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UniProtKB - Q9H0X9 (OSBL5_HUMAN)

Entry version 157 (16 Oct 2019)
Sequence version 1 (01 Mar 2001)
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Protein

Oxysterol-binding protein-related protein 5

Gene

OSBPL5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner (PubMed:23934110, PubMed:26206935). May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes (PubMed:21220512). Binds 25-hydroxycholesterol and cholesterol (PubMed:17428193).4 Publications

Miscellaneous

According to a report, the gene is imprinted in placenta, where it is predominantly expressed from the maternal allele only. Not imprinted in other tissues (PubMed:12504849). According to another report, it is not imprinted in trophoblast stem cells (PubMed:20644730).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei449PhosphatidylserineBy similarity1
Binding sitei504PhosphatidylserineBy similarity1
Binding sitei670Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei674Phosphatidylinositol 4-phosphateBy similarity1
Binding sitei678Phosphatidylinositol 4-phosphateBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1482801 Acyl chain remodelling of PS

Protein family/group databases

Transport Classification Database

More...TCDBi		2.D.1.1.1 the pi4p/ps counter transporter (p/p-ct) family

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000527

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 5
Short name:
ORP-5
Short name:
OSBP-related protein 5
Alternative name(s):
Oxysterol-binding protein homolog 11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OSBPL5
Synonyms:KIAA1534, OBPH11 Publication, ORP5
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16392 OSBPL5

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		606733 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H0X9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei860 – 878HelicalSequence analysisAdd BLAST19

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi389L → D: Impaired lipid countertransport between the endoplasmic reticulum and the plasma membrane. 1 Publication1
Mutagenesisi478 – 479HH → AA: Impaired lipid countertransport between the endoplasmic reticulum and the plasma membrane. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		114879

Open Targets

More...OpenTargetsi		ENSG00000021762

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32829

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H0X9

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		OSBPL5

Domain mapping of disease mutations (DMDM)

More...DMDMi		20139173

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001003731 – 879Oxysterol-binding protein-related protein 5Add BLAST879

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei12PhosphoserineBy similarity1
Modified residuei747PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H0X9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H0X9

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H0X9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H0X9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H0X9

PeptideAtlas

More...PeptideAtlasi		Q9H0X9

PRoteomics IDEntifications database

More...PRIDEi		Q9H0X9

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5257
80342 [Q9H0X9-1]
80343 [Q9H0X9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H0X9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H0X9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000021762 Expressed in 197 organ(s), highest expression level in amniotic fluid

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H0X9 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H0X9 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA038335
HPA038712
HPA058727

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		125380, 24 interactors

Database of interacting proteins

More...DIPi		DIP-52332N

Protein interaction database and analysis system

More...IntActi		Q9H0X9, 22 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263650

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H0X9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini126 – 243PHPROSITE-ProRule annotationAdd BLAST118

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni384 – 389Phosphatidylinositol 4-phosphate bindingBy similarity6
Regioni384 – 389Phosphatidylserine bindingBy similarity6
Regioni446 – 449Phosphatidylinositol 4-phosphate bindingBy similarity4
Regioni478 – 479Phosphatidylinositol 4-phosphate bindingBy similarity2

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili93 – 123Sequence analysisAdd BLAST31

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2210 Eukaryota
ENOG410XRW6 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000159535

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000233870

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H0X9

KEGG Orthology (KO)

More...KOi		K20464

Identification of Orthologs from Complete Genome Data

More...OMAi		CWFLLCI

Database of Orthologous Groups

More...OrthoDBi		949920at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H0X9

