UniProtKB - Q9H0W7 (THAP2_HUMAN)
Protein
THAP domain-containing protein 2
Gene
THAP2
Organism
Homo sapiens (Human)
Status
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 80 | THAP-typePROSITE-ProRule annotationAdd BLAST | 80 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-binding |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q9H0W7 |
Names & Taxonomyi
Protein namesi | Recommended name: THAP domain-containing protein 2 |
Gene namesi | Name:THAP2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20854, THAP2 |
MIMi | 612531, gene |
neXtProti | NX_Q9H0W7 |
VEuPathDBi | HostDB:ENSG00000173451.6 |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000173451 |
PharmGKBi | PA134886354 |
Miscellaneous databases
Pharosi | Q9H0W7, Tdark |
Genetic variation databases
BioMutai | THAP2 |
DMDMi | 29839633 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068642 | 1 – 228 | THAP domain-containing protein 2Add BLAST | 228 |
Proteomic databases
jPOSTi | Q9H0W7 |
MassIVEi | Q9H0W7 |
MaxQBi | Q9H0W7 |
PaxDbi | Q9H0W7 |
PeptideAtlasi | Q9H0W7 |
PRIDEi | Q9H0W7 |
ProteomicsDBi | 80332 |
PTM databases
iPTMneti | Q9H0W7 |
PhosphoSitePlusi | Q9H0W7 |
Expressioni
Gene expression databases
Bgeei | ENSG00000173451, Expressed in left coronary artery and 159 other tissues |
ExpressionAtlasi | Q9H0W7, baseline and differential |
Genevisiblei | Q9H0W7, HS |
Organism-specific databases
HPAi | ENSG00000173451, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 123687, 9 interactors |
ELMi | Q9H0W7 |
IntActi | Q9H0W7, 8 interactors |
MINTi | Q9H0W7 |
STRINGi | 9606.ENSP00000310796 |
Miscellaneous databases
RNActi | Q9H0W7, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | Q9H0W7 |
SMRi | Q9H0W7 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9H0W7 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 123 – 126 | HCFC1-binding motif (HBM)By similarity | 4 |
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1 – 80 | THAP-typePROSITE-ProRule annotationAdd BLAST | 80 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | ENOG502RYEP, Eukaryota |
GeneTreei | ENSGT00940000161088 |
HOGENOMi | CLU_076186_2_2_1 |
InParanoidi | Q9H0W7 |
OMAi | RRKMKIC |
OrthoDBi | 1382095at2759 |
PhylomeDBi | Q9H0W7 |
TreeFami | TF330127 |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR026521, THAP2 IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
PANTHERi | PTHR47696, PTHR47696, 1 hit |
Pfami | View protein in Pfam PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q9H0W7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPTNCAAAGC ATTYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT
60 70 80 90 100
FLCSKHFEAS CFDLTGQTRR LKMDAVPTIF DFCTHIKSMK LKSRNLLKKN
110 120 130 140 150
NSCSPAGPSN LKSNISSQQV LLEHSYAFRN PMEAKKRIIK LEKEIASLRR
160 170 180 190 200
KMKTCLQKER RATRRWIKAT CLVKNLEANS VLPKGTSEHM LPTALSSLPL
210 220
EDFKILEQDQ QDKTLLSLNL KQTKSTFI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8W1B8 | F8W1B8_HUMAN | THAP domain-containing protein 2 | THAP2 | 101 | Annotation score: | ||
F8VYP5 | F8VYP5_HUMAN | THAP domain-containing protein 2 | THAP2 | 110 | Annotation score: | ||
