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Entry version 141 (12 Aug 2020)
Sequence version 2 (03 Oct 2003)
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Protein

AP-5 complex subunit mu-1

Gene

AP5M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

As part of AP-5, a probable fifth adaptor protein complex it may be involved in endosomal transport. According to PubMed:18395520, it may play a role in cell death.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H0R1

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
Q9H0R1

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AP-5 complex subunit mu-1
Alternative name(s):
Adaptor-related protein complex 5 subunit mu-1
Short name:
Mu5
Mu-2-related death-inducing protein
Short name:
MuD
Putative HIV-1 infection-related protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AP5M1
Synonyms:C14orf108, MUDENG
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000053770.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:20192, AP5M1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
614368, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0R1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endosome, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55745

Open Targets

More...
OpenTargetsi
ENSG00000053770

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164723216

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0R1, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AP5M1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
37537844

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001937951 – 490AP-5 complex subunit mu-1Add BLAST490

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H0R1

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H0R1

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H0R1

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H0R1

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0R1

PeptideAtlas

More...
PeptideAtlasi
Q9H0R1

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0R1

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80312 [Q9H0R1-1]
80313 [Q9H0R1-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0R1

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0R1

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in various tumor cell lines including Jurkat, Hep-G2 and HeLa.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000053770, Expressed in jejunal mucosa and 240 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H0R1, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0R1, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000053770, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120863, 7 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-5181, AP-5 Adaptor complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H0R1

Database of interacting proteins

More...
DIPi
DIP-60180N

Protein interaction database and analysis system

More...
IntActi
Q9H0R1, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000261558

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H0R1, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini206 – 476MHDPROSITE-ProRule annotationAdd BLAST271

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0937, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000006191

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H0R1

KEGG Orthology (KO)

More...
KOi
K19023

Database of Orthologous Groups

More...
OrthoDBi
1481944at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0R1

TreeFam database of animal gene trees

More...
TreeFami
TF331963

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR039591, AP5M1
IPR028565, MHD

The PANTHER Classification System

More...
PANTHERi
PTHR16082, PTHR16082, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00928, Adap_comp_sub, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49447, SSF49447, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51072, MHD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0R1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQRAVWLIS HEPGTPLCGT VRFSRRYPTV EKRARVFNGA SYVPVPEDGP
60 70 80 90 100
FLKALLFELR LLDDDKDFVE SRDSCSRINK TSIYGLLIGG EELWPVVAFL
110 120 130 140 150
KNDMIYACVP LVEQTLSPRP PLISVSGVSQ GFEFLFGIQD FLYSGQKNDS
160 170 180 190 200
ELNTKLSQLP DLLLQACPFG TLLDANLQNS LDNTNFASVT QPQKQPAWKT
210 220 230 240 250
GTYKGKPQVS ISITEKVKSM QYDKQGIADT WQVVGTVTCK CDLEGIMPNV
260 270 280 290 300
TISLSLPTNG SPLQDILVHP CVTSLDSAIL TSSSIDAMDD SAFSGPYKFP
310 320 330 340 350
FTPPLESFNL CFYTSQVPVP PILGFYQMKE EEVQLRITIN LKLHESVKNN
360 370 380 390 400
FEFCEAHIPF YNRGPITHLE YKTSFGQLEV FREKSLLIWI IGQKFPKSME
410 420 430 440 450
ISLSGTVTFG AKSHEKQPFD PICTGETAYL KLHFRILDYT LTGCYADQHS
460 470 480 490
VQVFASGKPK ISAHRKLISS DYYIWNSKAP APVTYGSLLL
Length:490
Mass (Da):54,767
Last modified:October 3, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8B2FE622A2B8BD9
GO
Isoform 2 (identifier: Q9H0R1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-284: CDLEGIMPNV...LDSAILTSSS → VRFFSGTCFI...KQQFLNGRVM
     285-490: Missing.

