UniProtKB - Q9H0S4 (DDX47_HUMAN)

BLAST

>sp|Q9H0S4|DDX47_HUMAN Probable ATP-dependent RNA helicase DDX47 OS=Homo sapiens OX=9606 GN=DDX47 PE=1 SV=1
MAAPEEHDSPTEASQPIVEEEETKTFKDLGVTDVLCEACDQLGWTKPTKIQIEAIPLALQ
GRDIIGLAETGSGKTGAFALPILNALLETPQRLFALVLTPTRELAFQISEQFEALGSSIG
VQSAVIVGGIDSMSQSLALAKKPHIIIATPGRLIDHLENTKGFNLRALKYLVMDEADRIL
NMDFETEVDKILKVIPRDRKTFLFSATMTKKVQKLQRAALKNPVKCAVSSKYQTVEKLQQ
YYIFIPSKFKDTYLVYILNELAGNSFMIFCSTCNNTQRTALLLRNLGFTAIPLHGQMSQS
KRLGSLNKFKAKARSILLATDVASRGLDIPHVDVVVNFDIPTHSKDYIHRVGRTARAGRS
GKAITFVTQYDVELFQRIEHLIGKKLPGFPTQDDEVMMLTERVAEAQRFARMELREHGEK
KKRSREDAGDNDDTEGAIGVRNKVAGGKMKKRKGR

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History
Entry version 161 (07 Nov 2018)
Sequence version 1 (01 Mar 2001)
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Protein

Probable ATP-dependent RNA helicase DDX47

Gene

DDX47

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Involved in apoptosis. May have a role in rRNA processing and mRNA splicing. Associates with pre-rRNA precursors.2 Publications

Catalytic activityⁱ

ATP + H₂O = ADP + phosphate.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	68 – 75	ATP		8

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
helicase activity Source: UniProtKB-KW
RNA binding
Source: UniProtKB
Inferred from high throughput direct assayⁱ
- 22658674
- 22681889

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

extrinsic apoptotic signaling pathway via death domain receptors
Source: UniProtKB
Inferred from direct assayⁱ
- 15977068
mRNA processing Source: UniProtKB-KW
RNA splicing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16963496
rRNA processing
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16963496

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Helicase, Hydrolase, RNA-binding
Biological process	Apoptosis, mRNA processing, mRNA splicing, rRNA processing
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Probable ATP-dependent RNA helicase DDX47 (EC:3.6.4.13) Alternative name(s): DEAD box protein 47
Gene namesⁱ	Name:DDX47
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 12

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000213782.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18682 DDX47
MIMⁱ	615428 gene
neXtProtⁱ	NX_Q9H0S4

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000213782
PharmGKBⁱ	PA134918403

Polymorphism and mutation databases

BioMutaⁱ	DDX47
DMDMⁱ	52782792

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000055050	2 – 455	Probable ATP-dependent RNA helicase DDX47Add BLAST		454

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	9	PhosphoserineCombined sources	1
Modified residueⁱ	149	PhosphothreonineCombined sources	1
Modified residueⁱ	424	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H0S4
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H0S4
PaxDbⁱ	Q9H0S4
PeptideAtlas More...PeptideAtlasⁱ	Q9H0S4
PRIDEⁱ	Q9H0S4
ProteomicsDBⁱ	80322

2D gel databases

SWISS-2DPAGEⁱ	Q9H0S4

SWISS-2DPAGEⁱ

Q9H0S4

PTM databases

iPTMnetⁱ	Q9H0S4
PhosphoSitePlusⁱ	Q9H0S4
SwissPalmⁱ	Q9H0S4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000213782 Expressed in 94 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_DDX47
ExpressionAtlasⁱ	Q9H0S4 baseline and differential
Genevisibleⁱ	Q9H0S4 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA014855

HPAⁱ

HPA014855

Interactionⁱ

Subunit structureⁱ

Interacts with AGO1 and AGO2. Interacts with GABARAP. Interacts with NOL8; the interaction is RNA-dependent.4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
GABARAP	O95166	3	EBI-2515241,EBI-712001

With

Entry

#Exp.

