UniProtKB - Q9H0R3 (TM222_HUMAN)
Protein
Transmembrane protein 222
Gene
TMEM222
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane protein 222 |
Gene namesi | Name:TMEM222 Synonyms:C1orf160 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25363, TMEM222 |
neXtProti | NX_Q9H0R3 |
VEuPathDBi | HostDB:ENSG00000186501.14 |
Subcellular locationi
Other locations
- Membrane Curated; Multi-pass membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 55 | ExtracellularSequence analysisAdd BLAST | 55 | |
Transmembranei | 56 – 76 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 77 – 164 | CytoplasmicSequence analysisAdd BLAST | 88 | |
Transmembranei | 165 – 185 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 186 | ExtracellularSequence analysis | 1 | |
Transmembranei | 187 – 207 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 208 | CytoplasmicSequence analysis | 1 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
PharmGKBi | PA162406598 |
Miscellaneous databases
Pharosi | Q9H0R3, Tdark |
Genetic variation databases
BioMutai | TMEM222 |
DMDMi | 112823989 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000247963 | 1 – 208 | Transmembrane protein 222Add BLAST | 208 |
Proteomic databases
EPDi | Q9H0R3 |
jPOSTi | Q9H0R3 |
MassIVEi | Q9H0R3 |
MaxQBi | Q9H0R3 |
PaxDbi | Q9H0R3 |
PeptideAtlasi | Q9H0R3 |
PRIDEi | Q9H0R3 |
ProteomicsDBi | 80314 [Q9H0R3-1] 80315 [Q9H0R3-2] |
PTM databases
iPTMneti | Q9H0R3 |
PhosphoSitePlusi | Q9H0R3 |
SwissPalmi | Q9H0R3 |
Expressioni
Gene expression databases
Bgeei | ENSG00000186501, Expressed in prostate gland and 235 other tissues |
ExpressionAtlasi | Q9H0R3, baseline and differential |
Genevisiblei | Q9H0R3, HS |
Organism-specific databases
HPAi | ENSG00000186501, Low tissue specificity |
Interactioni
Binary interactionsi
Hide detailsQ9H0R3
Protein-protein interaction databases
BioGRIDi | 123860, 47 interactors |
IntActi | Q9H0R3, 41 interactors |
STRINGi | 9606.ENSP00000483276 |
Miscellaneous databases
RNActi | Q9H0R3, protein |
Family & Domainsi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3150, Eukaryota |
GeneTreei | ENSGT00390000007371 |
InParanoidi | Q9H0R3 |
OrthoDBi | 1452247at2759 |
PhylomeDBi | Q9H0R3 |
TreeFami | TF105899 |
Family and domain databases
InterProi | View protein in InterPro IPR008496, TMEM222/RTE1 |
PANTHERi | PTHR20921, PTHR20921, 1 hit |
Pfami | View protein in Pfam PF05608, DUF778, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H0R3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAEAEGSSLL LLPPPPPPPR MAEVEAPTAA ETDMKQYQGS GGVAMDVERS
60 70 80 90 100
RFPYCVVWTP IPVLTWFFPI IGHMGICTST GVIRDFAGPY FVSEDNMAFG
110 120 130 140 150
KPAKYWKLDP AQVYASGPNA WDTAVHDASE EYKHRMHNLC CDNCHSHVAL
160 170 180 190 200
ALNLMRYNNS TNWNMVTLCF FCLLYGKYVS VGAFVKTWLP FILLLGIILT
VSLVFNLR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y861 | H0Y861_HUMAN | Chromosome 1 open reading frame 160... | TMEM222 C1orf160, hCG_96585 | 154 | Annotation score: | ||
Q5SSC2 | Q5SSC2_HUMAN | Transmembrane protein 222 | TMEM222 | 199 | Annotation score: | ||
H0Y870 | H0Y870_HUMAN | Transmembrane protein 222 | TMEM222 | 147 | Annotation score: | ||
Q8TDQ4 | Q8TDQ4_HUMAN | Transmembrane protein 222 | TMEM222 | 175 | Annotation score: | ||
H0Y8D0 | H0Y8D0_HUMAN | Transmembrane protein 222 | TMEM222 | 80 | Annotation score: | ||
H7C5C5 | H7C5C5_HUMAN | Transmembrane protein 222 | TMEM222 | 72 | Annotation score: |
Sequence cautioni
