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UniProtKB - Q9H0X9 (OSBL5_HUMAN)

Protein

Oxysterol-binding protein-related protein 5

Gene

OSBPL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).4 Publications

Miscellaneous

According to a report, the gene is imprinted in placenta, where it is predominantly expressed from the maternal allele only. Not imprinted in other tissues (PubMed:12504849). According to another report, it is not imprinted in trophoblast stem cells (PubMed:20644730).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei449PhosphatidylserineBy similarity1
Binding sitei504PhosphatidylserineBy similarity1
Binding sitei670Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei674Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei678Phosphatidylinositol 4-phosphateBy similarity1

GO - Molecular functioni

  • cholesterol binding Source: BHF-UCL
  • lipid binding Source: GO_Central
  • oxysterol binding Source: UniProtKB
  • phosphatidylinositol-4-phosphate binding Source: UniProtKB
  • phosphatidylserine binding Source: UniProtKB
  • phospholipid transporter activity Source: UniProtKB
  • sterol binding Source: GO_Central
  • sterol transporter activity Source: GO_Central
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-HSA-1482801 Acyl chain remodelling of PS

Protein family/group databases

TCDBi2.D.1.1.1 the pi4p/ps counter transporter (p/p-ct) family

Chemistry databases

SwissLipidsiSLP:000000527

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 5
Short name:
ORP-5
Short name:
OSBP-related protein 5
Alternative name(s):
Oxysterol-binding protein homolog 11 Publication
Gene namesi
Name:OSBPL5
Synonyms:KIAA1534, OBPH11 Publication, ORP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000021762.19
HGNCiHGNC:16392 OSBPL5
MIMi606733 gene
neXtProtiNX_Q9H0X9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei860 – 878HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi389L → D: Impaired lipid countertransport between the endoplasmic reticulum and the plasma membrane. 1 Publication1
Mutagenesisi478 – 479HH → AA: Impaired lipid countertransport between the endoplasmic reticulum and the plasma membrane. 1 Publication2

Organism-specific databases

DisGeNETi114879
OpenTargetsiENSG00000021762
PharmGKBiPA32829

Polymorphism and mutation databases

BioMutaiOSBPL5
DMDMi20139173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001003731 – 879Oxysterol-binding protein-related protein 5Add BLAST879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei12PhosphoserineBy similarity1
Modified residuei747PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0X9
MaxQBiQ9H0X9
PaxDbiQ9H0X9
PeptideAtlasiQ9H0X9
PRIDEiQ9H0X9
ProteomicsDBi80342
80343 [Q9H0X9-2]

PTM databases

iPTMnetiQ9H0X9
PhosphoSitePlusiQ9H0X9

Expressioni

Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

BgeeiENSG00000021762 Expressed in 197 organ(s), highest expression level in amniotic fluid
CleanExiHS_OSBPL5
ExpressionAtlasiQ9H0X9 baseline and differential
GenevisibleiQ9H0X9 HS

Organism-specific databases

HPAiHPA038335
HPA038712
HPA058727

Interactioni

Protein-protein interaction databases

BioGridi125380, 23 interactors
DIPiDIP-52332N
IntActiQ9H0X9, 17 interactors
STRINGi9606.ENSP00000263650

Structurei

3D structure databases

ProteinModelPortaliQ9H0X9
SMRiQ9H0X9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 243PHPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni384 – 389Phosphatidylinositol 4-phosphate bindingBy similarity6
Regioni384 – 389Phosphatidylserine bindingBy similarity6
Regioni446 – 449Phosphatidylinositol 4-phosphate bindingBy similarity4
Regioni478 – 479Phosphatidylinositol 4-phosphate bindingBy similarity2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili93 – 123Sequence analysisAdd BLAST31

Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233870
HOVERGENiHBG053375
InParanoidiQ9H0X9
KOiK20464
OMAiYEEFGET
OrthoDBiEOG091G0A3R
PhylomeDBiQ9H0X9
TreeFamiTF312807

