UniProtKB - Q9H0X4 (F234A_HUMAN)
Protein
Protein FAM234A
Gene
FAM234A
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM234AAlternative name(s): Protein ITFG3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14163, FAM234A |
neXtProti | NX_Q9H0X4 |
VEuPathDBi | HostDB:ENSG00000167930.15 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cell surface Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 49 | CytoplasmicSequence analysisAdd BLAST | 49 | |
Transmembranei | 50 – 70 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 71 – 552 | ExtracellularSequence analysisAdd BLAST | 482 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 83986 |
OpenTargetsi | ENSG00000167930 |
PharmGKBi | PA25564 |
Miscellaneous databases
Pharosi | Q9H0X4, Tdark |
Genetic variation databases
BioMutai | FAM234A |
DMDMi | 74733531 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247993 | 1 – 552 | Protein FAM234AAdd BLAST | 552 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphoserineBy similarity | 1 | |
Glycosylationi | 116 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 314 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 389 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Glycosylationi | 473 | N-linked (GlcNAc...) asparagine1 Publication | 1 |
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | Q9H0X4 |
jPOSTi | Q9H0X4 |
MassIVEi | Q9H0X4 |
MaxQBi | Q9H0X4 |
PaxDbi | Q9H0X4 |
PeptideAtlasi | Q9H0X4 |
PRIDEi | Q9H0X4 |
ProteomicsDBi | 80339 [Q9H0X4-1] 80340 [Q9H0X4-2] |
PTM databases
GlyConnecti | 1662, 1 N-Linked glycan (1 site) |
GlyGeni | Q9H0X4, 5 sites |
iPTMneti | Q9H0X4 |
PhosphoSitePlusi | Q9H0X4 |
SwissPalmi | Q9H0X4 |
Expressioni
Gene expression databases
Bgeei | ENSG00000167930, Expressed in C1 segment of cervical spinal cord and 206 other tissues |
ExpressionAtlasi | Q9H0X4, baseline and differential |
Genevisiblei | Q9H0X4, HS |
Organism-specific databases
HPAi | ENSG00000167930, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123837, 20 interactors |
IntActi | Q9H0X4, 10 interactors |
MINTi | Q9H0X4 |
STRINGi | 9606.ENSP00000382814 |
Miscellaneous databases
RNActi | Q9H0X4, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM234 family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R0CE, Eukaryota |
GeneTreei | ENSGT00530000063694 |
HOGENOMi | CLU_036490_0_0_1 |
InParanoidi | Q9H0X4 |
OMAi | PCTFVAA |
OrthoDBi | 294858at2759 |
PhylomeDBi | Q9H0X4 |
TreeFami | TF327203 |
Family and domain databases
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam |
SUPFAMi | SSF50998, SSF50998, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 12 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H0X4-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MLDHKDLEAE IHPLKNEERK SQENLGNPSK NEDNVKSAPP QSRLSRCRAA
60 70 80 90 100
AFFLSLFLCL FVVFVVSFVI PCPDRPASQR MWRIDYSAAV IYDFLAVDDI
110 120 130 140 150
NGDRIQDVLF LYKNTNSSNN FSRSCVDEGF SSPCTFAAAV SGANGSTLWE
160 170 180 190 200
RPVAQDVALV ECAVPQPRGS EAPSACILVG RPSSFIAVNL FTGETLWNHS
210 220 230 240 250
SSFSGNASIL SPLLQVPDVD GDGAPDLLVL TQEREEVSGH LYSGSTGHQI
260 270 280 290 300
GLRGSLGVDG ESGFLLHVTR TGAHYILFPC ASSLCGCSVK GLYEKVTGSG
310 320 330 340 350
GPFKSDPHWE SMLNATTRRM LSHSSGAVRY LMHVPGNAGA DVLLVGSEAF
360 370 380 390 400
VLLDGQELTP RWTPKAAHVL RKPIFGRYKP DTLAVAVENG TGTDRQILFL
410 420 430 440 450
DLGTGAVLCS LALPSLPGGP LSASLPTADH RSAFFFWGLH ELGSTSETET
460 470 480 490 500
GEARHSLYMF HPTLPRVLLE LANVSTHIVA FDAVLFEPSR HAAYILLTGP
510 520 530 540 550
ADSEAPGLVS VIKHKVRDLV PSSRVVRLGE GGPDSDQAIR DRFSRLRYQS
EA
Computationally mapped potential isoform sequencesi
There are 12 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DGG1 | B4DGG1_HUMAN | Protein FAM234A | FAM234A | 531 | Annotation score: | ||
C9J3Y6 | C9J3Y6_HUMAN | Protein FAM234A | FAM234A | 233 | Annotation score: | ||
C9IYB9 | C9IYB9_HUMAN | Protein FAM234A | FAM234A | 236 | Annotation score: | ||
C9JJN3 | C9JJN3_HUMAN | Protein FAM234A | FAM234A | 87 | Annotation score: | ||
C9K0C5 | C9K0C5_HUMAN | Protein FAM234A | FAM234A | 242 | Annotation score: | ||
C9JTF7 | C9JTF7_HUMAN | Protein FAM234A | FAM234A | 103 | Annotation score: | ||
C9J8V3 | C9J8V3_HUMAN | Protein FAM234A | FAM234A | 68 | Annotation score: | ||
C9JP72 | C9JP72_HUMAN | Protein FAM234A | FAM234A | 131 | Annotation score: | ||
C9JR71 | C9JR71_HUMAN | Protein FAM234A | FAM234A | 102 | Annotation score: | ||
C9J1M4 | C9J1M4_HUMAN | Protein FAM234A | FAM234A | 50 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence AAK61220 differs from that shown. Reason: Erroneous gene model prediction.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 20 | K → E in BAB71374 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020121 | 516 – 540 | VRDLV…DQAIR → AHTGRQRRGSWTGQSSRRDL HVRVL in isoform 2. 1 PublicationAdd BLAST | 25 | |
Alternative sequenceiVSP_020122 | 541 – 552 | Missing in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136542 mRNA Translation: CAB66477.1 AK057165 mRNA Translation: BAB71374.1 AE006462 Genomic DNA Translation: AAK61220.1 Sequence problems. CH471112 Genomic DNA Translation: EAW85846.1 CH471112 Genomic DNA Translation: EAW85847.1 BC010521 mRNA Translation: AAH10521.1 BC013047 mRNA Translation: AAH13047.1 BC032112 mRNA Translation: AAH32112.1 |
CCDSi | CCDS10402.1 [Q9H0X4-1] |
RefSeqi | NP_001271426.1, NM_001284497.1 [Q9H0X4-1] NP_114428.1, NM_032039.3 [Q9H0X4-1] XP_005255679.1, XM_005255622.1 [Q9H0X4-1] XP_011520993.1, XM_011522691.1 [Q9H0X4-1] XP_011520994.1, XM_011522692.1 [Q9H0X4-1] XP_016879249.1, XM_017023760.1 [Q9H0X4-1] XP_016879250.1, XM_017023761.1 [Q9H0X4-1] XP_016879251.1, XM_017023762.1 [Q9H0X4-1] |
Genome annotation databases
Ensembli | ENST00000301678; ENSP00000301678; ENSG00000167930 [Q9H0X4-1] ENST00000301679; ENSP00000301679; ENSG00000167930 [Q9H0X4-2] ENST00000399932; ENSP00000382814; ENSG00000167930 [Q9H0X4-1] ENST00000654053; ENSP00000499447; ENSG00000167930 [Q9H0X4-2] ENST00000659283; ENSP00000499694; ENSG00000167930 [Q9H0X4-2] ENST00000666018; ENSP00000499687; ENSG00000167930 [Q9H0X4-2] |
GeneIDi | 83986 |
KEGGi | hsa:83986 |