IntAct

Notes

GABARAP

O95166

EBI-2515241,EBI-712001

Protein-protein interaction databases

BioGridⁱ	119375, 65 interactors
IntActⁱ	Q9H0S4, 36 interactors
Molecular INTeraction database More...MINTⁱ	Q9H0S4
STRINGⁱ	9606.ENSP00000350698

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	18 – 23	Combined sources	6
Helixⁱ	27 – 29	Combined sources	3
Helixⁱ	33 – 41	Combined sources	9
Helixⁱ	49 – 59	Combined sources	11
Beta strandⁱ	64 – 67	Combined sources	4
Helixⁱ	74 – 88	Combined sources	15
Beta strandⁱ	95 – 98	Combined sources	4
Helixⁱ	102 – 116	Combined sources	15
Helixⁱ	117 – 119	Combined sources	3
Beta strandⁱ	123 – 126	Combined sources	4
Helixⁱ	132 – 140	Combined sources	9
Beta strandⁱ	144 – 148	Combined sources	5
Helixⁱ	150 – 159	Combined sources	10
Beta strandⁱ	170 – 173	Combined sources	4
Helixⁱ	176 – 181	Combined sources	6
Helixⁱ	185 – 193	Combined sources	9
Beta strandⁱ	197 – 207	Combined sources	11
Helixⁱ	210 – 219	Combined sources	10
Beta strandⁱ	224 – 227	Combined sources	4

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H0S4
SMRⁱ	Q9H0S4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9H0S4

EvolutionaryTraceⁱ

Q9H0S4

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	55 – 226	Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST		172
Domainⁱ	237 – 397	Helicase C-terminalPROSITE-ProRule annotationAdd BLAST		161

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	24 – 52	Q motifAdd BLAST		29
Motifⁱ	174 – 177	DEAD box		4

Sequence similaritiesⁱ

Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0330 Eukaryota ENOG410XQU7 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110914
HOGENOMⁱ	HOG000268802
HOVERGENⁱ	HBG100512
InParanoidⁱ	Q9H0S4
KEGG Orthology (KO) More...KOⁱ	K14777
OMAⁱ	KAKNRSI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G07QH
PhylomeDBⁱ	Q9H0S4
TreeFamⁱ	TF105714

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR000629 RNA-helicase_DEAD-box_CS IPR014014 RNA_helicase_DEAD_Q_motif
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00039 DEAD_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q9H0S4-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPEEHDSP TEASQPIVEE EETKTFKDLG VTDVLCEACD QLGWTKPTKI 
        60         70         80         90        100
QIEAIPLALQ GRDIIGLAET GSGKTGAFAL PILNALLETP QRLFALVLTP 
       110        120        130        140        150
TRELAFQISE QFEALGSSIG VQSAVIVGGI DSMSQSLALA KKPHIIIATP 
       160        170        180        190        200
GRLIDHLENT KGFNLRALKY LVMDEADRIL NMDFETEVDK ILKVIPRDRK 
       210        220        230        240        250
TFLFSATMTK KVQKLQRAAL KNPVKCAVSS KYQTVEKLQQ YYIFIPSKFK 
       260        270        280        290        300
DTYLVYILNE LAGNSFMIFC STCNNTQRTA LLLRNLGFTA IPLHGQMSQS 
       310        320        330        340        350
KRLGSLNKFK AKARSILLAT DVASRGLDIP HVDVVVNFDI PTHSKDYIHR 
       360        370        380        390        400
VGRTARAGRS GKAITFVTQY DVELFQRIEH LIGKKLPGFP TQDDEVMMLT 
       410        420        430        440        450
ERVAEAQRFA RMELREHGEK KKRSREDAGD NDDTEGAIGV RNKVAGGKMK 

KRKGR

Length:455

Mass (Da):50,647

Last modified:March 1, 2001 - v1

Checksum:ⁱ5F64F26AD2C11286

Isoform 2 (identifier: Q9H0S4-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
251-299: Missing.

« Hide

        10         20         30         40         50
MAAPEEHDSP TEASQPIVEE EETKTFKDLG VTDVLCEACD QLGWTKPTKI 
        60         70         80         90        100
QIEAIPLALQ GRDIIGLAET GSGKTGAFAL PILNALLETP QRLFALVLTP 
       110        120        130        140        150
TRELAFQISE QFEALGSSIG VQSAVIVGGI DSMSQSLALA KKPHIIIATP 
       160        170        180        190        200
GRLIDHLENT KGFNLRALKY LVMDEADRIL NMDFETEVDK ILKVIPRDRK 
       210        220        230        240        250
TFLFSATMTK KVQKLQRAAL KNPVKCAVSS KYQTVEKLQQ YYIFIPSKFK 
       260        270        280        290        300
SKRLGSLNKF KAKARSILLA TDVASRGLDI PHVDVVVNFD IPTHSKDYIH 
       310        320        330        340        350
RVGRTARAGR SGKAITFVTQ YDVELFQRIE HLIGKKLPGF PTQDDEVMML 
       360        370        380        390        400
TERVAEAQRF ARMELREHGE KKKRSREDAG DNDDTEGAIG VRNKVAGGKM 

KKRKGR

Note: No experimental confirmation available.

Show »

Length:406

Mass (Da):45,169

Checksum:ⁱE6FFADA03AFAB679

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	F5H1N9	F5H1N9_HUMAN		Probable ATP-dependent RNA helicase... Probable ATP-dependent RNA helicase DDX47	DDX47	196	Annotation score:

Sequence cautionⁱ

The sequence AAF23354 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	55	I → V in BAB70762 (PubMed:16541075).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045239	251 – 299	Missing in isoform 2. 1 PublicationAdd BLAST		49

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136666 mRNA Translation: CAB66601.1 AK054574 mRNA Translation: BAB70762.1 AK127712 mRNA Translation: BAG54556.1 AC007215 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96277.1 CH471094 Genomic DNA Translation: EAW96283.1 BC009379 mRNA Translation: AAH09379.2 BC068009 mRNA Translation: AAH68009.1 AF078843 mRNA Translation: AAF23354.1 Different initiation.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8655.1 [Q9H0S4-1] CCDS8656.1 [Q9H0S4-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_057439.2, NM_016355.3 [Q9H0S4-1] NP_957518.1, NM_201224.1 [Q9H0S4-2]
UniGeneⁱ	Hs.719938

Genome annotation databases

Ensemblⁱ	ENST00000352940; ENSP00000319578; ENSG00000213782 [Q9H0S4-2] ENST00000358007; ENSP00000350698; ENSG00000213782 [Q9H0S4-1]
GeneIDⁱ	51202
KEGGⁱ	hsa:51202
UCSC genome browser More...UCSCⁱ	uc001rax.4 human [Q9H0S4-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H0S4	HCG27698, isoform CRA_a		HUMAN		455	UniRef100_Q9H0S4
HCG27698, isoform CRA_e		HUMAN		189
DEAD box polypeptide 47 isoform 1 variant (Fragment)		HUMAN		182

Protein	Similar proteins		Species	Score	Length	Source
Q9H0S4	Probable ATP-dependent RNA helicase DDX47		BOVIN		457	UniRef90_Q9H0S4
Probable ATP-dependent RNA helicase DDX47		MOUSE		455
HCG27698, isoform CRA_a		HUMAN		455
DEAD-box helicase 47		CANLF		482
Putative ATP-dependent RNA helicase DDX47		wild yak		457
+179
Q9H0S4-2	probable ATP-dependent RNA helicase DDX47 isoform X2		ODORO		407	UniRef90_Q9H0S4-2
DDX47 isoform 4		PANTR		406
Uncharacterized protein		PROCO		406
DEAD-box helicase 47		SAIBB		406
Uncharacterized protein		MACMU		406
+36

Protein	Similar proteins		Species	Score	Length	Source
Q9H0S4	Probable ATP-dependent RNA helicase DDX47		BOVIN		457	UniRef50_Q9H0S4
Probable ATP-dependent RNA helicase DDX47		MOUSE		455
HCG27698, isoform CRA_a		HUMAN		455
DEAD-box helicase 47		CANLF		482
Putative ATP-dependent RNA helicase DDX47		wild yak		457
+222
Q9H0S4-2	probable ATP-dependent RNA helicase DDX47 isoform X2		ODORO		407	UniRef50_Q9H0S4-2
Uncharacterized protein		Cebus capucinus imitator		406
DDX47 isoform 4		PANTR		406
Uncharacterized protein		PAPAN		406
probable ATP-dependent RNA helicase DDX47 isoform X1		Enhydra lutris kenyoni		406
+58

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL136666 mRNA Translation: CAB66601.1 AK054574 mRNA Translation: BAB70762.1 AK127712 mRNA Translation: BAG54556.1 AC007215 Genomic DNA No translation available. CH471094 Genomic DNA Translation: EAW96277.1 CH471094 Genomic DNA Translation: EAW96283.1 BC009379 mRNA Translation: AAH09379.2 BC068009 mRNA Translation: AAH68009.1 AF078843 mRNA Translation: AAF23354.1 Different initiation.
CCDSⁱ	CCDS8655.1 [Q9H0S4-1] CCDS8656.1 [Q9H0S4-2]
RefSeqⁱ	NP_057439.2, NM_016355.3 [Q9H0S4-1] NP_957518.1, NM_201224.1 [Q9H0S4-2]
UniGeneⁱ	Hs.719938

