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Protein

Ester hydrolase C11orf54

Gene

C11orf54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi266Zinc; catalytic1
Metal bindingi268Zinc; catalytic1
Metal bindingi278Zinc; catalytic1

GO - Molecular functioni

  • hydrolase activity, acting on ester bonds Source: FlyBase
  • zinc ion binding Source: FlyBase

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ester hydrolase C11orf54 (EC:3.1.-.-)
Gene namesi
ORF Names:LP4947, PTD012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000182919.14
HGNCiHGNC:30204 C11orf54
MIMi615810 gene
neXtProtiNX_Q9H0W9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi28970
OpenTargetsiENSG00000182919
PharmGKBiPA143485349

Polymorphism and mutation databases

DMDMi74718025

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002460291 – 315Ester hydrolase C11orf54Add BLAST315

Proteomic databases

EPDiQ9H0W9
MaxQBiQ9H0W9
PeptideAtlasiQ9H0W9
PRIDEiQ9H0W9
ProteomicsDBi80335
80336 [Q9H0W9-2]
80337 [Q9H0W9-3]
80338 [Q9H0W9-4]

PTM databases

iPTMnetiQ9H0W9
PhosphoSitePlusiQ9H0W9

Expressioni

Gene expression databases

BgeeiENSG00000182919
CleanExiHS_C11orf54
ExpressionAtlasiQ9H0W9 baseline and differential
GenevisibleiQ9H0W9 HS

Organism-specific databases

HPAiHPA040088
HPA040511

Interactioni

Subunit structurei

Monomer.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi118794, 35 interactors
IntActiQ9H0W9, 3 interactors

Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi4 – 7Combined sources4
Helixi13 – 27Combined sources15
Beta strandi28 – 37Combined sources10
Turni44 – 46Combined sources3
Beta strandi49 – 51Combined sources3
Beta strandi54 – 56Combined sources3
Beta strandi58 – 63Combined sources6
Helixi65 – 67Combined sources3
Beta strandi69 – 71Combined sources3
Beta strandi77 – 79Combined sources3
Helixi80 – 86Combined sources7
Beta strandi93 – 99Combined sources7
Helixi102 – 105Combined sources4
Beta strandi110 – 112Combined sources3
Beta strandi114 – 116Combined sources3
Beta strandi129 – 133Combined sources5
Turni135 – 137Combined sources3
Beta strandi140 – 144Combined sources5
Helixi145 – 148Combined sources4
Beta strandi153 – 163Combined sources11
Beta strandi169 – 178Combined sources10
Helixi184 – 196Combined sources13
Beta strandi202 – 218Combined sources17
Helixi231 – 237Combined sources7
Beta strandi238 – 245Combined sources8
Beta strandi247 – 256Combined sources10
Beta strandi264 – 270Combined sources7
Beta strandi272 – 274Combined sources3
Beta strandi277 – 283Combined sources7
Turni285 – 287Combined sources3
Beta strandi289 – 296Combined sources8
Beta strandi298 – 304Combined sources7

3D structure databases

ProteinModelPortaliQ9H0W9
SMRiQ9H0W9
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0W9

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000017214
HOVERGENiHBG081215
InParanoidiQ9H0W9
OMAiHTHCFSH
OrthoDBiEOG091G0J69
PhylomeDBiQ9H0W9
TreeFamiTF313169

Family and domain databases

InterProiView protein in InterPro
IPR015021 DUF1907
PANTHERiPTHR13204 PTHR13204, 1 hit
PfamiView protein in Pfam
PF08925 DUF1907, 1 hit
SMARTiView protein in SMART
SM01168 DUF1907, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H0W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV
60 70 80 90 100
KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG
110 120 130 140 150
PFQTLGFNSE FMPVIQTESE HKPPVNGSYF AHVNPADGGC LLEKYSEKCH
160 170 180 190 200
DFQCALLANL FASEGQPGKV IEVKAKRRTG PLNFVTCMRE TLEKHYGNKP
210 220 230 240 250
IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF YEMKAPLVCL
260 270 280 290 300
PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL
310
YRIDQPKETH SIGRD
Length:315
Mass (Da):35,117
Last modified:March 1, 2001 - v1
Checksum:iF084671CC1E3F72A
GO
Isoform 2 (identifier: Q9H0W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:296
Mass (Da):33,098
Checksum:i66962958EE2A4F17
GO
Isoform 3 (identifier: Q9H0W9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-219: Missing.

Note: Probably non-functional.
Show »
Length:265
Mass (Da):29,492
Checksum:i82F671A9F47F0906
GO
Isoform 4 (identifier: Q9H0W9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:204
Mass (Da):23,173
Checksum:iDBE4CAF56964ADFD
GO

Sequence cautioni

The sequence AAH07110 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP34483 differs from that shown. Reason: Frameshift at position 125.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10V → A in CAG38569 (Ref. 3) Curated1
Sequence conflicti184F → L in CAG38569 (Ref. 3) Curated1
Sequence conflicti304D → G in AAD40375 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0198171 – 111Missing in isoform 4. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0198181 – 19Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_019821170 – 219Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092133 mRNA Translation: AAD40375.1
AL136605 mRNA Translation: CAB66540.1
CR533538 mRNA Translation: CAG38569.1
AY203960 mRNA Translation: AAP34483.1 Frameshift.
AK292215 mRNA Translation: BAF84904.1
CH471065 Genomic DNA Translation: EAW66915.1
BC007110 mRNA Translation: AAH07110.2 Different initiation.
BC012298 mRNA Translation: AAH12298.1
CCDSiCCDS66204.1 [Q9H0W9-1]
CCDS73366.1 [Q9H0W9-2]
CCDS8294.1 [Q9H0W9-3]
RefSeqiNP_001272996.1, NM_001286067.1 [Q9H0W9-1]
NP_001272997.1, NM_001286068.1 [Q9H0W9-1]
NP_001272998.1, NM_001286069.1 [Q9H0W9-1]
NP_001272999.1, NM_001286070.1 [Q9H0W9-2]
NP_001273000.1, NM_001286071.1
NP_054758.2, NM_014039.3 [Q9H0W9-3]
XP_006718887.1, XM_006718824.1
XP_011541083.1, XM_011542781.2 [Q9H0W9-1]
XP_011541084.1, XM_011542782.2 [Q9H0W9-1]
XP_016873102.1, XM_017017613.1
XP_016873103.1, XM_017017614.1
XP_016873104.1, XM_017017615.1
XP_016873105.1, XM_017017616.1
UniGeneiHs.8360

Genome annotation databases

EnsembliENST00000331239; ENSP00000331209; ENSG00000182919 [Q9H0W9-1]
ENST00000354421; ENSP00000346403; ENSG00000182919 [Q9H0W9-1]
ENST00000528099; ENSP00000435113; ENSG00000182919 [Q9H0W9-1]
ENST00000528288; ENSP00000433721; ENSG00000182919 [Q9H0W9-3]
ENST00000540113; ENSP00000442094; ENSG00000182919 [Q9H0W9-2]
GeneIDi28970
KEGGihsa:28970
UCSCiuc001pef.5 human [Q9H0W9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCK054_HUMAN
AccessioniPrimary (citable) accession number: Q9H0W9
Secondary accession number(s): A8K850
, Q6FI88, Q6XYB0, Q96EI3, Q96IX1, Q9Y6B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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