UniProtKB - Q9H0W7 (THAP2_HUMAN)

BLAST

>sp|Q9H0W7|THAP2_HUMAN THAP domain-containing protein 2 OS=Homo sapiens OX=9606 GN=THAP2 PE=1 SV=1
MPTNCAAAGCATTYNKHINISFHRFPLDPKRRKEWVRLVRRKNFVPGKHTFLCSKHFEAS
CFDLTGQTRRLKMDAVPTIFDFCTHIKSMKLKSRNLLKKNNSCSPAGPSNLKSNISSQQV
LLEHSYAFRNPMEAKKRIIKLEKEIASLRRKMKTCLQKERRATRRWIKATCLVKNLEANS
VLPKGTSEHMLPTALSSLPLEDFKILEQDQQDKTLLSLNLKQTKSTFI

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History
Entry version 131 (07 Nov 2018)
Sequence version 1 (01 Mar 2001)
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Protein

THAP domain-containing protein 2

Gene

THAP2

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 80	THAP-typePROSITE-ProRule annotationAdd BLAST		80

GO - Molecular functionⁱ

DNA binding Source: UniProtKB-KW
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: THAP domain-containing protein 2
Gene namesⁱ	Name:THAP2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173451.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:20854 THAP2
MIMⁱ	612531 gene
neXtProtⁱ	NX_Q9H0W7

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000173451
PharmGKBⁱ	PA134886354

Polymorphism and mutation databases

BioMutaⁱ	THAP2
DMDMⁱ	29839633

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068642	1 – 228	THAP domain-containing protein 2Add BLAST		228

Proteomic databases

EPDⁱ	Q9H0W7
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H0W7
PaxDbⁱ	Q9H0W7
PeptideAtlas More...PeptideAtlasⁱ	Q9H0W7
PRIDEⁱ	Q9H0W7
ProteomicsDBⁱ	80332

PTM databases

iPTMnetⁱ	Q9H0W7
PhosphoSitePlusⁱ	Q9H0W7

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173451 Expressed in 145 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_THAP2
ExpressionAtlasⁱ	Q9H0W7 baseline and differential
Genevisibleⁱ	Q9H0W7 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA039790

HPAⁱ

HPA039790

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	123687, 8 interactors
ELMⁱ	Q9H0W7
IntActⁱ	Q9H0W7, 2 interactors
Molecular INTeraction database More...MINTⁱ	Q9H0W7
STRINGⁱ	9606.ENSP00000310796

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	7 – 9	Combined sources	3
Helixⁱ	29 – 38	Combined sources	10
Beta strandⁱ	47 – 49	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H0W7
SMRⁱ	Q9H0W7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

Q9H0W7

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	123 – 126	HCFC1-binding motif (HBM)By similarity		4

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	1 – 80	THAP-typePROSITE-ProRule annotationAdd BLAST		80

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	ENOG410IKCR Eukaryota ENOG41122AW LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00840000129785
HOGENOMⁱ	HOG000231117
HOVERGENⁱ	HBG097575
InParanoidⁱ	Q9H0W7
OMAⁱ	RRKMKIC
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G034R
PhylomeDBⁱ	Q9H0W7
TreeFamⁱ	TF330127

Family and domain databases

Gene3Dⁱ	3.30.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR026521 THAP2 IPR006612 THAP_Znf IPR038441 THAP_Znf_sf
PANTHERⁱ	PTHR23080:SF84 PTHR23080:SF84, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05485 THAP, 1 hit
SMARTⁱ	View protein in SMART SM00692 DM3, 1 hit SM00980 THAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50950 ZF_THAP, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q9H0W7-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MPTNCAAAGC ATTYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT 
        60         70         80         90        100
FLCSKHFEAS CFDLTGQTRR LKMDAVPTIF DFCTHIKSMK LKSRNLLKKN 
       110        120        130        140        150
NSCSPAGPSN LKSNISSQQV LLEHSYAFRN PMEAKKRIIK LEKEIASLRR 
       160        170        180        190        200
KMKTCLQKER RATRRWIKAT CLVKNLEANS VLPKGTSEHM LPTALSSLPL 
       210        220 
EDFKILEQDQ QDKTLLSLNL KQTKSTFI

Length:228

Mass (Da):26,260

Last modified:March 1, 2001 - v1

Checksum:ⁱ63D886376BC5CC4E

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8W1B8	F8W1B8_HUMAN	THAP domain-containing protein 2 THAP domain-containing protein 2	THAP2	101	Annotation score:
F8VYP5	F8VYP5_HUMAN	THAP domain-containing protein 2 THAP domain-containing protein 2	THAP2	110	Annotation score:
F8VW94	F8VW94_HUMAN	THAP domain-containing protein 2 THAP domain-containing protein 2	THAP2	52	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_034551	170	T → M. Corresponds to variant dbSNP:rs17110155Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136607 mRNA Translation: CAB66542.1 AK313452 mRNA Translation: BAG36240.1 CH471054 Genomic DNA Translation: EAW97265.1 BC008358 mRNA Translation: AAH08358.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9001.1
NCBI Reference Sequences More...RefSeqⁱ	NP_113623.1, NM_031435.3
UniGeneⁱ	Hs.245798

Genome annotation databases

Ensemblⁱ	ENST00000308086; ENSP00000310796; ENSG00000173451
GeneIDⁱ	83591
KEGGⁱ	hsa:83591
UCSC genome browser More...UCSCⁱ	uc001swq.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length	Source
Q9H0W7	THAP domain containing 2		PANTR		228	UniRef100_Q9H0W7
Uncharacterized protein		PANPA		228

Protein	Similar proteins		Species	Score	Length	Source
Q9H0W7	THAP domain containing 2		PANTR		228	UniRef90_Q9H0W7
Uncharacterized protein		PANPA		228
Uncharacterized protein		RHIBE		265
THAP domain-containing protein 2 (Fragment)		HUMAN		110
Uncharacterized protein		RHIRO		230
+93

Protein	Similar proteins		Species	Score	Length	Source
Q9H0W7	THAP domain containing 2		PANTR		228	UniRef50_Q9H0W7
Uncharacterized protein		PANPA		228
Uncharacterized protein		RHIBE		265
THAP domain-containing protein 2 (Fragment)		HUMAN		110
Uncharacterized protein		RHIRO		230
+95

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136607 mRNA Translation: CAB66542.1 AK313452 mRNA Translation: BAG36240.1 CH471054 Genomic DNA Translation: EAW97265.1 BC008358 mRNA Translation: AAH08358.1
CCDSⁱ	CCDS9001.1
RefSeqⁱ	NP_113623.1, NM_031435.3
UniGeneⁱ	Hs.245798

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2D8R	NMR	-	A	1-86	[»]
ProteinModelPortalⁱ	Q9H0W7
SMRⁱ	Q9H0W7
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	123687, 8 interactors
ELMⁱ	Q9H0W7
IntActⁱ	Q9H0W7, 2 interactors
MINTⁱ	Q9H0W7
STRINGⁱ	9606.ENSP00000310796

PTM databases

iPTMnetⁱ	Q9H0W7
PhosphoSitePlusⁱ	Q9H0W7

Polymorphism and mutation databases

BioMutaⁱ	THAP2
DMDMⁱ	29839633

Proteomic databases

EPDⁱ	Q9H0W7
MaxQBⁱ	Q9H0W7
PaxDbⁱ	Q9H0W7
PeptideAtlasⁱ	Q9H0W7
PRIDEⁱ	Q9H0W7
ProteomicsDBⁱ	80332

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	83591
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000308086; ENSP00000310796; ENSG00000173451
GeneIDⁱ	83591
KEGGⁱ	hsa:83591
UCSCⁱ	uc001swq.4 human

Organism-specific databases

CTDⁱ	83591
EuPathDBⁱ	HostDB:ENSG00000173451.6
GeneCardsⁱ	THAP2
HGNCⁱ	HGNC:20854 THAP2
HPAⁱ	HPA039790
MIMⁱ	612531 gene
neXtProtⁱ	NX_Q9H0W7
OpenTargetsⁱ	ENSG00000173451
PharmGKBⁱ	PA134886354
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IKCR Eukaryota ENOG41122AW LUCA
GeneTreeⁱ	ENSGT00840000129785
HOGENOMⁱ	HOG000231117
HOVERGENⁱ	HBG097575
InParanoidⁱ	Q9H0W7
OMAⁱ	RRKMKIC
OrthoDBⁱ	EOG091G034R
PhylomeDBⁱ	Q9H0W7
TreeFamⁱ	TF330127

Miscellaneous databases

EvolutionaryTraceⁱ	Q9H0W7
GeneWikiⁱ	THAP2
GenomeRNAiⁱ	83591
Protein Ontology More...PROⁱ	PR:Q9H0W7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173451 Expressed in 145 organ(s), highest expression level in left coronary artery
CleanExⁱ	HS_THAP2
ExpressionAtlasⁱ	Q9H0W7 baseline and differential
Genevisibleⁱ	Q9H0W7 HS

Family and domain databases

Gene3Dⁱ	3.30.40.180, 1 hit
InterProⁱ	View protein in InterPro IPR026521 THAP2 IPR006612 THAP_Znf IPR038441 THAP_Znf_sf
PANTHERⁱ	PTHR23080:SF84 PTHR23080:SF84, 1 hit
Pfamⁱ	View protein in Pfam PF05485 THAP, 1 hit
SMARTⁱ	View protein in SMART SM00692 DM3, 1 hit SM00980 THAP, 1 hit
PROSITEⁱ	View protein in PROSITE PS50950 ZF_THAP, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	THAP2_HUMAN
Accessionⁱ	Q9H0W7Primary (citable) accession number: Q9H0W7 Secondary accession number(s): B2R8P3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	April 11, 2003
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - Q9H0W7 (THAP2_HUMAN)

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THAP domain-containing protein 2

THAP2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