UCSCi | uc002cgf.4, human [Q9H0X4-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136542 mRNA Translation: CAB66477.1 AK057165 mRNA Translation: BAB71374.1 AE006462 Genomic DNA Translation: AAK61220.1 Sequence problems. CH471112 Genomic DNA Translation: EAW85846.1 CH471112 Genomic DNA Translation: EAW85847.1 BC010521 mRNA Translation: AAH10521.1 BC013047 mRNA Translation: AAH13047.1 BC032112 mRNA Translation: AAH32112.1 |
CCDSi | CCDS10402.1 [Q9H0X4-1] |
RefSeqi | NP_001271426.1, NM_001284497.1 [Q9H0X4-1] NP_114428.1, NM_032039.3 [Q9H0X4-1] XP_005255679.1, XM_005255622.1 [Q9H0X4-1] XP_011520993.1, XM_011522691.1 [Q9H0X4-1] XP_011520994.1, XM_011522692.1 [Q9H0X4-1] XP_016879249.1, XM_017023760.1 [Q9H0X4-1] XP_016879250.1, XM_017023761.1 [Q9H0X4-1] XP_016879251.1, XM_017023762.1 [Q9H0X4-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123837, 20 interactors |
IntActi | Q9H0X4, 10 interactors |
MINTi | Q9H0X4 |
STRINGi | 9606.ENSP00000382814 |
PTM databases
GlyConnecti | 1662, 1 N-Linked glycan (1 site) |
GlyGeni | Q9H0X4, 5 sites |
iPTMneti | Q9H0X4 |
PhosphoSitePlusi | Q9H0X4 |
SwissPalmi | Q9H0X4 |
Genetic variation databases
BioMutai | FAM234A |
DMDMi | 74733531 |
Proteomic databases
EPDi | Q9H0X4 |
jPOSTi | Q9H0X4 |
MassIVEi | Q9H0X4 |
MaxQBi | Q9H0X4 |
PaxDbi | Q9H0X4 |
PeptideAtlasi | Q9H0X4 |
PRIDEi | Q9H0X4 |
ProteomicsDBi | 80339 [Q9H0X4-1] 80340 [Q9H0X4-2] |
Protocols and materials databases
Antibodypediai | 2603, 140 antibodies |
DNASUi | 83986 |
Genome annotation databases
Ensembli | ENST00000301678; ENSP00000301678; ENSG00000167930 [Q9H0X4-1] ENST00000301679; ENSP00000301679; ENSG00000167930 [Q9H0X4-2] ENST00000399932; ENSP00000382814; ENSG00000167930 [Q9H0X4-1] ENST00000654053; ENSP00000499447; ENSG00000167930 [Q9H0X4-2] ENST00000659283; ENSP00000499694; ENSG00000167930 [Q9H0X4-2] ENST00000666018; ENSP00000499687; ENSG00000167930 [Q9H0X4-2] |
GeneIDi | 83986 |
KEGGi | hsa:83986 |
UCSCi | uc002cgf.4, human [Q9H0X4-1] |
Organism-specific databases
CTDi | 83986 |
DisGeNETi | 83986 |
GeneCardsi | FAM234A |
HGNCi | HGNC:14163, FAM234A |
HPAi | ENSG00000167930, Low tissue specificity |
neXtProti | NX_Q9H0X4 |
OpenTargetsi | ENSG00000167930 |
PharmGKBi | PA25564 |
VEuPathDBi | HostDB:ENSG00000167930.15 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502R0CE, Eukaryota |
GeneTreei | ENSGT00530000063694 |
HOGENOMi | CLU_036490_0_0_1 |
InParanoidi | Q9H0X4 |
OMAi | PCTFVAA |
OrthoDBi | 294858at2759 |
PhylomeDBi | Q9H0X4 |
TreeFami | TF327203 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0X4 |
Miscellaneous databases
BioGRID-ORCSi | 83986, 5 hits in 873 CRISPR screens |
ChiTaRSi | FAM234A, human |
GeneWikii | ITFG3 |
GenomeRNAii | 83986 |
Pharosi | Q9H0X4, Tdark |
PROi | PR:Q9H0X4 |
RNActi | Q9H0X4, protein |
Gene expression databases
Bgeei | ENSG00000167930, Expressed in C1 segment of cervical spinal cord and 206 other tissues |
ExpressionAtlasi | Q9H0X4, baseline and differential |
Genevisiblei | Q9H0X4, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011047, Quinoprotein_ADH-like_supfam |
SUPFAMi | SSF50998, SSF50998, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | F234A_HUMAN | |
Accessioni | Q9H0X4Primary (citable) accession number: Q9H0X4 Secondary accession number(s): D3DU45 Q96S30 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM