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Protein

Ras-related protein Rab-6C

Gene

RAB6C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of centrosome duplication and cell cycle progression.3 Publications

Miscellaneous

Primate-specific retrogene derived from isoform 2 of RAB6A transcript.
Previously reported to exhibit GTP-binding affinity comparable to that of RAB6A (PubMed:16103095). In contrast (PubMed:20064528) concludes that RAB6C is an inefficient GTP-binding.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi20 – 27GTPBy similarity8
Nucleotide bindingi68 – 72GTPBy similarity5
Nucleotide bindingi126 – 129GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • intra-Golgi vesicle-mediated transport Source: GO_Central
  • mitotic cell cycle Source: GO_Central
  • regulation of centrosome duplication Source: UniProtKB
  • response to drug Source: UniProtKB
  • retrograde transport, endosome to Golgi Source: GO_Central
  • retrograde vesicle-mediated transport, Golgi to ER Source: GO_Central
  • small GTPase mediated signal transduction Source: UniProtKB

Keywordsi

LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-6C
Alternative name(s):
Rab6-like protein WTH3
Gene namesi
Name:RAB6C
Synonyms:WTH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000222014.5
HGNCiHGNC:16525 RAB6C
MIMi612909 gene
neXtProtiNX_Q9H0N0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi25A → G: No GTP binding. No GTP binding; when associated with T-45. 1 Publication1
Mutagenesisi45I → T: No GTP binding; when associated with G-25. 1 Publication1

Organism-specific databases

DisGeNETi84084
OpenTargetsiENSG00000222014
PharmGKBiPA34148

Polymorphism and mutation databases

BioMutaiRAB6C
DMDMi166214970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211171 – 254Ras-related protein Rab-6CAdd BLAST254

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei82O-AMP-tyrosine; by Legionella DrrA1 Publication1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0N0
MaxQBiQ9H0N0
PaxDbiQ9H0N0
PeptideAtlasiQ9H0N0
PRIDEiQ9H0N0
ProteomicsDBi80303
TopDownProteomicsiQ9H0N0

PTM databases

iPTMnetiQ9H0N0
PhosphoSitePlusiQ9H0N0

Expressioni

Tissue specificityi

Highest levels are found in fetal and adult brain, prostate, testis and spinal cord. Undetectable expression in adrenal gland, skeletal muscle, bone marrow, fetal, and adult liver, heart, salivary gland, and trachea. Detected in the HEK293, HEK293T, LNCaP, MCF-7, T-47D and EVSA-T cell lines (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000222014
GenevisibleiQ9H0N0 HS

Organism-specific databases

HPAiHPA059131

Interactioni

Protein-protein interaction databases

BioGridi123878, 7 interactors
IntActiQ9H0N0, 5 interactors
MINTiQ9H0N0
STRINGi9606.ENSP00000387307

Structurei

3D structure databases

ProteinModelPortaliQ9H0N0
SMRiQ9H0N0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 174Required for centrosome localizationAdd BLAST174

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094 Eukaryota
ENOG410XPBI LUCA
GeneTreeiENSGT00910000144073
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ9H0N0
KOiK07895
OMAiPNIVIMN
OrthoDBiEOG091G0ORZ
PhylomeDBiQ9H0N0
TreeFamiTF300803

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H0N0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAGGDFGNP LRKFKLVFLG EQSVAKTSLI TRFRYDSFDN TYQAIIGIDF
60 70 80 90 100
LSKTMYLEDG TIGLRLWDTA GQERLRSLIP RYIRDSAAAV VVYDITNVNS
110 120 130 140 150
FQQTTKWIDD VRTERGSDVI ITLVGNRTDL ADKRQVSVEE GERKAKGLNV
160 170 180 190 200
TFIETRAKAG YNVKQLFRRV AAALPGMEST QDGSREDMSD IKLEKPQEQT
210 220 230 240 250
VSEGGCSCYS PMSSSTLPQK PPYSFIDCSV NIGLNLFPSL ITFCNSSLLP

VSWR
Length:254
Mass (Da):28,355
Last modified:January 15, 2008 - v2
Checksum:i72A4D8DED771F754
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_038161159A → T5 PublicationsCorresponds to variant dbSNP:rs4662674Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309646 mRNA Translation: AAN39685.1
AL136727 mRNA Translation: CAB66661.1
CR533469 mRNA Translation: CAG38500.1
AC079776 Genomic DNA Translation: AAY15045.1
CH471103 Genomic DNA Translation: EAW95362.1
CH471058 Genomic DNA Translation: EAX11700.1
BC120999 mRNA Translation: AAI21000.1
AF124200 Genomic DNA Translation: AAF28422.1
CCDSiCCDS46408.1
RefSeqiNP_115520.2, NM_032144.2
UniGeneiHs.591552

Genome annotation databases

EnsembliENST00000410061; ENSP00000387307; ENSG00000222014
GeneIDi84084
KEGGihsa:84084
UCSCiuc002tpx.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRAB6C_HUMAN
AccessioniPrimary (citable) accession number: Q9H0N0
Secondary accession number(s): Q53RU3, Q6FIF7, Q9P128
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2003
Last sequence update: January 15, 2008
Last modified: June 20, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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