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Entry version 189 (29 Sep 2021)
Sequence version 1 (01 Mar 2001)
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Protein

Magnesium transporter protein 1

Gene

MAGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.

Curated3 Publications

May be involved in Mg2+ transport in epithelial cells.

2 Publications

Caution

Although MAGT1 has been reported to be involved in mental retardation (PubMed:18455129), its pathological role is questionable (PubMed:23871722).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • magnesium ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandMagnesium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H0U3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-446203, Asparagine N-linked glycosylation
R-HSA-5223345, Miscellaneous transport and binding events
R-HSA-6798695, Neutrophil degranulation
R-HSA-9694548, Maturation of spike protein

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00378

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.76.1.1, the magnesium transporter1 (magt1) family
9.B.142.3.17, the integral membrane glycosyltransferase family 39 (gt39) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Magnesium transporter protein 1
Short name:
MagT1
Alternative name(s):
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit MAGT1
Short name:
Oligosaccharyl transferase subunit MAGT1
Implantation-associated protein
Short name:
IAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MAGT1
Synonyms:IAG2
ORF Names:PSEC0084, UNQ628/PRO1244
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:28880, MAGT1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300715, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0U3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000102158

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini30 – 184ExtracellularSequence analysisAdd BLAST155
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 209CytoplasmicSequence analysis4
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 270ExtracellularSequence analysisAdd BLAST40
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 300CytoplasmicSequence analysis9
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 335ExtracellularSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN)4 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_083418137 – 335Missing in XMEN; no protein expression. 2 PublicationsAdd BLAST199
Natural variantiVAR_083419238 – 335Missing in XMEN; decreased protein expression. 1 PublicationAdd BLAST98
Natural variantiVAR_083420313 – 335Missing in XMEN; no protein expression; decreased protein N-linked glycosylation of STT3B-specific substrates. 1 PublicationAdd BLAST23
Congenital disorder of glycosylation 1CC (CDG1CC)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions. CDG1CC is an X-linked recessive form mainly characterized by intellectual and developmental disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083421324K → N in CDG1CC; no effect on protein expression; decreased protein N-linked glycosylation of STT3B-specific substrates. 1 PublicationCorresponds to variant dbSNP:rs373260156EnsemblClinVar.1
Natural variantiVAR_083422331 – 335Missing in CDG1CC; no protein expression; decreased protein N-linked glycosylation of STT3B-specific substrates. 1 Publication5

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi87C → S: Reduces N-glycosylation of cysteine-proximal acceptor sites; when associated with S-90. 1 Publication1
Mutagenesisi90C → S: Reduces N-glycosylation of cysteine-proximal acceptor sites; when associated with S-87. 1 Publication1

Keywords - Diseasei

Congenital disorder of glycosylation, Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
84061

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
MAGT1

MalaCards human disease database

More...
MalaCardsi
MAGT1
MIMi300853, phenotype
301031, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000102158

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
317476, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162394900

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0U3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MAGT1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74761391

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 29Sequence analysisAdd BLAST29
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024605730 – 335Magnesium transporter protein 1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi87 ↔ 90Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H0U3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H0U3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H0U3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H0U3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0U3

PeptideAtlas

More...
PeptideAtlasi
Q9H0U3

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0U3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
66990
80324 [Q9H0U3-1]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9H0U3, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0U3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0U3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H0U3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous. Expressed at very low levels in brain, lung and kidney.4 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000102158, Expressed in female gonad and 248 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H0U3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0U3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000102158, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Accessory component of the STT3B-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. The association of TUSC3 or MAGT1 with the STT3B-containing complex seems to be mutually exclusvice.