TreeFam database of animal gene trees

More...TreeFami		TF312807

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...PANTHERi		PTHR10972 PTHR10972, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00233 PH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF144000 SSF144000, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0X9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKEEAFLRRR FSLCPPSSTP QKVDPRKLTR NLLLSGDNEL YPLSPGKDME 
        60         70         80         90        100
PNGPSLPRDE GPPTPSSATK VPPAEYRLCN GSDKECVSPT ARVTKKETLK 
       110        120        130        140        150
AQKENYRQEK KRATRQLLSA LTDPSVVIMA DSLKIRGTLK SWTKLWCVLK 
       160        170        180        190        200
PGVLLIYKTP KVGQWVGTVL LHCCELIERP SKKDGFCFKL FHPLDQSVWA 
       210        220        230        240        250
VKGPKGESVG SITQPLPSSY LIFRAASESD GRCWLDALEL ALRCSSLLRL 
       260        270        280        290        300
GTCKPGRDGE PGTSPDASPS SLCGLPASAT VHPDQDLFPL NGSSLENDAF 
       310        320        330        340        350
SDKSERENPE ESDTETQDHS RKTESGSDQS ETPGAPVRRG TTYVEQVQEE 
       360        370        380        390        400
LGELGEASQV ETVSEENKSL MWTLLKQLRP GMDLSRVVLP TFVLEPRSFL 
       410        420        430        440        450
NKLSDYYYHA DLLSRAAVEE DAYSRMKLVL RWYLSGFYKK PKGIKKPYNP 
       460        470        480        490        500
ILGETFRCCW FHPQTDSRTF YIAEQVSHHP PVSAFHVSNR KDGFCISGSI 
       510        520        530        540        550
TAKSRFYGNS LSALLDGKAT LTFLNRAEDY TLTMPYAHCK GILYGTMTLE 
       560        570        580        590        600
LGGKVTIECA KNNFQAQLEF KLKPFFGGST SINQISGKIT SGEEVLASLS 
       610        620        630        640        650
GHWDRDVFIK EEGSGSSALF WTPSGEVRRQ RLRQHTVPLE EQTELESERL 
       660        670        680        690        700
WQHVTRAISK GDQHRATQEK FALEEAQRQR ARERQESLMP WKPQLFHLDP 
       710        720        730        740        750
ITQEWHYRYE DHSPWDPLKD IAQFEQDGIL RTLQQEAVAR QTTFLGSPGP 
       760        770        780        790        800
RHERSGPDQR LRKASDQPSG HSQATESSGS TPESCPELSD EEQDGDFVPG 
       810        820        830        840        850
GESPCPRCRK EARRLQALHE AILSIREAQQ ELHRHLSAML SSTARAAQAP 
       860        870 
TPGLLQSPRS WFLLCVFLAC QLFINHILK
Length:879
Mass (Da):98,616
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7EF06544347CC60A
GO
Isoform 2 (identifier: Q9H0X9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     134-201: Missing.

Note: No experimental confirmation available.
Show »
Length:811
Mass (Da):90,794
Checksum:iECBEEE16DCF1B998
GO
Isoform 3 (identifier: Q9H0X9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-48: Missing.
     161-201: Missing.

Note: No experimental confirmation available.
Show »
Length:790
Mass (Da):88,435
Checksum:i6DAA25EEFBC0CEB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YCD7H0YCD7_HUMAN
Oxysterol-binding protein
OSBPL5
432Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJE6E9PJE6_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPQ2E9PPQ2_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNH0E9PNH0_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
333Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIJ6E9PIJ6_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
98Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQB4E9PQB4_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PRA9E9PRA9_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLN3E9PLN3_HUMAN
Oxysterol-binding protein-related p...
OSBPL5
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA96058 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_06007990T → I. Corresponds to variant dbSNP:rs6578323Ensembl.1
Natural variantiVAR_020414774A → T. Corresponds to variant dbSNP:rs2277301Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0574081 – 48Missing in isoform 3. 1 PublicationAdd BLAST48
Alternative sequenceiVSP_043071134 – 201Missing in isoform 2. 1 PublicationAdd BLAST68
Alternative sequenceiVSP_057409161 – 201Missing in isoform 3. 1 PublicationAdd BLAST41

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB074006 mRNA Translation: BAB85686.1
AF392453 mRNA Translation: AAL40666.1
AF410430 mRNA Translation: AAK98617.1
AL136918 mRNA Translation: CAB66852.1
AK056510 mRNA Translation: BAG51735.1
AK301003 mRNA Translation: BAG62622.1
AC108448 Genomic DNA No translation available.
KC877382 Genomic DNA No translation available.
KF455307 Genomic DNA No translation available.
KF455310 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02542.1
CH471158 Genomic DNA Translation: EAX02543.1
BC032646 mRNA Translation: AAH32646.2
BC039579 mRNA Translation: AAH39579.1
AF331964 mRNA Translation: AAG53417.1
AB040967 mRNA Translation: BAA96058.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS31343.1 [Q9H0X9-2]
CCDS31344.1 [Q9H0X9-1]

NCBI Reference Sequences

More...RefSeqi		NP_001137535.1, NM_001144063.1 [Q9H0X9-2]
NP_065947.1, NM_020896.3 [Q9H0X9-1]
NP_663613.1, NM_145638.2 [Q9H0X9-2]
XP_011518175.1, XM_011519873.2 [Q9H0X9-1]
XP_016872652.1, XM_017017163.1 [Q9H0X9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263650; ENSP00000263650; ENSG00000021762 [Q9H0X9-1]
ENST00000348039; ENSP00000302872; ENSG00000021762 [Q9H0X9-2]
ENST00000389989; ENSP00000374639; ENSG00000021762 [Q9H0X9-2]
ENST00000525498; ENSP00000433342; ENSG00000021762 [Q9H0X9-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		114879

