UniProtKB - Q9H115 (SNAB_HUMAN)
Protein
Beta-soluble NSF attachment protein
Gene
NAPB
Organism
Homo sapiens (Human)
Status
Functioni
Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.By similarity
GO - Molecular functioni
- soluble NSF attachment protein activity Source: GO_Central
- syntaxin binding Source: GO_Central
GO - Biological processi
- intracellular protein transport Source: GO_Central
- regulation of synaptic vesicle priming Source: GO_Central
- SNARE complex disassembly Source: GO_Central
- synaptic transmission, glutamatergic Source: GO_Central
Keywordsi
Biological process | ER-Golgi transport, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q9H115 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-soluble NSF attachment proteinShort name: SNAP-beta Alternative name(s): N-ethylmaleimide-sensitive factor attachment protein beta |
Gene namesi | Name:NAPB Synonyms:SNAPB |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:15751, NAPB |
MIMi | 611270, gene |
neXtProti | NX_Q9H115 |
VEuPathDBi | HostDB:ENSG00000125814.17 |
Subcellular locationi
Other locations
- Membrane By similarity; Peripheral membrane protein By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- SNARE complex Source: GO_Central
- synapse Source: GOC
- synaptobrevin 2-SNAP-25-syntaxin-1a complex Source: GO_Central
- vacuolar membrane Source: GO_Central
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 63908 |
MalaCardsi | NAPB |
OpenTargetsi | ENSG00000125814 |
PharmGKBi | PA31444 |
Miscellaneous databases
Pharosi | Q9H115, Tbio |
Genetic variation databases
BioMutai | NAPB |
DMDMi | 18202933 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219060 | 1 – 298 | Beta-soluble NSF attachment proteinAdd BLAST | 298 |
Proteomic databases
EPDi | Q9H115 |
jPOSTi | Q9H115 |
MassIVEi | Q9H115 |
MaxQBi | Q9H115 |
PaxDbi | Q9H115 |
PeptideAtlasi | Q9H115 |
PRIDEi | Q9H115 |
ProteomicsDBi | 4427 62109 80352 [Q9H115-1] |
PTM databases
iPTMneti | Q9H115 |
PhosphoSitePlusi | Q9H115 |
Expressioni
Gene expression databases
Bgeei | ENSG00000125814, Expressed in middle temporal gyrus and 207 other tissues |
ExpressionAtlasi | Q9H115, baseline and differential |
Genevisiblei | Q9H115, HS |
Organism-specific databases
HPAi | ENSG00000125814, Tissue enriched (brain) |
Interactioni
Subunit structurei
Interacts with PRKCABP, and disrupts the interaction between GRIA2 and PRKCABP, leading to the internalization of GRIA2.
By similarityBinary interactionsi
Hide detailsQ9H115
GO - Molecular functioni
- syntaxin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 121983, 40 interactors |
CORUMi | Q9H115 |
IntActi | Q9H115, 41 interactors |
MINTi | Q9H115 |
STRINGi | 9606.ENSP00000482826 |
Miscellaneous databases
RNActi | Q9H115, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the SNAP family.Curated
Phylogenomic databases
eggNOGi | KOG1586, Eukaryota |
GeneTreei | ENSGT00390000005826 |
HOGENOMi | CLU_046329_1_1_1 |
InParanoidi | Q9H115 |
OrthoDBi | 1191204at2759 |
PhylomeDBi | Q9H115 |
TreeFami | TF316547 |
Family and domain databases
CDDi | cd15832, SNAP, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR000744, NSF_attach IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR13768, PTHR13768, 1 hit |
PRINTSi | PR00448, NSFATTACHMNT |
SUPFAMi | SSF48452, SSF48452, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H115-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDNAGKEREA VQLMAEAEKR VKASHSFLRG LFGGNTRIEE ACEMYTRAAN
60 70 80 90 100
MFKMAKNWSA AGNAFCQAAK LHMQLQSKHD SATSFVDAGN AYKKADPQEA
110 120 130 140 150
INCLNAAIDI YTDMGRFTIA AKHHITIAEI YETELVDIEK AIAHYEQSAD
160 170 180 190 200
YYKGEESNSS ANKCLLKVAA YAAQLEQYQK AIEIYEQVGA NTMDNPLLKY
210 220 230 240 250
SAKDYFFKAA LCHFIVDELN AKLALEKYEE MFPAFTDSRE CKLLKKLLEA
260 270 280 290
HEEQNSEAYT EAVKEFDSIS RLDQWLTTML LRIKKSIQGD GEGDGDLK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087WZQ7 | A0A087WZQ7_HUMAN | Beta-soluble NSF attachment protein | NAPB hCG_22369 | 302 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_052026 | 61 | A → T. Corresponds to variant dbSNP:rs6036399Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055276 | 1 – 20 | MDNAG…EAEKR → MTLLPALWMLEMLTKRQIPK in isoform 3. 1 PublicationAdd BLAST | 20 | |
Alternative sequenceiVSP_055277 | 21 – 114 | Missing in isoform 3. 1 PublicationAdd BLAST | 94 | |