Curated1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123856, 95 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5622, Oligosaccharyltransferase complex B

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H0U3

Protein interaction database and analysis system

More...
IntActi
Q9H0U3, 38 interactors

Molecular INTeraction database

More...
MINTi
Q9H0U3

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354649

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H0U3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1335
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H0U3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini47 – 175ThioredoxinAdd BLAST129

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the OST3/OST6 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2603, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000012030

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_052855_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H0U3

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0U3

TreeFam database of animal gene trees

More...
TreeFami
TF314850

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006844, Mg_transporter-1
IPR021149, OligosaccharylTrfase_OST3/OST6
IPR036249, Thioredoxin-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR12692, PTHR12692, 1 hit
PTHR12692:SF2, PTHR12692:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04756, OST3_OST6, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52833, SSF52833, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0U3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARWRFWCV SVTMVVALLI VCDVPSASAQ RKKEMVLSEK VSQLMEWTNK
60 70 80 90 100
RPVIRMNGDK FRRLVKAPPR NYSVIVMFTA LQLHRQCVVC KQADEEFQIL
110 120 130 140 150
ANSWRYSSAF TNRIFFAMVD FDEGSDVFQM LNMNSAPTFI NFPAKGKPKR
160 170 180 190 200
GDTYELQVRG FSAEQIARWI ADRTDVNIRV IRPPNYAGPL MLGLLLAVIG
210 220 230 240 250
GLVYLRRSNM EFLFNKTGWA FAALCFVLAM TSGQMWNHIR GPPYAHKNPH
260 270 280 290 300
TGHVNYIHGS SQAQFVAETH IVLLFNGGVT LGMVLLCEAA TSDMDIGKRK
310 320 330
IMCVAGIGLV VLFFSWMLSI FRSKYHGYPY SFLMS
Length:335
Mass (Da):38,037
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i29B8E9888FDE593E
GO
Isoform 2 (identifier: Q9H0U3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-134: LNMN → FQVF
     135-335: Missing.

Show »
Length:134
Mass (Da):15,699
Checksum:i6F2B4EFDCB2CCD7C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WU53A0A087WU53_HUMAN
Dolichyl-diphosphooligosaccharide--...
MAGT1
367Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti30Q → K in BAC11592 (PubMed:16303743).Curated1
Sequence conflicti290A → V in BAD96851 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_083418137 – 335Missing in XMEN; no protein expression. 2 PublicationsAdd BLAST199
Natural variantiVAR_083419238 – 335Missing in XMEN; decreased protein expression. 1 PublicationAdd BLAST98
Natural variantiVAR_045837311V → G Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145245774EnsemblClinVar.1
Natural variantiVAR_083420313 – 335Missing in XMEN; no protein expression; decreased protein N-linked glycosylation of STT3B-specific substrates. 1 PublicationAdd BLAST23
Natural variantiVAR_083421324K → N in CDG1CC; no effect on protein expression; decreased protein N-linked glycosylation of STT3B-specific substrates. 1 PublicationCorresponds to variant dbSNP:rs373260156EnsemblClinVar.1
Natural variantiVAR_083422331 – 335Missing in CDG1CC; no protein expression; decreased protein N-linked glycosylation of STT3B-specific substrates. 1 Publication5

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056556131 – 134LNMN → FQVF in isoform 2. 1 Publication4
Alternative sequenceiVSP_056557135 – 335Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ000004 mRNA Translation: AAY18811.1
AY358691 mRNA Translation: AAQ89054.1
AK075394 mRNA Translation: BAC11592.1
AL136636 mRNA Translation: CAB66571.1
AK223131 mRNA Translation: BAD96851.1
AK314309 mRNA Translation: BAG36961.1
AL138743 Genomic DNA No translation available.
AL356235 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98608.1
CH471104 Genomic DNA Translation: EAW98609.1
CH471104 Genomic DNA Translation: EAW98610.1
BC041014 mRNA Translation: AAH41014.1
BC060842 mRNA Translation: AAH60842.1
BC063037 mRNA Translation: AAH63037.1

NCBI Reference Sequences

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RefSeqi
NP_115497.4, NM_032121.5

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000358075; ENSP00000354649; ENSG00000102158 [Q9H0U3-1]
ENST00000373336; ENSP00000362433; ENSG00000102158 [Q9H0U3-2]
ENST00000618282; ENSP00000480732; ENSG00000102158 [Q9H0U3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
84061

