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UniProtKB - Q9H0Y0 (ATG10_HUMAN)

Entry version 155 (23 Feb 2022)
Sequence version 1 (01 Mar 2001)
Previous versions | rss
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Protein

Ubiquitin-like-conjugating enzyme ATG10

Gene

ATG10

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity).

Plays a role in adenovirus-mediated cell lysis.

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei166Glycyl thioester intermediateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processAutophagy, Protein transport, Transport, Ubl conjugation pathway

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H0Y0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1632852, Macroautophagy

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q9H0Y0

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H0Y0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ubiquitin-like-conjugating enzyme ATG10 (EC:2.3.2.-)
Alternative name(s):
Autophagy-related protein 10
Short name:
APG10-like
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATG10
Synonyms:APG10L
ORF Names:PP12616
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20315, ATG10

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		610800, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H0Y0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000152348

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		83734

Open Targets

More...OpenTargetsi		ENSG00000152348

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134872167

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H0Y0, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATG10

Domain mapping of disease mutations (DMDM)

More...DMDMi		62286633

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000961831 – 220Ubiquitin-like-conjugating enzyme ATG10Add BLAST220

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H0Y0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H0Y0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H0Y0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H0Y0

PeptideAtlas

More...PeptideAtlasi		Q9H0Y0

PRoteomics IDEntifications database

More...PRIDEi		Q9H0Y0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80344 [Q9H0Y0-1]
80345 [Q9H0Y0-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H0Y0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H0Y0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000152348, Expressed in islet of Langerhans and 187 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H0Y0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H0Y0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000152348, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with MAP1LC3A. By interacting with MAP1LC3A, it plays a role in the conjugation of ATG12 to ATG5. Also able to directly interact either with ATG5 or ATG7 (By similarity).

Interacts with IRGM.

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		123745, 212 interactors

Protein interaction database and analysis system

More...IntActi		Q9H0Y0, 29 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000282185

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H0Y0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H0Y0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATG10 family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4741, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000000924

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_1991882_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H0Y0

Identification of Orthologs from Complete Genome Data

More...OMAi		WKTSKDC

Database of Orthologous Groups

More...OrthoDBi		1538225at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H0Y0

TreeFam database of animal gene trees

More...TreeFami		TF314016

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR007135, Atg3/Atg10

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03987, Autophagy_act_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEEDEFIGEK TFQRYCAEFI KHSQQIGDSW EWRPSKDCSD GYMCKIHFQI 
        60         70         80         90        100
KNGSVMSHLG ASTHGQTCLP MEEAFELPLD DCEVIETAAA SEVIKYEYHV 
       110        120        130        140        150
LYSCSYQVPV LYFRASFLDG RPLTLKDIWE GVHECYKMRL LQGPWDTITQ 
       160        170        180        190        200
QEHPILGQPF FVLHPCKTNE FMTPVLKNSQ KINKNVNYIT SWLSIVGPVV 
       210        220
GLNLPLSYAK ATSQDERNVP
Length:220
Mass (Da):25,279
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EDA80E385779B69
GO
Isoform 2 (identifier: Q9H0Y0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     73-125: EAFELPLDDC...SFLDGRPLTL → VKSCSVTQAG...PLHLANFLYF
     126-220: Missing.

Show »
Length:125
Mass (Da):14,217
Checksum:i57CE9269957F02CA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RDX3D6RDX3_HUMAN
Ubiquitin-like-conjugating enzyme A...
ATG10
184Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBD1D6RBD1_HUMAN
Ubiquitin-like-conjugating enzyme A...
ATG10
171Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RC89D6RC89_HUMAN
Ubiquitin-like-conjugating enzyme A...
ATG10
36Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BC004551 differs from that shown. Reason: Frameshift.Curated
The sequence BC027718 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02437062S → P. Corresponds to variant dbSNP:rs3734114Ensembl.1
Natural variantiVAR_021562212T → M1 PublicationCorresponds to variant dbSNP:rs1864183Ensembl.1
Natural variantiVAR_021563220P → H1 PublicationCorresponds to variant dbSNP:rs1864182Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01327273 – 125EAFEL…RPLTL → VKSCSVTQAGVQLRDLSSLQ PPPSGFKQFSCLSLPSNWDY RGSPLHLANFLYF in isoform 2. 2 PublicationsAdd BLAST53
Alternative sequenceiVSP_013273126 – 220Missing in isoform 2. 2 PublicationsAdd BLAST95

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF318326 mRNA Translation: AAL55833.1
AK024016 mRNA Translation: BAB14778.1
AK315752 mRNA Translation: BAG38106.1
AL136912 mRNA Translation: CAB66846.1
BC004551 mRNA No translation available.
BC027718 mRNA No translation available.
BC029268 mRNA Translation: AAH29268.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4057.1 [Q9H0Y0-1]