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKEEAFLRRR FSLCPPSSTP QKVDPRKLTR NLLLSGDNEL YPLSPGKDME 
        60         70         80         90        100
PNGPSLPRDE GPPTPSSATK VPPAEYRLCN GSDKECVSPT ARVTKKETLK 
       110        120        130        140        150
AQKENYRQEK KRATRQLLSA LTDPSVVIMA DSLKIRGTLK SWTKLWCVLK 
       160        170        180        190        200
PGVLLIYKTP KVGQWVGTVL LHCCELIERP SKKDGFCFKL FHPLDQSVWA 
       210        220        230        240        250
VKGPKGESVG SITQPLPSSY LIFRAASESD GRCWLDALEL ALRCSSLLRL 
       260        270        280        290        300
GTCKPGRDGE PGTSPDASPS SLCGLPASAT VHPDQDLFPL NGSSLENDAF 
       310        320        330        340        350
SDKSERENPE ESDTETQDHS RKTESGSDQS ETPGAPVRRG TTYVEQVQEE 
       360        370        380        390        400
LGELGEASQV ETVSEENKSL MWTLLKQLRP GMDLSRVVLP TFVLEPRSFL 
       410        420        430        440        450
NKLSDYYYHA DLLSRAAVEE DAYSRMKLVL RWYLSGFYKK PKGIKKPYNP 
       460        470        480        490        500
ILGETFRCCW FHPQTDSRTF YIAEQVSHHP PVSAFHVSNR KDGFCISGSI 
       510        520        530        540        550
TAKSRFYGNS LSALLDGKAT LTFLNRAEDY TLTMPYAHCK GILYGTMTLE 
       560        570        580        590        600
LGGKVTIECA KNNFQAQLEF KLKPFFGGST SINQISGKIT SGEEVLASLS 
       610        620        630        640        650
GHWDRDVFIK EEGSGSSALF WTPSGEVRRQ RLRQHTVPLE EQTELESERL 
       660        670        680        690        700
WQHVTRAISK GDQHRATQEK FALEEAQRQR ARERQESLMP WKPQLFHLDP 
       710        720        730        740        750
ITQEWHYRYE DHSPWDPLKD IAQFEQDGIL RTLQQEAVAR QTTFLGSPGP 
       760        770        780        790        800
RHERSGPDQR LRKASDQPSG HSQATESSGS TPESCPELSD EEQDGDFVPG 
       810        820        830        840        850
GESPCPRCRK EARRLQALHE AILSIREAQQ ELHRHLSAML SSTARAAQAP 
       860        870 
TPGLLQSPRS WFLLCVFLAC QLFINHILK
Length:879
Mass (Da):98,616
Last modified:March 1, 2001 - v1
Checksum:i7EF06544347CC60A
GO
Isoform 2 (identifier: Q9H0X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-201: Missing.

Note: No experimental confirmation available.
Show »
Length:811
Mass (Da):90,794
Checksum:iECBEEE16DCF1B998
GO
Isoform 3 (identifier: Q9H0X9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     161-201: Missing.

Note: No experimental confirmation available.
Show »
Length:790
Mass (Da):88,435
Checksum:i6DAA25EEFBC0CEB6
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCD7H0YCD7_HUMAN
Oxysterol-binding protein
OSBPL5
432Annotation score:
E9PPQ2E9PPQ2_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
139Annotation score:
E9PJE6E9PJE6_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
124Annotation score:
E9PIJ6E9PIJ6_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
98Annotation score:
E9PQB4E9PQB4_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
89Annotation score:
E9PNH0E9PNH0_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
333Annotation score:
E9PRA9E9PRA9_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
115Annotation score:
E9PLN3E9PLN3_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
69Annotation score:

Sequence cautioni

The sequence BAA96058 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06007990T → I. Corresponds to variant dbSNP:rs6578323Ensembl.1
Natural variantiVAR_020414774A → T. Corresponds to variant dbSNP:rs2277301Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0574081 – 48Missing in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_043071134 – 201Missing in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_057409161 – 201Missing in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074006 mRNA Translation: BAB85686.1
AF392453 mRNA Translation: AAL40666.1
AF410430 mRNA Translation: AAK98617.1
AL136918 mRNA Translation: CAB66852.1
AK056510 mRNA Translation: BAG51735.1
AK301003 mRNA Translation: BAG62622.1
AC108448 Genomic DNA No translation available.
KC877382 Genomic DNA No translation available.
KF455307 Genomic DNA No translation available.
KF455310 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02542.1
CH471158 Genomic DNA Translation: EAX02543.1
BC032646 mRNA Translation: AAH32646.2
BC039579 mRNA Translation: AAH39579.1
AF331964 mRNA Translation: AAG53417.1
AB040967 mRNA Translation: BAA96058.1 Sequence problems.
CCDSiCCDS31343.1 [Q9H0X9-2]
CCDS31344.1 [Q9H0X9-1]
RefSeqiNP_001137535.1, NM_001144063.1 [Q9H0X9-2]
NP_065947.1, NM_020896.3 [Q9H0X9-1]
NP_663613.1, NM_145638.2 [Q9H0X9-2]
XP_011518175.1, XM_011519873.2 [Q9H0X9-1]
XP_016872652.1, XM_017017163.1 [Q9H0X9-1]
UniGeneiHs.436166

