UniProtKB - Q9H0W9 (CK054_HUMAN)
Protein
Ester hydrolase C11orf54
Gene
C11orf54
Organism
Homo sapiens (Human)
Status
Functioni
Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 266 | Zinc; catalytic | 1 | |
Metal bindingi | 268 | Zinc; catalytic | 1 | |
Metal bindingi | 278 | Zinc; catalytic | 1 |
GO - Molecular functioni
- hydrolase activity, acting on ester bonds Source: FlyBase
- zinc ion binding Source: FlyBase
Keywordsi
Molecular function | Hydrolase |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H0W9 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:C11orf54 ORF Names:LP4947, PTD012 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:30204, C11orf54 |
MIMi | 615810, gene |
neXtProti | NX_Q9H0W9 |
VEuPathDBi | HostDB:ENSG00000182919.14 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nuclear body Source: HPA
- nucleoplasm Source: HPA
- nucleus Source: LIFEdb
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 28970 |
OpenTargetsi | ENSG00000182919 |
PharmGKBi | PA143485349 |
Miscellaneous databases
Pharosi | Q9H0W9, Tbio |
Genetic variation databases
BioMutai | C11orf54 |
DMDMi | 74718025 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000246029 | 1 – 315 | Ester hydrolase C11orf54Add BLAST | 315 |
Proteomic databases
EPDi | Q9H0W9 |
jPOSTi | Q9H0W9 |
MassIVEi | Q9H0W9 |
MaxQBi | Q9H0W9 |
PeptideAtlasi | Q9H0W9 |
PRIDEi | Q9H0W9 |
ProteomicsDBi | 80335 [Q9H0W9-1] 80336 [Q9H0W9-2] 80337 [Q9H0W9-3] 80338 [Q9H0W9-4] |
PTM databases
iPTMneti | Q9H0W9 |
PhosphoSitePlusi | Q9H0W9 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182919, Expressed in kidney epithelium and 215 other tissues |
ExpressionAtlasi | Q9H0W9, baseline and differential |
Genevisiblei | Q9H0W9, HS |
Organism-specific databases
HPAi | ENSG00000182919, Tissue enhanced (kidney, liver) |
Interactioni
Subunit structurei
Monomer.
1 PublicationBinary interactionsi
Hide detailsQ9H0W9
With | #Exp. | IntAct |
---|---|---|
SSX2IP [Q9Y2D8] | 3 | EBI-740204,EBI-2212028 |
TRIP13 [Q15645] | 3 | EBI-740204,EBI-358993 |
VAC14 [Q08AM6] | 4 | EBI-740204,EBI-2107455 |
Isoform 3 [Q9H0W9-3]
Isoform 4 [Q9H0W9-4]
With | #Exp. | IntAct |
---|---|---|
HSPB1 [P04792] | 3 | EBI-25849710,EBI-352682 |
KIF1B - isoform 2 [O60333-2] | 3 | EBI-25849710,EBI-10975473 |
WFS1 [O76024] | 3 | EBI-25849710,EBI-720609 |
Protein-protein interaction databases
BioGRIDi | 118794, 36 interactors |
IntActi | Q9H0W9, 17 interactors |
STRINGi | 9606.ENSP00000331209 |
Miscellaneous databases
RNActi | Q9H0W9, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q9H0W9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9H0W9 |
Family & Domainsi
Phylogenomic databases
eggNOGi | KOG4048, Eukaryota |
GeneTreei | ENSGT00390000017214 |
InParanoidi | Q9H0W9 |
OMAi | HIMPDFS |
OrthoDBi | 877242at2759 |
PhylomeDBi | Q9H0W9 |
TreeFami | TF313169 |
Family and domain databases
InterProi | View protein in InterPro IPR015021, DUF1907 |
PANTHERi | PTHR13204, PTHR13204, 1 hit |
Pfami | View protein in Pfam PF08925, DUF1907, 1 hit |
SMARTi | View protein in SMART SM01168, DUF1907, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H0W9-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV
60 70 80 90 100
KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG
110 120 130 140 150
PFQTLGFNSE FMPVIQTESE HKPPVNGSYF AHVNPADGGC LLEKYSEKCH
160 170 180 190 200
DFQCALLANL FASEGQPGKV IEVKAKRRTG PLNFVTCMRE TLEKHYGNKP
