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Protein

Ras-related protein Rab-17

Gene

RAB17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in transcytosis, the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. Mainly observed in epithelial cells, transcytosis mediates for instance, the transcellular transport of immunoglobulins from the basolateral surface to the apical surface. Most probably controls membrane trafficking through apical recycling endosomes in a post-endocytic step of transcytosis. Required for melanosome transport and release from melanocytes, it also regulates dendrite and dendritic spine development (By similarity). May also play a role in cell migration.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 33GTPBy similarity8
Nucleotide bindingi73 – 77GTPBy similarity5
Nucleotide bindingi132 – 135GTPBy similarity4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-17
Gene namesi
Name:RAB17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000124839.12
HGNCiHGNC:16523 RAB17
MIMi602206 gene
neXtProtiNX_Q9H0T7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Endosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi64284
OpenTargetsiENSG00000124839
PharmGKBiPA34105

Polymorphism and mutation databases

BioMutaiRAB17
DMDMi37999892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211911 – 212Ras-related protein Rab-17Add BLAST212

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Lipidationi209S-geranylgeranyl cysteineBy similarity1
Lipidationi210S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

EPDiQ9H0T7
MaxQBiQ9H0T7
PaxDbiQ9H0T7
PeptideAtlasiQ9H0T7
PRIDEiQ9H0T7
ProteomicsDBi80323

PTM databases

iPTMnetiQ9H0T7
PhosphoSitePlusiQ9H0T7

Expressioni

Tissue specificityi

Expressed in melanocytes (at protein level).1 Publication

Inductioni

Up-regulated by forskolin probably through the transcription factor MITF.1 Publication

Gene expression databases

BgeeiENSG00000124839 Expressed in 135 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_RAB17
ExpressionAtlasiQ9H0T7 baseline and differential
GenevisibleiQ9H0T7 HS

Organism-specific databases

HPAiHPA035176

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi122128, 15 interactors
IntActiQ9H0T7, 6 interactors
STRINGi9606.ENSP00000264601

Structurei

3D structure databases

ProteinModelPortaliQ9H0T7
SMRiQ9H0T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi47 – 55Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9H0T7
KOiK07909
OMAiSVCHLYY
OrthoDBiEOG091G0KZI
PhylomeDBiQ9H0T7
TreeFamiTF300199

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0T7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQAHRTPQP RAAPSQPRVF KLVLLGSGSV GKSSLALRYV KNDFKSILPT
60 70 80 90 100
VGCAFFTKVV DVGATSLKLE IWDTAGQEKY HSVCHLYFRG ANAALLVYDI
110 120 130 140 150
TRKDSFLKAQ QWLKDLEEEL HPGEVLVMLV GNKTDLSQER EVTFQEGKEF
160 170 180 190 200
ADSQKLLFME TSAKLNHQVS EVFNTVAQEL LQRSDEEGQA LRGDAAVALN
210
KGPARQAKCC AH
Length:212
Mass (Da):23,491
Last modified:October 10, 2003 - v2
Checksum:i40E8CE5F445E5CF2
GO
Isoform 2 (identifier: Q9H0T7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-127: Missing.

Note: No experimental confirmation available.
Show »
Length:85
Mass (Da):9,394
Checksum:i5C22A7948C107A54
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J0T6C9J0T6_HUMAN
Ras-related protein Rab-17
RAB17
130Annotation score:
F8WAG1F8WAG1_HUMAN
Ras-related protein Rab-17
RAB17
52Annotation score:
H7C1P7H7C1P7_HUMAN
Ras-related protein Rab-17
RAB17
140Annotation score:
F8WBE9F8WBE9_HUMAN
Ras-related protein Rab-17
RAB17
54Annotation score:
B8ZZM5B8ZZM5_HUMAN
Ras-related protein Rab-17
RAB17
53Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157L → P in CAB66580 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05171119V → A1 PublicationCorresponds to variant dbSNP:rs3751112Ensembl.1
Natural variantiVAR_051712184S → G. Corresponds to variant dbSNP:rs34311889Ensembl.1
Natural variantiVAR_022102191L → P. Corresponds to variant dbSNP:rs2280289Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564001 – 127Missing in isoform 2. 1 PublicationAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136645 mRNA Translation: CAB66580.1
AK022600 mRNA Translation: BAB14121.1
CR457282 mRNA Translation: CAG33563.1
AC104667 Genomic DNA Translation: AAY24047.1
CH471063 Genomic DNA Translation: EAW71118.1
CH471063 Genomic DNA Translation: EAW71119.1
BC000929 mRNA Translation: AAH00929.1
BC050426 mRNA Translation: AAH50426.1
BC007907 mRNA Translation: AAH07907.1
BC009827 mRNA Translation: AAH09827.1
CCDSiCCDS2520.1 [Q9H0T7-1]
RefSeqiNP_071894.1, NM_022449.3 [Q9H0T7-1]
UniGeneiHs.44278

