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Protein

Magnesium transporter protein 1

Gene

MAGT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Involved in N-glycosylation of STT3B-dependent substrates. Specifically required for the glycosylation of a subset of acceptor sites that are near cysteine residues; in this function seems to act redundantly with TUSC3. In its oxidized form proposed to form transient mixed disulfides with a glycoprotein substrate to facilitate access of STT3B to the unmodified acceptor site. Has also oxidoreductase-independent functions in the STT3B-containing OST complex possibly involving substrate recognition.Curated2 Publications
May be involved in Mg2+ transport in epithelial cells.2 Publications

Caution

Although MAGT1 has been reported to be involved in mental retardation (PubMed:18455129), its pathological role is questionable (PubMed:23871722).2 Publications

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

  • magnesium ion transmembrane transporter activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTransport
LigandMagnesium

Enzyme and pathway databases

ReactomeiR-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5223345 Miscellaneous transport and binding events
R-HSA-6798695 Neutrophil degranulation
UniPathwayi
UPA00378

Protein family/group databases

TCDBi1.A.76.1.1 the magnesium transporter1 (magt1) family

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transporter protein 1
Short name:
MagT1
Alternative name(s):
Implantation-associated protein
Short name:
IAP
Gene namesi
Name:MAGT1
Synonyms:IAG2
ORF Names:PSEC0084, UNQ628/PRO1244
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102158.19
HGNCiHGNC:28880 MAGT1
MIMi300715 gene
neXtProtiNX_Q9H0U3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 184ExtracellularSequence analysisAdd BLAST155
Transmembranei185 – 205HelicalSequence analysisAdd BLAST21
Topological domaini206 – 209CytoplasmicSequence analysis4
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 270ExtracellularSequence analysisAdd BLAST40
Transmembranei271 – 291HelicalSequence analysisAdd BLAST21
Topological domaini292 – 300CytoplasmicSequence analysis9
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 335ExtracellularSequence analysisAdd BLAST14

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Immunodeficiency, X-linked, with magnesium defect, Epstein-Barr virus infection and neoplasia (XMEN)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by CD4 lymphopenia, severe chronic viral infections, and defective T-lymphocyte activation.
See also OMIM:300853

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi87C → S: Reduces N-glycosylation of cysteine-proximal acceptor sites; when associated with S-90. 1 Publication1
Mutagenesisi90C → S: Reduces N-glycosylation of cysteine-proximal acceptor sites; when associated with S-87. 1 Publication1

Organism-specific databases

DisGeNETi84061
GeneReviewsiMAGT1
MalaCardsiMAGT1
MIMi300853 phenotype
OpenTargetsiENSG00000102158
Orphaneti317476 X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
PharmGKBiPA162394900

Polymorphism and mutation databases

BioMutaiMAGT1
DMDMi74761391

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000024605730 – 335Magnesium transporter protein 1Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi71N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi87 ↔ 90Redox-activeBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ9H0U3
MaxQBiQ9H0U3
PaxDbiQ9H0U3
PeptideAtlasiQ9H0U3
PRIDEiQ9H0U3
ProteomicsDBi80324

PTM databases

iPTMnetiQ9H0U3
PhosphoSitePlusiQ9H0U3
SwissPalmiQ9H0U3

Expressioni

Tissue specificityi

Ubiquitous. Expressed at very low levels in brain, lung and kidney.3 Publications

Inductioni

Up-regulated by low extracellular Mg2+.1 Publication

Gene expression databases

BgeeiENSG00000102158 Expressed in 236 organ(s), highest expression level in female gonad
CleanExiHS_MAGT1
ExpressionAtlasiQ9H0U3 baseline and differential
GenevisibleiQ9H0U3 HS

Organism-specific databases

HPAiHPA049851

Interactioni

Subunit structurei

Accessory component of the STT3B-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. The association of TUSC3 or MAGT1 with the STT3B-containing complex seems to be mutually exclusvice.Curated1 Publication

