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Protein

Cystatin-11

Gene

CST11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.1 Publication

GO - Molecular functioni

GO - Biological processi

  • androgen receptor signaling pathway Source: UniProtKB
  • defense response to Gram-negative bacterium Source: UniProtKB
  • killing of cells of other organism Source: UniProtKB

Keywordsi

Molecular functionAntibiotic, Antimicrobial, Protease inhibitor, Thiol protease inhibitor

Protein family/group databases

MEROPSiI25.027

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-11
Gene namesi
Name:CST11
Synonyms:CST8L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125831.9
HGNCiHGNC:15959 CST11
MIMi609731 gene
neXtProtiNX_Q9H112

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125831
PharmGKBiPA26974

Polymorphism and mutation databases

BioMutaiCST11
DMDMi76803548

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000665827 – 138Cystatin-11Add BLAST112

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 102By similarity
Disulfide bondi115 ↔ 135By similarity
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9H112
PRIDEiQ9H112
ProteomicsDBi80349
80350 [Q9H112-2]

PTM databases

iPTMnetiQ9H112
PhosphoSitePlusiQ9H112

Expressioni

Tissue specificityi

Detected in the epithelium and lumen of the epididymis, and in sperm (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000125831 Expressed in 45 organ(s), highest expression level in caput epididymis
CleanExiHS_CST11
GenevisibleiQ9H112 HS

Organism-specific databases

HPAiHPA053399

Interactioni

Protein-protein interaction databases

BioGridi126748, 1 interactor
STRINGi9606.ENSP00000366208

Structurei

3D structure databases

ProteinModelPortaliQ9H112
SMRiQ9H112
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ0B Eukaryota
ENOG4111EFC LUCA
GeneTreeiENSGT00910000144356
HOGENOMiHOG000231754
HOVERGENiHBG096361
InParanoidiQ9H112
KOiK13906
OMAiEMRRTTC
OrthoDBiEOG091G0TP1
PhylomeDBiQ9H112

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H112-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMAEPWQALQ LLLAILLTLM ALPYQARKKT FLSVHEVMAV ENYAKDSLQW
60 70 80 90 100
ITDQYNKESD DKYHFRIFRV LKVQRQVTDH LEYHLNVEMQ WTTCQKPETT
110 120 130
NCVPQERELH KQVNCFFSVF AVPWFEQYKI LNKSCSSD
Length:138
Mass (Da):16,506
Last modified:September 27, 2005 - v2
Checksum:iE49440ACA3585C64
GO
Isoform 2 (identifier: Q9H112-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     77-111: Missing.

Show »
Length:103
Mass (Da):12,285
Checksum:i05DD92C47387B022
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00126077 – 111Missing in isoform 2. 2 PublicationsAdd BLAST35

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335480 mRNA Translation: AAL71991.1
AF335481 mRNA Translation: AAL71992.1
AL096677 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10146.1
BC121079 mRNA Translation: AAI21080.1
BC121080 mRNA Translation: AAI21081.1
CCDSiCCDS13154.1 [Q9H112-2]
CCDS13155.1 [Q9H112-1]
RefSeqiNP_543020.2, NM_080830.2 [Q9H112-2]
NP_570612.1, NM_130794.1 [Q9H112-1]
UniGeneiHs.128100

Genome annotation databases

EnsembliENST00000377007; ENSP00000366206; ENSG00000125831 [Q9H112-2]
ENST00000377009; ENSP00000366208; ENSG00000125831 [Q9H112-1]
GeneIDi140880
KEGGihsa:140880
UCSCiuc002wtf.2 human [Q9H112-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF335480 mRNA Translation: AAL71991.1
AF335481 mRNA Translation: AAL71992.1
AL096677 Genomic DNA No translation available.
CH471133 Genomic DNA Translation: EAX10146.1
BC121079 mRNA Translation: AAI21080.1
BC121080 mRNA Translation: AAI21081.1
CCDSiCCDS13154.1 [Q9H112-2]
CCDS13155.1 [Q9H112-1]
RefSeqiNP_543020.2, NM_080830.2 [Q9H112-2]
NP_570612.1, NM_130794.1 [Q9H112-1]
UniGeneiHs.128100

3D structure databases

ProteinModelPortaliQ9H112
SMRiQ9H112
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126748, 1 interactor
STRINGi9606.ENSP00000366208

Protein family/group databases

MEROPSiI25.027

PTM databases

iPTMnetiQ9H112
PhosphoSitePlusiQ9H112

Polymorphism and mutation databases

BioMutaiCST11
DMDMi76803548

Proteomic databases

PaxDbiQ9H112
PRIDEiQ9H112
ProteomicsDBi80349
80350 [Q9H112-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377007; ENSP00000366206; ENSG00000125831 [Q9H112-2]
ENST00000377009; ENSP00000366208; ENSG00000125831 [Q9H112-1]
GeneIDi140880
KEGGihsa:140880
UCSCiuc002wtf.2 human [Q9H112-1]

Organism-specific databases

CTDi140880
EuPathDBiHostDB:ENSG00000125831.9
GeneCardsiCST11
HGNCiHGNC:15959 CST11
HPAiHPA053399
MIMi609731 gene
neXtProtiNX_Q9H112
OpenTargetsiENSG00000125831
PharmGKBiPA26974
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ0B Eukaryota
ENOG4111EFC LUCA
GeneTreeiENSGT00910000144356
HOGENOMiHOG000231754
HOVERGENiHBG096361
InParanoidiQ9H112
KOiK13906
OMAiEMRRTTC
OrthoDBiEOG091G0TP1
PhylomeDBiQ9H112

Miscellaneous databases

GeneWikiiCST11
GenomeRNAii140880
PROiPR:Q9H112
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125831 Expressed in 45 organ(s), highest expression level in caput epididymis
CleanExiHS_CST11
GenevisibleiQ9H112 HS

Family and domain databases

CDDicd00042 CY, 1 hit
InterProiView protein in InterPro
IPR027214 Cystatin
IPR000010 Cystatin_dom
PANTHERiPTHR11413 PTHR11413, 1 hit
PfamiView protein in Pfam
PF00031 Cystatin, 1 hit
SMARTiView protein in SMART
SM00043 CY, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCST11_HUMAN
AccessioniPrimary (citable) accession number: Q9H112
Secondary accession number(s): Q0VAF2
, Q0VAF3, Q8WXU5, Q8WXU6, Q9H113
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: September 27, 2005
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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