F8VW94 | F8VW94_HUMAN | THAP domain-containing protein 2 | THAP2 | 52 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_034551 | 170 | T → M. Corresponds to variant dbSNP:rs17110155Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136607 mRNA Translation: CAB66542.1 AK313452 mRNA Translation: BAG36240.1 CH471054 Genomic DNA Translation: EAW97265.1 BC008358 mRNA Translation: AAH08358.1 |
CCDSi | CCDS9001.1 |
RefSeqi | NP_113623.1, NM_031435.3 |
Genome annotation databases
Ensembli | ENST00000308086; ENSP00000310796; ENSG00000173451 |
GeneIDi | 83591 |
KEGGi | hsa:83591 |
UCSCi | uc001swq.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136607 mRNA Translation: CAB66542.1 AK313452 mRNA Translation: BAG36240.1 CH471054 Genomic DNA Translation: EAW97265.1 BC008358 mRNA Translation: AAH08358.1 |
CCDSi | CCDS9001.1 |
RefSeqi | NP_113623.1, NM_031435.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2D8R | NMR | - | A | 1-86 | [»] | |
BMRBi | Q9H0W7 | |||||
SMRi | Q9H0W7 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 123687, 9 interactors |
ELMi | Q9H0W7 |
IntActi | Q9H0W7, 8 interactors |
MINTi | Q9H0W7 |
STRINGi | 9606.ENSP00000310796 |
PTM databases
iPTMneti | Q9H0W7 |
PhosphoSitePlusi | Q9H0W7 |
Genetic variation databases
BioMutai | THAP2 |
DMDMi | 29839633 |
Proteomic databases
jPOSTi | Q9H0W7 |
MassIVEi | Q9H0W7 |
MaxQBi | Q9H0W7 |
PaxDbi | Q9H0W7 |
PeptideAtlasi | Q9H0W7 |
PRIDEi | Q9H0W7 |
ProteomicsDBi | 80332 |
Protocols and materials databases
Antibodypediai | 44377, 65 antibodies |
DNASUi | 83591 |
Genome annotation databases
Ensembli | ENST00000308086; ENSP00000310796; ENSG00000173451 |
GeneIDi | 83591 |
KEGGi | hsa:83591 |
UCSCi | uc001swq.4, human |
Organism-specific databases
CTDi | 83591 |
GeneCardsi | THAP2 |
HGNCi | HGNC:20854, THAP2 |
HPAi | ENSG00000173451, Low tissue specificity |
MIMi | 612531, gene |
neXtProti | NX_Q9H0W7 |
OpenTargetsi | ENSG00000173451 |
PharmGKBi | PA134886354 |
VEuPathDBi | HostDB:ENSG00000173451.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RYEP, Eukaryota |
GeneTreei | ENSGT00940000161088 |
HOGENOMi | CLU_076186_2_2_1 |
InParanoidi | Q9H0W7 |
OMAi | RRKMKIC |
OrthoDBi | 1382095at2759 |
PhylomeDBi | Q9H0W7 |
TreeFami | TF330127 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0W7 |
Miscellaneous databases
BioGRID-ORCSi | 83591, 4 hits in 1017 CRISPR screens |
EvolutionaryTracei | Q9H0W7 |
GeneWikii | THAP2 |
GenomeRNAii | 83591 |
Pharosi | Q9H0W7, Tdark |
PROi | PR:Q9H0W7 |
RNActi | Q9H0W7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000173451, Expressed in left coronary artery and 159 other tissues |
ExpressionAtlasi | Q9H0W7, baseline and differential |
Genevisiblei | Q9H0W7, HS |
Family and domain databases
Gene3Di | 3.30.40.180, 1 hit |
InterProi | View protein in InterPro IPR026521, THAP2 IPR006612, THAP_Znf IPR038441, THAP_Znf_sf |
PANTHERi | PTHR47696, PTHR47696, 1 hit |
Pfami | View protein in Pfam PF05485, THAP, 1 hit |
SMARTi | View protein in SMART SM00692, DM3, 1 hit SM00980, THAP, 1 hit |
PROSITEi | View protein in PROSITE PS50950, ZF_THAP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THAP2_HUMAN | |
Accessioni | Q9H0W7Primary (citable) accession number: Q9H0W7 Secondary accession number(s): B2R8P3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 11, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | April 7, 2021 | |
This is version 147 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references