UniProtKB - Q9H160 (ING2_HUMAN)
Inhibitor of growth protein 2
ING2
Functioni
Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 214 | Histone H3K4me3 bindingBy similarity | 1 | |
Metal bindingi | 215 | Zinc 1By similarity | 1 | |
Metal bindingi | 217 | Zinc 1By similarity | 1 | |
Sitei | 225 | Histone H3K4me3 bindingBy similarity | 1 | |
Metal bindingi | 228 | Zinc 2By similarity | 1 | |
Sitei | 229 | Histone H3K4me3 bindingBy similarity | 1 | |
Metal bindingi | 233 | Zinc 2By similarity | 1 | |
Sitei | 237 | Histone H3K4me3 bindingBy similarity | 1 | |
Metal bindingi | 239 | Zinc 1; via pros nitrogenBy similarity | 1 | |
Metal bindingi | 242 | Zinc 1By similarity | 1 | |
Metal bindingi | 255 | Zinc 2By similarity | 1 | |
Metal bindingi | 258 | Zinc 2By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 212 – 261 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
GO - Molecular functioni
- chromatin binding Source: ProtInc
- DNA binding Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
- methylated histone binding Source: UniProtKB
- phosphatidylinositol binding Source: UniProtKB
- protein-containing complex binding Source: UniProtKB
GO - Biological processi
- chromatin organization Source: UniProtKB-KW
- flagellated sperm motility Source: BHF-UCL
- male germ-line stem cell asymmetric division Source: BHF-UCL
- male meiosis I Source: BHF-UCL
- negative regulation of cell population proliferation Source: InterPro
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: BHF-UCL
- positive regulation of histone deacetylation Source: BHF-UCL
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
- regulation of cellular senescence Source: BHF-UCL
- regulation of growth Source: UniProtKB-KW
- regulation of response to DNA damage stimulus Source: BHF-UCL
- regulation of transcription, DNA-templated Source: UniProtKB
- seminiferous tubule development Source: BHF-UCL
- signal transduction Source: ProtInc
- spermatid development Source: BHF-UCL
- spermatogenesis Source: BHF-UCL
Keywordsi
Molecular function | Chromatin regulator |
Biological process | Growth regulation, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H160 |
Reactomei | R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-6811555, PI5P Regulates TP53 Acetylation |
SignaLinki | Q9H160 |
SIGNORi | Q9H160 |
Names & Taxonomyi
Protein namesi | Recommended name: Inhibitor of growth protein 2Alternative name(s): Inhibitor of growth 1-like protein Short name: ING1Lp p32 p33ING2 |
Gene namesi | Name:ING2 Synonyms:ING1L |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6063, ING2 |
MIMi | 604215, gene |
neXtProti | NX_Q9H160 |
VEuPathDBi | HostDB:ENSG00000168556 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Note: Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns5P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm.
Nucleus
- CCAAT-binding factor complex Source: UniProtKB
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
- Sin3 complex Source: UniProtKB
Plasma Membrane
- plasma membrane Source: ParkinsonsUK-UCL
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3622 |
OpenTargetsi | ENSG00000168556 |
PharmGKBi | PA29873 |
Miscellaneous databases
Pharosi | Q9H160, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3784904 |
Genetic variation databases
BioMutai | ING2 |
DMDMi | 59798471 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212663 | 1 – 280 | Inhibitor of growth protein 2Add BLAST | 280 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 195 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
EPDi | Q9H160 |
jPOSTi | Q9H160 |
MassIVEi | Q9H160 |
MaxQBi | Q9H160 |
PaxDbi | Q9H160 |
PeptideAtlasi | Q9H160 |
PRIDEi | Q9H160 |
ProteomicsDBi | 6258 80360 [Q9H160-1] |
PTM databases
iPTMneti | Q9H160 |
PhosphoSitePlusi | Q9H160 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000168556, Expressed in left adrenal gland and 240 other tissues |
ExpressionAtlasi | Q9H160, baseline and differential |
Genevisiblei | Q9H160, HS |
Organism-specific databases
HPAi | ENSG00000168556, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with H3K4me3 and to a lesser extent with H3K4me2.
Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2.
