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Entry version 167 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

FXYD domain-containing ion transport regulator 6

Gene

FXYD6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9H0Q3

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5578775, Ion homeostasis
R-HSA-936837, Ion transport by P-type ATPases

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.27.1.3, the phospholemman (plm) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FXYD domain-containing ion transport regulator 6
Alternative name(s):
Phosphohippolin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FXYD6
ORF Names:UNQ521/PRO1056
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000137726.16

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4030, FXYD6

Online Mendelian Inheritance in Man (OMIM)

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MIMi
606683, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0Q3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini19 – 35ExtracellularSequence analysisAdd BLAST17
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 58HelicalSequence analysisAdd BLAST23
Topological domaini59 – 95CytoplasmicSequence analysisAdd BLAST37

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Schizophrenia

Organism-specific databases

DisGeNET

More...
DisGeNETi
53826

Open Targets

More...
OpenTargetsi
ENSG00000137726
ENSG00000255245

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28446

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0Q3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
FXYD6

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20138342

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 18By similarityAdd BLAST18
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001037219 – 95FXYD domain-containing ion transport regulator 6Add BLAST77

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H0Q3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H0Q3

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q9H0Q3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H0Q3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0Q3

PeptideAtlas

More...
PeptideAtlasi
Q9H0Q3

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0Q3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80311 [Q9H0Q3-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0Q3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0Q3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H0Q3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137726, Expressed in cerebellar vermis and 231 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q9H0Q3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q9H0Q3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000137726, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9H0Q3
With#Exp.IntAct
APCDD1L [Q8NCL9]3EBI-713304,EBI-12904424
APH1A [Q96BI3]3EBI-713304,EBI-2606935
AQP6 [Q13520]3EBI-713304,EBI-13059134
ARL13B [Q3SXY8]3EBI-713304,EBI-11343438
CD74 - isoform 2 [P04233-2]3EBI-713304,EBI-12222807
CERS4 [Q9HA82]3EBI-713304,EBI-2622997
CLDN7 [O95471]3EBI-713304,EBI-740744
CLEC10A [Q8IUN9]3EBI-713304,EBI-2873246
CREB3L1 [Q96BA8]6EBI-713304,EBI-6942903
DERL2 [Q9GZP9]3EBI-713304,EBI-7962814
EBP [Q15125]3EBI-713304,EBI-3915253
ELOVL2 [Q9NXB9]3EBI-713304,EBI-17206972
ELOVL4 [Q9GZR5]3EBI-713304,EBI-18535450
ERGIC3 [Q9Y282]3EBI-713304,EBI-781551
FFAR2 [O15552]3EBI-713304,EBI-2833872
FPR2 [P25090]3EBI-713304,EBI-17291771
GJA8 [P48165]3EBI-713304,EBI-17458373
GPR42 [O15529]3EBI-713304,EBI-18076404
JAGN1 [Q8N5M9]3EBI-713304,EBI-10266796
KCNJ6 [P48051]3EBI-713304,EBI-12017638
LHFPL2 [Q6ZUX7]3EBI-713304,EBI-17566767
LHFPL5 [Q8TAF8]3EBI-713304,EBI-2820517
MFF - isoform 5 [Q9GZY8-5]3EBI-713304,EBI-11956541
MGST3 [O14880]3EBI-713304,EBI-724754
MMGT1 [Q8N4V1]3EBI-713304,EBI-6163737
OCIAD1 [Q9NX40]3EBI-713304,EBI-2683029
PEX12 [O00623]3EBI-713304,EBI-594836
PGRMC2 [O15173]3EBI-713304,EBI-1050125
RHBDL1 [O75783]3EBI-713304,EBI-12104986
RHCG [Q9UBD6]3EBI-713304,EBI-15853497
RNASEK [Q6P5S7]3EBI-713304,EBI-18397230
SLC10A1 [Q14973]3EBI-713304,EBI-3923031
SLC10A6 [Q3KNW5]3EBI-713304,EBI-18159983
SLC16A7 [O60669]3EBI-713304,EBI-3921243
SLC30A2 [Q9BRI3]3EBI-713304,EBI-8644112
SLC35C2 - isoform 3 [Q9NQQ7-3]3EBI-713304,EBI-17295964
SLC35E3 [Q7Z769]3EBI-713304,EBI-13389236
SLC39A2 [Q9NP94]3EBI-713304,EBI-12898013
SLC47A1 [Q96FL8]3EBI-713304,EBI-12887226
SVOP [Q8N4V2]4EBI-713304,EBI-12883142
TLCD4 [Q96MV1]3EBI-713304,EBI-12947623
TM4SF18 [Q96CE8]3EBI-713304,EBI-13351685
TMEM154 [Q6P9G4]3EBI-713304,EBI-13329239
TMEM237 - isoform 2 [Q96Q45-2]3EBI-713304,EBI-10982110
TMEM239 - isoform 2 [Q8WW34-2]3EBI-713304,EBI-11528917
TMEM35A [Q53FP2]3EBI-713304,EBI-11722971
TMEM72 [A0PK05]3EBI-713304,EBI-12878352
TMEM86B [Q8N661]3EBI-713304,EBI-2548832
TMPPE [Q6ZT21]3EBI-713304,EBI-11724433