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:84061

UCSC genome browser

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UCSCi
uc065abq.1, human [Q9H0U3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ000004 mRNA Translation: AAY18811.1
AY358691 mRNA Translation: AAQ89054.1
AK075394 mRNA Translation: BAC11592.1
AL136636 mRNA Translation: CAB66571.1
AK223131 mRNA Translation: BAD96851.1
AK314309 mRNA Translation: BAG36961.1
AL138743 Genomic DNA No translation available.
AL356235 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98608.1
CH471104 Genomic DNA Translation: EAW98609.1
CH471104 Genomic DNA Translation: EAW98610.1
BC041014 mRNA Translation: AAH41014.1
BC060842 mRNA Translation: AAH60842.1
BC063037 mRNA Translation: AAH63037.1
RefSeqiNP_115497.4, NM_032121.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6S7Telectron microscopy3.50H1-335[»]
SMRiQ9H0U3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi123856, 95 interactors
ComplexPortaliCPX-5622, Oligosaccharyltransferase complex B
CORUMiQ9H0U3
IntActiQ9H0U3, 38 interactors
MINTiQ9H0U3
STRINGi9606.ENSP00000354649

Protein family/group databases

TCDBi1.A.76.1.1, the magnesium transporter1 (magt1) family
9.B.142.3.17, the integral membrane glycosyltransferase family 39 (gt39) family

PTM databases

GlyGeniQ9H0U3, 1 site
iPTMnetiQ9H0U3
PhosphoSitePlusiQ9H0U3
SwissPalmiQ9H0U3

Genetic variation databases

BioMutaiMAGT1
DMDMi74761391

Proteomic databases

EPDiQ9H0U3
jPOSTiQ9H0U3
MassIVEiQ9H0U3
MaxQBiQ9H0U3
PaxDbiQ9H0U3
PeptideAtlasiQ9H0U3
PRIDEiQ9H0U3
ProteomicsDBi66990
80324 [Q9H0U3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
43998, 119 antibodies

The DNASU plasmid repository

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DNASUi
84061

Genome annotation databases

EnsembliENST00000358075; ENSP00000354649; ENSG00000102158 [Q9H0U3-1]
ENST00000373336; ENSP00000362433; ENSG00000102158 [Q9H0U3-2]
ENST00000618282; ENSP00000480732; ENSG00000102158 [Q9H0U3-1]
GeneIDi84061
KEGGihsa:84061
UCSCiuc065abq.1, human [Q9H0U3-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84061
DisGeNETi84061

GeneCards: human genes, protein and diseases

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GeneCardsi
MAGT1
GeneReviewsiMAGT1
HGNCiHGNC:28880, MAGT1
HPAiENSG00000102158, Low tissue specificity
MalaCardsiMAGT1
MIMi300715, gene
300853, phenotype
301031, phenotype
neXtProtiNX_Q9H0U3
OpenTargetsiENSG00000102158
Orphaneti317476, X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
PharmGKBiPA162394900
VEuPathDBiHostDB:ENSG00000102158

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2603, Eukaryota
GeneTreeiENSGT00390000012030
HOGENOMiCLU_052855_0_0_1
InParanoidiQ9H0U3
OrthoDBi172471at2759
PhylomeDBiQ9H0U3
TreeFamiTF314850

Enzyme and pathway databases

UniPathwayiUPA00378
PathwayCommonsiQ9H0U3
ReactomeiR-HSA-446203, Asparagine N-linked glycosylation
R-HSA-5223345, Miscellaneous transport and binding events
R-HSA-6798695, Neutrophil degranulation
R-HSA-9694548, Maturation of spike protein

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84061, 14 hits in 644 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
MAGT1, human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
RP11-217H1.1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84061
PharosiQ9H0U3, Tbio

Protein Ontology

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PROi
PR:Q9H0U3
RNActiQ9H0U3, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000102158, Expressed in female gonad and 248 other tissues
ExpressionAtlasiQ9H0U3, baseline and differential
GenevisibleiQ9H0U3, HS

Family and domain databases

InterProiView protein in InterPro
IPR006844, Mg_transporter-1
IPR021149, OligosaccharylTrfase_OST3/OST6
IPR036249, Thioredoxin-like_sf
PANTHERiPTHR12692, PTHR12692, 1 hit
PTHR12692:SF2, PTHR12692:SF2, 1 hit
PfamiView protein in Pfam
PF04756, OST3_OST6, 1 hit
SUPFAMiSSF52833, SSF52833, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMAGT1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0U3
Secondary accession number(s): B2RAR4
, D3DTE3, Q53G00, Q6P577, Q8NBN6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: September 29, 2021
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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