Genome annotation databases

EnsembliENST00000264601; ENSP00000264601; ENSG00000124839 [Q9H0T7-1]
ENST00000409822; ENSP00000386589; ENSG00000124839 [Q9H0T7-2]
GeneIDi64284
KEGGihsa:64284
UCSCiuc002vwz.3 human [Q9H0T7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136645 mRNA Translation: CAB66580.1
AK022600 mRNA Translation: BAB14121.1
CR457282 mRNA Translation: CAG33563.1
AC104667 Genomic DNA Translation: AAY24047.1
CH471063 Genomic DNA Translation: EAW71118.1
CH471063 Genomic DNA Translation: EAW71119.1
BC000929 mRNA Translation: AAH00929.1
BC050426 mRNA Translation: AAH50426.1
BC007907 mRNA Translation: AAH07907.1
BC009827 mRNA Translation: AAH09827.1
CCDSiCCDS2520.1 [Q9H0T7-1]
RefSeqiNP_071894.1, NM_022449.3 [Q9H0T7-1]
UniGeneiHs.44278

3D structure databases

ProteinModelPortaliQ9H0T7
SMRiQ9H0T7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122128, 15 interactors
IntActiQ9H0T7, 6 interactors
STRINGi9606.ENSP00000264601

PTM databases

iPTMnetiQ9H0T7
PhosphoSitePlusiQ9H0T7

Polymorphism and mutation databases

BioMutaiRAB17
DMDMi37999892

Proteomic databases

EPDiQ9H0T7
MaxQBiQ9H0T7
PaxDbiQ9H0T7
PeptideAtlasiQ9H0T7
PRIDEiQ9H0T7
ProteomicsDBi80323

Protocols and materials databases

DNASUi64284
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000264601; ENSP00000264601; ENSG00000124839 [Q9H0T7-1]
ENST00000409822; ENSP00000386589; ENSG00000124839 [Q9H0T7-2]
GeneIDi64284
KEGGihsa:64284
UCSCiuc002vwz.3 human [Q9H0T7-1]

Organism-specific databases

CTDi64284
DisGeNETi64284
EuPathDBiHostDB:ENSG00000124839.12
GeneCardsiRAB17
HGNCiHGNC:16523 RAB17
HPAiHPA035176
MIMi602206 gene
neXtProtiNX_Q9H0T7
OpenTargetsiENSG00000124839
PharmGKBiPA34105
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0092 Eukaryota
ENOG410YCCP LUCA
GeneTreeiENSGT00760000119101
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9H0T7
KOiK07909
OMAiSVCHLYY
OrthoDBiEOG091G0KZI
PhylomeDBiQ9H0T7
TreeFamiTF300199

Enzyme and pathway databases

ReactomeiR-HSA-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRAB17 human
GeneWikiiRAB17
GenomeRNAii64284
PROiPR:Q9H0T7
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124839 Expressed in 135 organ(s), highest expression level in left lobe of thyroid gland
CleanExiHS_RAB17
ExpressionAtlasiQ9H0T7 baseline and differential
GenevisibleiQ9H0T7 HS

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB17_HUMAN
AccessioniPrimary (citable) accession number: Q9H0T7
Secondary accession number(s): Q53QV6
, Q6IA73, Q6PJZ0, Q9BVU1, Q9H9U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 10, 2003
Last modified: November 7, 2018
This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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