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Protein

Serine/threonine-protein kinase SIK2

Gene

SIK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactori

Mg2+1 Publication

Activity regulationi

Activated by phosphorylation on Thr-175.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49ATPPROSITE-ProRule annotationBy similarity1
Active sitei142Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi26 – 34ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9H0K1
SIGNORiQ9H0K1

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase SIK2 (EC:2.7.11.1)
Alternative name(s):
Qin-induced kinase
Salt-inducible kinase 2
Short name:
SIK-2
Serine/threonine-protein kinase SNF1-like kinase 2
Gene namesi
Name:SIK2
Synonyms:KIAA0781Imported, QIK, SNF1LK2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000170145.4
HGNCiHGNC:21680 SIK2
MIMi608973 gene
neXtProtiNX_Q9H0K1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi175T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication1
Mutagenesisi175T → E: Constitutively active. 1 Publication1

Organism-specific databases

DisGeNETi23235
OpenTargetsiENSG00000170145
PharmGKBiPA164725750

Chemistry databases

ChEMBLiCHEMBL5699
GuidetoPHARMACOLOGYi2198

Polymorphism and mutation databases

BioMutaiSIK2
DMDMi59798973

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000866621 – 926Serine/threonine-protein kinase SIK2Add BLAST926

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei25PhosphothreonineCombined sources1
Modified residuei53N6-acetyllysine; by EP3001 Publication1
Modified residuei175Phosphothreonine; by LKB11 Publication1
Modified residuei534PhosphoserineBy similarity1
Modified residuei587PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.1 Publication
Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H0K1
MaxQBiQ9H0K1
PaxDbiQ9H0K1
PeptideAtlasiQ9H0K1
PRIDEiQ9H0K1
ProteomicsDBi80290

PTM databases

iPTMnetiQ9H0K1
PhosphoSitePlusiQ9H0K1

Expressioni

Gene expression databases

BgeeiENSG00000170145 Expressed in 230 organ(s), highest expression level in adipose tissue
ExpressionAtlasiQ9H0K1 baseline and differential
GenevisibleiQ9H0K1 HS

Organism-specific databases

HPAiHPA016026

Interactioni

Subunit structurei

Interacts with and phosphorylates TORC2/CRTC2.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi116840, 35 interactors
IntActiQ9H0K1, 24 interactors
STRINGi9606.ENSP00000305976

Chemistry databases

BindingDBiQ9H0K1

Structurei

3D structure databases

ProteinModelPortaliQ9H0K1
SMRiQ9H0K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 271Protein kinasePROSITE-ProRule annotationAdd BLAST252
Domaini295 – 335UBAPROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00900000140806
HOVERGENiHBG079197
InParanoidiQ9H0K1
KOiK16311
OMAiDCPRSSG
OrthoDBiEOG091G03A4
PhylomeDBiQ9H0K1
TreeFamiTF315213

Family and domain databases

CDDicd14071 STKc_SIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR017090 Ser/Thr_kinase_SIK1/2
IPR034672 SIK
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF037014 Ser/Thr_PK_SNF1-like, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H0K1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI
60 70 80 90 100
IDKSQLDAVN LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK
110 120 130 140 150
NGEIFDYLAN HGRLNESEAR RKFWQILSAV DYCHGRKIVH RDLKAENLLL
160 170 180 190 200
DNNMNIKIAD FGFGNFFKSG ELLATWCGSP PYAAPEVFEG QQYEGPQLDI
210 220 230 240 250
WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM SEDCEHLIRR
260 270 280 290 300
MLVLDPSKRL TIAQIKEHKW MLIEVPVQRP VLYPQEQENE PSIGEFNEQV
310 320 330 340 350
LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL
360 370 380 390 400
DGRQRRPSTI AEQTVAKAQT VGLPVTMHSP NMRLLRSALL PQASNVEAFS
410 420 430 440 450
FPASGCQAEA AFMEEECVDT PKVNGCLLDP VPPVLVRKGC QSLPSNMMET
460 470 480 490 500
SIDEGLETEG EAEEDPAHAF EAFQSTRSGQ RRHTLSEVTN QLVVMPGAGK
510 520 530 540 550
IFSMNDSPSL DSVDSEYDMG SVQRDLNFLE DNPSLKDIML ANQPSPRMTS
560 570 580 590 600
PFISLRPTNP AMQALSSQKR EVHNRSPVSF REGRRASDTS LTQGIVAFRQ
610 620 630 640 650
HLQNLARTKG ILELNKVQLL YEQIGPEADP NLAPAAPQLQ DLASSCPQEE
660 670 680 690 700
VSQQQESVST LPASVHPQLS PRQSLETQYL QHRLQKPSLL SKAQNTCQLY
710 720 730 740 750
CKEPPRSLEQ QLQEHRLQQK RLFLQKQSQL QAYFNQMQIA ESSYPQPSQQ
760 770 780 790 800
LPLPRQETPP PSQQAPPFSL TQPLSPVLEP SSEQMQYSPF LSQYQEMQLQ
810 820 830 840 850
PLPSTSGPRA APPLPTQLQQ QQPPPPPPPP PPRQPGAAPA PLQFSYQTCE
860 870 880 890 900
LPSAASPAPD YPTPCQYPVD GAQQSDLTGP DCPRSPGLQE APSSYDPLAL
910 920
SELPGLFDCE MLDAVDPQHN GYVLVN
Length:926
Mass (Da):103,915
Last modified:March 1, 2001 - v1
Checksum:i9D7F9BF81FD65CCF
GO