3 PublicationsBinary interactionsi
Q9H160
With | #Exp. | IntAct |
---|---|---|
PCNA [P12004] | 3 | EBI-389787,EBI-358311 |
SIN3A [Q96ST3] | 2 | EBI-389787,EBI-347218 |
SMURF1 - isoform Short [Q9HCE7-2] | 3 | EBI-389787,EBI-9845742 |
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 109834, 54 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9H160 |
IntActi | Q9H160, 31 interactors |
MINTi | Q9H160 |
STRINGi | 9606.ENSP00000307183 |
Chemistry databases
BindingDBi | Q9H160 |
Miscellaneous databases
RNActi | Q9H160, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 122 – 204 | DisorderedSequence analysisAdd BLAST | 83 | |
Regioni | 258 – 280 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 264 – 280 | PBR1 PublicationAdd BLAST | 17 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 48 – 120 | Sequence analysisAdd BLAST | 73 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 130 – 182 | Basic and acidic residuesSequence analysisAdd BLAST | 53 | |
Compositional biasi | 258 – 274 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 212 – 261 | PHD-typePROSITE-ProRule annotationAdd BLAST | 50 |
Keywords - Domaini
Coiled coil, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000158194 |
HOGENOMi | CLU_031900_5_0_1 |
InParanoidi | Q9H160 |
OMAi | ESRDSTH |
PhylomeDBi | Q9H160 |
TreeFami | TF352014 |
Family and domain databases
CDDi | cd15683, PHD_ING2, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028639, ING2 IPR042019, ING2_PHD IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF37, PTHR10333:SF37, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR
60 70 80 90 100
ELDNKYQETL KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK
110 120 130 140 150
IQIVTQMLEL VENRARQMEL HSQCFQDPAE SERASDKAKM DSSQPERSSR
160 170 180 190 200
RPRRQRTSES RDLCHMANGI EDCDDQPPKE KKSKSAKKKK RSKAKQEREA
210 220 230 240 250
SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF SCVSLTYKPK
260 270 280
GKWYCPKCRG DNEKTMDKST EKTKKDRRSR
The sequence of this isoform differs from the canonical sequence as follows:
1-58: MLGQQQQQLY...LRELDNKYQE → MDQDGDQQLGPSRILAPQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9J4X5 | C9J4X5_HUMAN | Inhibitor of growth protein 2 | ING2 | 138 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 21 | S → T in CAC20567 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047821 | 1 – 58 | MLGQQ…NKYQE → MDQDGDQQLGPSRILAPQ in isoform ING2b. 2 PublicationsAdd BLAST | 58 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012853 mRNA Translation: BAA36419.1 AF053537 mRNA Translation: AAG11395.1 AF062748, AF062747 Genomic DNA Translation: AAG11396.1 AB196793 mRNA Translation: BAF30476.1 AJ006851 mRNA Translation: CAC20567.1 AK294310 mRNA Translation: BAH11731.1 AC107214 Genomic DNA No translation available. BC030128 mRNA Translation: AAH30128.1 |
CCDSi | CCDS3833.1 [Q9H160-1] |
RefSeqi | NP_001278888.1, NM_001291959.1 [Q9H160-2] NP_001555.1, NM_001564.3 [Q9H160-1] |
Genome annotation databases
Ensembli | ENST00000302327; ENSP00000307183; ENSG00000168556 |
GeneIDi | 3622 |
KEGGi | hsa:3622 |
MANE-Selecti | ENST00000302327.4; ENSP00000307183.3; NM_001564.4; NP_001555.1 |
UCSCi | uc003ivs.2, human [Q9H160-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB012853 mRNA Translation: BAA36419.1 AF053537 mRNA Translation: AAG11395.1 AF062748, AF062747 Genomic DNA Translation: AAG11396.1 AB196793 mRNA Translation: BAF30476.1 AJ006851 mRNA Translation: CAC20567.1 AK294310 mRNA Translation: BAH11731.1 AC107214 Genomic DNA No translation available. BC030128 mRNA Translation: AAH30128.1 |
