UniProtKB - Q9H0W8 (SMG9_HUMAN)
Protein SMG9
SMG9
Functioni
GO - Molecular functioni
- identical protein binding Source: IntAct
GO - Biological processi
- brain development Source: UniProtKB
- eye development Source: UniProtKB
- heart development Source: UniProtKB
- in utero embryonic development Source: Ensembl
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay Source: UniProtKB
Keywordsi
Biological process | Nonsense-mediated mRNA decay |
Enzyme and pathway databases
PathwayCommonsi | Q9H0W8 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Names & Taxonomyi
Protein namesi | Recommended name: Protein SMG9CuratedAlternative name(s): Protein SMG-91 Publication |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25763, SMG9 |
MIMi | 613176, gene |
neXtProti | NX_Q9H0W8 |
VEuPathDBi | HostDB:ENSG00000105771.13 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Pathology & Biotechi
Involvement in diseasei
Heart and brain malformation syndrome (HBMS)1 Publication
Organism-specific databases
DisGeNETi | 56006 |
MalaCardsi | SMG9 |
MIMi | 616920, phenotype |
OpenTargetsi | ENSG00000105771 |
PharmGKBi | PA162378734 |
Miscellaneous databases
Pharosi | Q9H0W8, Tdark |
Genetic variation databases
BioMutai | SMG9 |
DMDMi | 74733529 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000289163 | 2 – 520 | Protein SMG9Add BLAST | 519 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineCombined sources | 1 | |
Modified residuei | 2 | PhosphoserineCombined sources | 1 | |
Modified residuei | 4 | PhosphoserineCombined sources | 1 | |
Modified residuei | 7 | PhosphoserineCombined sources | 1 | |
Modified residuei | 32 | PhosphoserineCombined sources | 1 | |
Modified residuei | 53 | PhosphoserineCombined sources | 1 | |
Modified residuei | 451 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9H0W8 |
jPOSTi | Q9H0W8 |
MassIVEi | Q9H0W8 |
MaxQBi | Q9H0W8 |
PaxDbi | Q9H0W8 |
PeptideAtlasi | Q9H0W8 |
PRIDEi | Q9H0W8 |
ProteomicsDBi | 80333 [Q9H0W8-1] 80334 [Q9H0W8-2] |
PTM databases
iPTMneti | Q9H0W8 |
PhosphoSitePlusi | Q9H0W8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000105771, Expressed in testis and 200 other tissues |
ExpressionAtlasi | Q9H0W8, baseline and differential |
Genevisiblei | Q9H0W8, HS |
Organism-specific databases
HPAi | ENSG00000105771, Low tissue specificity |
Interactioni
Subunit structurei
Component of the SMG1C complex composed of SMG1, SMG8 and SMG9. Self-associates to form homodimers and forms heterodimers with SMG8; these assembly forms may represent SMG1C intermediate forms.
2 PublicationsBinary interactionsi
Hide detailsQ9H0W8
GO - Molecular functioni
- identical protein binding Source: IntAct
Protein-protein interaction databases
BioGRIDi | 121029, 55 interactors |
IntActi | Q9H0W8, 49 interactors |
STRINGi | 9606.ENSP00000270066 |
Miscellaneous databases
RNActi | Q9H0W8, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9H0W8 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 71 – 133 | Pro-richAdd BLAST | 63 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG4181, Eukaryota |
GeneTreei | ENSGT00390000003568 |
HOGENOMi | CLU_037795_0_0_1 |
InParanoidi | Q9H0W8 |
OMAi | QMHLVID |
OrthoDBi | 1436399at2759 |
PhylomeDBi | Q9H0W8 |
TreeFami | TF319763 |
Family and domain databases
InterProi | View protein in InterPro IPR019354, Smg8/Smg9 IPR039177, SMG9 |
PANTHERi | PTHR14270, PTHR14270, 1 hit |
Pfami | View protein in Pfam PF10220, Smg8_Smg9, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSESGHSQPG LYGIERRRRW KEPGSGGPQN LSGPGGRERD YIAPWERERR
60 70 80 90 100
DASEETSTSV MQKTPIILSK PPAERSKQPP PPTAPAAPPA PAPLEKPIVL
110 120 130 140 150
MKPREEGKGP VAVTGASTPE GTAPPPPAAP APPKGEKEGQ RPTQPVYQIQ
160 170 180 190 200
NRGMGTAAPA AMDPVVGQAK LLPPERMKHS IKLVDDQMNW CDSAIEYLLD
210 220 230 240 250
QTDVLVVGVL GLQGTGKSMV MSLLSANTPE EDQRTYVFRA QSAEMKERGG
260 270 280 290 300
NQTSGIDFFI TQERIVFLDT QPILSPSILD HLINNDRKLP PEYNLPHTYV
310 320 330 340 350
EMQSLQIAAF LFTVCHVVIV VQDWFTDLSL YRFLQTAEMV KPSTPSPSHE
360 370 380 390 400
SSSSSGSDEG TEYYPHLVFL QNKARREDFC PRKLRQMHLM IDQLMAHSHL
410 420 430 440 450
RYKGTLSMLQ CNVFPGLPPD FLDSEVNLFL VPFMDSEAES ENPPRAGPGS
460 470 480 490 500
SPLFSLLPGY RGHPSFQSLV SKLRSQVMSM ARPQLSHTIL TEKNWFHYAA