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:114879

UCSC genome browser

More...UCSCi		uc001lxk.3 human [Q9H0X9-1]
uc010qxq.2 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB074006 mRNA Translation: BAB85686.1
AF392453 mRNA Translation: AAL40666.1
AF410430 mRNA Translation: AAK98617.1
AL136918 mRNA Translation: CAB66852.1
AK056510 mRNA Translation: BAG51735.1
AK301003 mRNA Translation: BAG62622.1
AC108448 Genomic DNA No translation available.
KC877382 Genomic DNA No translation available.
KF455307 Genomic DNA No translation available.
KF455310 Genomic DNA No translation available.
CH471158 Genomic DNA Translation: EAX02542.1
CH471158 Genomic DNA Translation: EAX02543.1
BC032646 mRNA Translation: AAH32646.2
BC039579 mRNA Translation: AAH39579.1
AF331964 mRNA Translation: AAG53417.1
AB040967 mRNA Translation: BAA96058.1 Sequence problems.
CCDSiCCDS31343.1 [Q9H0X9-2]
CCDS31344.1 [Q9H0X9-1]
RefSeqiNP_001137535.1, NM_001144063.1 [Q9H0X9-2]
NP_065947.1, NM_020896.3 [Q9H0X9-1]
NP_663613.1, NM_145638.2 [Q9H0X9-2]
XP_011518175.1, XM_011519873.2 [Q9H0X9-1]
XP_016872652.1, XM_017017163.1 [Q9H0X9-1]

3D structure databases

SMRiQ9H0X9
ModBaseiSearch...

Protein-protein interaction databases

BioGridi125380, 24 interactors
DIPiDIP-52332N
IntActiQ9H0X9, 22 interactors
STRINGi9606.ENSP00000263650

Chemistry databases

SwissLipidsiSLP:000000527

Protein family/group databases

TCDBi2.D.1.1.1 the pi4p/ps counter transporter (p/p-ct) family

PTM databases

iPTMnetiQ9H0X9
PhosphoSitePlusiQ9H0X9

Polymorphism and mutation databases

BioMutaiOSBPL5
DMDMi20139173

Proteomic databases

EPDiQ9H0X9
jPOSTiQ9H0X9
MassIVEiQ9H0X9
MaxQBiQ9H0X9
PaxDbiQ9H0X9
PeptideAtlasiQ9H0X9
PRIDEiQ9H0X9
ProteomicsDBi5257
80342 [Q9H0X9-1]
80343 [Q9H0X9-2]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		114879

Genome annotation databases

EnsembliENST00000263650; ENSP00000263650; ENSG00000021762 [Q9H0X9-1]
ENST00000348039; ENSP00000302872; ENSG00000021762 [Q9H0X9-2]
ENST00000389989; ENSP00000374639; ENSG00000021762 [Q9H0X9-2]
ENST00000525498; ENSP00000433342; ENSG00000021762 [Q9H0X9-3]
GeneIDi114879
KEGGihsa:114879
UCSCiuc001lxk.3 human [Q9H0X9-1]
uc010qxq.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		114879
DisGeNETi114879

GeneCards: human genes, protein and diseases

More...GeneCardsi		OSBPL5
HGNCiHGNC:16392 OSBPL5
HPAiHPA038335
HPA038712
HPA058727
MIMi606733 gene
neXtProtiNX_Q9H0X9
OpenTargetsiENSG00000021762
PharmGKBiPA32829

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2210 Eukaryota
ENOG410XRW6 LUCA
GeneTreeiENSGT00940000159535
HOGENOMiHOG000233870
InParanoidiQ9H0X9
KOiK20464
OMAiCWFLLCI
OrthoDBi949920at2759
PhylomeDBiQ9H0X9
TreeFamiTF312807

Enzyme and pathway databases

ReactomeiR-HSA-1482801 Acyl chain remodelling of PS

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		OSBPL5 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		OSBPL5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		114879
PharosiQ9H0X9

Protein Ontology

More...PROi		PR:Q9H0X9

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000021762 Expressed in 197 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiQ9H0X9 baseline and differential
GenevisibleiQ9H0X9 HS

Family and domain databases

Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR037239 OSBP_sf
IPR000648 Oxysterol-bd
IPR018494 Oxysterol-bd_CS
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR10972 PTHR10972, 1 hit
PfamiView protein in Pfam
PF01237 Oxysterol_BP, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
SUPFAMiSSF144000 SSF144000, 1 hit
PROSITEiView protein in PROSITE
PS01013 OSBP, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOSBL5_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0X9
Secondary accession number(s): A6NDP0
, A6NJS8, B4DVB0, Q54A90, Q8N596, Q9BZB0, Q9P1Z4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: March 1, 2001
Last modified: October 16, 2019
This is version 157 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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