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3BER	X-ray	1.40	A	5-230	[»]
ProteinModelPortalⁱ	Q9H0S4
SMRⁱ	Q9H0S4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	119375, 65 interactors
IntActⁱ	Q9H0S4, 36 interactors
MINTⁱ	Q9H0S4
STRINGⁱ	9606.ENSP00000350698

PTM databases

iPTMnetⁱ	Q9H0S4
PhosphoSitePlusⁱ	Q9H0S4
SwissPalmⁱ	Q9H0S4

Polymorphism and mutation databases

BioMutaⁱ	DDX47
DMDMⁱ	52782792

2D gel databases

SWISS-2DPAGEⁱ	Q9H0S4

SWISS-2DPAGEⁱ

Q9H0S4

Proteomic databases

EPDⁱ	Q9H0S4
MaxQBⁱ	Q9H0S4
PaxDbⁱ	Q9H0S4
PeptideAtlasⁱ	Q9H0S4
PRIDEⁱ	Q9H0S4
ProteomicsDBⁱ	80322

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	51202
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000352940; ENSP00000319578; ENSG00000213782 [Q9H0S4-2] ENST00000358007; ENSP00000350698; ENSG00000213782 [Q9H0S4-1]
GeneIDⁱ	51202
KEGGⁱ	hsa:51202
UCSCⁱ	uc001rax.4 human [Q9H0S4-1]

Organism-specific databases

CTDⁱ	51202
EuPathDBⁱ	HostDB:ENSG00000213782.7
GeneCardsⁱ	DDX47
HGNCⁱ	HGNC:18682 DDX47
HPAⁱ	HPA014855
MIMⁱ	615428 gene
neXtProtⁱ	NX_Q9H0S4
OpenTargetsⁱ	ENSG00000213782
PharmGKBⁱ	PA134918403
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0330 Eukaryota ENOG410XQU7 LUCA
GeneTreeⁱ	ENSGT00730000110914
HOGENOMⁱ	HOG000268802
HOVERGENⁱ	HBG100512
InParanoidⁱ	Q9H0S4
KOⁱ	K14777
OMAⁱ	KAKNRSI
OrthoDBⁱ	EOG091G07QH
PhylomeDBⁱ	Q9H0S4
TreeFamⁱ	TF105714

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6790901 rRNA modification in the nucleus and cytosol R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Reactomeⁱ

R-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSⁱ	DDX47 human
EvolutionaryTraceⁱ	Q9H0S4
GeneWikiⁱ	DDX47
GenomeRNAiⁱ	51202
Protein Ontology More...PROⁱ	PR:Q9H0S4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000213782 Expressed in 94 organ(s), highest expression level in ectocervix
CleanExⁱ	HS_DDX47
ExpressionAtlasⁱ	Q9H0S4 baseline and differential
Genevisibleⁱ	Q9H0S4 HS

Family and domain databases

CDDⁱ	cd00079 HELICc, 1 hit
InterProⁱ	View protein in InterPro IPR011545 DEAD/DEAH_box_helicase_dom IPR014001 Helicase_ATP-bd IPR001650 Helicase_C IPR027417 P-loop_NTPase IPR000629 RNA-helicase_DEAD-box_CS IPR014014 RNA_helicase_DEAD_Q_motif
Pfamⁱ	View protein in Pfam PF00270 DEAD, 1 hit PF00271 Helicase_C, 1 hit
SMARTⁱ	View protein in SMART SM00487 DEXDc, 1 hit SM00490 HELICc, 1 hit
SUPFAMⁱ	SSF52540 SSF52540, 1 hit
PROSITEⁱ	View protein in PROSITE PS00039 DEAD_ATP_HELICASE, 1 hit PS51192 HELICASE_ATP_BIND_1, 1 hit PS51194 HELICASE_CTER, 1 hit PS51195 Q_MOTIF, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DDX47_HUMAN
Accessionⁱ	Q9H0S4Primary (citable) accession number: Q9H0S4 Secondary accession number(s): B3KXP4 , G5E955, Q96GM0, Q96NV8, Q9UI98
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	September 27, 2004
	Last sequence update:	March 1, 2001
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM

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Supporting data

UniProtKB - Q9H0S4 (DDX47_HUMAN)

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Probable ATP-dependent RNA helicase DDX47

DDX47

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