ING2

Functionⁱ

Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs).2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	214	Histone H3K4me3By similarity	1
Metal bindingⁱ	215	Zinc 1By similarity	1
Metal bindingⁱ	217	Zinc 1By similarity	1
Binding siteⁱ	225	Histone H3K4me3By similarity	1
Metal bindingⁱ	228	Zinc 2By similarity	1
Binding siteⁱ	229	Histone H3K4me3By similarity	1
Metal bindingⁱ	233	Zinc 2By similarity	1
Binding siteⁱ	237	Histone H3K4me3By similarity	1
Metal bindingⁱ	239	Zinc 1; via pros nitrogenBy similarity	1
Metal bindingⁱ	242	Zinc 1By similarity	1
Metal bindingⁱ	255	Zinc 2By similarity	1
Metal bindingⁱ	258	Zinc 2By similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	212 – 261	PHD-typePROSITE-ProRule annotationAdd BLAST		50

GO - Molecular functionⁱ

chromatin binding
Source: ProtInc
Traceable author statementⁱ
- 10072587
DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
- 15243141
metal ion binding Source: UniProtKB-KW
methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16728974
phosphatidylinositol binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16893883
protein-containing complex binding
Source: UniProtKB
Inferred from direct assayⁱ
- 18334480

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chromatin organization Source: UniProtKB-KW
flagellated sperm motility
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21124965
male germ-line stem cell asymmetric division
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21124965
male meiosis I
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21124965
negative regulation of cell proliferation Source: InterPro
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Source: BHF-UCL
Traceable author statementⁱ
- 21124965
positive regulation of histone deacetylation
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21124965
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 18334480
positive regulation of transforming growth factor beta receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 18334480
regulation of cellular senescence
Source: BHF-UCL
Non-traceable author statementⁱ
- 21124965
regulation of growth Source: UniProtKB-KW
regulation of response to DNA damage stimulus
Source: BHF-UCL
Non-traceable author statementⁱ
- 21124965
regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15243141
seminiferous tubule development
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21124965
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 10072587
spermatid development
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21124965
spermatogenesis
Source: BHF-UCL
Inferred from sequence or structural similarityⁱ
- 21124965
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chromatin regulator
Biological process	Growth regulation, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3899300 SUMOylation of transcription cofactors R-HSA-6811555 PI5P Regulates TP53 Acetylation
SIGNORⁱ	Q9H160

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Inhibitor of growth protein 2 Alternative name(s): Inhibitor of growth 1-like protein Short name: ING1Lp p32 p33ING2
Gene namesⁱ	Name:ING2 Synonyms:ING1L
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 4

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000168556.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6063 ING2
MIMⁱ	604215 gene
neXtProtⁱ	NX_Q9H160

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3622
Open Targets More...OpenTargetsⁱ	ENSG00000168556
PharmGKBⁱ	PA29873

Chemistry databases

ChEMBLⁱ	CHEMBL3784904

ChEMBLⁱ

CHEMBL3784904

Polymorphism and mutation databases

BioMutaⁱ	ING2
DMDMⁱ	59798471

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000212663	1 – 280	Inhibitor of growth protein 2Add BLAST		280

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Cross-linkⁱ	195	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)1 Publication

Post-translational modificationⁱ

Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71.1 Publication

Keywords - PTMⁱ

Isopeptide bond, Ubl conjugation

Proteomic databases

EPDⁱ	Q9H160
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H160
PaxDbⁱ	Q9H160
PeptideAtlas More...PeptideAtlasⁱ	Q9H160
PRIDEⁱ	Q9H160
ProteomicsDBⁱ	80360

PTM databases

iPTMnetⁱ	Q9H160
PhosphoSitePlusⁱ	Q9H160

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues.1 Publication

Inductionⁱ

Induced by the DNA-damaging agents etoposide and neocarzinostatin.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000168556 Expressed in 224 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_ING2
ExpressionAtlasⁱ	Q9H160 baseline and differential
Genevisibleⁱ	Q9H160 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA019486 HPA021517

HPAⁱ

HPA019486
HPA021517

Interactionⁱ

Subunit structureⁱ

Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2.3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
PCNA	P12004	3	EBI-389787,EBI-358311
SMURF1	Q9HCE7-2	3	EBI-389787,EBI-9845742

GO - Molecular functionⁱ

methylated histone binding
Source: UniProtKB
Inferred from direct assayⁱ
- 16728974

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109834, 47 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9H160
IntActⁱ	Q9H160, 12 interactors
Molecular INTeraction database More...MINTⁱ	Q9H160
STRINGⁱ	9606.ENSP00000307183

Chemistry databases

BindingDBⁱ

Q9H160

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H160
SMRⁱ	Q9H160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	264 – 280	PBR1 PublicationAdd BLAST		17

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	48 – 120	Sequence analysisAdd BLAST		73

Domainⁱ

Sequence similaritiesⁱ

Belongs to the ING family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	212 – 261	PHD-typePROSITE-ProRule annotationAdd BLAST		50