510 520
RIWDGVRKSS ALAEYSRLLA
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketM0R0U0 | M0R0U0_HUMAN | Protein SMG9 | SMG9 | 157 | Annotation score: | ||
M0QZH1 | M0QZH1_HUMAN | Protein SMG9 | SMG9 | 115 | Annotation score: | ||
M0R2N0 | M0R2N0_HUMAN | Protein SMG9 | SMG9 | 156 | Annotation score: | ||
M0QX70 | M0QX70_HUMAN | Protein SMG9 | SMG9 | 120 | Annotation score: | ||
M0QYR7 | M0QYR7_HUMAN | Protein SMG9 | SMG9 | 148 | Annotation score: | ||
M0QZC7 | M0QZC7_HUMAN | Protein SMG9 | SMG9 | 183 | Annotation score: |
Sequence cautioni
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_025946 | 496 – 520 | Missing in isoform 2. 1 PublicationAdd BLAST | 25 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136606 mRNA Translation: CAB66541.1 AK022948 mRNA Translation: BAB14323.1 AC004780 Genomic DNA Translation: AAC17932.1 Sequence problems. BC008869 mRNA Translation: AAH08869.1 |
CCDSi | CCDS33043.2 [Q9H0W8-1] |
RefSeqi | NP_061981.2, NM_019108.3 [Q9H0W8-1] |
Genome annotation databases
Ensembli | ENST00000270066; ENSP00000270066; ENSG00000105771 [Q9H0W8-1] ENST00000601170; ENSP00000471398; ENSG00000105771 [Q9H0W8-2] |
GeneIDi | 56006 |
KEGGi | hsa:56006 |
UCSCi | uc002oxj.3, human [Q9H0W8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136606 mRNA Translation: CAB66541.1 AK022948 mRNA Translation: BAB14323.1 AC004780 Genomic DNA Translation: AAC17932.1 Sequence problems. BC008869 mRNA Translation: AAH08869.1 |
CCDSi | CCDS33043.2 [Q9H0W8-1] |
RefSeqi | NP_061981.2, NM_019108.3 [Q9H0W8-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6L54 | electron microscopy | 3.43 | C | 1-520 | [»] | |
6SYT | electron microscopy | 3.45 | C | 1-520 | [»] | |
6Z3R | electron microscopy | 2.97 | C | 1-520 | [»] | |
SMRi | Q9H0W8 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 121029, 55 interactors |
IntActi | Q9H0W8, 49 interactors |
STRINGi | 9606.ENSP00000270066 |
PTM databases
iPTMneti | Q9H0W8 |
PhosphoSitePlusi | Q9H0W8 |
Genetic variation databases
BioMutai | SMG9 |
DMDMi | 74733529 |
Proteomic databases
EPDi | Q9H0W8 |
jPOSTi | Q9H0W8 |
MassIVEi | Q9H0W8 |
MaxQBi | Q9H0W8 |
PaxDbi | Q9H0W8 |
PeptideAtlasi | Q9H0W8 |
PRIDEi | Q9H0W8 |
ProteomicsDBi | 80333 [Q9H0W8-1] 80334 [Q9H0W8-2] |
Protocols and materials databases
Antibodypediai | 31101, 55 antibodies |
Genome annotation databases
Ensembli | ENST00000270066; ENSP00000270066; ENSG00000105771 [Q9H0W8-1] ENST00000601170; ENSP00000471398; ENSG00000105771 [Q9H0W8-2] |
GeneIDi | 56006 |
KEGGi | hsa:56006 |
UCSCi | uc002oxj.3, human [Q9H0W8-1] |
Organism-specific databases
CTDi | 56006 |
DisGeNETi | 56006 |
GeneCardsi | SMG9 |
HGNCi | HGNC:25763, SMG9 |
HPAi | ENSG00000105771, Low tissue specificity |
MalaCardsi | SMG9 |
MIMi | 613176, gene 616920, phenotype |
neXtProti | NX_Q9H0W8 |
OpenTargetsi | ENSG00000105771 |
PharmGKBi | PA162378734 |
VEuPathDBi | HostDB:ENSG00000105771.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4181, Eukaryota |
GeneTreei | ENSGT00390000003568 |
HOGENOMi | CLU_037795_0_0_1 |
InParanoidi | Q9H0W8 |
OMAi | QMHLVID |
OrthoDBi | 1436399at2759 |
PhylomeDBi | Q9H0W8 |
TreeFami | TF319763 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0W8 |
Reactomei | R-HSA-975957, Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
Miscellaneous databases
BioGRID-ORCSi | 56006, 17 hits in 875 CRISPR screens |
ChiTaRSi | SMG9, human |
GenomeRNAii | 56006 |
Pharosi | Q9H0W8, Tdark |
PROi | PR:Q9H0W8 |
RNActi | Q9H0W8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105771, Expressed in testis and 200 other tissues |
ExpressionAtlasi | Q9H0W8, baseline and differential |
Genevisiblei | Q9H0W8, HS |
Family and domain databases
InterProi | View protein in InterPro IPR019354, Smg8/Smg9 IPR039177, SMG9 |
PANTHERi | PTHR14270, PTHR14270, 1 hit |
Pfami | View protein in Pfam PF10220, Smg8_Smg9, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMG9_HUMAN | |
Accessioni | Q9H0W8Primary (citable) accession number: Q9H0W8 Secondary accession number(s): O60429, Q9H9A9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 29, 2007 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 148 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families