NCBI Reference Sequences

More...RefSeqi		NP_001124500.1, NM_001131028.1 [Q9H0Y0-1]
NP_113670.1, NM_031482.4 [Q9H0Y0-1]
XP_005248667.1, XM_005248610.4 [Q9H0Y0-1]
XP_005248668.1, XM_005248611.4 [Q9H0Y0-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000282185; ENSP00000282185; ENSG00000152348
ENST00000355178; ENSP00000347309; ENSG00000152348 [Q9H0Y0-2]
ENST00000458350; ENSP00000404938; ENSG00000152348
ENST00000513443; ENSP00000425182; ENSG00000152348 [Q9H0Y0-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83734

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83734

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000282185.8; ENSP00000282185.3; NM_031482.5; NP_113670.1

UCSC genome browser

More...UCSCi		uc003khq.2, human [Q9H0Y0-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318326 mRNA Translation: AAL55833.1
AK024016 mRNA Translation: BAB14778.1
AK315752 mRNA Translation: BAG38106.1
AL136912 mRNA Translation: CAB66846.1
BC004551 mRNA No translation available.
BC027718 mRNA No translation available.
BC029268 mRNA Translation: AAH29268.1
CCDSiCCDS4057.1 [Q9H0Y0-1]
RefSeqiNP_001124500.1, NM_001131028.1 [Q9H0Y0-1]
NP_113670.1, NM_031482.4 [Q9H0Y0-1]
XP_005248667.1, XM_005248610.4 [Q9H0Y0-1]
XP_005248668.1, XM_005248611.4 [Q9H0Y0-1]

3D structure databases

SMRiQ9H0Y0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123745, 212 interactors
IntActiQ9H0Y0, 29 interactors
STRINGi9606.ENSP00000282185

PTM databases

iPTMnetiQ9H0Y0
PhosphoSitePlusiQ9H0Y0

Genetic variation databases

BioMutaiATG10
DMDMi62286633

Proteomic databases

EPDiQ9H0Y0
MassIVEiQ9H0Y0
MaxQBiQ9H0Y0
PaxDbiQ9H0Y0
PeptideAtlasiQ9H0Y0
PRIDEiQ9H0Y0
ProteomicsDBi80344 [Q9H0Y0-1]
80345 [Q9H0Y0-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		24713, 392 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		83734

Genome annotation databases

EnsembliENST00000282185; ENSP00000282185; ENSG00000152348
ENST00000355178; ENSP00000347309; ENSG00000152348 [Q9H0Y0-2]
ENST00000458350; ENSP00000404938; ENSG00000152348
ENST00000513443; ENSP00000425182; ENSG00000152348 [Q9H0Y0-2]
GeneIDi83734
KEGGihsa:83734
MANE-SelectiENST00000282185.8; ENSP00000282185.3; NM_031482.5; NP_113670.1
UCSCiuc003khq.2, human [Q9H0Y0-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83734
DisGeNETi83734

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATG10
HGNCiHGNC:20315, ATG10
HPAiENSG00000152348, Low tissue specificity
MIMi610800, gene
neXtProtiNX_Q9H0Y0
OpenTargetsiENSG00000152348
PharmGKBiPA134872167
VEuPathDBiHostDB:ENSG00000152348

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4741, Eukaryota
GeneTreeiENSGT00390000000924
HOGENOMiCLU_1991882_0_0_1
InParanoidiQ9H0Y0
OMAiWKTSKDC
OrthoDBi1538225at2759
PhylomeDBiQ9H0Y0
TreeFamiTF314016

Enzyme and pathway databases

PathwayCommonsiQ9H0Y0
ReactomeiR-HSA-1632852, Macroautophagy
SignaLinkiQ9H0Y0
SIGNORiQ9H0Y0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		83734, 21 hits in 1053 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATG10, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ATG10

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83734
PharosiQ9H0Y0, Tbio

Protein Ontology

More...PROi		PR:Q9H0Y0
RNActiQ9H0Y0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000152348, Expressed in islet of Langerhans and 187 other tissues
ExpressionAtlasiQ9H0Y0, baseline and differential
GenevisibleiQ9H0Y0, HS

Family and domain databases

InterProiView protein in InterPro
IPR007135, Atg3/Atg10
PfamiView protein in Pfam
PF03987, Autophagy_act_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATG10_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0Y0
Secondary accession number(s): B2RE09, Q6PIX1, Q9H842
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: March 1, 2001
Last modified: February 23, 2022
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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