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Entry version 160 (11 Dec 2019)
Sequence version 1 (01 Mar 2001)
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Protein

SLIT and NTRK-like protein 2

Gene

SLITRK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

It is involved in synaptogenesis and promotes excitatory synapse differentiation (PubMed:27273464, PubMed:27812321). Suppresses neurite outgrowth (By similarity).By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-388844 Receptor-type tyrosine-protein phosphatases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SLIT and NTRK-like protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLITRK2
Synonyms:CXorf2, KIAA1854, SLITL1
ORF Names:UNQ9197/PRO34756
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185985.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13449 SLITRK2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300561 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H156

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 621ExtracellularSequence analysisAdd BLAST600
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei622 – 642HelicalSequence analysisAdd BLAST21
Topological domaini643 – 845CytoplasmicSequence analysisAdd BLAST203

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84631

Open Targets

More...
OpenTargetsi
ENSG00000185985

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134968225

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H156 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLITRK2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
46397026

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003267522 – 845SLIT and NTRK-like protein 2Sequence analysisAdd BLAST824

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi29 ↔ 35By similarity
Disulfide bondi33 ↔ 46By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 243By similarity
Disulfide bondi222 ↔ 263By similarity
Glycosylationi421N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei756PhosphotyrosineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H156

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H156

PeptideAtlas

More...
PeptideAtlasi
Q9H156

PRoteomics IDEntifications database

More...
PRIDEi
Q9H156

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80355 [Q9H156-1]
80356 [Q9H156-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H156

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H156

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in the cerebral cortex of the brain but also at low levels in the spinal cord and medulla. Also expressed in some astrocytic brain tumors such as astrocytomas, oligodendrogliomas, glioblastomas, gangliogliomas and primitive neuroectodermal tumors.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185985 Expressed in 103 organ(s), highest expression level in medial globus pallidus

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H156 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H156 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PTPRD; this interaction is PTPRD splicing-dependent and may induce pre-synaptic differentiation.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
124160, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000359521

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H156 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H156

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 84LRR 1Add BLAST22
Repeati87 – 108LRR 2Add BLAST22
Repeati111 – 132LRR 3Add BLAST22
Repeati135 – 156LRR 4Add BLAST22
Repeati159 – 180LRR 5Add BLAST22
Repeati182 – 203LRR 6Add BLAST22
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini216 – 265LRRCT 1Add BLAST50
Domaini331 – 373LRRNTAdd BLAST43
Repeati376 – 397LRR 7Add BLAST22
Repeati400 – 421LRR 8Add BLAST22
Repeati424 – 445LRR 9Add BLAST22
Repeati448 – 469LRR 10Add BLAST22
Repeati472 – 493LRR 11Add BLAST22
Repeati495 – 516LRR 12Add BLAST22
Domaini529 – 580LRRCT 2Add BLAST52

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni167 – 215Required for interaction with PTPRDBy similarityAdd BLAST49

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLITRK family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGN5 Eukaryota
ENOG4111D19 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161248

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000290667

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H156

Identification of Orthologs from Complete Genome Data

More...
OMAi
VLREDTF

Database of Orthologous Groups

More...
OrthoDBi
217854at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H156