The sequence CAB66618 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 101 | K → E in BAD96362 (Ref. 5) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020090 | 1 – 96 | Missing in isoform 2. 1 PublicationAdd BLAST | 96 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO393419 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07764.1 CH471059 Genomic DNA Translation: EAX07766.1 BC011579 mRNA Translation: AAH11579.2 BC090039 mRNA Translation: AAH90039.1 AL136683 mRNA Translation: CAB66618.1 Different initiation. AK222642 mRNA Translation: BAD96362.1 |
CCDSi | CCDS297.2 [Q9H0R3-1] |
RefSeqi | NP_115501.2, NM_032125.2 [Q9H0R3-1] |
Genome annotation databases
Ensembli | ENST00000374076; ENSP00000363189; ENSG00000186501 [Q9H0R3-1] ENST00000611517; ENSP00000483276; ENSG00000186501 [Q9H0R3-1] |
GeneIDi | 84065 |
KEGGi | hsa:84065 |
UCSCi | uc001bnr.5, human [Q9H0R3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | FO393419 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX07764.1 CH471059 Genomic DNA Translation: EAX07766.1 BC011579 mRNA Translation: AAH11579.2 BC090039 mRNA Translation: AAH90039.1 AL136683 mRNA Translation: CAB66618.1 Different initiation. AK222642 mRNA Translation: BAD96362.1 |
CCDSi | CCDS297.2 [Q9H0R3-1] |
RefSeqi | NP_115501.2, NM_032125.2 [Q9H0R3-1] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 123860, 47 interactors |
IntActi | Q9H0R3, 41 interactors |
STRINGi | 9606.ENSP00000483276 |
PTM databases
iPTMneti | Q9H0R3 |
PhosphoSitePlusi | Q9H0R3 |
SwissPalmi | Q9H0R3 |
Genetic variation databases
BioMutai | TMEM222 |
DMDMi | 112823989 |
Proteomic databases
EPDi | Q9H0R3 |
jPOSTi | Q9H0R3 |
MassIVEi | Q9H0R3 |
MaxQBi | Q9H0R3 |
PaxDbi | Q9H0R3 |
PeptideAtlasi | Q9H0R3 |
PRIDEi | Q9H0R3 |
ProteomicsDBi | 80314 [Q9H0R3-1] 80315 [Q9H0R3-2] |
Protocols and materials databases
Antibodypediai | 54779, 92 antibodies |
DNASUi | 84065 |
Genome annotation databases
Ensembli | ENST00000374076; ENSP00000363189; ENSG00000186501 [Q9H0R3-1] ENST00000611517; ENSP00000483276; ENSG00000186501 [Q9H0R3-1] |
GeneIDi | 84065 |
KEGGi | hsa:84065 |
UCSCi | uc001bnr.5, human [Q9H0R3-1] |
Organism-specific databases
CTDi | 84065 |
GeneCardsi | TMEM222 |
HGNCi | HGNC:25363, TMEM222 |
HPAi | ENSG00000186501, Low tissue specificity |
neXtProti | NX_Q9H0R3 |
PharmGKBi | PA162406598 |
VEuPathDBi | HostDB:ENSG00000186501.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3150, Eukaryota |
GeneTreei | ENSGT00390000007371 |
InParanoidi | Q9H0R3 |
OrthoDBi | 1452247at2759 |
PhylomeDBi | Q9H0R3 |
TreeFami | TF105899 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0R3 |
Miscellaneous databases
BioGRID-ORCSi | 84065, 7 hits in 869 CRISPR screens |
ChiTaRSi | TMEM222, human |
GeneWikii | Transmembrane_protein_222 |
GenomeRNAii | 84065 |
Pharosi | Q9H0R3, Tdark |
PROi | PR:Q9H0R3 |
RNActi | Q9H0R3, protein |
Gene expression databases
Bgeei | ENSG00000186501, Expressed in prostate gland and 235 other tissues |
ExpressionAtlasi | Q9H0R3, baseline and differential |
Genevisiblei | Q9H0R3, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008496, TMEM222/RTE1 |
PANTHERi | PTHR20921, PTHR20921, 1 hit |
Pfami | View protein in Pfam PF05608, DUF778, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | TM222_HUMAN | |
Accessioni | Q9H0R3Primary (citable) accession number: Q9H0R3 Secondary accession number(s): D3DPL6, Q53HD8, Q5FVE9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | August 22, 2006 |
Last sequence update: | August 22, 2006 | |
Last modified: | February 10, 2021 | |
This is version 150 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM