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Entry version 150 (12 Aug 2020)
Sequence version 2 (14 Oct 2008)
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Protein

Zinc finger CW-type PWWP domain protein 1

Gene

ZCWPW1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri250 – 304CW-typePROSITE-ProRule annotationAdd BLAST55

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H0M4

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CW-type PWWP domain protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZCWPW1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078487.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23486, ZCWPW1

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0M4

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
55063

Open Targets

More...
OpenTargetsi
ENSG00000078487

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134913967

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0M4, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZCWPW1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
209572701

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000665671 – 648Zinc finger CW-type PWWP domain protein 1Add BLAST648

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei636PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H0M4

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0M4

PeptideAtlas

More...
PeptideAtlasi
Q9H0M4

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0M4

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
5202
80298 [Q9H0M4-1]
80299 [Q9H0M4-2]
80300 [Q9H0M4-3]
80301 [Q9H0M4-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0M4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0M4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078487, Expressed in right testis and 160 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H0M4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0M4, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000078487, Tissue enhanced (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
120381, 5 interactors

Database of interacting proteins

More...
DIPi
DIP-59044N

Protein interaction database and analysis system

More...
IntActi
Q9H0M4, 5 interactors

Molecular INTeraction database

More...
MINTi
Q9H0M4

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000381109

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H0M4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1648
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H0M4

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H0M4

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini317 – 383PWWPPROSITE-ProRule annotationAdd BLAST67

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili74 – 109Sequence analysisAdd BLAST36

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri250 – 304CW-typePROSITE-ProRule annotationAdd BLAST55

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QSQZ, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00560000077278

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_029321_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H0M4

Identification of Orthologs from Complete Genome Data

More...
OMAi
CLETSCA

Database of Orthologous Groups

More...
OrthoDBi
1159953at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0M4

TreeFam database of animal gene trees

More...
TreeFami
TF336904

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000313, PWWP_dom
IPR042778, ZCWPW1/ZCWPW2
IPR011124, Znf_CW

The PANTHER Classification System

More...
PANTHERi
PTHR15999, PTHR15999, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00855, PWWP, 1 hit
PF07496, zf-CW, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00293, PWWP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50812, PWWP, 1 hit
PS51050, ZF_CW, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0M4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MMTTLQNKEE CGKGPKRIFA PPAQKSYSLL PCSPNSPKEE TPGISSPETE
60 70 80 90 100
ARISLPKASL KKKEEKATMK NVPSREQEKK RKAQINKQAE KKEKEKSSLT
110 120 130 140 150
NAEFEEIVQI VLQKSLQECL GMGSGLDFAE TSCAQPVVST QSDKEPGITA
160 170 180 190 200
SATDTDNANG EEVPHTQEIS VSWEGEAAPE IRTSKLGQPD PAPSKKKSNR
210 220 230 240 250
LTLSKRKKEA HEKVEKTQGG HEHRQEDRLK KTVQDHSQIR DQQKGEISGF
260 270 280 290 300
GQCLVWVQCS FPNCGKWRRL CGNIDPSVLP DNWSCDQNTD VQYNRCDIPE
310 320 330 340 350
ETWTGLESDV AYASYIPGSI IWAKQYGYPW WPGMIESDPD LGEYFLFTSH
360 370 380 390 400
LDSLPSKYHV TFFGETVSRA WIPVNMLKNF QELSLELSVM KKRRNDCSQK
410 420 430 440 450
LGVALMMAQE AEQISIQERV NLFGFWSRFN GSNSNGERKD LQLSGLNSPG
460 470 480 490 500
SCLEKKEKEE ELEKEEGEKT DPILPIRKRV KIQTQKTKPR GLGGDAGTAD
510 520 530 540 550
GRGRTLQRKI MKRSLGRKST APPAPRMGRK EGQGNSDSDQ PGPKKKFKAP
560 570 580 590 600
QSKALAASFS EGKEVRTVPK NLGLSACKGA CPSSAKEEPR HREPLTQEAG
610 620 630 640
SVPLEDEASS DLDLEQLMED VGRELGQSGE LQHSNSDGED FPVALFGK
Length:648
Mass (Da):72,007
Last modified:October 14, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4F267947AC00B1B4
GO
Isoform 2 (identifier: Q9H0M4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     289-289: T → TA
     453-466: LEKKEKEEELEKEE → TQNGKERRPREFRF
     467-648: Missing.

Show »
Length:468
Mass (Da):52,707
Checksum:i4C4FB22E68EBAB5C
GO
Isoform 3 (identifier: Q9H0M4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Show »
Length:403
Mass (Da):45,754
Checksum:i1B5D2124275EF437
GO
Isoform 4 (identifier: Q9H0M4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     211-211: H → QD
     491-541: Missing.

Show »
Length:477
Mass (Da):53,255
Checksum:i11CE8B21646182C3
GO
Isoform 5 (identifier: Q9H0M4-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     211-211: H → QD
     471-523: DPILPIRKRV...SLGRKSTAPP → ALRKNLKLPR...RKKSPDTGNP
     524-648: Missing.

Show »
Length:524
Mass (Da):59,308
Checksum:i181EF4397C263B80
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C4V9H7C4V9_HUMAN
Zinc finger CW-type PWWP domain pro...
ZCWPW1
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JUV7C9JUV7_HUMAN
Zinc finger CW-type PWWP domain pro...
ZCWPW1
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB66669 differs from that shown. Reason: Frameshift.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_019659153T → A2 PublicationsCorresponds to variant dbSNP:rs6465770Ensembl.1
Natural variantiVAR_047050365E → K. Corresponds to variant dbSNP:rs6970350Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0114311 – 121Missing in isoform 3 and isoform 4. 2 PublicationsAdd BLAST121
Alternative sequenceiVSP_011432211H → QD in isoform 2, isoform 3, isoform 4 and isoform 5. 2 Publications1
Alternative sequenceiVSP_011433289T → TA in isoform 2. 1 Publication1
Alternative sequenceiVSP_011434453 – 466LEKKE…LEKEE → TQNGKERRPREFRF in isoform 2. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_035590467 – 648Missing in isoform 2. 1 PublicationAdd BLAST182
Alternative sequenceiVSP_011436471 – 523DPILP…STAPP → ALRKNLKLPRARPWQPAFQR EKKLEQCQRTWAYQRVRGPA PHLRKKSPDTGNP in isoform 3 and isoform 5. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_035591491 – 541Missing in isoform 4. 1 PublicationAdd BLAST51
Alternative sequenceiVSP_035592524 – 648Missing in isoform 3 and isoform 5. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136735 mRNA Translation: CAB66669.1 Frameshift.
AK000919 mRNA Translation: BAA91424.1
AK093038 mRNA Translation: BAC04028.1
AK300745 mRNA Translation: BAG62414.1
AC005071 Genomic DNA No translation available.
AC092849 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76540.1
CH471091 Genomic DNA Translation: EAW76541.1
BC002725 mRNA Translation: AAH02725.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS43623.1 [Q9H0M4-1]
CCDS59067.1 [Q9H0M4-5]

NCBI Reference Sequences

More...
RefSeqi
NP_001244937.1, NM_001258008.1 [Q9H0M4-5]
NP_060454.3, NM_017984.4 [Q9H0M4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000360951; ENSP00000354210; ENSG00000078487 [Q9H0M4-5]
ENST00000398027; ENSP00000381109; ENSG00000078487 [Q9H0M4-1]
ENST00000490721; ENSP00000419187; ENSG00000078487 [Q9H0M4-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
55063

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:55063

UCSC genome browser

More...
UCSCi
uc003uus.4, human [Q9H0M4-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136735 mRNA Translation: CAB66669.1 Frameshift.
AK000919 mRNA Translation: BAA91424.1
AK093038 mRNA Translation: BAC04028.1
AK300745 mRNA Translation: BAG62414.1
AC005071 Genomic DNA No translation available.
AC092849 Genomic DNA No translation available.
CH471091 Genomic DNA Translation: EAW76540.1
CH471091 Genomic DNA Translation: EAW76541.1
BC002725 mRNA Translation: AAH02725.1
CCDSiCCDS43623.1 [Q9H0M4-1]
CCDS59067.1 [Q9H0M4-5]
RefSeqiNP_001244937.1, NM_001258008.1 [Q9H0M4-5]
NP_060454.3, NM_017984.4 [Q9H0M4-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2E61NMR-A246-307[»]
2RR4NMR-A246-307[»]
SMRiQ9H0M4
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi120381, 5 interactors
DIPiDIP-59044N
IntActiQ9H0M4, 5 interactors
MINTiQ9H0M4
STRINGi9606.ENSP00000381109

PTM databases

iPTMnetiQ9H0M4
PhosphoSitePlusiQ9H0M4

Polymorphism and mutation databases

BioMutaiZCWPW1
DMDMi209572701

Proteomic databases

MassIVEiQ9H0M4
PaxDbiQ9H0M4
PeptideAtlasiQ9H0M4
PRIDEiQ9H0M4
ProteomicsDBi5202
80298 [Q9H0M4-1]
80299 [Q9H0M4-2]
80300 [Q9H0M4-3]
80301 [Q9H0M4-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
8914, 66 antibodies

Genome annotation databases

EnsembliENST00000360951; ENSP00000354210; ENSG00000078487 [Q9H0M4-5]
ENST00000398027; ENSP00000381109; ENSG00000078487 [Q9H0M4-1]
ENST00000490721; ENSP00000419187; ENSG00000078487 [Q9H0M4-4]
GeneIDi55063
KEGGihsa:55063
UCSCiuc003uus.4, human [Q9H0M4-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
55063
DisGeNETi55063
EuPathDBiHostDB:ENSG00000078487.17

GeneCards: human genes, protein and diseases

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GeneCardsi
ZCWPW1
HGNCiHGNC:23486, ZCWPW1
HPAiENSG00000078487, Tissue enhanced (testis)
neXtProtiNX_Q9H0M4
OpenTargetsiENSG00000078487
PharmGKBiPA134913967

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QSQZ, Eukaryota
GeneTreeiENSGT00560000077278
HOGENOMiCLU_029321_1_0_1
InParanoidiQ9H0M4
OMAiCLETSCA
OrthoDBi1159953at2759
PhylomeDBiQ9H0M4
TreeFamiTF336904

Enzyme and pathway databases

PathwayCommonsiQ9H0M4

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
55063, 11 hits in 874 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZCWPW1, human
EvolutionaryTraceiQ9H0M4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
55063
PharosiQ9H0M4, Tdark

Protein Ontology

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PROi
PR:Q9H0M4
RNActiQ9H0M4, protein

Gene expression databases

BgeeiENSG00000078487, Expressed in right testis and 160 other tissues
ExpressionAtlasiQ9H0M4, baseline and differential
GenevisibleiQ9H0M4, HS

Family and domain databases

InterProiView protein in InterPro
IPR000313, PWWP_dom
IPR042778, ZCWPW1/ZCWPW2
IPR011124, Znf_CW
PANTHERiPTHR15999, PTHR15999, 1 hit
PfamiView protein in Pfam
PF00855, PWWP, 1 hit
PF07496, zf-CW, 1 hit
SMARTiView protein in SMART
SM00293, PWWP, 1 hit
PROSITEiView protein in PROSITE
PS50812, PWWP, 1 hit
PS51050, ZF_CW, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCPW1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0M4
Secondary accession number(s): A8MVF5
, B4DUQ2, Q8NA98, Q9BUD0, Q9NWF7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: October 14, 2008
Last modified: August 12, 2020
This is version 150 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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