210 220 230 240 250
IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF YEMKAPLVCL
260 270 280 290 300
PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL
310
YRIDQPKETH SIGRD
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A087WT99 | A0A087WT99_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 256 | Annotation score: | ||
E9PPB5 | E9PPB5_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 185 | Annotation score: | ||
E9PIP1 | E9PIP1_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 171 | Annotation score: | ||
E9PQS1 | E9PQS1_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 239 | Annotation score: | ||
E9PLC5 | E9PLC5_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 100 | Annotation score: | ||
E9PLB3 | E9PLB3_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 149 | Annotation score: | ||
E9PSC3 | E9PSC3_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 95 | Annotation score: | ||
E9PJU8 | E9PJU8_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 187 | Annotation score: | ||
E9PR95 | E9PR95_HUMAN | Ester hydrolase C11orf54 | C11orf54 | 76 | Annotation score: |
Sequence cautioni
The sequence AAH07110 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP34483 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | V → A in CAG38569 (Ref. 3) Curated | 1 | |
Sequence conflicti | 184 | F → L in CAG38569 (Ref. 3) Curated | 1 | |
Sequence conflicti | 304 | D → G in AAD40375 (Ref. 1) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_019817 | 1 – 111 | Missing in isoform 4. 1 PublicationAdd BLAST | 111 | |
Alternative sequenceiVSP_019818 | 1 – 19 | Missing in isoform 2. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_019821 | 170 – 219 | Missing in isoform 3. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF092133 mRNA Translation: AAD40375.1 AL136605 mRNA Translation: CAB66540.1 CR533538 mRNA Translation: CAG38569.1 AY203960 mRNA Translation: AAP34483.1 Frameshift. AK292215 mRNA Translation: BAF84904.1 CH471065 Genomic DNA Translation: EAW66915.1 BC007110 mRNA Translation: AAH07110.2 Different initiation. BC012298 mRNA Translation: AAH12298.1 |
CCDSi | CCDS66204.1 [Q9H0W9-1] CCDS73366.1 [Q9H0W9-2] CCDS8294.1 [Q9H0W9-3] |
RefSeqi | NP_001272996.1, NM_001286067.1 [Q9H0W9-1] NP_001272997.1, NM_001286068.1 [Q9H0W9-1] NP_001272998.1, NM_001286069.1 [Q9H0W9-1] NP_001272999.1, NM_001286070.1 [Q9H0W9-2] NP_001273000.1, NM_001286071.1 NP_054758.2, NM_014039.3 [Q9H0W9-3] XP_006718887.1, XM_006718824.1 XP_011541083.1, XM_011542781.2 [Q9H0W9-1] XP_011541084.1, XM_011542782.2 [Q9H0W9-1] XP_016873102.1, XM_017017613.1 XP_016873103.1, XM_017017614.1 XP_016873104.1, XM_017017615.1 XP_016873105.1, XM_017017616.1 |
Genome annotation databases
Ensembli | ENST00000331239; ENSP00000331209; ENSG00000182919 [Q9H0W9-1] ENST00000354421; ENSP00000346403; ENSG00000182919 [Q9H0W9-1] ENST00000528099; ENSP00000435113; ENSG00000182919 [Q9H0W9-1] ENST00000528288; ENSP00000433721; ENSG00000182919 [Q9H0W9-3] ENST00000540113; ENSP00000442094; ENSG00000182919 [Q9H0W9-2] |
GeneIDi | 28970 |
KEGGi | hsa:28970 |
UCSCi | uc001pef.5, human [Q9H0W9-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF092133 mRNA Translation: AAD40375.1 AL136605 mRNA Translation: CAB66540.1 CR533538 mRNA Translation: CAG38569.1 AY203960 mRNA Translation: AAP34483.1 Frameshift. AK292215 mRNA Translation: BAF84904.1 CH471065 Genomic DNA Translation: EAW66915.1 BC007110 mRNA Translation: AAH07110.2 Different initiation. BC012298 mRNA Translation: AAH12298.1 |
CCDSi | CCDS66204.1 [Q9H0W9-1] CCDS73366.1 [Q9H0W9-2] CCDS8294.1 [Q9H0W9-3] |
RefSeqi | NP_001272996.1, NM_001286067.1 [Q9H0W9-1] NP_001272997.1, NM_001286068.1 [Q9H0W9-1] NP_001272998.1, NM_001286069.1 [Q9H0W9-1] NP_001272999.1, NM_001286070.1 [Q9H0W9-2] NP_001273000.1, NM_001286071.1 NP_054758.2, NM_014039.3 [Q9H0W9-3] XP_006718887.1, XM_006718824.1 XP_011541083.1, XM_011542781.2 [Q9H0W9-1] XP_011541084.1, XM_011542782.2 [Q9H0W9-1] XP_016873102.1, XM_017017613.1 XP_016873103.1, XM_017017614.1 XP_016873104.1, XM_017017615.1 XP_016873105.1, XM_017017616.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1XCR | X-ray | 1.70 | A/B | 2-315 | [»] | |
SMRi | Q9H0W9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 118794, 36 interactors |
IntActi | Q9H0W9, 17 interactors |
STRINGi | 9606.ENSP00000331209 |
PTM databases
iPTMneti | Q9H0W9 |
PhosphoSitePlusi | Q9H0W9 |
Genetic variation databases
BioMutai | C11orf54 |
DMDMi | 74718025 |
Proteomic databases
EPDi | Q9H0W9 |
jPOSTi | Q9H0W9 |
MassIVEi | Q9H0W9 |
MaxQBi | Q9H0W9 |
PeptideAtlasi | Q9H0W9 |
PRIDEi | Q9H0W9 |
ProteomicsDBi | 80335 [Q9H0W9-1] 80336 [Q9H0W9-2] 80337 [Q9H0W9-3] 80338 [Q9H0W9-4] |
Protocols and materials databases
Antibodypediai | 31588, 57 antibodies |
DNASUi | 28970 |
Genome annotation databases
Ensembli | ENST00000331239; ENSP00000331209; ENSG00000182919 [Q9H0W9-1] ENST00000354421; ENSP00000346403; ENSG00000182919 [Q9H0W9-1] ENST00000528099; ENSP00000435113; ENSG00000182919 [Q9H0W9-1] ENST00000528288; ENSP00000433721; ENSG00000182919 [Q9H0W9-3] ENST00000540113; ENSP00000442094; ENSG00000182919 [Q9H0W9-2] |
GeneIDi | 28970 |
KEGGi | hsa:28970 |
UCSCi | uc001pef.5, human [Q9H0W9-1] |
Organism-specific databases
CTDi | 28970 |
DisGeNETi | 28970 |
GeneCardsi | C11orf54 |
HGNCi | HGNC:30204, C11orf54 |
HPAi | ENSG00000182919, Tissue enhanced (kidney, liver) |
MIMi | 615810, gene |
neXtProti | NX_Q9H0W9 |
OpenTargetsi | ENSG00000182919 |
PharmGKBi | PA143485349 |
VEuPathDBi | HostDB:ENSG00000182919.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4048, Eukaryota |
GeneTreei | ENSGT00390000017214 |
InParanoidi | Q9H0W9 |
OMAi | HIMPDFS |
OrthoDBi | 877242at2759 |
PhylomeDBi | Q9H0W9 |
TreeFami | TF313169 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0W9 |
Miscellaneous databases
BioGRID-ORCSi | 28970, 13 hits in 862 CRISPR screens |
ChiTaRSi | C11orf54, human |
EvolutionaryTracei | Q9H0W9 |
GeneWikii | C11orf54 |
GenomeRNAii | 28970 |
Pharosi | Q9H0W9, Tbio |
PROi | PR:Q9H0W9 |
RNActi | Q9H0W9, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000182919, Expressed in kidney epithelium and 215 other tissues |
ExpressionAtlasi | Q9H0W9, baseline and differential |
Genevisiblei | Q9H0W9, HS |
Family and domain databases
InterProi | View protein in InterPro IPR015021, DUF1907 |
PANTHERi | PTHR13204, PTHR13204, 1 hit |
Pfami | View protein in Pfam PF08925, DUF1907, 1 hit |
SMARTi | View protein in SMART SM01168, DUF1907, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CK054_HUMAN | |
Accessioni | Q9H0W9Primary (citable) accession number: Q9H0W9 Secondary accession number(s): A8K850 Q9Y6B4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 144 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references