TreeFam database of animal gene trees

More...
TreeFami
TF351826

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13855 LRR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00369 LRR_TYP, 10 hits
SM00082 LRRCT, 2 hits
SM00013 LRRNT, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450 LRR, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1Curated (identifier: Q9H156-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSGVWFLSV LTVAGILQTE SRKTAKDICK IRCLCEEKEN VLNINCENKG
60 70 80 90 100
FTTVSLLQPP QYRIYQLFLN GNLLTRLYPN EFVNYSNAVT LHLGNNGLQE
110 120 130 140 150
IRTGAFSGLK TLKRLHLNNN KLEILREDTF LGLESLEYLQ ADYNYISAIE
160 170 180 190 200
AGAFSKLNKL KVLILNDNLL LSLPSNVFRF VLLTHLDLRG NRLKVMPFAG
210 220 230 240 250
VLEHIGGIME IQLEENPWNC TCDLLPLKAW LDTITVFVGE IVCETPFRLH
260 270 280 290 300
GKDVTQLTRQ DLCPRKSASD SSQRGSHADT HVQRLSPTMN PALNPTRAPK
310 320 330 340 350
ASRPPKMRNR PTPRVTVSKD RQSFGPIMVY QTKSPVPLTC PSSCVCTSQS
360 370 380 390 400
SDNGLNVNCQ ERKFTNISDL QPKPTSPKKL YLTGNYLQTV YKNDLLEYSS
410 420 430 440 450
LDLLHLGNNR IAVIQEGAFT NLTSLRRLYL NGNYLEVLYP SMFDGLQSLQ
460 470 480 490 500
YLYLEYNVIK EIKPLTFDAL INLQLLFLNN NLLRSLPDNI FGGTALTRLN
510 520 530 540 550
LRNNHFSHLP VKGVLDQLPA FIQIDLQENP WDCTCDIMGL KDWTEHANSP
560 570 580 590 600
VIINEVTCES PAKHAGEILK FLGREAICPD SPNLSDGTVL SMNHNTDTPR
610 620 630 640 650
SLSVSPSSYP ELHTEVPLSV LILGLLVVFI LSVCFGAGLF VFVLKRRKGV
660 670 680 690 700
PSVPRNTNNL DVSSFQLQYG SYNTETHDKT DGHVYNYIPP PVGQMCQNPI
710 720 730 740 750
YMQKEGDPVA YYRNLQEFSY SNLEEKKEEP ATPAYTISAT ELLEKQATPR
760 770 780 790 800
EPELLYQNIA ERVKELPSAG LVHYNFCTLP KRQFAPSYES RRQNQDRINK
810 820 830 840
TVLYGTPRKC FVGQSKPNHP LLQAKPQSEP DYLEVLEKQT AISQL
Length:845
Mass (Da):95,404
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i20E35DBD1584F9A4
GO
Isoform 2Curated (identifier: Q9H156-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     719-733: SYSNLEEKKEEPATP → KTSLENIWRPCLHKK
     734-845: Missing.

Show »
Length:733
Mass (Da):82,695
Checksum:i3AB315438E97F2A8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B3KTY4B3KTY4_HUMAN
SLIT and NTRK-like family, member 2...
SLITRK2 hCG_1646164
724Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB47483 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti721S → G in BAC03566 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07763089V → M Found in a patient with schizophrenia; unknown pathological significance; does not impair synaptogenesis; no effect on localization to cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs1402893590Ensembl.1
Natural variantiVAR_077631549S → F Found in a patient with schizophrenia; unknown pathological significance; does not impair synaptogenesis; no effect on localization to cell membrane. 2 PublicationsCorresponds to variant dbSNP:rs1239180055Ensembl.1
Natural variantiVAR_027756601S → P Polymorphism; does not affect synaptogenesis; no effect on localization to cell membrane. 1 PublicationCorresponds to variant dbSNP:rs2295336Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_050706719 – 733SYSNL…EPATP → KTSLENIWRPCLHKK in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_050707734 – 845Missing in isoform 2. 1 PublicationAdd BLAST112

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y19205 Genomic DNA Translation: CAC80724.1
AY358828 mRNA Translation: AAQ89187.1
AK091015 mRNA Translation: BAC03566.1
AK289732 mRNA Translation: BAF82421.1
AL109653 Genomic DNA Translation: CAI41645.1
AL109653 Genomic DNA Translation: CAC18888.1
BC113011 mRNA Translation: AAI13012.1
BC113012 mRNA Translation: AAI13013.1
AB058757 mRNA Translation: BAB47483.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14680.1 [Q9H156-1]

NCBI Reference Sequences

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RefSeqi
NP_001137475.1, NM_001144003.2 [Q9H156-1]
NP_001137476.1, NM_001144004.2 [Q9H156-1]
NP_001137477.1, NM_001144005.2 [Q9H156-1]
NP_001137478.1, NM_001144006.2 [Q9H156-1]
NP_001137480.1, NM_001144008.2 [Q9H156-1]
NP_001137481.1, NM_001144009.2 [Q9H156-1]
NP_001137482.1, NM_001144010.2 [Q9H156-1]
NP_115928.1, NM_032539.4 [Q9H156-1]
XP_005262399.1, XM_005262342.3 [Q9H156-1]
XP_005262400.1, XM_005262343.3 [Q9H156-1]
XP_005262401.1, XM_005262344.3 [Q9H156-1]
XP_005262402.1, XM_005262345.3 [Q9H156-1]