Genome annotation databases

EnsembliENST00000263650; ENSP00000263650; ENSG00000021762 [Q9H0X9-1]
ENST00000348039; ENSP00000302872; ENSG00000021762 [Q9H0X9-2]
ENST00000389989; ENSP00000374639; ENSG00000021762 [Q9H0X9-2]
ENST00000525498; ENSP00000433342; ENSG00000021762 [Q9H0X9-3]
GeneIDi114879
KEGGihsa:114879
UCSCiuc001lxk.3 human [Q9H0X9-1]
uc010qxq.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074006 mRNA Translation: BAB85686.1
AF392453 mRNA Translation: AAL40666.1
AF410430 mRNA Translation: AAK98617.1
AL136918 mRNA Translation: CAB66852.1
AK056510 mRNA Translation: BAG51735.1
AK301003 mRNA Translation: BAG62622.1
AC108448 Genomic DNA No translation available.
KC877382 Genomic DNA No translation available.
KF455307 Genomic DNA No translation available.
KF455310 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02542.1
CH471158 Genomic DNA Translation: EAX02543.1
BC032646 mRNA Translation: AAH32646.2
BC039579 mRNA Translation: AAH39579.1
AF331964 mRNA Translation: AAG53417.1
AB040967 mRNA Translation: BAA96058.1 Sequence problems.
CCDSiCCDS31343.1 [Q9H0X9-2]
CCDS31344.1 [Q9H0X9-1]
RefSeqiNP_001137535.1, NM_001144063.1 [Q9H0X9-2]
NP_065947.1, NM_020896.3 [Q9H0X9-1]
NP_663613.1, NM_145638.2 [Q9H0X9-2]
XP_011518175.1, XM_011519873.2 [Q9H0X9-1]
XP_016872652.1, XM_017017163.1 [Q9H0X9-1]
UniGeneiHs.436166

3D structure databases

ProteinModelPortaliQ9H0X9
SMRiQ9H0X9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125380, 23 interactors
DIPiDIP-52332N
IntActiQ9H0X9, 17 interactors
STRINGi9606.ENSP00000263650

Chemistry databases

SwissLipidsiSLP:000000527

Protein family/group databases

TCDBi2.D.1.1.1 the pi4p/ps counter transporter (p/p-ct) family

PTM databases

iPTMnetiQ9H0X9
PhosphoSitePlusiQ9H0X9

Polymorphism and mutation databases

BioMutaiOSBPL5
DMDMi20139173

Proteomic databases

EPDiQ9H0X9
MaxQBiQ9H0X9
PaxDbiQ9H0X9
PeptideAtlasiQ9H0X9
PRIDEiQ9H0X9
ProteomicsDBi80342
80343 [Q9H0X9-2]

Protocols and materials databases

DNASUi114879
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263650; ENSP00000263650; ENSG00000021762 [Q9H0X9-1]
ENST00000348039; ENSP00000302872; ENSG00000021762 [Q9H0X9-2]
ENST00000389989; ENSP00000374639; ENSG00000021762 [Q9H0X9-2]
ENST00000525498; ENSP00000433342; ENSG00000021762 [Q9H0X9-3]
GeneIDi114879
KEGGihsa:114879
UCSCiuc001lxk.3 human [Q9H0X9-1]
uc010qxq.2 human

Organism-specific databases

CTDi114879
DisGeNETi114879
EuPathDBiHostDB:ENSG00000021762.19
GeneCardsiOSBPL5
HGNCiHGNC:16392 OSBPL5
HPAiHPA038335
HPA038712
HPA058727
MIMi606733 gene
neXtProtiNX_Q9H0X9
OpenTargetsiENSG00000021762
PharmGKBiPA32829
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00550000074515
HOGENOMiHOG000233870
HOVERGENiHBG053375
InParanoidiQ9H0X9
KOiK20464
OMAiYEEFGET
OrthoDBiEOG091G0A3R
PhylomeDBiQ9H0X9
TreeFamiTF312807

Enzyme and pathway databases

ReactomeiR-HSA-1482801 Acyl chain remodelling of PS

Miscellaneous databases

ChiTaRSiOSBPL5 human
GeneWikiiOSBPL5
GenomeRNAii114879
PROiPR:Q9H0X9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000021762 Expressed in 197 organ(s), highest expression level in amniotic fluid
CleanExiHS_OSBPL5
ExpressionAtlasiQ9H0X9 baseline and differential
GenevisibleiQ9H0X9 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOSBL5_HUMAN
AccessioniPrimary (citable) accession number: Q9H0X9
Secondary accession number(s): A6NDP0
, A6NJS8, B4DVB0, Q54A90, Q8N596, Q9BZB0, Q9P1Z4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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