Keywords - Domainⁱ

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1973 Eukaryota COG5034 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074538
HOGENOMⁱ	HOG000239724
HOVERGENⁱ	HBG006607
InParanoidⁱ	Q9H160
KEGG Orthology (KO) More...KOⁱ	K19198
OMAⁱ	LCHMTNG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0J8Y
PhylomeDBⁱ	Q9H160
TreeFamⁱ	TF352014

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR028639 ING2 IPR024610 ING_N_histone_binding IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR10333:SF37 PTHR10333:SF37, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12998 ING, 1 hit
SMARTⁱ	View protein in SMART SM01408 ING, 1 hit SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform ING2a (identifier: Q9H160-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR 
        60         70         80         90        100
ELDNKYQETL KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL INSQELGDEK 
       110        120        130        140        150
IQIVTQMLEL VENRARQMEL HSQCFQDPAE SERASDKAKM DSSQPERSSR 
       160        170        180        190        200
RPRRQRTSES RDLCHMANGI EDCDDQPPKE KKSKSAKKKK RSKAKQEREA 
       210        220        230        240        250
SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF SCVSLTYKPK 
       260        270        280
GKWYCPKCRG DNEKTMDKST EKTKKDRRSR

Length:280

Mass (Da):32,808

Last modified:February 15, 2005 - v2

Checksum:ⁱDC85A6ECAF7A5D81

GO

Isoform ING2b (identifier: Q9H160-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-58: MLGQQQQQLY...LRELDNKYQE → MDQDGDQQLGPSRILAPQ

« Hide

        10         20         30         40         50
MDQDGDQQLG PSRILAPQTL KEIDDVYEKY KKEDDLNQKK RLQQLLQRAL 
        60         70         80         90        100
INSQELGDEK IQIVTQMLEL VENRARQMEL HSQCFQDPAE SERASDKAKM 
       110        120        130        140        150
DSSQPERSSR RPRRQRTSES RDLCHMANGI EDCDDQPPKE KKSKSAKKKK 
       160        170        180        190        200
RSKAKQEREA SPVEFAIDPN EPTYCLCNQV SYGEMIGCDN EQCPIEWFHF 
       210        220        230        240
SCVSLTYKPK GKWYCPKCRG DNEKTMDKST EKTKKDRRSR

Note: Low expression except in testis, where it reaches half of ING2a levels.

Show »

Length:240

Mass (Da):27,984

Checksum:ⁱA445AEC5BBFA3B35

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9J4X5	C9J4X5_HUMAN		Inhibitor of growth protein 2 Inhibitor of growth protein 2	ING2	138	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	21	S → T in CAC20567 (Ref. 4) Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_047821	1 – 58	MLGQQ…NKYQE → MDQDGDQQLGPSRILAPQ in isoform ING2b. 2 PublicationsAdd BLAST		58

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012853 mRNA Translation: BAA36419.1 AF053537 mRNA Translation: AAG11395.1 AF062748, AF062747 Genomic DNA Translation: AAG11396.1 AB196793 mRNA Translation: BAF30476.1 AJ006851 mRNA Translation: CAC20567.1 AK294310 mRNA Translation: BAH11731.1 AC107214 Genomic DNA No translation available. BC030128 mRNA Translation: AAH30128.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3833.1 [Q9H160-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001278888.1, NM_001291959.1 [Q9H160-2] NP_001555.1, NM_001564.3 [Q9H160-1]
UniGeneⁱ	Hs.107153

Genome annotation databases

Ensemblⁱ	ENST00000302327; ENSP00000307183; ENSG00000168556 [Q9H160-1]
GeneIDⁱ	3622
KEGGⁱ	hsa:3622
UCSC genome browser More...UCSCⁱ	uc003ivs.2 human [Q9H160-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H160	Inhibitor of growth protein		MACMU		280	UniRef100_Q9H160
Inhibitor of growth protein		PANTR		280
Inhibitor of growth protein		CERAT		280
Inhibitor of growth protein		RHIRO		280
Inhibitor of growth protein		PAPAN		280
+8
Q9H160-2	Inhibitor of growth protein 2 (Fragment)		HUMAN		138	UniRef100_Q9H160-2
ING2 isoform 2 (Fragment)		PANTR		138

Protein	Similar proteins		Species	Score	Length	Source
Q9H160	Inhibitor of growth protein 2	)	MOUSE		281	UniRef90_Q9H160
Inhibitor of growth protein		MACMU		280
Inhibitor of growth protein		PANTR		280
Inhibitor of growth protein		CERAT		280
Inhibitor of growth protein		RHIRO		280
+87
Q9H160-2	Inhibitor of growth protein 2 (Fragment)		HUMAN		138	UniRef90_Q9H160-2
ING2 isoform 2 (Fragment)		PANTR		138
Inhibitor of growth protein (Fragment)		DESRO		296
Inhibitor of growth protein		HORSE		293
Inhibitor of growth protein		SHEEP		283
+20