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
84631

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84631

UCSC genome browser

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UCSCi
uc033eyj.2 human [Q9H156-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y19205 Genomic DNA Translation: CAC80724.1
AY358828 mRNA Translation: AAQ89187.1
AK091015 mRNA Translation: BAC03566.1
AK289732 mRNA Translation: BAF82421.1
AL109653 Genomic DNA Translation: CAI41645.1
AL109653 Genomic DNA Translation: CAC18888.1
BC113011 mRNA Translation: AAI13012.1
BC113012 mRNA Translation: AAI13013.1
AB058757 mRNA Translation: BAB47483.1 Different initiation.
CCDSiCCDS14680.1 [Q9H156-1]
RefSeqiNP_001137475.1, NM_001144003.2 [Q9H156-1]
NP_001137476.1, NM_001144004.2 [Q9H156-1]
NP_001137477.1, NM_001144005.2 [Q9H156-1]
NP_001137478.1, NM_001144006.2 [Q9H156-1]
NP_001137480.1, NM_001144008.2 [Q9H156-1]
NP_001137481.1, NM_001144009.2 [Q9H156-1]
NP_001137482.1, NM_001144010.2 [Q9H156-1]
NP_115928.1, NM_032539.4 [Q9H156-1]
XP_005262399.1, XM_005262342.3 [Q9H156-1]
XP_005262400.1, XM_005262343.3 [Q9H156-1]
XP_005262401.1, XM_005262344.3 [Q9H156-1]
XP_005262402.1, XM_005262345.3 [Q9H156-1]

3D structure databases

SMRiQ9H156
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124160, 2 interactors
STRINGi9606.ENSP00000359521

PTM databases

iPTMnetiQ9H156
PhosphoSitePlusiQ9H156

Polymorphism and mutation databases

BioMutaiSLITRK2
DMDMi46397026

Proteomic databases

MassIVEiQ9H156
PaxDbiQ9H156
PeptideAtlasiQ9H156
PRIDEiQ9H156
ProteomicsDBi80355 [Q9H156-1]
80356 [Q9H156-2]

Genome annotation databases

GeneIDi84631
KEGGihsa:84631
UCSCiuc033eyj.2 human [Q9H156-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84631
DisGeNETi84631
EuPathDBiHostDB:ENSG00000185985.8

GeneCards: human genes, protein and diseases

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GeneCardsi
SLITRK2
HGNCiHGNC:13449 SLITRK2
MIMi300561 gene
neXtProtiNX_Q9H156
OpenTargetsiENSG00000185985
PharmGKBiPA134968225

Human Unidentified Gene-Encoded large proteins database

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HUGEi
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GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGN5 Eukaryota
ENOG4111D19 LUCA
GeneTreeiENSGT00940000161248
HOGENOMiHOG000290667
InParanoidiQ9H156
OMAiVLREDTF
OrthoDBi217854at2759
PhylomeDBiQ9H156
TreeFamiTF351826

Enzyme and pathway databases

ReactomeiR-HSA-388844 Receptor-type tyrosine-protein phosphatases

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLITRK2 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLITRK2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84631
PharosiQ9H156 Tbio

Protein Ontology

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PROi
PR:Q9H156
RNActiQ9H156 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185985 Expressed in 103 organ(s), highest expression level in medial globus pallidus
ExpressionAtlasiQ9H156 baseline and differential
GenevisibleiQ9H156 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 10 hits
SM00082 LRRCT, 2 hits
SM00013 LRRNT, 2 hits
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSLIK2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H156
Secondary accession number(s): A8K117
, Q2KHN3, Q5JXB1, Q8NBC7, Q96JH3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: March 1, 2001
Last modified: December 11, 2019
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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