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Protein

39S ribosomal protein L18, mitochondrial

Gene

MRPL18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.1 Publication

GO - Molecular functioni

  • 5S rRNA binding Source: UniProtKB
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionChaperone, Ribonucleoprotein, Ribosomal protein, RNA-binding
Biological processTransport

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
39S ribosomal protein L18, mitochondrial
Short name:
L18mt
Short name:
MRP-L18
Alternative name(s):
Mitochondrial large ribosomal subunit protein uL18m1 Publication
Gene namesi
Name:MRPL18
ORF Names:HSPC071
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000112110.9
HGNCiHGNC:14477 MRPL18
MIMi611831 gene
neXtProtiNX_Q9H0U6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi29074
OpenTargetsiENSG00000112110
PharmGKBiPA30947

Polymorphism and mutation databases

BioMutaiMRPL18
DMDMi41017797

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000030556? – 18039S ribosomal protein L18, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

EPDiQ9H0U6
MaxQBiQ9H0U6
PaxDbiQ9H0U6
PeptideAtlasiQ9H0U6
PRIDEiQ9H0U6
ProteomicsDBi80326
TopDownProteomicsiQ9H0U6

PTM databases

iPTMnetiQ9H0U6
PhosphoSitePlusiQ9H0U6

Expressioni

Gene expression databases

BgeeiENSG00000112110 Expressed in 227 organ(s), highest expression level in oocyte
CleanExiHS_MRPL18
GenevisibleiQ9H0U6 HS

Organism-specific databases

HPAiHPA028774
HPA028775

Interactioni

Subunit structurei

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.2 Publications

Protein-protein interaction databases

BioGridi118846, 98 interactors
CORUMiQ9H0U6
DIPiDIP-56844N
IntActiQ9H0U6, 31 interactors
MINTiQ9H0U6
STRINGi9606.ENSP00000356001

Structurei

Secondary structure

1180
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ9H0U6
SMRiQ9H0U6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3333 Eukaryota
ENOG4111MCR LUCA
GeneTreeiENSGT00390000006394
HOGENOMiHOG000043958
HOVERGENiHBG001529
InParanoidiQ9H0U6
KOiK02881
OMAiSTSEWAI
OrthoDBiEOG091G0P8F
PhylomeDBiQ9H0U6
TreeFamiTF313292

Family and domain databases

Gene3Di3.30.420.80, 1 hit
InterProiView protein in InterPro
IPR005484 Ribosomal_L18
IPR036967 Ribosomal_S11_sf
PANTHERiPTHR12899 PTHR12899, 1 hit
PfamiView protein in Pfam
PF00861 Ribosomal_L18p, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9H0U6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALRSRFWGL FSVCRNPGCR FAALSTSSEP AAKPEVDPVE NEAVAPEFTN
60 70 80 90 100
RNPRNLELLS VARKERGWRT VFPSREFWHR LRVIRTQHHV EALVEHQNGK
110 120 130 140 150
VVVSASTREW AIKKHLYSTR NVVACESIGR VLAQRCLEAG INFMVYQPTP
160 170 180
WEAASDSMKR LQSAMTEGGV VLREPQRIYE
Length:180
Mass (Da):20,577
Last modified:March 1, 2001 - v1
Checksum:iC0CAD23465FE93B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10Missing in AAF29043 (PubMed:11042152).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0246096R → Q1 PublicationCorresponds to variant dbSNP:rs1128670Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136633 mRNA Translation: CAB66568.1
AF161556 mRNA Translation: AAF29043.1
CR533491 mRNA Translation: CAG38522.1
AL139045 Genomic DNA No translation available.
AL135914 Genomic DNA No translation available.
BC001623 mRNA Translation: AAH01623.1
CCDSiCCDS5270.1
RefSeqiNP_001305746.1, NM_001318817.1
NP_054880.2, NM_014161.4
UniGeneiHs.416998

Genome annotation databases

EnsembliENST00000367034; ENSP00000356001; ENSG00000112110
GeneIDi29074
KEGGihsa:29074
UCSCiuc003qsw.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136633 mRNA Translation: CAB66568.1
AF161556 mRNA Translation: AAF29043.1
CR533491 mRNA Translation: CAG38522.1
AL139045 Genomic DNA No translation available.
AL135914 Genomic DNA No translation available.
BC001623 mRNA Translation: AAH01623.1
CCDSiCCDS5270.1
RefSeqiNP_001305746.1, NM_001318817.1
NP_054880.2, NM_014161.4
UniGeneiHs.416998

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J7Yelectron microscopy3.40P1-180[»]
5OOLelectron microscopy3.06P1-180[»]
5OOMelectron microscopy3.03P1-180[»]
ProteinModelPortaliQ9H0U6
SMRiQ9H0U6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118846, 98 interactors
CORUMiQ9H0U6
DIPiDIP-56844N
IntActiQ9H0U6, 31 interactors
MINTiQ9H0U6
STRINGi9606.ENSP00000356001

PTM databases

iPTMnetiQ9H0U6
PhosphoSitePlusiQ9H0U6

Polymorphism and mutation databases

BioMutaiMRPL18
DMDMi41017797

Proteomic databases

EPDiQ9H0U6
MaxQBiQ9H0U6
PaxDbiQ9H0U6
PeptideAtlasiQ9H0U6
PRIDEiQ9H0U6
ProteomicsDBi80326
TopDownProteomicsiQ9H0U6

Protocols and materials databases

DNASUi29074
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367034; ENSP00000356001; ENSG00000112110
GeneIDi29074
KEGGihsa:29074
UCSCiuc003qsw.5 human

Organism-specific databases

CTDi29074
DisGeNETi29074
EuPathDBiHostDB:ENSG00000112110.9
GeneCardsiMRPL18
HGNCiHGNC:14477 MRPL18
HPAiHPA028774
HPA028775
MIMi611831 gene
neXtProtiNX_Q9H0U6
OpenTargetsiENSG00000112110
PharmGKBiPA30947
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3333 Eukaryota
ENOG4111MCR LUCA
GeneTreeiENSGT00390000006394
HOGENOMiHOG000043958
HOVERGENiHBG001529
InParanoidiQ9H0U6
KOiK02881
OMAiSTSEWAI
OrthoDBiEOG091G0P8F
PhylomeDBiQ9H0U6
TreeFamiTF313292

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Miscellaneous databases

ChiTaRSiMRPL18 human
GeneWikiiMRPL18
GenomeRNAii29074
PROiPR:Q9H0U6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000112110 Expressed in 227 organ(s), highest expression level in oocyte
CleanExiHS_MRPL18
GenevisibleiQ9H0U6 HS

Family and domain databases

Gene3Di3.30.420.80, 1 hit
InterProiView protein in InterPro
IPR005484 Ribosomal_L18
IPR036967 Ribosomal_S11_sf
PANTHERiPTHR12899 PTHR12899, 1 hit
PfamiView protein in Pfam
PF00861 Ribosomal_L18p, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRM18_HUMAN
AccessioniPrimary (citable) accession number: Q9H0U6
Secondary accession number(s): Q5TAP9, Q9NZW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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