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Protein

Radial spoke head protein 6 homolog A

Gene

RSPH6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Radial spoke head protein 6 homolog A
Alternative name(s):
Radial spoke head-like protein 1
Gene namesi
Name:RSPH6A
Synonyms:RSHL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000104941.7
HGNCiHGNC:14241 RSPH6A
MIMi607548 gene
neXtProtiNX_Q9H0K4

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi81492
OpenTargetsiENSG00000104941
PharmGKBiPA34873

Polymorphism and mutation databases

BioMutaiRSPH6A
DMDMi74717992

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003127601 – 717Radial spoke head protein 6 homolog AAdd BLAST717

Proteomic databases

PaxDbiQ9H0K4
PeptideAtlasiQ9H0K4
PRIDEiQ9H0K4
ProteomicsDBi80291

PTM databases

iPTMnetiQ9H0K4
PhosphoSitePlusiQ9H0K4

Expressioni

Gene expression databases

BgeeiENSG00000104941 Expressed in 45 organ(s), highest expression level in testis
CleanExiHS_RSHL1
ExpressionAtlasiQ9H0K4 baseline and differential
GenevisibleiQ9H0K4 HS

Organism-specific databases

HPAiHPA045382

Interactioni

Protein-protein interaction databases

IntActiQ9H0K4, 2 interactors
STRINGi9606.ENSP00000221538

Structurei

3D structure databases

ProteinModelPortaliQ9H0K4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi359 – 397Glu-richAdd BLAST39
Compositional biasi504 – 714Glu-richAdd BLAST211

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IF1Z Eukaryota
ENOG410XQP5 LUCA
GeneTreeiENSGT00500000044869
HOGENOMiHOG000006653
HOVERGENiHBG070874
InParanoidiQ9H0K4
OMAiVPNIMET
OrthoDBiEOG091G0FGU
PhylomeDBiQ9H0K4
TreeFamiTF324531

Family and domain databases

InterProiView protein in InterPro
IPR006802 Radial_spoke
PANTHERiPTHR13159 PTHR13159, 1 hit
PfamiView protein in Pfam
PF04712 Radial_spoke, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q9H0K4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGDLPPYPER PAQQPPGRRT SQASQRRHSR DQAQALAADP EERQQIPPDA
60 70 80 90 100
QRNAPGWSQR GSLSQQENLL MPQVFQAEEA RLGGMEYPSV NTGFPSEFQP
110 120 130 140 150
QPYSDESRMQ VAELTTSLML QRLQQGQSSL FQQLDPTFQE PPVNPLGQFN
160 170 180 190 200
LYQTDQFSEG AQHGPYIRDD PALQFLPSEL GFPHYSAQVP EPEPLELAVQ
210 220 230 240 250
NAKAYLLQTS INCDLSLYEH LVNLLTKILN QRPEDPLSVL ESLNRTTQWE
260 270 280 290 300
WFHPKLDTLR DDPEMQPTYK MAEKQKALFT RSGGGTEGEQ EMEEEVGETP
310 320 330 340 350
VPNIMETAFY FEQAGVGLSS DESFRIFLAM KQLVEQQPIH TCRFWGKILG
360 370 380 390 400
IKRSYLVAEV EFREGEEEAE EEEVEEMTEG GEVMEAHGEE EGEEDEEKAV
410 420 430 440 450
DIVPKSVWKP PPVIPKEESR SGANKYLYFV CNEPGLPWTR LPHVTPAQIV
460 470 480 490 500
NARKIKKFFT GYLDTPVVSY PPFPGNEANY LRAQIARISA ATQVSPLGFY
510 520 530 540 550
QFSEEEGDEE EEGGAGRDSY EENPDFEGIP VLELVDSMAN WVHHTQHILP
560 570 580 590 600
QGRCTWVNPL QKTEEEEDLG EEEEKADEGP EEVEQEVGPP LLTPLSEDAE
610 620 630 640 650
IMHLAPWTTR LSCSLCPQYS VAVVRSNLWP GAYAYASGKK FENIYIGWGH
660 670 680 690 700
KYSPESFNPA LPAPIQQEYP SGPEIMEMSD PTVEEEQALK AAQEQALGAT
710
EEEEEGEEEE EGEETDD
Length:717
Mass (Da):80,913
Last modified:March 1, 2001 - v1
Checksum:i120C31FA0726AD76
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R103M0R103_HUMAN
Radial spoke head protein 6 homolog...
RSPH6A
453Annotation score:
M0R2K1M0R2K1_HUMAN
Radial spoke head protein 6 homolog...
RSPH6A
676Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti55P → S in BAD97067 (Ref. 2) Curated1
Sequence conflicti139Q → R in BAD97067 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03756050A → V. Corresponds to variant dbSNP:rs12459916Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136761 mRNA Translation: CAB66695.1
AK223347 mRNA Translation: BAD97067.1
CH471126 Genomic DNA Translation: EAW57388.1
BC057785 mRNA Translation: AAH57785.1
CCDSiCCDS12675.1
RefSeqiNP_110412.1, NM_030785.3
UniGeneiHs.146544

Genome annotation databases

EnsembliENST00000221538; ENSP00000221538; ENSG00000104941
GeneIDi81492
KEGGihsa:81492
UCSCiuc002pdm.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136761 mRNA Translation: CAB66695.1
AK223347 mRNA Translation: BAD97067.1
CH471126 Genomic DNA Translation: EAW57388.1
BC057785 mRNA Translation: AAH57785.1
CCDSiCCDS12675.1
RefSeqiNP_110412.1, NM_030785.3
UniGeneiHs.146544

3D structure databases

ProteinModelPortaliQ9H0K4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9H0K4, 2 interactors
STRINGi9606.ENSP00000221538

PTM databases

iPTMnetiQ9H0K4
PhosphoSitePlusiQ9H0K4

Polymorphism and mutation databases

BioMutaiRSPH6A
DMDMi74717992

Proteomic databases

PaxDbiQ9H0K4
PeptideAtlasiQ9H0K4
PRIDEiQ9H0K4
ProteomicsDBi80291

Protocols and materials databases

DNASUi81492
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000221538; ENSP00000221538; ENSG00000104941
GeneIDi81492
KEGGihsa:81492
UCSCiuc002pdm.4 human

Organism-specific databases

CTDi81492
DisGeNETi81492
EuPathDBiHostDB:ENSG00000104941.7
GeneCardsiRSPH6A
HGNCiHGNC:14241 RSPH6A
HPAiHPA045382
MIMi607548 gene
neXtProtiNX_Q9H0K4
OpenTargetsiENSG00000104941
PharmGKBiPA34873
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF1Z Eukaryota
ENOG410XQP5 LUCA
GeneTreeiENSGT00500000044869
HOGENOMiHOG000006653
HOVERGENiHBG070874
InParanoidiQ9H0K4
OMAiVPNIMET
OrthoDBiEOG091G0FGU
PhylomeDBiQ9H0K4
TreeFamiTF324531

Miscellaneous databases

GeneWikiiRSPH6A
GenomeRNAii81492
PROiPR:Q9H0K4
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000104941 Expressed in 45 organ(s), highest expression level in testis
CleanExiHS_RSHL1
ExpressionAtlasiQ9H0K4 baseline and differential
GenevisibleiQ9H0K4 HS

Family and domain databases

InterProiView protein in InterPro
IPR006802 Radial_spoke
PANTHERiPTHR13159 PTHR13159, 1 hit
PfamiView protein in Pfam
PF04712 Radial_spoke, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRSH6A_HUMAN
AccessioniPrimary (citable) accession number: Q9H0K4
Secondary accession number(s): Q53FE2, Q6PEZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
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