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Protein

Beta-soluble NSF attachment protein

Gene

NAPB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-204005 COPII-mediated vesicle transport
R-HSA-6807878 COPI-mediated anterograde transport
R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic
R-HSA-6811438 Intra-Golgi traffic
R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-soluble NSF attachment protein
Short name:
SNAP-beta
Alternative name(s):
N-ethylmaleimide-sensitive factor attachment protein beta
Gene namesi
Name:NAPB
Synonyms:SNAPB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125814.17
HGNCiHGNC:15751 NAPB
MIMi611270 gene
neXtProtiNX_Q9H115

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi63908
OpenTargetsiENSG00000125814
PharmGKBiPA31444

Polymorphism and mutation databases

BioMutaiNAPB
DMDMi18202933

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002190601 – 298Beta-soluble NSF attachment proteinAdd BLAST298

Proteomic databases

EPDiQ9H115
MaxQBiQ9H115
PaxDbiQ9H115
PeptideAtlasiQ9H115
PRIDEiQ9H115
ProteomicsDBi80352

PTM databases

iPTMnetiQ9H115
PhosphoSitePlusiQ9H115

Expressioni

Gene expression databases

BgeeiENSG00000125814
CleanExiHS_NAPB
ExpressionAtlasiQ9H115 baseline and differential
GenevisibleiQ9H115 HS

Organism-specific databases

HPAiCAB037225
CAB037227
HPA046149
HPA050196

Interactioni

Subunit structurei

Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi121983, 17 interactors
CORUMiQ9H115
IntActiQ9H115, 32 interactors
MINTiQ9H115
STRINGi9606.ENSP00000366225

Structurei

3D structure databases

ProteinModelPortaliQ9H115
SMRiQ9H115
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SNAP family.Curated

Phylogenomic databases

eggNOGiKOG1586 Eukaryota
ENOG410XPQ6 LUCA
GeneTreeiENSGT00390000005826
HOGENOMiHOG000165015
HOVERGENiHBG001325
InParanoidiQ9H115
PhylomeDBiQ9H115
TreeFamiTF316547

Family and domain databases

CDDicd15832 SNAP, 1 hit
Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR000744 NSF_attach
IPR011990 TPR-like_helical_dom_sf
PANTHERiPTHR13768 PTHR13768, 1 hit
PRINTSiPR00448 NSFATTACHMNT
SUPFAMiSSF48452 SSF48452, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H115-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIYEQVGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Length:298
Mass (Da):33,557
Last modified:August 29, 2001 - v2
Checksum:i5B7BE0FB84BABD83
GO
Isoform 2 (identifier: Q9H115-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-98: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):29,453
Checksum:iE61D9F7BF5A19EBD
GO
Isoform 3 (identifier: Q9H115-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MDNAGKEREAVQLMAEAEKR → MTLLPALWMLEMLTKRQIPK
     21-114: Missing.

Note: No experimental confirmation available.
Show »
Length:204
Mass (Da):23,403
Checksum:iA15BFEAA5D5E0775
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05202661A → T. Corresponds to variant dbSNP:rs6036399Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0552761 – 20MDNAG…EAEKR → MTLLPALWMLEMLTKRQIPK in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_05527721 – 114Missing in isoform 3. 1 PublicationAdd BLAST94
Alternative sequenceiVSP_05527860 – 98Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK296385 mRNA Translation: BAG59056.1
AL096677 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10152.1
CH471133 Genomic DNA Translation: EAX10156.1
BC047426 mRNA Translation: AAH47426.1
BC060840 mRNA Translation: AAH60840.1
AL834445 mRNA Translation: CAD39105.1
CCDSiCCDS13152.1 [Q9H115-1]
CCDS63241.1 [Q9H115-3]
CCDS63242.1 [Q9H115-2]
RefSeqiNP_001269947.1, NM_001283018.1
NP_001269949.1, NM_001283020.1 [Q9H115-2]
NP_001269955.1, NM_001283026.1 [Q9H115-3]
NP_071363.1, NM_022080.2 [Q9H115-1]
UniGeneiHs.269471

Genome annotation databases

EnsembliENST00000377026; ENSP00000366225; ENSG00000125814 [Q9H115-1]
ENST00000398425; ENSP00000381459; ENSG00000125814 [Q9H115-3]
ENST00000432543; ENSP00000413600; ENSG00000125814 [Q9H115-2]
GeneIDi63908
KEGGihsa:63908
UCSCiuc002wta.4 human [Q9H115-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSNAB_HUMAN
AccessioniPrimary (citable) accession number: Q9H115
Secondary accession number(s): B4DK44
, Q4G0M0, Q4G187, Q5JXF9, Q8N3C4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2001
Last sequence update: August 29, 2001
Last modified: July 18, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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