF062747 Genomic DNA Translation: AAG11396.1
AB196793 mRNA Translation: BAF30476.1
AJ006851 mRNA Translation: CAC20567.1
AK294310 mRNA Translation: BAH11731.1
AC107214 Genomic DNA No translation available.
BC030128 mRNA Translation: AAH30128.1
CCDSiCCDS3833.1 [Q9H160-1]
RefSeqiNP_001278888.1, NM_001291959.1 [Q9H160-2]
NP_001555.1, NM_001564.3 [Q9H160-1]
UniGeneiHs.107153

Genome annotation databases

EnsembliENST00000302327; ENSP00000307183; ENSG00000168556 [Q9H160-1]
GeneIDi3622
KEGGihsa:3622
UCSCiuc003ivs.2 human [Q9H160-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB012853 mRNA Translation: BAA36419.1
AF053537 mRNA Translation: AAG11395.1
AF062748, AF062747 Genomic DNA Translation: AAG11396.1
AB196793 mRNA Translation: BAF30476.1
AJ006851 mRNA Translation: CAC20567.1
AK294310 mRNA Translation: BAH11731.1
AC107214 Genomic DNA No translation available.
BC030128 mRNA Translation: AAH30128.1
CCDSiCCDS3833.1 [Q9H160-1]
RefSeqiNP_001278888.1, NM_001291959.1 [Q9H160-2]
NP_001555.1, NM_001564.3 [Q9H160-1]
UniGeneiHs.107153

3D structure databases

ProteinModelPortaliQ9H160
SMRiQ9H160
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109834, 47 interactors
ComplexPortaliCPX-3321 SIN3A histone deacetylase complex
CPX-3322 SIN3B histone deacetylase complex
CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMiQ9H160
IntActiQ9H160, 12 interactors
MINTiQ9H160
STRINGi9606.ENSP00000307183

Chemistry databases

BindingDBiQ9H160
ChEMBLiCHEMBL3784904

PTM databases

iPTMnetiQ9H160
PhosphoSitePlusiQ9H160

Polymorphism and mutation databases

BioMutaiING2
DMDMi59798471

Proteomic databases

EPDiQ9H160
MaxQBiQ9H160
PaxDbiQ9H160
PeptideAtlasiQ9H160
PRIDEiQ9H160
ProteomicsDBi80360

Protocols and materials databases

DNASUi3622
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000302327; ENSP00000307183; ENSG00000168556 [Q9H160-1]
GeneIDi3622
KEGGihsa:3622
UCSCiuc003ivs.2 human [Q9H160-1]

Organism-specific databases

CTDi3622
DisGeNETi3622
EuPathDBiHostDB:ENSG00000168556.6
GeneCardsiING2
HGNCiHGNC:6063 ING2
HPAiHPA019486
HPA021517
MIMi604215 gene
neXtProtiNX_Q9H160
OpenTargetsiENSG00000168556
PharmGKBiPA29873
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1973 Eukaryota
COG5034 LUCA
GeneTreeiENSGT00550000074538
HOGENOMiHOG000239724
HOVERGENiHBG006607
InParanoidiQ9H160
KOiK19198
OMAiLCHMTNG
OrthoDBiEOG091G0J8Y
PhylomeDBiQ9H160
TreeFamiTF352014

Enzyme and pathway databases

ReactomeiR-HSA-3899300 SUMOylation of transcription cofactors
R-HSA-6811555 PI5P Regulates TP53 Acetylation
SIGNORiQ9H160

Miscellaneous databases

ChiTaRSiING2 human
GeneWikiiING2
GenomeRNAii3622
PROiPR:Q9H160
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168556 Expressed in 224 organ(s), highest expression level in left adrenal gland
CleanExiHS_ING2
ExpressionAtlasiQ9H160 baseline and differential
GenevisibleiQ9H160 HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR028639 ING2
IPR024610 ING_N_histone_binding
IPR019786 Zinc_finger_PHD-type_CS
IPR011011 Znf_FYVE_PHD
IPR001965 Znf_PHD
IPR019787 Znf_PHD-finger
IPR013083 Znf_RING/FYVE/PHD
PANTHERiPTHR10333:SF37 PTHR10333:SF37, 1 hit
PfamiView protein in Pfam
PF12998 ING, 1 hit
SMARTiView protein in SMART
SM01408 ING, 1 hit
SM00249 PHD, 1 hit
SUPFAMiSSF57903 SSF57903, 1 hit
PROSITEiView protein in PROSITE
PS01359 ZF_PHD_1, 1 hit
PS50016 ZF_PHD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiING2_HUMAN
AccessioniPrimary (citable) accession number: Q9H160
Secondary accession number(s): B6ZDS1, O95698
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: February 15, 2005
Last modified: September 12, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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