ATG10

Functionⁱ

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.By similarity1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	166	Glycyl thioester intermediateBy similarity		1

GO - Molecular functionⁱ

Atg12 transferase activity
Source: UniProtKB
Inferred from sequence or structural similarityⁱ
- 20723759

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

autophagy
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 15657430
ER overload response
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17256008
macroautophagy
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of protein modification process Source: UniProtKB
protein lipidation Source: UniProtKB
protein modification by small protein conjugation
Source: UniProtKB
Inferred from direct assayⁱ
- 16963840
protein transport Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Autophagy, Protein transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy
SIGNORⁱ	Q9H0Y0

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ubiquitin-like-conjugating enzyme ATG10 (EC:2.3.2.-) Alternative name(s): Autophagy-related protein 10 Short name: APG10-like
Gene namesⁱ	Name:ATG10 Synonyms:APG10L ORF Names:PP12616
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000152348.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20315 ATG10
MIMⁱ	610800 gene
neXtProtⁱ	NX_Q9H0Y0

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	83734
Open Targets More...OpenTargetsⁱ	ENSG00000152348
PharmGKBⁱ	PA134872167

Polymorphism and mutation databases

BioMutaⁱ	ATG10
DMDMⁱ	62286633

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000096183	1 – 220	Ubiquitin-like-conjugating enzyme ATG10Add BLAST		220

Proteomic databases

EPDⁱ	Q9H0Y0
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H0Y0
PaxDbⁱ	Q9H0Y0
PeptideAtlas More...PeptideAtlasⁱ	Q9H0Y0
PRIDEⁱ	Q9H0Y0
ProteomicsDBⁱ	80344 80345 [Q9H0Y0-2]

PTM databases

PhosphoSitePlusⁱ	Q9H0Y0

PhosphoSitePlusⁱ

Q9H0Y0

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000152348 Expressed in 170 organ(s), highest expression level in testis
CleanExⁱ	HS_ATG10
ExpressionAtlasⁱ	Q9H0Y0 baseline and differential
Genevisibleⁱ	Q9H0Y0 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044163

HPAⁱ

HPA044163

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

BioGridⁱ	123745, 11 interactors
IntActⁱ	Q9H0Y0, 16 interactors
STRINGⁱ	9606.ENSP00000282185

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H0Y0
SMRⁱ	Q9H0Y0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the ATG10 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG4741 Eukaryota ENOG4111W4Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000924
HOGENOMⁱ	HOG000034127
HOVERGENⁱ	HBG080874
InParanoidⁱ	Q9H0Y0
KEGG Orthology (KO) More...KOⁱ	K17888
OMAⁱ	TSKDCSD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KGP
PhylomeDBⁱ	Q9H0Y0
TreeFamⁱ	TF314016

Family and domain databases

InterProⁱ	View protein in InterPro IPR007135 Autophagy-rel_prot_3
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03987 Autophagy_act_C, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q9H0Y0-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI 
        60         70         80         90        100
KNGSVMSHLG ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV 
       110        120        130        140        150
LYSCSYQVPV LYFRASFLDG RPLTLKDIWE GVHECYKMRL LQGPWDTITQ 
       160        170        180        190        200
QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ KINKNVNYIT SWLSIVGPVV 
       210        220
GLNLPLSYAK ATSQDERNVP

Length:220

Mass (Da):25,279

Last modified:March 1, 2001 - v1

Checksum:ⁱ1EDA80E385779B69

GO

Isoform 2 (identifier: Q9H0Y0-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
73-125: EAFELPLDDC...SFLDGRPLTL → VKSCSVTQAG...PLHLANFLYF
126-220: Missing.

« Hide

        10         20         30         40         50
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI 
        60         70         80         90        100
KNGSVMSHLG ASTHGQTCLP MEVKSCSVTQ AGVQLRDLSS LQPPPSGFKQ 
       110        120 
FSCLSLPSNW DYRGSPLHLA NFLYF

Show »

Length:125

Mass (Da):14,217

Checksum:ⁱ57CE9269957F02CA

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D6RBD1	D6RBD1_HUMAN	Ubiquitin-like-conjugating enzyme A... Ubiquitin-like-conjugating enzyme ATG10	ATG10	171	Annotation score:
D6RDX3	D6RDX3_HUMAN	Ubiquitin-like-conjugating enzyme A... Ubiquitin-like-conjugating enzyme ATG10	ATG10	184	Annotation score:
D6RC89	D6RC89_HUMAN	Ubiquitin-like-conjugating enzyme A... Ubiquitin-like-conjugating enzyme ATG10	ATG10	36	Annotation score:

Sequence cautionⁱ

The sequence BC004551 differs from that shown. Reason: Frameshift at position 26.Curated

The sequence BC027718 differs from that shown. Reason: Frameshift at position 26.Curated

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_024370	62	S → P. Corresponds to variant dbSNP:rs3734114Ensembl.	1
Natural variantⁱVAR_021562	212	T → M1 PublicationCorresponds to variant dbSNP:rs1864183Ensembl.	1
Natural variantⁱVAR_021563	220	P → H1 PublicationCorresponds to variant dbSNP:rs1864182Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013272	73 – 125	EAFEL…RPLTL → VKSCSVTQAGVQLRDLSSLQ PPPSGFKQFSCLSLPSNWDY RGSPLHLANFLYF in isoform 2. 2 PublicationsAdd BLAST		53
Alternative sequenceⁱVSP_013273	126 – 220	Missing in isoform 2. 2 PublicationsAdd BLAST		95

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF318326 mRNA Translation: AAL55833.1 AK024016 mRNA Translation: BAB14778.1 AK315752 mRNA Translation: BAG38106.1 AL136912 mRNA Translation: CAB66846.1 BC004551 mRNA No translation available. BC027718 mRNA No translation available. BC029268 mRNA Translation: AAH29268.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4057.1 [Q9H0Y0-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001124500.1, NM_001131028.1 [Q9H0Y0-1] NP_113670.1, NM_031482.4 [Q9H0Y0-1] XP_005248667.1, XM_005248610.4 [Q9H0Y0-1] XP_005248668.1, XM_005248611.4 [Q9H0Y0-1]
UniGeneⁱ	Hs.713698

Genome annotation databases

Ensemblⁱ	ENST00000282185; ENSP00000282185; ENSG00000152348 [Q9H0Y0-1] ENST00000355178; ENSP00000347309; ENSG00000152348 [Q9H0Y0-2] ENST00000458350; ENSP00000404938; ENSG00000152348 [Q9H0Y0-1] ENST00000513443; ENSP00000425182; ENSG00000152348 [Q9H0Y0-2]
GeneIDⁱ	83734
KEGGⁱ	hsa:83734
UCSC genome browser More...UCSCⁱ	uc003khq.2 human [Q9H0Y0-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H0Y0	Ubiquitin-like-conjugating enzyme ATG10		HUMAN		184	UniRef100_Q9H0Y0
ATG10 isoform 10 (Fragment)		PANTR		36
Ubiquitin-like-conjugating enzyme ATG10 (Fragment)		HUMAN		36
UPI0005CFF97C		HUMAN		178
Q9H0Y0-2	ATG10 autophagy related 10 homolog (S. cerevisiae), isoform CRA_a		HUMAN		125	UniRef100_A0A024RAK8

Protein	Similar proteins		Species	Score	Length	Source
Q9H0Y0	Ubiquitin-like-conjugating enzyme ATG10		HUMAN		184	UniRef90_Q9H0Y0
ATG10 isoform 10 (Fragment)		PANTR		36
Uncharacterized protein		MACFA		248
Uncharacterized protein		MACMU		216
Uncharacterized protein		CERAT		216
+29
Q9H0Y0-2	ATG10 isoform 8		PANTR		125	UniRef90_A0A2J8NMZ2
Autophagy related 10		GORGO		125
ATG10 isoform 1 (Fragment)		PONAB		126
ATG10 autophagy related 10 homolog (S. cerevisiae), isoform CRA_a		HUMAN		125
Uncharacterized protein		PANPA		125
+5

Protein	Similar proteins		Species	Score	Length	Source
Q9H0Y0	Ubiquitin-like-conjugating enzyme ATG10		HUMAN		184	UniRef50_Q9H0Y0
ATG10 isoform 10 (Fragment)		PANTR		36
Uncharacterized protein		MACFA		248
Uncharacterized protein		MACMU		216
Uncharacterized protein		CERAT		216
+66
Q9H0Y0-2	ATG10 isoform 8		PANTR		125	UniRef50_A0A2J8NMZ2
Autophagy related 10		GORGO		125
ATG10 isoform 1 (Fragment)		PONAB		126
ATG10 autophagy related 10 homolog (S. cerevisiae), isoform CRA_a		HUMAN		125
Uncharacterized protein		PANPA		125
+7

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF318326 mRNA Translation: AAL55833.1 AK024016 mRNA Translation: BAB14778.1 AK315752 mRNA Translation: BAG38106.1 AL136912 mRNA Translation: CAB66846.1 BC004551 mRNA No translation available. BC027718 mRNA No translation available. BC029268 mRNA Translation: AAH29268.1
CCDSⁱ	CCDS4057.1 [Q9H0Y0-1]
RefSeqⁱ	NP_001124500.1, NM_001131028.1 [Q9H0Y0-1] NP_113670.1, NM_031482.4 [Q9H0Y0-1] XP_005248667.1, XM_005248610.4 [Q9H0Y0-1] XP_005248668.1, XM_005248611.4 [Q9H0Y0-1]
UniGeneⁱ	Hs.713698

3D structure databases

ProteinModelPortalⁱ	Q9H0Y0
SMRⁱ	Q9H0Y0
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123745, 11 interactors
IntActⁱ	Q9H0Y0, 16 interactors
STRINGⁱ	9606.ENSP00000282185

PTM databases

PhosphoSitePlusⁱ	Q9H0Y0

PhosphoSitePlusⁱ

Q9H0Y0

Polymorphism and mutation databases

BioMutaⁱ	ATG10
DMDMⁱ	62286633

Proteomic databases

EPDⁱ	Q9H0Y0
MaxQBⁱ	Q9H0Y0
PaxDbⁱ	Q9H0Y0
PeptideAtlasⁱ	Q9H0Y0
PRIDEⁱ	Q9H0Y0
ProteomicsDBⁱ	80344 80345 [Q9H0Y0-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	83734
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000282185; ENSP00000282185; ENSG00000152348 [Q9H0Y0-1] ENST00000355178; ENSP00000347309; ENSG00000152348 [Q9H0Y0-2] ENST00000458350; ENSP00000404938; ENSG00000152348 [Q9H0Y0-1] ENST00000513443; ENSP00000425182; ENSG00000152348 [Q9H0Y0-2]
GeneIDⁱ	83734
KEGGⁱ	hsa:83734
UCSCⁱ	uc003khq.2 human [Q9H0Y0-1]

Organism-specific databases

CTDⁱ	83734
DisGeNETⁱ	83734
EuPathDBⁱ	HostDB:ENSG00000152348.15
GeneCardsⁱ	ATG10
HGNCⁱ	HGNC:20315 ATG10
HPAⁱ	HPA044163
MIMⁱ	610800 gene
neXtProtⁱ	NX_Q9H0Y0
OpenTargetsⁱ	ENSG00000152348
PharmGKBⁱ	PA134872167
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4741 Eukaryota ENOG4111W4Q LUCA
GeneTreeⁱ	ENSGT00390000000924
HOGENOMⁱ	HOG000034127
HOVERGENⁱ	HBG080874
InParanoidⁱ	Q9H0Y0
KOⁱ	K17888
OMAⁱ	TSKDCSD
OrthoDBⁱ	EOG091G0KGP
PhylomeDBⁱ	Q9H0Y0
TreeFamⁱ	TF314016

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1632852 Macroautophagy
SIGNORⁱ	Q9H0Y0

Miscellaneous databases

ChiTaRSⁱ	ATG10 human
GeneWikiⁱ	ATG10
GenomeRNAiⁱ	83734
Protein Ontology More...PROⁱ	PR:Q9H0Y0
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000152348 Expressed in 170 organ(s), highest expression level in testis
CleanExⁱ	HS_ATG10
ExpressionAtlasⁱ	Q9H0Y0 baseline and differential
Genevisibleⁱ	Q9H0Y0 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007135 Autophagy-rel_prot_3
Pfamⁱ	View protein in Pfam PF03987 Autophagy_act_C, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ATG10_HUMAN
Accessionⁱ	Q9H0Y0Primary (citable) accession number: Q9H0Y0 Secondary accession number(s): B2RE09, Q6PIX1, Q9H842
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM

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UniProtKB - Q9H0Y0 (ATG10_HUMAN)

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Ubiquitin-like-conjugating enzyme ATG10

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

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Cytosol

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