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119799, 34 interactors

Protein interaction database and analysis system

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IntActi
Q9H0Q3, 69 interactors

Molecular INTeraction database

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MINTi
Q9H0Q3

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H0Q3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H0Q3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the FXYD family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153062

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_171208_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H0Q3

KEGG Orthology (KO)

More...
KOi
K13363

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0Q3

TreeFam database of animal gene trees

More...
TreeFami
TF333443

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000272, Ion-transport_regulator_FXYD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02038, ATP1G1_PLM_MAT8, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01310, FXYD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0Q3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MELVLVFLCS LLAPMVLASA AEKEKEMDPF HYDYQTLRIG GLVFAVVLFS
60 70 80 90
VGILLILSRR CKCSFNQKPR APGDEEAQVE NLITANATEP QKAEN
Length:95
Mass (Da):10,542
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3F083146A42422CE
GO
Isoform 2 (identifier: Q9H0Q3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     58-95: SRRCKCSFNQ...NATEPQKAEN → RPQEMRKPRW...LWQKIPLWGQ

Show »
Length:112
Mass (Da):12,769
Checksum:i8DA3A17AA5C551D1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PHZ3E9PHZ3_HUMAN
FXYD domain-containing ion transpor...
FXYD6
111Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKN1J3QKN1_HUMAN
FXYD domain-containing ion transpor...
FXYD6 hCG_41157
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ02E9PJ02_HUMAN
FXYD domain-containing ion transpor...
FXYD6
90Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAQ89335 differs from that shown. Reason: Frameshift.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04599658 – 95SRRCK…QKAEN → RPQEMRKPRWRTSSPPMQQS PRKQRTEVQPSGGRRQPQGG RGPVLLWQKIPLWGQ in isoform 2. 1 PublicationAdd BLAST38

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136699 mRNA Translation: CAB66634.1
AY358976 mRNA Translation: AAQ89335.1 Frameshift.
BT006717 mRNA Translation: AAP35363.1
CN310658 mRNA No translation available.
CR533457 mRNA Translation: CAG38488.1
AK289629 mRNA Translation: BAF82318.1
AK290757 mRNA Translation: BAF83446.1
AL832811 mRNA Translation: CAI46171.1
AP000757 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67327.1
BC018652 mRNA Translation: AAH18652.1
BC093040 mRNA Translation: AAH93040.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8387.1 [Q9H0Q3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001158303.1, NM_001164831.2 [Q9H0Q3-1]
NP_001158304.1, NM_001164832.2 [Q9H0Q3-1]
NP_001158308.1, NM_001164836.2 [Q9H0Q3-1]
NP_001158309.1, NM_001164837.2 [Q9H0Q3-1]
NP_071286.1, NM_022003.3 [Q9H0Q3-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000260282; ENSP00000260282; ENSG00000137726 [Q9H0Q3-1]
ENST00000524656; ENSP00000431427; ENSG00000137726 [Q9H0Q3-1]
ENST00000526014; ENSP00000433312; ENSG00000137726 [Q9H0Q3-1]
ENST00000527717; ENSP00000431446; ENSG00000137726 [Q9H0Q3-1]
ENST00000530956; ENSP00000463158; ENSG00000137726 [Q9H0Q3-1]
ENST00000539526; ENSP00000442756; ENSG00000137726 [Q9H0Q3-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
53826