Protein	Similar proteins		Species	Score	Length	Source
Q9H160	Inhibitor of growth protein 2	)	MOUSE		281	UniRef50_Q9H160
Inhibitor of growth protein		MACMU		280
Inhibitor of growth protein		PANTR		280
Inhibitor of growth protein		CERAT		280
Inhibitor of growth protein		RHIRO		280
+371
Q9H160-2	Inhibitor of growth protein 2 (Fragment)		HUMAN		138	UniRef50_Q9H160-2
ING2 isoform 2 (Fragment)		PANTR		138
Inhibitor of growth protein (Fragment)		DESRO		296
Inhibitor of growth protein		HORSE		293
Inhibitor of growth protein		SHEEP		283
+84

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB012853 mRNA Translation: BAA36419.1 AF053537 mRNA Translation: AAG11395.1 AF062748, AF062747 Genomic DNA Translation: AAG11396.1 AB196793 mRNA Translation: BAF30476.1 AJ006851 mRNA Translation: CAC20567.1 AK294310 mRNA Translation: BAH11731.1 AC107214 Genomic DNA No translation available. BC030128 mRNA Translation: AAH30128.1
CCDSⁱ	CCDS3833.1 [Q9H160-1]
RefSeqⁱ	NP_001278888.1, NM_001291959.1 [Q9H160-2] NP_001555.1, NM_001564.3 [Q9H160-1]
UniGeneⁱ	Hs.107153

3D structure databases

ProteinModelPortalⁱ	Q9H160
SMRⁱ	Q9H160
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109834, 47 interactors
ComplexPortalⁱ	CPX-3321 SIN3A histone deacetylase complex CPX-3322 SIN3B histone deacetylase complex CPX-3323 SIN3A histone deacetylase complex, ES cell-specific variant
CORUMⁱ	Q9H160
IntActⁱ	Q9H160, 12 interactors
MINTⁱ	Q9H160
STRINGⁱ	9606.ENSP00000307183

Chemistry databases

BindingDBⁱ	Q9H160
ChEMBLⁱ	CHEMBL3784904

PTM databases

iPTMnetⁱ	Q9H160
PhosphoSitePlusⁱ	Q9H160

Polymorphism and mutation databases

BioMutaⁱ	ING2
DMDMⁱ	59798471

Proteomic databases

EPDⁱ	Q9H160
MaxQBⁱ	Q9H160
PaxDbⁱ	Q9H160
PeptideAtlasⁱ	Q9H160
PRIDEⁱ	Q9H160
ProteomicsDBⁱ	80360

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3622
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000302327; ENSP00000307183; ENSG00000168556 [Q9H160-1]
GeneIDⁱ	3622
KEGGⁱ	hsa:3622
UCSCⁱ	uc003ivs.2 human [Q9H160-1]

Organism-specific databases

CTDⁱ	3622
DisGeNETⁱ	3622
EuPathDBⁱ	HostDB:ENSG00000168556.6
GeneCardsⁱ	ING2
HGNCⁱ	HGNC:6063 ING2
HPAⁱ	HPA019486 HPA021517
MIMⁱ	604215 gene
neXtProtⁱ	NX_Q9H160
OpenTargetsⁱ	ENSG00000168556
PharmGKBⁱ	PA29873
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1973 Eukaryota COG5034 LUCA
GeneTreeⁱ	ENSGT00550000074538
HOGENOMⁱ	HOG000239724
HOVERGENⁱ	HBG006607
InParanoidⁱ	Q9H160
KOⁱ	K19198
OMAⁱ	LCHMTNG
OrthoDBⁱ	EOG091G0J8Y
PhylomeDBⁱ	Q9H160
TreeFamⁱ	TF352014

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3899300 SUMOylation of transcription cofactors R-HSA-6811555 PI5P Regulates TP53 Acetylation
SIGNORⁱ	Q9H160

Miscellaneous databases

ChiTaRSⁱ	ING2 human
GeneWikiⁱ	ING2
GenomeRNAiⁱ	3622
Protein Ontology More...PROⁱ	PR:Q9H160
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000168556 Expressed in 224 organ(s), highest expression level in left adrenal gland
CleanExⁱ	HS_ING2
ExpressionAtlasⁱ	Q9H160 baseline and differential
Genevisibleⁱ	Q9H160 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR028639 ING2 IPR024610 ING_N_histone_binding IPR019786 Zinc_finger_PHD-type_CS IPR011011 Znf_FYVE_PHD IPR001965 Znf_PHD IPR019787 Znf_PHD-finger IPR013083 Znf_RING/FYVE/PHD
PANTHERⁱ	PTHR10333:SF37 PTHR10333:SF37, 1 hit
Pfamⁱ	View protein in Pfam PF12998 ING, 1 hit
SMARTⁱ	View protein in SMART SM01408 ING, 1 hit SM00249 PHD, 1 hit
SUPFAMⁱ	SSF57903 SSF57903, 1 hit
PROSITEⁱ	View protein in PROSITE PS01359 ZF_PHD_1, 1 hit PS50016 ZF_PHD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ING2_HUMAN
Accessionⁱ	Q9H160Primary (citable) accession number: Q9H160 Secondary accession number(s): B6ZDS1, O95698
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	February 15, 2005
	Last modified:	September 12, 2018
	This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM
SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H160 (ING2_HUMAN)

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Inhibitor of growth protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Golgi apparatus

Nucleus

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Coiled coil

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