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Protein

Cleavage stimulation factor subunit 2 tau variant

Gene

CSTF2T

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs (By similarity).By similarity

GO - Molecular functioni

  • mRNA binding Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-77595 Processing of Intronless Pre-mRNAs

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage stimulation factor subunit 2 tau variant
Alternative name(s):
CF-1 64 kDa subunit tau variant
Cleavage stimulation factor 64 kDa subunit tau variant
Short name:
CSTF 64 kDa subunit tau variant
TauCstF-64
Gene namesi
Name:CSTF2T
Synonyms:KIAA0689
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000177613.8
HGNCiHGNC:17086 CSTF2T
MIMi611968 gene
neXtProtiNX_Q9H0L4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23283
OpenTargetsiENSG00000177613
PharmGKBiPA134933809

Polymorphism and mutation databases

BioMutaiCSTF2T
DMDMi71153234

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815341 – 616Cleavage stimulation factor subunit 2 tau variantAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei320PhosphothreonineCombined sources1
Modified residuei563PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0L4
MaxQBiQ9H0L4
PaxDbiQ9H0L4
PeptideAtlasiQ9H0L4
PRIDEiQ9H0L4
ProteomicsDBi80293

2D gel databases

REPRODUCTION-2DPAGEiIPI00550906

PTM databases

iPTMnetiQ9H0L4
PhosphoSitePlusiQ9H0L4

Expressioni

Gene expression databases

BgeeiENSG00000177613 Expressed in 228 organ(s), highest expression level in left coronary artery
CleanExiHS_CSTF2T
GenevisibleiQ9H0L4 HS

Organism-specific databases

HPAiHPA039216
HPA062021

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi116881, 31 interactors
IntActiQ9H0L4, 27 interactors
MINTiQ9H0L4
STRINGi9606.ENSP00000332444

Structurei

3D structure databases

ProteinModelPortaliQ9H0L4
SMRiQ9H0L4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 94RRMPROSITE-ProRule annotationAdd BLAST79
Repeati418 – 4221-15
Repeati423 – 4271-2; approximate5
Repeati428 – 4321-3; approximate5
Repeati433 – 4371-4; approximate5
Repeati438 – 4421-5; approximate5
Repeati443 – 4471-65
Repeati448 – 4521-7; approximate5
Repeati453 – 4571-8; approximate5
Repeati458 – 4621-9; approximate5
Repeati505 – 5092-15
Repeati510 – 5142-25
Repeati515 – 5192-35
Repeati520 – 5242-45
Repeati525 – 5292-5; approximate5
Repeati530 – 5342-65
Repeati535 – 5392-7; approximate5
Repeati540 – 5442-8; approximate5
Repeati545 – 5492-9; approximate5

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni418 – 4629 X 5 AA tandem repeats of M-E-T-R-[AG]Add BLAST45
Regioni505 – 5499 X 5 AA tandem repeats of G-[AT]-G-[MI]-QAdd BLAST45

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi260 – 556Gly-richAdd BLAST297

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0108 Eukaryota
ENOG410XQBV LUCA
GeneTreeiENSGT00890000139457
HOGENOMiHOG000214373
HOVERGENiHBG051145
InParanoidiQ9H0L4
KOiK14407
OMAiIQGTGMQ
OrthoDBiEOG091G0A7G
PhylomeDBiQ9H0L4
TreeFamiTF314948

Family and domain databases

Gene3Di1.10.20.70, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038192 CSTF2_C_sf
IPR025742 CSTF2_hinge
IPR026896 CSTF_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF14327 CSTF2_hinge, 1 hit
PF14304 CSTF_C, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H0L4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSLAVRDPA MDRSLRSVFV GNIPYEATEE QLKDIFSEVG SVVSFRLVYD
60 70 80 90 100
RETGKPKGYG FCEYQDQETA LSAMRNLNGR EFSGRALRVD NAASEKNKEE
110 120 130 140 150
LKSLGPAAPI IDSPYGDPID PEDAPESITR AVASLPPEQM FELMKQMKLC
160 170 180 190 200
VQNSHQEARN MLLQNPQLAY ALLQAQVVMR IMDPEIALKI LHRKIHVTPL
210 220 230 240 250
IPGKSQSVSV SGPGPGPGPG LCPGPNVLLN QQNPPAPQPQ HLARRPVKDI
260 270 280 290 300
PPLMQTPIQG GIPAPGPIPA AVPGAGPGSL TPGGAMQPQL GMPGVGPVPL
310 320 330 340 350
ERGQVQMSDP RAPIPRGPVT PGGLPPRGLL GDAPNDPRGG TLLSVTGEVE
360 370 380 390 400
PRGYLGPPHQ GPPMHHASGH DTRGPSSHEM RGGPLGDPRL LIGEPRGPMI
410 420 430 440 450
DQRGLPMDGR GGRDSRAMET RAMETEVLET RVMERRGMET CAMETRGMEA
460 470 480 490 500
RGMDARGLEM RGPVPSSRGP MTGGIQGPGP INIGAGGPPQ GPRQVPGISG
510 520 530 540 550
VGNPGAGMQG TGIQGTGMQG AGIQGGGMQG AGIQGVSIQG GGIQGGGIQG
560 570 580 590 600
ASKQGGSQPS SFSPGQSQVT PQDQEKAALI MQVLQLTADQ IAMLPPEQRQ
610
SILILKEQIQ KSTGAS
Length:616
Mass (Da):64,437
Last modified:March 1, 2001 - v1
Checksum:i916BB9B0802AC847
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22N → S in BAD96294 (Ref. 4) Curated1
Sequence conflicti553K → R in AAH28239 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130299 mRNA Translation: AAN05429.1
AL136747 mRNA Translation: CAB66681.1
AK222574 mRNA Translation: BAD96294.1
AK314318 mRNA Translation: BAG36966.1
CH471083 Genomic DNA Translation: EAW54142.1
BC028239 mRNA Translation: AAH28239.1
AB014589 mRNA Translation: BAA31664.1
CCDSiCCDS7245.1
RefSeqiNP_056050.1, NM_015235.2
UniGeneiHs.591358

Genome annotation databases

EnsembliENST00000331173; ENSP00000332444; ENSG00000177613
GeneIDi23283
KEGGihsa:23283
UCSCiuc001jjp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY130299 mRNA Translation: AAN05429.1
AL136747 mRNA Translation: CAB66681.1
AK222574 mRNA Translation: BAD96294.1
AK314318 mRNA Translation: BAG36966.1
CH471083 Genomic DNA Translation: EAW54142.1
BC028239 mRNA Translation: AAH28239.1
AB014589 mRNA Translation: BAA31664.1
CCDSiCCDS7245.1
RefSeqiNP_056050.1, NM_015235.2
UniGeneiHs.591358

3D structure databases

ProteinModelPortaliQ9H0L4
SMRiQ9H0L4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116881, 31 interactors
IntActiQ9H0L4, 27 interactors
MINTiQ9H0L4
STRINGi9606.ENSP00000332444

PTM databases

iPTMnetiQ9H0L4
PhosphoSitePlusiQ9H0L4

Polymorphism and mutation databases

BioMutaiCSTF2T
DMDMi71153234

2D gel databases

REPRODUCTION-2DPAGEiIPI00550906

Proteomic databases

EPDiQ9H0L4
MaxQBiQ9H0L4
PaxDbiQ9H0L4
PeptideAtlasiQ9H0L4
PRIDEiQ9H0L4
ProteomicsDBi80293

Protocols and materials databases

DNASUi23283
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331173; ENSP00000332444; ENSG00000177613
GeneIDi23283
KEGGihsa:23283
UCSCiuc001jjp.4 human

Organism-specific databases

CTDi23283
DisGeNETi23283
EuPathDBiHostDB:ENSG00000177613.8
GeneCardsiCSTF2T
HGNCiHGNC:17086 CSTF2T
HPAiHPA039216
HPA062021
MIMi611968 gene
neXtProtiNX_Q9H0L4
OpenTargetsiENSG00000177613
PharmGKBiPA134933809
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0108 Eukaryota
ENOG410XQBV LUCA
GeneTreeiENSGT00890000139457
HOGENOMiHOG000214373
HOVERGENiHBG051145
InParanoidiQ9H0L4
KOiK14407
OMAiIQGTGMQ
OrthoDBiEOG091G0A7G
PhylomeDBiQ9H0L4
TreeFamiTF314948

Enzyme and pathway databases

ReactomeiR-HSA-109688 Cleavage of Growing Transcript in the Termination Region
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72187 mRNA 3'-end processing
R-HSA-77595 Processing of Intronless Pre-mRNAs

Miscellaneous databases

GeneWikiiCSTF2T
GenomeRNAii23283
PROiPR:Q9H0L4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177613 Expressed in 228 organ(s), highest expression level in left coronary artery
CleanExiHS_CSTF2T
GenevisibleiQ9H0L4 HS

Family and domain databases

Gene3Di1.10.20.70, 1 hit
3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR038192 CSTF2_C_sf
IPR025742 CSTF2_hinge
IPR026896 CSTF_C
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF14327 CSTF2_hinge, 1 hit
PF14304 CSTF_C, 1 hit
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSTFT_HUMAN
AccessioniPrimary (citable) accession number: Q9H0L4
Secondary accession number(s): B2RAR9
, O75174, Q53HK6, Q7LGE8, Q8N6T1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 141 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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