UniProtKB - Q9H0M0 (WWP1_HUMAN)
NEDD4-like E3 ubiquitin-protein ligase WWP1
WWP1
Functioni
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates ERBB4 isoforms JM-A CYT-1 and JM-B CYT-1, KLF2, KLF5 and TP63 and promotes their proteasomal degradation. Ubiquitinates RNF11 without targeting it for degradation. Ubiquitinates and promotes degradation of TGFBR1; the ubiquitination is enhanced by SMAD7. Ubiquitinates SMAD6 and SMAD7. Ubiquitinates and promotes degradation of SMAD2 in response to TGF-beta signaling, which requires interaction with TGIF.
3 PublicationsCatalytic activityi
- S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.26
Activity regulationi
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 890 | Glycyl thioester intermediatePROSITE-ProRule annotation | 1 | |
Sitei | 890 | Required for ubiquitin-thioester formationBy similarity | 1 |
GO - Molecular functioni
- ubiquitin protein ligase activity Source: GO_Central
- ubiquitin-protein transferase activity Source: UniProtKB
GO - Biological processi
- central nervous system development Source: UniProtKB
- ion transmembrane transport Source: Reactome
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of protein catabolic process Source: GO_Central
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: GO_Central
- protein polyubiquitination Source: GO_Central
- protein ubiquitination Source: GO_Central
- signal transduction Source: UniProtKB
- viral entry into host cell Source: UniProtKB
Keywordsi
Molecular function | Transferase |
Biological process | Host-virus interaction, Ubl conjugation pathway |
Enzyme and pathway databases
BRENDAi | 2.3.2.26, 2681 |
PathwayCommonsi | Q9H0M0 |
Reactomei | R-HSA-1253288, Downregulation of ERBB4 signaling R-HSA-2672351, Stimuli-sensing channels R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9H0M0 |
SIGNORi | Q9H0M0 |
UniPathwayi | UPA00143 |
Protein family/group databases
MoonDBi | Q9H0M0, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: NEDD4-like E3 ubiquitin-protein ligase WWP1 (EC:2.3.2.26)Alternative name(s): Atrophin-1-interacting protein 5 Short name: AIP5 HECT-type E3 ubiquitin transferase WWP1 TGIF-interacting ubiquitin ligase 1 Short name: Tiul1 WW domain-containing protein 1 |
Gene namesi | Name:WWP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:17004, WWP1 |
MIMi | 602307, gene |
neXtProti | NX_Q9H0M0 |
VEuPathDBi | HostDB:ENSG00000123124 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity; Peripheral membrane protein By similarity
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: GO_Central
- ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 614 | E → A: Reduces ubiquitin transfer. 1 Publication | 1 | |
Mutagenesisi | 621 | H → A: Strongly reduces ubiquitin transfer. 1 Publication | 1 | |
Mutagenesisi | 675 | D → A: Reduces ubiquitin transfer. 1 Publication | 1 | |
Mutagenesisi | 798 | E → A: Reduces ubiquitin transfer. Strongly reduces ubiquitin transfer; when associated with A-845. 1 Publication | 1 | |
Mutagenesisi | 804 | M → P: Strongly reduces ubiquitin transfer; when associated with P-806. 1 Publication | 1 | |
Mutagenesisi | 806 | E → P: Strongly reduces ubiquitin transfer; when associated with P-804. 1 Publication | 1 | |
Mutagenesisi | 845 | R → A: No effect. 1 Publication | 1 | |
Mutagenesisi | 848 | Q → A: Abolishes ubiquitin transfer; when associated with A-855. 1 Publication | 1 | |
Mutagenesisi | 855 | R → A: Abolishes ubiquitin transfer; when associated with A-848. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 11059 |
OpenTargetsi | ENSG00000123124 |
PharmGKBi | PA134960138 |
Miscellaneous databases
Pharosi | Q9H0M0, Tbio |
Genetic variation databases
BioMutai | WWP1 |
DMDMi | 32171908 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000120336 | 1 – 922 | NEDD4-like E3 ubiquitin-protein ligase WWP1Add BLAST | 922 |
Post-translational modificationi
Keywords - PTMi
Ubl conjugationProteomic databases
jPOSTi | Q9H0M0 |
MassIVEi | Q9H0M0 |
MaxQBi | Q9H0M0 |
PaxDbi | Q9H0M0 |
PeptideAtlasi | Q9H0M0 |
PRIDEi | Q9H0M0 |
ProteomicsDBi | 80294 [Q9H0M0-1] 80295 [Q9H0M0-2] 80296 [Q9H0M0-3] 80297 [Q9H0M0-6] |
PTM databases
iPTMneti | Q9H0M0 |
PhosphoSitePlusi | Q9H0M0 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000123124, Expressed in skeletal muscle tissue of rectus abdominis and 260 other tissues |
ExpressionAtlasi | Q9H0M0, baseline and differential |
Genevisiblei | Q9H0M0, HS |
Organism-specific databases
HPAi | ENSG00000123124, Tissue enhanced (skeletal) |
Interactioni
Subunit structurei
Binds KLF2 AND HIVEP3 (By similarity). Binds SCNN1A, SCNN1B, SCNN1G, WBP1, WBP2, DRPLA and adenovirus type 2 PIII.
Interacts with RNF11 (By similarity).
Interacts with SPART.
Interacts with ERBB4 isoforms JM-B CYT-1 and JM-A CYT-1.
Interacts with SMAD1, SMAD2, SMAD3, SMAD5, SMAD6, SMAD7, TGFBR1 AND TGFBR2. Associates with the TGFBR1:TGFBR2 receptor complex in presence of SMAD7.
Interacts with SKIL isoform 1.
Interacts with TP63 isoform 1 and isoform 2.
Interacts with STAMBP and RNF11.
Interacts with NDFIP1 and NDFIP2 (Probable); this interaction activates the E3 ubiquitin-protein ligase.
Interacts with TGIF.
Interacts (via WW domains) with ARRDC1, ARRDC2 and ARRDC3 (PubMed:21191027).
By similarity8 Publications(Microbial infection) Interacts with HTLV-1 protein Gag.
1 Publication(Microbial infection) Interacts with ebola virus protein VP40.
1 PublicationBinary interactionsi
Q9H0M0
Protein-protein interaction databases
BioGRIDi | 116243, 177 interactors |
CORUMi | Q9H0M0 |
IntActi | Q9H0M0, 60 interactors |
MINTi | Q9H0M0 |
STRINGi | 9606.ENSP00000427793 |
Miscellaneous databases
RNActi | Q9H0M0, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q9H0M0 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q9H0M0 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 116 | C2PROSITE-ProRule annotationAdd BLAST | 116 | |
Domaini | 349 – 382 | WW 1PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 381 – 414 | WW 2PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 456 – 489 | WW 3PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 496 – 529 | WW 4PROSITE-ProRule annotationAdd BLAST | 34 | |
Domaini | 588 – 922 | HECTPROSITE-ProRule annotationAdd BLAST | 335 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 210 – 388 | DisorderedSequence analysisAdd BLAST | 179 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 240 – 327 | Polar residuesSequence analysisAdd BLAST | 88 | |
Compositional biasi | 336 – 354 | Polar residuesSequence analysisAdd BLAST | 19 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0940, Eukaryota |
GeneTreei | ENSGT00940000154635 |
HOGENOMi | CLU_002173_0_1_1 |
InParanoidi | Q9H0M0 |
OMAi | GIDNQVP |
OrthoDBi | 167687at2759 |
PhylomeDBi | Q9H0M0 |
TreeFami | TF323658 |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit cd00201, WW, 3 hits |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR024928, E3_ub_ligase_SMURF1 IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00632, HECT, 1 hit PF00397, WW, 4 hits |
PIRSFi | PIRSF001569, E3_ub_ligase_SMURF1, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00119, HECTc, 1 hit SM00456, WW, 4 hits |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF51045, SSF51045, 4 hits SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50237, HECT, 1 hit PS01159, WW_DOMAIN_1, 4 hits PS50020, WW_DOMAIN_2, 4 hits |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATASPRSDT SNNHSGRLQL QVTVSSAKLK RKKNWFGTAI YTEVVVDGEI
60 70 80 90 100
TKTAKSSSSS NPKWDEQLTV NVTPQTTLEF QVWSHRTLKA DALLGKATID
110 120 130 140 150
LKQALLIHNR KLERVKEQLK LSLENKNGIA QTGELTVVLD GLVIEQENIT
160 170 180 190 200
NCSSSPTIEI QENGDALHEN GEPSARTTAR LAVEGTNGID NHVPTSTLVQ
210 220 230 240 250
NSCCSYVVNG DNTPSSPSQV AARPKNTPAP KPLASEPADD TVNGESSSFA
260 270 280 290 300
PTDNASVTGT PVVSEENALS PNCTSTTVED PPVQEILTSS ENNECIPSTS
310 320 330 340 350
AELESEARSI LEPDTSNSRS SSAFEAAKSR QPDGCMDPVR QQSGNANTET
360 370 380 390 400
LPSGWEQRKD PHGRTYYVDH NTRTTTWERP QPLPPGWERR VDDRRRVYYV
410 420 430 440 450
DHNTRTTTWQ RPTMESVRNF EQWQSQRNQL QGAMQQFNQR YLYSASMLAA
460 470 480 490 500
ENDPYGPLPP GWEKRVDSTD RVYFVNHNTK TTQWEDPRTQ GLQNEEPLPE
510 520 530 540 550
GWEIRYTREG VRYFVDHNTR TTTFKDPRNG KSSVTKGGPQ IAYERGFRWK
560 570 580 590 600
LAHFRYLCQS NALPSHVKIN VSRQTLFEDS FQQIMALKPY DLRRRLYVIF
610 620 630 640 650
RGEEGLDYGG LAREWFFLLS HEVLNPMYCL FEYAGKNNYC LQINPASTIN
660 670 680 690 700
PDHLSYFCFI GRFIAMALFH GKFIDTGFSL PFYKRMLSKK LTIKDLESID
710 720 730 740 750
TEFYNSLIWI RDNNIEECGL EMYFSVDMEI LGKVTSHDLK LGGSNILVTE
760 770 780 790 800
ENKDEYIGLM TEWRFSRGVQ EQTKAFLDGF NEVVPLQWLQ YFDEKELEVM
810 820 830 840 850
LCGMQEVDLA DWQRNTVYRH YTRNSKQIIW FWQFVKETDN EVRMRLLQFV
860 870 880 890 900
TGTCRLPLGG FAELMGSNGP QKFCIEKVGK DTWLPRSHTC FNRLDLPPYK
910 920
SYEQLKEKLL FAIEETEGFG QE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YBS9 | H0YBS9_HUMAN | NEDD4-like E3 ubiquitin-protein lig... | WWP1 | 55 | Annotation score: | ||
H0YBA4 | H0YBA4_HUMAN | NEDD4-like E3 ubiquitin-protein lig... | WWP1 | 232 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_007600 | 23 – 240 | Missing in isoform 6. 1 PublicationAdd BLAST | 218 | |
Alternative sequenceiVSP_007602 | 112 – 242 | LERVK…ADDTV → F in isoform 3. 1 PublicationAdd BLAST | 131 | |
Alternative sequenceiVSP_007601 | 112 – 120 | LERVKEQLK → CWLLKARME in isoform 2. 1 Publication | 9 | |
Alternative sequenceiVSP_007603 | 121 – 922 | Missing in isoform 2. 1 PublicationAdd BLAST | 802 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136739 mRNA Translation: CAB66673.1 AY043361 mRNA Translation: AAK94668.1 AY345857 mRNA Translation: AAQ22764.1 AC083845 Genomic DNA No translation available. AC103817 Genomic DNA No translation available. BC015380 mRNA Translation: AAH15380.2 BC036065 mRNA Translation: AAH36065.1 U96113 mRNA Translation: AAC51324.1 |
CCDSi | CCDS6242.1 [Q9H0M0-1] |
RefSeqi | NP_008944.1, NM_007013.3 [Q9H0M0-1] XP_005250817.1, XM_005250760.3 [Q9H0M0-1] |
Genome annotation databases
Ensembli | ENST00000265428; ENSP00000265428; ENSG00000123124 ENST00000517970; ENSP00000427793; ENSG00000123124 |
GeneIDi | 11059 |
KEGGi | hsa:11059 |
MANE-Selecti | ENST00000517970.6; ENSP00000427793.1; NM_007013.4; NP_008944.1 |
UCSCi | uc003ydt.4, human [Q9H0M0-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136739 mRNA Translation: CAB66673.1 AY043361 mRNA Translation: AAK94668.1 AY345857 mRNA Translation: AAQ22764.1 AC083845 Genomic DNA No translation available. AC103817 Genomic DNA No translation available. BC015380 mRNA Translation: AAH15380.2 BC036065 mRNA Translation: AAH36065.1 U96113 mRNA Translation: AAC51324.1 |
CCDSi | CCDS6242.1 [Q9H0M0-1] |
RefSeqi | NP_008944.1, NM_007013.3 [Q9H0M0-1] XP_005250817.1, XM_005250760.3 [Q9H0M0-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ND7 | X-ray | 2.10 | A | 546-917 | [»] | |
2OP7 | NMR | - | A | 494-532 | [»] | |
5HPS | X-ray | 2.05 | A | 537-917 | [»] | |
5HPT | X-ray | 2.84 | A/D/G | 537-917 | [»] | |
6J1X | X-ray | 2.30 | B | 379-922 | [»] | |
6J1Y | X-ray | 2.55 | A/B | 410-922 | [»] | |
SMRi | Q9H0M0 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 116243, 177 interactors |
CORUMi | Q9H0M0 |
IntActi | Q9H0M0, 60 interactors |
MINTi | Q9H0M0 |
STRINGi | 9606.ENSP00000427793 |
Protein family/group databases
MoonDBi | Q9H0M0, Predicted |
PTM databases
iPTMneti | Q9H0M0 |
PhosphoSitePlusi | Q9H0M0 |
Genetic variation databases
BioMutai | WWP1 |
DMDMi | 32171908 |
Proteomic databases
jPOSTi | Q9H0M0 |
MassIVEi | Q9H0M0 |
MaxQBi | Q9H0M0 |
PaxDbi | Q9H0M0 |
PeptideAtlasi | Q9H0M0 |
PRIDEi | Q9H0M0 |
ProteomicsDBi | 80294 [Q9H0M0-1] 80295 [Q9H0M0-2] 80296 [Q9H0M0-3] 80297 [Q9H0M0-6] |
Protocols and materials databases
Antibodypediai | 25465, 150 antibodies from 28 providers |
DNASUi | 11059 |
Genome annotation databases
Ensembli | ENST00000265428; ENSP00000265428; ENSG00000123124 ENST00000517970; ENSP00000427793; ENSG00000123124 |
GeneIDi | 11059 |
KEGGi | hsa:11059 |
MANE-Selecti | ENST00000517970.6; ENSP00000427793.1; NM_007013.4; NP_008944.1 |
UCSCi | uc003ydt.4, human [Q9H0M0-1] |
Organism-specific databases
CTDi | 11059 |
DisGeNETi | 11059 |
GeneCardsi | WWP1 |
HGNCi | HGNC:17004, WWP1 |
HPAi | ENSG00000123124, Tissue enhanced (skeletal) |
MIMi | 602307, gene |
neXtProti | NX_Q9H0M0 |
OpenTargetsi | ENSG00000123124 |
PharmGKBi | PA134960138 |
VEuPathDBi | HostDB:ENSG00000123124 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0940, Eukaryota |
GeneTreei | ENSGT00940000154635 |
HOGENOMi | CLU_002173_0_1_1 |
InParanoidi | Q9H0M0 |
OMAi | GIDNQVP |
OrthoDBi | 167687at2759 |
PhylomeDBi | Q9H0M0 |
TreeFami | TF323658 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
BRENDAi | 2.3.2.26, 2681 |
PathwayCommonsi | Q9H0M0 |
Reactomei | R-HSA-1253288, Downregulation of ERBB4 signaling R-HSA-2672351, Stimuli-sensing channels R-HSA-8939902, Regulation of RUNX2 expression and activity R-HSA-983168, Antigen processing: Ubiquitination & Proteasome degradation |
SignaLinki | Q9H0M0 |
SIGNORi | Q9H0M0 |
Miscellaneous databases
BioGRID-ORCSi | 11059, 8 hits in 1092 CRISPR screens |
ChiTaRSi | WWP1, human |
EvolutionaryTracei | Q9H0M0 |
GeneWikii | WWP1 |
GenomeRNAii | 11059 |
Pharosi | Q9H0M0, Tbio |
PROi | PR:Q9H0M0 |
RNActi | Q9H0M0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000123124, Expressed in skeletal muscle tissue of rectus abdominis and 260 other tissues |
ExpressionAtlasi | Q9H0M0, baseline and differential |
Genevisiblei | Q9H0M0, HS |
Family and domain databases
CDDi | cd00078, HECTc, 1 hit cd00201, WW, 3 hits |
Gene3Di | 2.60.40.150, 1 hit |
InterProi | View protein in InterPro IPR000008, C2_dom IPR035892, C2_domain_sf IPR024928, E3_ub_ligase_SMURF1 IPR000569, HECT_dom IPR035983, Hect_E3_ubiquitin_ligase IPR001202, WW_dom IPR036020, WW_dom_sf |
Pfami | View protein in Pfam PF00168, C2, 1 hit PF00632, HECT, 1 hit PF00397, WW, 4 hits |
PIRSFi | PIRSF001569, E3_ub_ligase_SMURF1, 1 hit |
SMARTi | View protein in SMART SM00239, C2, 1 hit SM00119, HECTc, 1 hit SM00456, WW, 4 hits |
SUPFAMi | SSF49562, SSF49562, 1 hit SSF51045, SSF51045, 4 hits SSF56204, SSF56204, 1 hit |
PROSITEi | View protein in PROSITE PS50004, C2, 1 hit PS50237, HECT, 1 hit PS01159, WW_DOMAIN_1, 4 hits PS50020, WW_DOMAIN_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | WWP1_HUMAN | |
Accessioni | Q9H0M0Primary (citable) accession number: Q9H0M0 Secondary accession number(s): O00307, Q5YLC1, Q96BP4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2003 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 198 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references