CCDSi | CCDS3833.1 [Q9H160-1] |
RefSeqi | NP_001278888.1, NM_001291959.1 [Q9H160-2] NP_001555.1, NM_001564.3 [Q9H160-1] |
3D structure databases
SMRi | Q9H160 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109834, 54 interactors |
ComplexPortali | CPX-3321, SIN3A histone deacetylase complex CPX-3322, SIN3B histone deacetylase complex CPX-3323, SIN3A histone deacetylase complex, ES cell-specific variant |
CORUMi | Q9H160 |
IntActi | Q9H160, 31 interactors |
MINTi | Q9H160 |
STRINGi | 9606.ENSP00000307183 |
Chemistry databases
BindingDBi | Q9H160 |
ChEMBLi | CHEMBL3784904 |
PTM databases
iPTMneti | Q9H160 |
PhosphoSitePlusi | Q9H160 |
Genetic variation databases
BioMutai | ING2 |
DMDMi | 59798471 |
Proteomic databases
EPDi | Q9H160 |
jPOSTi | Q9H160 |
MassIVEi | Q9H160 |
MaxQBi | Q9H160 |
PaxDbi | Q9H160 |
PeptideAtlasi | Q9H160 |
PRIDEi | Q9H160 |
ProteomicsDBi | 6258 80360 [Q9H160-1] |
Protocols and materials databases
Antibodypediai | 17300, 310 antibodies from 32 providers |
DNASUi | 3622 |
Genome annotation databases
Ensembli | ENST00000302327; ENSP00000307183; ENSG00000168556 |
GeneIDi | 3622 |
KEGGi | hsa:3622 |
MANE-Selecti | ENST00000302327.4; ENSP00000307183.3; NM_001564.4; NP_001555.1 |
UCSCi | uc003ivs.2, human [Q9H160-1] |
Organism-specific databases
CTDi | 3622 |
DisGeNETi | 3622 |
GeneCardsi | ING2 |
HGNCi | HGNC:6063, ING2 |
HPAi | ENSG00000168556, Low tissue specificity |
MIMi | 604215, gene |
neXtProti | NX_Q9H160 |
OpenTargetsi | ENSG00000168556 |
PharmGKBi | PA29873 |
VEuPathDBi | HostDB:ENSG00000168556 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1973, Eukaryota |
GeneTreei | ENSGT00940000158194 |
HOGENOMi | CLU_031900_5_0_1 |
InParanoidi | Q9H160 |
OMAi | ESRDSTH |
PhylomeDBi | Q9H160 |
TreeFami | TF352014 |
Enzyme and pathway databases
PathwayCommonsi | Q9H160 |
Reactomei | R-HSA-3899300, SUMOylation of transcription cofactors R-HSA-6811555, PI5P Regulates TP53 Acetylation |
SignaLinki | Q9H160 |
SIGNORi | Q9H160 |
Miscellaneous databases
BioGRID-ORCSi | 3622, 12 hits in 1051 CRISPR screens |
ChiTaRSi | ING2, human |
GeneWikii | ING2 |
GenomeRNAii | 3622 |
Pharosi | Q9H160, Tbio |
PROi | PR:Q9H160 |
RNActi | Q9H160, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000168556, Expressed in left adrenal gland and 240 other tissues |
ExpressionAtlasi | Q9H160, baseline and differential |
Genevisiblei | Q9H160, HS |
Family and domain databases
CDDi | cd15683, PHD_ING2, 1 hit |
Gene3Di | 3.30.40.10, 1 hit |
InterProi | View protein in InterPro IPR028639, ING2 IPR042019, ING2_PHD IPR028651, ING_fam IPR024610, ING_N_histone-binding IPR019786, Zinc_finger_PHD-type_CS IPR011011, Znf_FYVE_PHD IPR001965, Znf_PHD IPR019787, Znf_PHD-finger IPR013083, Znf_RING/FYVE/PHD |
PANTHERi | PTHR10333, PTHR10333, 1 hit PTHR10333:SF37, PTHR10333:SF37, 1 hit |
Pfami | View protein in Pfam PF12998, ING, 1 hit |
SMARTi | View protein in SMART SM01408, ING, 1 hit SM00249, PHD, 1 hit |
SUPFAMi | SSF57903, SSF57903, 1 hit |
PROSITEi | View protein in PROSITE PS01359, ZF_PHD_1, 1 hit PS50016, ZF_PHD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ING2_HUMAN | |
Accessioni | Q9H160Primary (citable) accession number: Q9H160 Secondary accession number(s): B6ZDS1, O95698 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | February 15, 2005 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families