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Protein

Protein FAM49A

Gene

FAM49A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM49A
Gene namesi
Name:FAM49A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000197872.11
HGNCiHGNC:25373 FAM49A
neXtProtiNX_Q9H0Q0

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi81553
OpenTargetsiENSG00000197872
PharmGKBiPA128394730

Polymorphism and mutation databases

BioMutaiFAM49A
DMDMi52782791

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870581 – 323Protein FAM49AAdd BLAST323

Proteomic databases

EPDiQ9H0Q0
MaxQBiQ9H0Q0
PaxDbiQ9H0Q0
PeptideAtlasiQ9H0Q0
PRIDEiQ9H0Q0
ProteomicsDBi80310

PTM databases

iPTMnetiQ9H0Q0
PhosphoSitePlusiQ9H0Q0
SwissPalmiQ9H0Q0

Expressioni

Gene expression databases

BgeeiENSG00000197872 Expressed in 196 organ(s), highest expression level in neocortex
CleanExiHS_FAM49A
ExpressionAtlasiQ9H0Q0 baseline and differential
GenevisibleiQ9H0Q0 HS

Organism-specific databases

HPAiCAB017847
HPA060398

Interactioni

Protein-protein interaction databases

BioGridi123517, 1 interactor
STRINGi9606.ENSP00000347744

Structurei

3D structure databases

ProteinModelPortaliQ9H0Q0
SMRiQ9H0Q0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM49 family.Curated

Phylogenomic databases

eggNOGiKOG3951 Eukaryota
ENOG410XQDW LUCA
GeneTreeiENSGT00390000015159
HOGENOMiHOG000007560
HOVERGENiHBG057586
InParanoidiQ9H0Q0
OMAiIRIKECI
OrthoDBiEOG091G0KGM
PhylomeDBiQ9H0Q0
TreeFamiTF314541

Family and domain databases

InterProiView protein in InterPro
IPR009828 DUF1394
IPR039789 FAM49
PANTHERiPTHR12422 PTHR12422, 1 hit
PfamiView protein in Pfam
PF07159 DUF1394, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H0Q0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNLLKVLTR EIENYPHFFL DFENAQPTEG EREIWNQISA VLQDSESILA
60 70 80 90 100
DLQAYKGAGP EIRDAIQNPN DIQLQEKAWN AVCPLVVRLK RFYEFSIRLE
110 120 130 140 150
KALQSLLESL TCPPYTPTQH LEREQALAKE FAEILHFTLR FDELKMRNPA
160 170 180 190 200
IQNDFSYYRR TISRNRINNM HLDIENEVNN EMANRMSLFY AEATPMLKTL
210 220 230 240 250
SNATMHFVSE NKTLPIENTT DCLSTMTSVC KVMLETPEYR SRFTSEETLM
260 270 280 290 300
FCMRVMVGVI ILYDHVHPVG AFCKTSKIDM KGCIKVLKEQ APDSVEGLLN
310 320
ALRFTTKHLN DESTSKQIRA MLQ
Length:323
Mass (Da):37,313
Last modified:March 1, 2001 - v1
Checksum:i21B0CD613FFD6BD5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9IYV6C9IYV6_HUMAN
Protein FAM49A
FAM49A
94Annotation score:
C9JPE5C9JPE5_HUMAN
Protein FAM49A
FAM49A
87Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti29E → D in BAG51503 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136704 mRNA Translation: CAB66639.1
AK055334 mRNA Translation: BAG51503.1
AK315065 mRNA Translation: BAG37539.1
CR533504 mRNA Translation: CAG38535.1
AC104623 Genomic DNA Translation: AAY24282.1
CH471053 Genomic DNA Translation: EAX00879.1
BC038971 mRNA Translation: AAH38971.1
CCDSiCCDS1688.1
RefSeqiNP_110424.1, NM_030797.3
XP_005262687.1, XM_005262630.3
XP_006712171.1, XM_006712108.3
UniGeneiHs.467769

Genome annotation databases

EnsembliENST00000381323; ENSP00000370724; ENSG00000197872
ENST00000406434; ENSP00000384771; ENSG00000197872
GeneIDi81553
KEGGihsa:81553
UCSCiuc002rck.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136704 mRNA Translation: CAB66639.1
AK055334 mRNA Translation: BAG51503.1
AK315065 mRNA Translation: BAG37539.1
CR533504 mRNA Translation: CAG38535.1
AC104623 Genomic DNA Translation: AAY24282.1
CH471053 Genomic DNA Translation: EAX00879.1
BC038971 mRNA Translation: AAH38971.1
CCDSiCCDS1688.1
RefSeqiNP_110424.1, NM_030797.3
XP_005262687.1, XM_005262630.3
XP_006712171.1, XM_006712108.3
UniGeneiHs.467769

3D structure databases

ProteinModelPortaliQ9H0Q0
SMRiQ9H0Q0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123517, 1 interactor
STRINGi9606.ENSP00000347744

PTM databases

iPTMnetiQ9H0Q0
PhosphoSitePlusiQ9H0Q0
SwissPalmiQ9H0Q0

Polymorphism and mutation databases

BioMutaiFAM49A
DMDMi52782791

Proteomic databases

EPDiQ9H0Q0
MaxQBiQ9H0Q0
PaxDbiQ9H0Q0
PeptideAtlasiQ9H0Q0
PRIDEiQ9H0Q0
ProteomicsDBi80310

Protocols and materials databases

DNASUi81553
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000381323; ENSP00000370724; ENSG00000197872
ENST00000406434; ENSP00000384771; ENSG00000197872
GeneIDi81553
KEGGihsa:81553
UCSCiuc002rck.3 human

Organism-specific databases

CTDi81553
DisGeNETi81553
EuPathDBiHostDB:ENSG00000197872.11
GeneCardsiFAM49A
HGNCiHGNC:25373 FAM49A
HPAiCAB017847
HPA060398
neXtProtiNX_Q9H0Q0
OpenTargetsiENSG00000197872
PharmGKBiPA128394730
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3951 Eukaryota
ENOG410XQDW LUCA
GeneTreeiENSGT00390000015159
HOGENOMiHOG000007560
HOVERGENiHBG057586
InParanoidiQ9H0Q0
OMAiIRIKECI
OrthoDBiEOG091G0KGM
PhylomeDBiQ9H0Q0
TreeFamiTF314541

Miscellaneous databases

ChiTaRSiFAM49A human
GeneWikiiFAM49A
GenomeRNAii81553
PROiPR:Q9H0Q0

Gene expression databases

BgeeiENSG00000197872 Expressed in 196 organ(s), highest expression level in neocortex
CleanExiHS_FAM49A
ExpressionAtlasiQ9H0Q0 baseline and differential
GenevisibleiQ9H0Q0 HS

Family and domain databases

InterProiView protein in InterPro
IPR009828 DUF1394
IPR039789 FAM49
PANTHERiPTHR12422 PTHR12422, 1 hit
PfamiView protein in Pfam
PF07159 DUF1394, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFA49A_HUMAN
AccessioniPrimary (citable) accession number: Q9H0Q0
Secondary accession number(s): B3KNZ1, Q53QW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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