Note: May be due to an intron retention.Curated
Show »
Length:284
Mass (Da):32,073
Checksum:i2294C5ED351ECB1B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQ45E7EQ45_HUMAN
AP-5 complex subunit mu-1
AP5M1
504Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R311S4R311_HUMAN
AP-5 complex subunit mu-1
AP5M1
93Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V573G3V573_HUMAN
AP-5 complex subunit mu-1
AP5M1
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YIY0H0YIY0_HUMAN
AP-5 complex subunit mu-1
AP5M1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3V3L4G3V3L4_HUMAN
AP-5 complex subunit mu-1
AP5M1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD18791 differs from that shown. Reason: Frameshift.Curated
The sequence BAD18791 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti319V → A in CAB66620 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055484226G → R. Corresponds to variant dbSNP:rs10137359Ensembl.1
Natural variantiVAR_055485379E → D. Corresponds to variant dbSNP:rs10140245Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_008407241 – 284CDLEG…LTSSS → VRFFSGTCFIVLFNIWRKVK FASCILNNIFYFHLKQQFLN GRVM in isoform 2. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_008408285 – 490Missing in isoform 2. 1 PublicationAdd BLAST206

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136685 mRNA Translation: CAB66620.1
AK001675 mRNA Translation: BAA91828.1
AK172824 mRNA Translation: BAD18791.1 Sequence problems.
BC013174 mRNA Translation: AAH13174.1
AF094583 mRNA Translation: AAC78130.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9729.1 [Q9H0R1-1]

NCBI Reference Sequences

More...
RefSeqi
NP_060699.3, NM_018229.3 [Q9H0R1-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000261558; ENSP00000261558; ENSG00000053770 [Q9H0R1-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55745

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55745

UCSC genome browser

More...
UCSCi
uc001xcv.4, human [Q9H0R1-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136685 mRNA Translation: CAB66620.1
AK001675 mRNA Translation: BAA91828.1
AK172824 mRNA Translation: BAD18791.1 Sequence problems.
BC013174 mRNA Translation: AAH13174.1
AF094583 mRNA Translation: AAC78130.1
CCDSiCCDS9729.1 [Q9H0R1-1]
RefSeqiNP_060699.3, NM_018229.3 [Q9H0R1-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi120863, 7 interactors
ComplexPortaliCPX-5181, AP-5 Adaptor complex
CORUMiQ9H0R1
DIPiDIP-60180N
IntActiQ9H0R1, 6 interactors
STRINGi9606.ENSP00000261558

PTM databases

iPTMnetiQ9H0R1
PhosphoSitePlusiQ9H0R1

Polymorphism and mutation databases

BioMutaiAP5M1
DMDMi37537844

Proteomic databases

EPDiQ9H0R1
jPOSTiQ9H0R1
MassIVEiQ9H0R1
MaxQBiQ9H0R1
PaxDbiQ9H0R1
PeptideAtlasiQ9H0R1
PRIDEiQ9H0R1
ProteomicsDBi80312 [Q9H0R1-1]
80313 [Q9H0R1-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
68208, 56 antibodies

Genome annotation databases

EnsembliENST00000261558; ENSP00000261558; ENSG00000053770 [Q9H0R1-1]
GeneIDi55745
KEGGihsa:55745
UCSCiuc001xcv.4, human [Q9H0R1-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55745
DisGeNETi55745
EuPathDBiHostDB:ENSG00000053770.11

GeneCards: human genes, protein and diseases

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GeneCardsi
AP5M1
HGNCiHGNC:20192, AP5M1
HPAiENSG00000053770, Low tissue specificity
MIMi614368, gene
neXtProtiNX_Q9H0R1
OpenTargetsiENSG00000053770
PharmGKBiPA164723216

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0937, Eukaryota
GeneTreeiENSGT00390000006191
InParanoidiQ9H0R1
KOiK19023
OrthoDBi1481944at2759
PhylomeDBiQ9H0R1
TreeFamiTF331963

Enzyme and pathway databases

PathwayCommonsiQ9H0R1
SignaLinkiQ9H0R1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55745, 1 hit in 869 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
AP5M1, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55745
PharosiQ9H0R1, Tdark

Protein Ontology

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PROi
PR:Q9H0R1
RNActiQ9H0R1, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000053770, Expressed in jejunal mucosa and 240 other tissues
ExpressionAtlasiQ9H0R1, baseline and differential
GenevisibleiQ9H0R1, HS

Family and domain databases

InterProiView protein in InterPro
IPR036168, AP2_Mu_C_sf
IPR039591, AP5M1
IPR028565, MHD
PANTHERiPTHR16082, PTHR16082, 1 hit
PfamiView protein in Pfam
PF00928, Adap_comp_sub, 1 hit
SUPFAMiSSF49447, SSF49447, 1 hit
PROSITEiView protein in PROSITE
PS51072, MHD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAP5M1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0R1
Secondary accession number(s): O95354
, Q6ZMD7, Q96DX3, Q9NVC5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: October 3, 2003
Last modified: August 12, 2020
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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