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Entry version 145 (07 Apr 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Ester hydrolase C11orf54

Gene

C11orf54

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi266Zinc; catalytic1
Metal bindingi268Zinc; catalytic1
Metal bindingi278Zinc; catalytic1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9H0W9

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ester hydrolase C11orf54 (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:LP4947, PTD012
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:30204, C11orf54

Online Mendelian Inheritance in Man (OMIM)

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MIMi
615810, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q9H0W9

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000182919.14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
28970

Open Targets

More...
OpenTargetsi
ENSG00000182919

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485349

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0W9, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C11orf54

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74718025

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002460291 – 315Ester hydrolase C11orf54Add BLAST315

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H0W9

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H0W9

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H0W9

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H0W9

PeptideAtlas

More...
PeptideAtlasi
Q9H0W9

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0W9

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80335 [Q9H0W9-1]
80336 [Q9H0W9-2]
80337 [Q9H0W9-3]
80338 [Q9H0W9-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0W9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0W9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000182919, Expressed in kidney epithelium and 215 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H0W9, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H0W9, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000182919, Tissue enhanced (kidney, liver)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
118794, 36 interactors

Protein interaction database and analysis system

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IntActi
Q9H0W9, 17 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000331209

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

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RNActi
Q9H0W9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1315
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H0W9

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H0W9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4048, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000017214

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H0W9

Identification of Orthologs from Complete Genome Data

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OMAi
HIMPDFS

Database of Orthologous Groups

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OrthoDBi
877242at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0W9

TreeFam database of animal gene trees

More...
TreeFami
TF313169

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015021, DUF1907

The PANTHER Classification System

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PANTHERi
PTHR13204, PTHR13204, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08925, DUF1907, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01168, DUF1907, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 9 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0W9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACAEFSFHV PSLEELAGVM QKGLKDNFAD VQVSVVDCPD LTKEPFTFPV
60 70 80 90 100
KGICGKTRIA EVGGVPYLLP LVNQKKVYDL NKIAKEIKLP GAFILGAGAG
110 120 130 140 150
PFQTLGFNSE FMPVIQTESE HKPPVNGSYF AHVNPADGGC LLEKYSEKCH
160 170 180 190 200
DFQCALLANL FASEGQPGKV IEVKAKRRTG PLNFVTCMRE TLEKHYGNKP
210 220 230 240 250
IGMGGTFIIQ KGKVKSHIMP AEFSSCPLNS DEEVNKWLHF YEMKAPLVCL
260 270 280 290 300
PVFVSRDPGF DLRLEHTHFF SRHGEGGHYH YDTTPDIVEY LGYFLPAEFL
310
YRIDQPKETH SIGRD
Length:315
Mass (Da):35,117
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF084671CC1E3F72A
GO
Isoform 2 (identifier: Q9H0W9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-19: Missing.

Show »
Length:296
Mass (Da):33,098
Checksum:i66962958EE2A4F17
GO
Isoform 3 (identifier: Q9H0W9-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-219: Missing.

Note: Probably non-functional.Curated
Show »
Length:265
Mass (Da):29,492
Checksum:i82F671A9F47F0906
GO
Isoform 4 (identifier: Q9H0W9-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-111: Missing.

Show »
Length:204
Mass (Da):23,173
Checksum:iDBE4CAF56964ADFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WT99A0A087WT99_HUMAN
Ester hydrolase C11orf54
C11orf54
256Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PPB5E9PPB5_HUMAN
Ester hydrolase C11orf54
C11orf54
185Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIP1E9PIP1_HUMAN
Ester hydrolase C11orf54
C11orf54
171Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQS1E9PQS1_HUMAN
Ester hydrolase C11orf54
C11orf54
239Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLC5E9PLC5_HUMAN
Ester hydrolase C11orf54
C11orf54
100Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLB3E9PLB3_HUMAN
Ester hydrolase C11orf54
C11orf54
149Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PSC3E9PSC3_HUMAN
Ester hydrolase C11orf54
C11orf54
95Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJU8E9PJU8_HUMAN
Ester hydrolase C11orf54
C11orf54
187Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PR95E9PR95_HUMAN
Ester hydrolase C11orf54
C11orf54
76Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH07110 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAP34483 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti10V → A in CAG38569 (Ref. 3) Curated1
Sequence conflicti184F → L in CAG38569 (Ref. 3) Curated1
Sequence conflicti304D → G in AAD40375 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0198171 – 111Missing in isoform 4. 1 PublicationAdd BLAST111
Alternative sequenceiVSP_0198181 – 19Missing in isoform 2. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_019821170 – 219Missing in isoform 3. 1 PublicationAdd BLAST50

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF092133 mRNA Translation: AAD40375.1
AL136605 mRNA Translation: CAB66540.1
CR533538 mRNA Translation: CAG38569.1
AY203960 mRNA Translation: AAP34483.1 Frameshift.
AK292215 mRNA Translation: BAF84904.1
CH471065 Genomic DNA Translation: EAW66915.1
BC007110 mRNA Translation: AAH07110.2 Different initiation.
BC012298 mRNA Translation: AAH12298.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS66204.1 [Q9H0W9-1]
CCDS73366.1 [Q9H0W9-2]
CCDS8294.1 [Q9H0W9-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001272996.1, NM_001286067.1 [Q9H0W9-1]
NP_001272997.1, NM_001286068.1 [Q9H0W9-1]
NP_001272998.1, NM_001286069.1 [Q9H0W9-1]
NP_001272999.1, NM_001286070.1 [Q9H0W9-2]
NP_001273000.1, NM_001286071.1
NP_054758.2, NM_014039.3 [Q9H0W9-3]
XP_006718887.1, XM_006718824.1
XP_011541083.1, XM_011542781.2 [Q9H0W9-1]
XP_011541084.1, XM_011542782.2 [Q9H0W9-1]
XP_016873102.1, XM_017017613.1
XP_016873103.1, XM_017017614.1
XP_016873104.1, XM_017017615.1
XP_016873105.1, XM_017017616.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331239; ENSP00000331209; ENSG00000182919 [Q9H0W9-1]
ENST00000354421; ENSP00000346403; ENSG00000182919 [Q9H0W9-1]
ENST00000528099; ENSP00000435113; ENSG00000182919 [Q9H0W9-1]
ENST00000528288; ENSP00000433721; ENSG00000182919 [Q9H0W9-3]
ENST00000540113; ENSP00000442094; ENSG00000182919 [Q9H0W9-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
28970

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:28970

UCSC genome browser

More...
UCSCi
uc001pef.5, human [Q9H0W9-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092133 mRNA Translation: AAD40375.1
AL136605 mRNA Translation: CAB66540.1
CR533538 mRNA Translation: CAG38569.1
AY203960 mRNA Translation: AAP34483.1 Frameshift.
AK292215 mRNA Translation: BAF84904.1
CH471065 Genomic DNA Translation: EAW66915.1
BC007110 mRNA Translation: AAH07110.2 Different initiation.
BC012298 mRNA Translation: AAH12298.1
CCDSiCCDS66204.1 [Q9H0W9-1]
CCDS73366.1 [Q9H0W9-2]
CCDS8294.1 [Q9H0W9-3]
RefSeqiNP_001272996.1, NM_001286067.1 [Q9H0W9-1]
NP_001272997.1, NM_001286068.1 [Q9H0W9-1]
NP_001272998.1, NM_001286069.1 [Q9H0W9-1]
NP_001272999.1, NM_001286070.1 [Q9H0W9-2]
NP_001273000.1, NM_001286071.1
NP_054758.2, NM_014039.3 [Q9H0W9-3]
XP_006718887.1, XM_006718824.1
XP_011541083.1, XM_011542781.2 [Q9H0W9-1]
XP_011541084.1, XM_011542782.2 [Q9H0W9-1]
XP_016873102.1, XM_017017613.1
XP_016873103.1, XM_017017614.1
XP_016873104.1, XM_017017615.1
XP_016873105.1, XM_017017616.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XCRX-ray1.70A/B2-315[»]
SMRiQ9H0W9
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi118794, 36 interactors
IntActiQ9H0W9, 17 interactors
STRINGi9606.ENSP00000331209

PTM databases

iPTMnetiQ9H0W9
PhosphoSitePlusiQ9H0W9

Genetic variation databases

BioMutaiC11orf54
DMDMi74718025

Proteomic databases

EPDiQ9H0W9
jPOSTiQ9H0W9
MassIVEiQ9H0W9
MaxQBiQ9H0W9
PeptideAtlasiQ9H0W9
PRIDEiQ9H0W9
ProteomicsDBi80335 [Q9H0W9-1]
80336 [Q9H0W9-2]
80337 [Q9H0W9-3]
80338 [Q9H0W9-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
31588, 57 antibodies

The DNASU plasmid repository

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DNASUi
28970

Genome annotation databases

EnsembliENST00000331239; ENSP00000331209; ENSG00000182919 [Q9H0W9-1]
ENST00000354421; ENSP00000346403; ENSG00000182919 [Q9H0W9-1]
ENST00000528099; ENSP00000435113; ENSG00000182919 [Q9H0W9-1]
ENST00000528288; ENSP00000433721; ENSG00000182919 [Q9H0W9-3]
ENST00000540113; ENSP00000442094; ENSG00000182919 [Q9H0W9-2]
GeneIDi28970
KEGGihsa:28970
UCSCiuc001pef.5, human [Q9H0W9-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
28970
DisGeNETi28970

GeneCards: human genes, protein and diseases

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GeneCardsi
C11orf54
HGNCiHGNC:30204, C11orf54
HPAiENSG00000182919, Tissue enhanced (kidney, liver)
MIMi615810, gene
neXtProtiNX_Q9H0W9
OpenTargetsiENSG00000182919
PharmGKBiPA143485349
VEuPathDBiHostDB:ENSG00000182919.14

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4048, Eukaryota
GeneTreeiENSGT00390000017214
InParanoidiQ9H0W9
OMAiHIMPDFS
OrthoDBi877242at2759
PhylomeDBiQ9H0W9
TreeFamiTF313169

Enzyme and pathway databases

PathwayCommonsiQ9H0W9

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
28970, 13 hits in 980 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
C11orf54, human
EvolutionaryTraceiQ9H0W9

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
C11orf54

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
28970
PharosiQ9H0W9, Tbio

Protein Ontology

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PROi
PR:Q9H0W9
RNActiQ9H0W9, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000182919, Expressed in kidney epithelium and 215 other tissues
ExpressionAtlasiQ9H0W9, baseline and differential
GenevisibleiQ9H0W9, HS

Family and domain databases

InterProiView protein in InterPro
IPR015021, DUF1907
PANTHERiPTHR13204, PTHR13204, 1 hit
PfamiView protein in Pfam
PF08925, DUF1907, 1 hit
SMARTiView protein in SMART
SM01168, DUF1907, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCK054_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0W9
Secondary accession number(s): A8K850
, Q6FI88, Q6XYB0, Q96EI3, Q96IX1, Q9Y6B4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: April 7, 2021
This is version 145 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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