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Protein

THAP domain-containing protein 2

Gene

THAP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 80THAP-typePROSITE-ProRule annotationAdd BLAST80

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
THAP domain-containing protein 2
Gene namesi
Name:THAP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000173451.6
HGNCiHGNC:20854 THAP2
MIMi612531 gene
neXtProtiNX_Q9H0W7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000173451
PharmGKBiPA134886354

Polymorphism and mutation databases

BioMutaiTHAP2
DMDMi29839633

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000686421 – 228THAP domain-containing protein 2Add BLAST228

Proteomic databases

EPDiQ9H0W7
MaxQBiQ9H0W7
PaxDbiQ9H0W7
PeptideAtlasiQ9H0W7
PRIDEiQ9H0W7
ProteomicsDBi80332

PTM databases

iPTMnetiQ9H0W7
PhosphoSitePlusiQ9H0W7

Expressioni

Gene expression databases

BgeeiENSG00000173451 Expressed in 145 organ(s), highest expression level in left coronary artery
CleanExiHS_THAP2
ExpressionAtlasiQ9H0W7 baseline and differential
GenevisibleiQ9H0W7 HS

Organism-specific databases

HPAiHPA039790

Interactioni

Protein-protein interaction databases

BioGridi123687, 8 interactors
ELMiQ9H0W7
IntActiQ9H0W7, 2 interactors
MINTiQ9H0W7
STRINGi9606.ENSP00000310796

Structurei

Secondary structure

1228
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H0W7
SMRiQ9H0W7
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9H0W7

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi123 – 126HCFC1-binding motif (HBM)By similarity4

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1 – 80THAP-typePROSITE-ProRule annotationAdd BLAST80

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiENOG410IKCR Eukaryota
ENOG41122AW LUCA
GeneTreeiENSGT00840000129785
HOGENOMiHOG000231117
HOVERGENiHBG097575
InParanoidiQ9H0W7
OMAiRRKMKIC
OrthoDBiEOG091G034R
PhylomeDBiQ9H0W7
TreeFamiTF330127

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026521 THAP2
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF84 PTHR23080:SF84, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H0W7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPTNCAAAGC ATTYNKHINI SFHRFPLDPK RRKEWVRLVR RKNFVPGKHT
60 70 80 90 100
FLCSKHFEAS CFDLTGQTRR LKMDAVPTIF DFCTHIKSMK LKSRNLLKKN
110 120 130 140 150
NSCSPAGPSN LKSNISSQQV LLEHSYAFRN PMEAKKRIIK LEKEIASLRR
160 170 180 190 200
KMKTCLQKER RATRRWIKAT CLVKNLEANS VLPKGTSEHM LPTALSSLPL
210 220
EDFKILEQDQ QDKTLLSLNL KQTKSTFI
Length:228
Mass (Da):26,260
Last modified:March 1, 2001 - v1
Checksum:i63D886376BC5CC4E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W1B8F8W1B8_HUMAN
THAP domain-containing protein 2
THAP2
101Annotation score:
F8VYP5F8VYP5_HUMAN
THAP domain-containing protein 2
THAP2
110Annotation score:
F8VW94F8VW94_HUMAN
THAP domain-containing protein 2
THAP2
52Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034551170T → M. Corresponds to variant dbSNP:rs17110155Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136607 mRNA Translation: CAB66542.1
AK313452 mRNA Translation: BAG36240.1
CH471054 Genomic DNA Translation: EAW97265.1
BC008358 mRNA Translation: AAH08358.1
CCDSiCCDS9001.1
RefSeqiNP_113623.1, NM_031435.3
UniGeneiHs.245798

Genome annotation databases

EnsembliENST00000308086; ENSP00000310796; ENSG00000173451
GeneIDi83591
KEGGihsa:83591
UCSCiuc001swq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136607 mRNA Translation: CAB66542.1
AK313452 mRNA Translation: BAG36240.1
CH471054 Genomic DNA Translation: EAW97265.1
BC008358 mRNA Translation: AAH08358.1
CCDSiCCDS9001.1
RefSeqiNP_113623.1, NM_031435.3
UniGeneiHs.245798

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2D8RNMR-A1-86[»]
ProteinModelPortaliQ9H0W7
SMRiQ9H0W7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123687, 8 interactors
ELMiQ9H0W7
IntActiQ9H0W7, 2 interactors
MINTiQ9H0W7
STRINGi9606.ENSP00000310796

PTM databases

iPTMnetiQ9H0W7
PhosphoSitePlusiQ9H0W7

Polymorphism and mutation databases

BioMutaiTHAP2
DMDMi29839633

Proteomic databases

EPDiQ9H0W7
MaxQBiQ9H0W7
PaxDbiQ9H0W7
PeptideAtlasiQ9H0W7
PRIDEiQ9H0W7
ProteomicsDBi80332

Protocols and materials databases

DNASUi83591
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308086; ENSP00000310796; ENSG00000173451
GeneIDi83591
KEGGihsa:83591
UCSCiuc001swq.4 human

Organism-specific databases

CTDi83591
EuPathDBiHostDB:ENSG00000173451.6
GeneCardsiTHAP2
HGNCiHGNC:20854 THAP2
HPAiHPA039790
MIMi612531 gene
neXtProtiNX_Q9H0W7
OpenTargetsiENSG00000173451
PharmGKBiPA134886354
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKCR Eukaryota
ENOG41122AW LUCA
GeneTreeiENSGT00840000129785
HOGENOMiHOG000231117
HOVERGENiHBG097575
InParanoidiQ9H0W7
OMAiRRKMKIC
OrthoDBiEOG091G034R
PhylomeDBiQ9H0W7
TreeFamiTF330127

Miscellaneous databases

EvolutionaryTraceiQ9H0W7
GeneWikiiTHAP2
GenomeRNAii83591
PROiPR:Q9H0W7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173451 Expressed in 145 organ(s), highest expression level in left coronary artery
CleanExiHS_THAP2
ExpressionAtlasiQ9H0W7 baseline and differential
GenevisibleiQ9H0W7 HS

Family and domain databases

Gene3Di3.30.40.180, 1 hit
InterProiView protein in InterPro
IPR026521 THAP2
IPR006612 THAP_Znf
IPR038441 THAP_Znf_sf
PANTHERiPTHR23080:SF84 PTHR23080:SF84, 1 hit
PfamiView protein in Pfam
PF05485 THAP, 1 hit
SMARTiView protein in SMART
SM00692 DM3, 1 hit
SM00980 THAP, 1 hit
PROSITEiView protein in PROSITE
PS50950 ZF_THAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTHAP2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0W7
Secondary accession number(s): B2R8P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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