Alternative sequenceiVSP_055278 | 60 – 98 | Missing in isoform 2. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK296385 mRNA Translation: BAG59056.1 AL096677 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10152.1 CH471133 Genomic DNA Translation: EAX10156.1 BC047426 mRNA Translation: AAH47426.1 BC060840 mRNA Translation: AAH60840.1 AL834445 mRNA Translation: CAD39105.1 |
CCDSi | CCDS13152.1 [Q9H115-1] CCDS63241.1 [Q9H115-3] CCDS63242.1 [Q9H115-2] |
RefSeqi | NP_001269947.1, NM_001283018.1 NP_001269949.1, NM_001283020.1 [Q9H115-2] NP_001269955.1, NM_001283026.1 [Q9H115-3] NP_071363.1, NM_022080.2 [Q9H115-1] |
Genome annotation databases
Ensembli | ENST00000377026; ENSP00000366225; ENSG00000125814 [Q9H115-1] ENST00000398425; ENSP00000381459; ENSG00000125814 [Q9H115-3] ENST00000432543; ENSP00000413600; ENSG00000125814 [Q9H115-2] |
GeneIDi | 63908 |
KEGGi | hsa:63908 |
UCSCi | uc002wta.4, human [Q9H115-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK296385 mRNA Translation: BAG59056.1 AL096677 Genomic DNA No translation available. CH471133 Genomic DNA Translation: EAX10152.1 CH471133 Genomic DNA Translation: EAX10156.1 BC047426 mRNA Translation: AAH47426.1 BC060840 mRNA Translation: AAH60840.1 AL834445 mRNA Translation: CAD39105.1 |
CCDSi | CCDS13152.1 [Q9H115-1] CCDS63241.1 [Q9H115-3] CCDS63242.1 [Q9H115-2] |
RefSeqi | NP_001269947.1, NM_001283018.1 NP_001269949.1, NM_001283020.1 [Q9H115-2] NP_001269955.1, NM_001283026.1 [Q9H115-3] NP_071363.1, NM_022080.2 [Q9H115-1] |
3D structure databases
SMRi | Q9H115 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 121983, 40 interactors |
CORUMi | Q9H115 |
IntActi | Q9H115, 41 interactors |
MINTi | Q9H115 |
STRINGi | 9606.ENSP00000482826 |
PTM databases
iPTMneti | Q9H115 |
PhosphoSitePlusi | Q9H115 |
Genetic variation databases
BioMutai | NAPB |
DMDMi | 18202933 |
Proteomic databases
EPDi | Q9H115 |
jPOSTi | Q9H115 |
MassIVEi | Q9H115 |
MaxQBi | Q9H115 |
PaxDbi | Q9H115 |
PeptideAtlasi | Q9H115 |
PRIDEi | Q9H115 |
ProteomicsDBi | 4427 62109 80352 [Q9H115-1] |
Protocols and materials databases
Antibodypediai | 42862, 102 antibodies |
DNASUi | 63908 |
Genome annotation databases
Ensembli | ENST00000377026; ENSP00000366225; ENSG00000125814 [Q9H115-1] ENST00000398425; ENSP00000381459; ENSG00000125814 [Q9H115-3] ENST00000432543; ENSP00000413600; ENSG00000125814 [Q9H115-2] |
GeneIDi | 63908 |
KEGGi | hsa:63908 |
UCSCi | uc002wta.4, human [Q9H115-1] |
Organism-specific databases
CTDi | 63908 |
DisGeNETi | 63908 |
GeneCardsi | NAPB |
HGNCi | HGNC:15751, NAPB |
HPAi | ENSG00000125814, Tissue enriched (brain) |
MalaCardsi | NAPB |
MIMi | 611270, gene |
neXtProti | NX_Q9H115 |
OpenTargetsi | ENSG00000125814 |
PharmGKBi | PA31444 |
VEuPathDBi | HostDB:ENSG00000125814.17 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1586, Eukaryota |
GeneTreei | ENSGT00390000005826 |
HOGENOMi | CLU_046329_1_1_1 |
InParanoidi | Q9H115 |
OrthoDBi | 1191204at2759 |
PhylomeDBi | Q9H115 |
TreeFami | TF316547 |
Enzyme and pathway databases
PathwayCommonsi | Q9H115 |
Reactomei | R-HSA-204005, COPII-mediated vesicle transport R-HSA-6807878, COPI-mediated anterograde transport R-HSA-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-HSA-6811438, Intra-Golgi traffic R-HSA-6811440, Retrograde transport at the Trans-Golgi-Network |
Miscellaneous databases
BioGRID-ORCSi | 63908, 7 hits in 995 CRISPR screens |
ChiTaRSi | NAPB, human |
GeneWikii | NAPB |
GenomeRNAii | 63908 |
Pharosi | Q9H115, Tbio |
PROi | PR:Q9H115 |
RNActi | Q9H115, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000125814, Expressed in middle temporal gyrus and 207 other tissues |
ExpressionAtlasi | Q9H115, baseline and differential |
Genevisiblei | Q9H115, HS |
Family and domain databases
CDDi | cd15832, SNAP, 1 hit |
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR000744, NSF_attach IPR011990, TPR-like_helical_dom_sf |
PANTHERi | PTHR13768, PTHR13768, 1 hit |
PRINTSi | PR00448, NSFATTACHMNT |
SUPFAMi | SSF48452, SSF48452, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SNAB_HUMAN | |
Accessioni | Q9H115Primary (citable) accession number: Q9H115 Secondary accession number(s): B4DK44 Q8N3C4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 29, 2001 |
Last sequence update: | August 29, 2001 | |
Last modified: | April 7, 2021 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families