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:53826

UCSC genome browser

More...
UCSCi
uc001pro.3, human [Q9H0Q3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136699 mRNA Translation: CAB66634.1
AY358976 mRNA Translation: AAQ89335.1 Frameshift.
BT006717 mRNA Translation: AAP35363.1
CN310658 mRNA No translation available.
CR533457 mRNA Translation: CAG38488.1
AK289629 mRNA Translation: BAF82318.1
AK290757 mRNA Translation: BAF83446.1
AL832811 mRNA Translation: CAI46171.1
AP000757 Genomic DNA No translation available.
CH471065 Genomic DNA Translation: EAW67327.1
BC018652 mRNA Translation: AAH18652.1
BC093040 mRNA Translation: AAH93040.1
CCDSiCCDS8387.1 [Q9H0Q3-1]
RefSeqiNP_001158303.1, NM_001164831.2 [Q9H0Q3-1]
NP_001158304.1, NM_001164832.2 [Q9H0Q3-1]
NP_001158308.1, NM_001164836.2 [Q9H0Q3-1]
NP_001158309.1, NM_001164837.2 [Q9H0Q3-1]
NP_071286.1, NM_022003.3 [Q9H0Q3-1]

3D structure databases

SMRiQ9H0Q3
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi119799, 34 interactors
IntActiQ9H0Q3, 69 interactors
MINTiQ9H0Q3

Protein family/group databases

TCDBi1.A.27.1.3, the phospholemman (plm) family

PTM databases

iPTMnetiQ9H0Q3
PhosphoSitePlusiQ9H0Q3
SwissPalmiQ9H0Q3

Polymorphism and mutation databases

BioMutaiFXYD6
DMDMi20138342

Proteomic databases

EPDiQ9H0Q3
jPOSTiQ9H0Q3
MassIVEiQ9H0Q3
MaxQBiQ9H0Q3
PaxDbiQ9H0Q3
PeptideAtlasiQ9H0Q3
PRIDEiQ9H0Q3
ProteomicsDBi80311 [Q9H0Q3-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
45759, 118 antibodies

The DNASU plasmid repository

More...
DNASUi
53826

Genome annotation databases

EnsembliENST00000260282; ENSP00000260282; ENSG00000137726 [Q9H0Q3-1]
ENST00000524656; ENSP00000431427; ENSG00000137726 [Q9H0Q3-1]
ENST00000526014; ENSP00000433312; ENSG00000137726 [Q9H0Q3-1]
ENST00000527717; ENSP00000431446; ENSG00000137726 [Q9H0Q3-1]
ENST00000530956; ENSP00000463158; ENSG00000137726 [Q9H0Q3-1]
ENST00000539526; ENSP00000442756; ENSG00000137726 [Q9H0Q3-1]
GeneIDi53826
KEGGihsa:53826
UCSCiuc001pro.3, human [Q9H0Q3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
53826
DisGeNETi53826
EuPathDBiHostDB:ENSG00000137726.16

GeneCards: human genes, protein and diseases

More...
GeneCardsi
FXYD6
HGNCiHGNC:4030, FXYD6
HPAiENSG00000137726, Tissue enhanced (brain)
MIMi606683, gene
neXtProtiNX_Q9H0Q3
OpenTargetsiENSG00000137726
ENSG00000255245
PharmGKBiPA28446

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00940000153062
HOGENOMiCLU_171208_3_0_1
InParanoidiQ9H0Q3
KOiK13363
PhylomeDBiQ9H0Q3
TreeFamiTF333443

Enzyme and pathway databases

PathwayCommonsiQ9H0Q3
ReactomeiR-HSA-5578775, Ion homeostasis
R-HSA-936837, Ion transport by P-type ATPases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
53826, 11 hits in 860 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
FXYD6, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
53826
PharosiQ9H0Q3, Tbio

Protein Ontology

More...
PROi
PR:Q9H0Q3
RNActiQ9H0Q3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137726, Expressed in cerebellar vermis and 231 other tissues
ExpressionAtlasiQ9H0Q3, baseline and differential
GenevisibleiQ9H0Q3, HS

Family and domain databases

InterProiView protein in InterPro
IPR000272, Ion-transport_regulator_FXYD
PfamiView protein in Pfam
PF02038, ATP1G1_PLM_MAT8, 1 hit
PROSITEiView protein in PROSITE
PS01310, FXYD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFXYD6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0Q3
Secondary accession number(s): A8K0R4
, J3QLD2, Q6FIG9, Q6UW52
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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