Protein-protein interaction databases

BioGridi123856, 37 interactors
CORUMiQ9H0U3
IntActiQ9H0U3, 19 interactors
MINTiQ9H0U3
STRINGi9606.ENSP00000354649

Structurei

3D structure databases

ProteinModelPortaliQ9H0U3
SMRiQ9H0U3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 175ThioredoxinAdd BLAST129

Sequence similaritiesi

Belongs to the OST3/OST6 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2603 Eukaryota
ENOG410XR1F LUCA
GeneTreeiENSGT00390000012030
HOGENOMiHOG000231301
HOVERGENiHBG002493
InParanoidiQ9H0U3
KOiK19478
PhylomeDBiQ9H0U3
TreeFamiTF314850

Family and domain databases

InterProiView protein in InterPro
IPR006844 Mg_transporter-1
IPR021149 OligosaccharylTrfase_OST3/OST6
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12692 PTHR12692, 1 hit
PTHR12692:SF2 PTHR12692:SF2, 1 hit
PfamiView protein in Pfam
PF04756 OST3_OST6, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0U3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAARWRFWCV SVTMVVALLI VCDVPSASAQ RKKEMVLSEK VSQLMEWTNK
60 70 80 90 100
RPVIRMNGDK FRRLVKAPPR NYSVIVMFTA LQLHRQCVVC KQADEEFQIL
110 120 130 140 150
ANSWRYSSAF TNRIFFAMVD FDEGSDVFQM LNMNSAPTFI NFPAKGKPKR
160 170 180 190 200
GDTYELQVRG FSAEQIARWI ADRTDVNIRV IRPPNYAGPL MLGLLLAVIG
210 220 230 240 250
GLVYLRRSNM EFLFNKTGWA FAALCFVLAM TSGQMWNHIR GPPYAHKNPH
260 270 280 290 300
TGHVNYIHGS SQAQFVAETH IVLLFNGGVT LGMVLLCEAA TSDMDIGKRK
310 320 330
IMCVAGIGLV VLFFSWMLSI FRSKYHGYPY SFLMS
Length:335
Mass (Da):38,037
Last modified:March 1, 2001 - v1
Checksum:i29B8E9888FDE593E
GO
Isoform 2 (identifier: Q9H0U3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-134: LNMN → FQVF
     135-335: Missing.

Note: No experimental confirmation available.
Show »
Length:134
Mass (Da):15,699
Checksum:i6F2B4EFDCB2CCD7C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WU53A0A087WU53_HUMAN
Magnesium transporter protein 1
MAGT1
367Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Q → K in BAC11592 (PubMed:16303743).Curated1
Sequence conflicti290A → V in BAD96851 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_045837311V → G Rare variant found in patients with X-linked mental retardation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs145245774Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056556131 – 134LNMN → FQVF in isoform 2. 1 Publication4
Alternative sequenceiVSP_056557135 – 335Missing in isoform 2. 1 PublicationAdd BLAST201

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ000004 mRNA Translation: AAY18811.1
AY358691 mRNA Translation: AAQ89054.1
AK075394 mRNA Translation: BAC11592.1
AL136636 mRNA Translation: CAB66571.1
AK223131 mRNA Translation: BAD96851.1
AK314309 mRNA Translation: BAG36961.1
AL138743 Genomic DNA No translation available.
AL356235 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98608.1
CH471104 Genomic DNA Translation: EAW98609.1
CH471104 Genomic DNA Translation: EAW98610.1
BC041014 mRNA Translation: AAH41014.1
BC060842 mRNA Translation: AAH60842.1
BC063037 mRNA Translation: AAH63037.1
RefSeqiNP_115497.4, NM_032121.5
UniGeneiHs.323562

Genome annotation databases

EnsembliENST00000373336; ENSP00000362433; ENSG00000102158 [Q9H0U3-2]
ENST00000618282; ENSP00000480732; ENSG00000102158 [Q9H0U3-1]
GeneIDi84061
KEGGihsa:84061
UCSCiuc065abq.1 human [Q9H0U3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ000004 mRNA Translation: AAY18811.1
AY358691 mRNA Translation: AAQ89054.1
AK075394 mRNA Translation: BAC11592.1
AL136636 mRNA Translation: CAB66571.1
AK223131 mRNA Translation: BAD96851.1
AK314309 mRNA Translation: BAG36961.1
AL138743 Genomic DNA No translation available.
AL356235 Genomic DNA No translation available.
CH471104 Genomic DNA Translation: EAW98608.1
CH471104 Genomic DNA Translation: EAW98609.1
CH471104 Genomic DNA Translation: EAW98610.1
BC041014 mRNA Translation: AAH41014.1
BC060842 mRNA Translation: AAH60842.1
BC063037 mRNA Translation: AAH63037.1
RefSeqiNP_115497.4, NM_032121.5
UniGeneiHs.323562

3D structure databases

ProteinModelPortaliQ9H0U3
SMRiQ9H0U3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123856, 37 interactors
CORUMiQ9H0U3
IntActiQ9H0U3, 19 interactors
MINTiQ9H0U3
STRINGi9606.ENSP00000354649

Protein family/group databases

TCDBi1.A.76.1.1 the magnesium transporter1 (magt1) family

PTM databases

iPTMnetiQ9H0U3
PhosphoSitePlusiQ9H0U3
SwissPalmiQ9H0U3

Polymorphism and mutation databases

BioMutaiMAGT1
DMDMi74761391

Proteomic databases

EPDiQ9H0U3
MaxQBiQ9H0U3
PaxDbiQ9H0U3
PeptideAtlasiQ9H0U3
PRIDEiQ9H0U3
ProteomicsDBi80324

Protocols and materials databases

DNASUi84061
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373336; ENSP00000362433; ENSG00000102158 [Q9H0U3-2]
ENST00000618282; ENSP00000480732; ENSG00000102158 [Q9H0U3-1]
GeneIDi84061
KEGGihsa:84061
UCSCiuc065abq.1 human [Q9H0U3-1]

Organism-specific databases

CTDi84061
DisGeNETi84061
EuPathDBiHostDB:ENSG00000102158.19
GeneCardsiMAGT1
GeneReviewsiMAGT1
H-InvDBiHIX0016886
HGNCiHGNC:28880 MAGT1
HPAiHPA049851
MalaCardsiMAGT1
MIMi300715 gene
300853 phenotype
neXtProtiNX_Q9H0U3
OpenTargetsiENSG00000102158
Orphaneti317476 X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia
PharmGKBiPA162394900
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2603 Eukaryota
ENOG410XR1F LUCA
GeneTreeiENSGT00390000012030
HOGENOMiHOG000231301
HOVERGENiHBG002493
InParanoidiQ9H0U3
KOiK19478
PhylomeDBiQ9H0U3
TreeFamiTF314850

Enzyme and pathway databases

UniPathwayi
UPA00378

ReactomeiR-HSA-446203 Asparagine N-linked glycosylation
R-HSA-5223345 Miscellaneous transport and binding events
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiMAGT1 human
GeneWikiiRP11-217H1.1
GenomeRNAii84061
PROiPR:Q9H0U3
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102158 Expressed in 236 organ(s), highest expression level in female gonad
CleanExiHS_MAGT1
ExpressionAtlasiQ9H0U3 baseline and differential
GenevisibleiQ9H0U3 HS

Family and domain databases

InterProiView protein in InterPro
IPR006844 Mg_transporter-1
IPR021149 OligosaccharylTrfase_OST3/OST6
IPR036249 Thioredoxin-like_sf
PANTHERiPTHR12692 PTHR12692, 1 hit
PTHR12692:SF2 PTHR12692:SF2, 1 hit
PfamiView protein in Pfam
PF04756 OST3_OST6, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMAGT1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0U3
Secondary accession number(s): B2RAR4
, D3DTE3, Q53G00, Q6P577, Q8NBN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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