UniProtKB - Q9H0Y0 (ATG10_HUMAN)
Protein
Ubiquitin-like-conjugating enzyme ATG10
Gene
ATG10
Organism
Homo sapiens (Human)
Status
Functioni
E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity). Plays a role in adenovirus-mediated cell lysis.By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 166 | Glycyl thioester intermediateBy similarity | 1 |
GO - Molecular functioni
- Atg12 transferase activity Source: UniProtKB
GO - Biological processi
- autophagy Source: UniProtKB
- ER overload response Source: BHF-UCL
- macroautophagy Source: GO_Central
- positive regulation of protein modification process Source: UniProtKB
- protein lipidation Source: UniProtKB
- protein modification by small protein conjugation Source: UniProtKB
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | Transferase |
Biological process | Autophagy, Protein transport, Transport, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | Q9H0Y0 |
Reactomei | R-HSA-1632852, Macroautophagy |
SIGNORi | Q9H0Y0 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin-like-conjugating enzyme ATG10 (EC:2.3.2.-)Alternative name(s): Autophagy-related protein 10 Short name: APG10-like |
Gene namesi | Name:ATG10 Synonyms:APG10L ORF Names:PP12616 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20315, ATG10 |
MIMi | 610800, gene |
neXtProti | NX_Q9H0Y0 |
VEuPathDBi | HostDB:ENSG00000152348.15 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: Reactome
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Organism-specific databases
DisGeNETi | 83734 |
OpenTargetsi | ENSG00000152348 |
PharmGKBi | PA134872167 |
Miscellaneous databases
Pharosi | Q9H0Y0, Tbio |
Genetic variation databases
BioMutai | ATG10 |
DMDMi | 62286633 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096183 | 1 – 220 | Ubiquitin-like-conjugating enzyme ATG10Add BLAST | 220 |
Proteomic databases
EPDi | Q9H0Y0 |
MassIVEi | Q9H0Y0 |
MaxQBi | Q9H0Y0 |
PaxDbi | Q9H0Y0 |
PeptideAtlasi | Q9H0Y0 |
PRIDEi | Q9H0Y0 |
ProteomicsDBi | 80344 [Q9H0Y0-1] 80345 [Q9H0Y0-2] |
PTM databases
iPTMneti | Q9H0Y0 |
PhosphoSitePlusi | Q9H0Y0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000152348, Expressed in islet of Langerhans and 187 other tissues |
ExpressionAtlasi | Q9H0Y0, baseline and differential |
Genevisiblei | Q9H0Y0, HS |
Organism-specific databases
HPAi | ENSG00000152348, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity).
Interacts with IRGM.
By similarity1 PublicationBinary interactionsi
Hide detailsQ9H0Y0
Protein-protein interaction databases
BioGRIDi | 123745, 14 interactors |
IntActi | Q9H0Y0, 29 interactors |
STRINGi | 9606.ENSP00000282185 |
Miscellaneous databases
RNActi | Q9H0Y0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATG10 family.Curated
Phylogenomic databases
eggNOGi | KOG4741, Eukaryota |
GeneTreei | ENSGT00390000000924 |
HOGENOMi | CLU_1991882_0_0_1 |
InParanoidi | Q9H0Y0 |
OMAi | TSKDCSD |
OrthoDBi | 1538225at2759 |
PhylomeDBi | Q9H0Y0 |
TreeFami | TF314016 |
Family and domain databases
InterProi | View protein in InterPro IPR007135, Autophagy-rel_prot_3 |
Pfami | View protein in Pfam PF03987, Autophagy_act_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H0Y0-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI
60 70 80 90 100
KNGSVMSHLG ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV
110 120 130 140 150
LYSCSYQVPV LYFRASFLDG RPLTLKDIWE GVHECYKMRL LQGPWDTITQ
160 170 180 190 200
QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ KINKNVNYIT SWLSIVGPVV
210 220
GLNLPLSYAK ATSQDERNVP
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD6RBD1 | D6RBD1_HUMAN | Ubiquitin-like-conjugating enzyme A... | ATG10 | 171 | Annotation score: | ||
D6RDX3 | D6RDX3_HUMAN | Ubiquitin-like-conjugating enzyme A... | ATG10 | 184 | Annotation score: | ||
D6RC89 | D6RC89_HUMAN | Ubiquitin-like-conjugating enzyme A... | ATG10 | 36 | Annotation score: |
Sequence cautioni
The sequence BC004551 differs from that shown. Reason: Frameshift.Curated
The sequence BC027718 differs from that shown. Reason: Frameshift.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_024370 | 62 | S → P. Corresponds to variant dbSNP:rs3734114Ensembl. | 1 | |
Natural variantiVAR_021562 | 212 | T → M1 PublicationCorresponds to variant dbSNP:rs1864183Ensembl. | 1 | |
Natural variantiVAR_021563 | 220 | P → H1 PublicationCorresponds to variant dbSNP:rs1864182Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_013272 | 73 – 125 | EAFEL…RPLTL → VKSCSVTQAGVQLRDLSSLQ PPPSGFKQFSCLSLPSNWDY RGSPLHLANFLYF in isoform 2. 2 PublicationsAdd BLAST | 53 | |
Alternative sequenceiVSP_013273 | 126 – 220 | Missing in isoform 2. 2 PublicationsAdd BLAST | 95 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF318326 mRNA Translation: AAL55833.1 AK024016 mRNA Translation: BAB14778.1 AK315752 mRNA Translation: BAG38106.1 AL136912 mRNA Translation: CAB66846.1 BC004551 mRNA No translation available. BC027718 mRNA No translation available. BC029268 mRNA Translation: AAH29268.1 |
CCDSi | CCDS4057.1 [Q9H0Y0-1] |
RefSeqi | NP_001124500.1, NM_001131028.1 [Q9H0Y0-1] NP_113670.1, NM_031482.4 [Q9H0Y0-1] XP_005248667.1, XM_005248610.4 [Q9H0Y0-1] XP_005248668.1, XM_005248611.4 [Q9H0Y0-1] |
Genome annotation databases
Ensembli | ENST00000282185; ENSP00000282185; ENSG00000152348 [Q9H0Y0-1] ENST00000355178; ENSP00000347309; ENSG00000152348 [Q9H0Y0-2] ENST00000458350; ENSP00000404938; ENSG00000152348 [Q9H0Y0-1] ENST00000513443; ENSP00000425182; ENSG00000152348 [Q9H0Y0-2] |
GeneIDi | 83734 |
KEGGi | hsa:83734 |
UCSCi | uc003khq.2, human [Q9H0Y0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF318326 mRNA Translation: AAL55833.1 AK024016 mRNA Translation: BAB14778.1 AK315752 mRNA Translation: BAG38106.1 AL136912 mRNA Translation: CAB66846.1 BC004551 mRNA No translation available. BC027718 mRNA No translation available. BC029268 mRNA Translation: AAH29268.1 |
CCDSi | CCDS4057.1 [Q9H0Y0-1] |
RefSeqi | NP_001124500.1, NM_001131028.1 [Q9H0Y0-1] NP_113670.1, NM_031482.4 [Q9H0Y0-1] XP_005248667.1, XM_005248610.4 [Q9H0Y0-1] XP_005248668.1, XM_005248611.4 [Q9H0Y0-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123745, 14 interactors |
IntActi | Q9H0Y0, 29 interactors |
STRINGi | 9606.ENSP00000282185 |
PTM databases
iPTMneti | Q9H0Y0 |
PhosphoSitePlusi | Q9H0Y0 |
Genetic variation databases
BioMutai | ATG10 |
DMDMi | 62286633 |
Proteomic databases
EPDi | Q9H0Y0 |
MassIVEi | Q9H0Y0 |
MaxQBi | Q9H0Y0 |
PaxDbi | Q9H0Y0 |
PeptideAtlasi | Q9H0Y0 |
PRIDEi | Q9H0Y0 |
ProteomicsDBi | 80344 [Q9H0Y0-1] 80345 [Q9H0Y0-2] |
Protocols and materials databases
Antibodypediai | 24713, 383 antibodies |
DNASUi | 83734 |
Genome annotation databases
Ensembli | ENST00000282185; ENSP00000282185; ENSG00000152348 [Q9H0Y0-1] ENST00000355178; ENSP00000347309; ENSG00000152348 [Q9H0Y0-2] ENST00000458350; ENSP00000404938; ENSG00000152348 [Q9H0Y0-1] ENST00000513443; ENSP00000425182; ENSG00000152348 [Q9H0Y0-2] |
GeneIDi | 83734 |
KEGGi | hsa:83734 |
UCSCi | uc003khq.2, human [Q9H0Y0-1] |
Organism-specific databases
CTDi | 83734 |
DisGeNETi | 83734 |
GeneCardsi | ATG10 |
HGNCi | HGNC:20315, ATG10 |
HPAi | ENSG00000152348, Low tissue specificity |
MIMi | 610800, gene |
neXtProti | NX_Q9H0Y0 |
OpenTargetsi | ENSG00000152348 |
PharmGKBi | PA134872167 |
VEuPathDBi | HostDB:ENSG00000152348.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4741, Eukaryota |
GeneTreei | ENSGT00390000000924 |
HOGENOMi | CLU_1991882_0_0_1 |
InParanoidi | Q9H0Y0 |
OMAi | TSKDCSD |
OrthoDBi | 1538225at2759 |
PhylomeDBi | Q9H0Y0 |
TreeFami | TF314016 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0Y0 |
Reactomei | R-HSA-1632852, Macroautophagy |
SIGNORi | Q9H0Y0 |
Miscellaneous databases
BioGRID-ORCSi | 83734, 18 hits in 1001 CRISPR screens |
ChiTaRSi | ATG10, human |
GeneWikii | ATG10 |
GenomeRNAii | 83734 |
Pharosi | Q9H0Y0, Tbio |
PROi | PR:Q9H0Y0 |
RNActi | Q9H0Y0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000152348, Expressed in islet of Langerhans and 187 other tissues |
ExpressionAtlasi | Q9H0Y0, baseline and differential |
Genevisiblei | Q9H0Y0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR007135, Autophagy-rel_prot_3 |
Pfami | View protein in Pfam PF03987, Autophagy_act_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATG10_HUMAN | |
Accessioni | Q9H0Y0Primary (citable) accession number: Q9H0Y0 Secondary accession number(s): B2RE09, Q6PIX1, Q9H842 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 152 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families