Sequence cautioni

The sequence BAA34501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192Q → H in BAF83922 (PubMed:14702039).Curated1
Sequence conflicti463E → V in BAF83922 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_041093458T → I1 PublicationCorresponds to variant dbSNP:rs35789057Ensembl.1
Natural variantiVAR_041094809R → Q1 PublicationCorresponds to variant dbSNP:rs34223841Ensembl.1
Natural variantiVAR_041095825P → L1 PublicationCorresponds to variant dbSNP:rs55889697Ensembl.1
Natural variantiVAR_051667828P → L. Corresponds to variant dbSNP:rs45520245Ensembl.1
Natural variantiVAR_051668829P → S. Corresponds to variant dbSNP:rs45586732Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018324 mRNA Translation: BAA34501.3 Different initiation.
AL136764 mRNA Translation: CAB66698.1
AK291233 mRNA Translation: BAF83922.1
EF445030 Genomic DNA Translation: ACA06072.1
CH471065 Genomic DNA Translation: EAW67148.1
BC013612 mRNA Translation: AAH13612.1
BC078150 mRNA Translation: AAH78150.1
BC113459 mRNA Translation: AAI13460.1
BC117183 mRNA Translation: AAI17184.1
AB084424 mRNA Translation: BAB91442.1
CCDSiCCDS8347.1
RefSeqiNP_056006.1, NM_015191.2
UniGeneiHs.269128

Genome annotation databases

EnsembliENST00000304987; ENSP00000305976; ENSG00000170145
GeneIDi23235
KEGGihsa:23235
UCSCiuc001plt.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018324 mRNA Translation: BAA34501.3 Different initiation.
AL136764 mRNA Translation: CAB66698.1
AK291233 mRNA Translation: BAF83922.1
EF445030 Genomic DNA Translation: ACA06072.1
CH471065 Genomic DNA Translation: EAW67148.1
BC013612 mRNA Translation: AAH13612.1
BC078150 mRNA Translation: AAH78150.1
BC113459 mRNA Translation: AAI13460.1
BC117183 mRNA Translation: AAI17184.1
AB084424 mRNA Translation: BAB91442.1
CCDSiCCDS8347.1
RefSeqiNP_056006.1, NM_015191.2
UniGeneiHs.269128

3D structure databases

ProteinModelPortaliQ9H0K1
SMRiQ9H0K1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116840, 35 interactors
IntActiQ9H0K1, 24 interactors
STRINGi9606.ENSP00000305976

Chemistry databases

BindingDBiQ9H0K1
ChEMBLiCHEMBL5699
GuidetoPHARMACOLOGYi2198

PTM databases

iPTMnetiQ9H0K1
PhosphoSitePlusiQ9H0K1

Polymorphism and mutation databases

BioMutaiSIK2
DMDMi59798973

Proteomic databases

EPDiQ9H0K1
MaxQBiQ9H0K1
PaxDbiQ9H0K1
PeptideAtlasiQ9H0K1
PRIDEiQ9H0K1
ProteomicsDBi80290

Protocols and materials databases

DNASUi23235
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000304987; ENSP00000305976; ENSG00000170145
GeneIDi23235
KEGGihsa:23235
UCSCiuc001plt.4 human

Organism-specific databases

CTDi23235
DisGeNETi23235
EuPathDBiHostDB:ENSG00000170145.4
GeneCardsiSIK2
HGNCiHGNC:21680 SIK2
HPAiHPA016026
MIMi608973 gene
neXtProtiNX_Q9H0K1
OpenTargetsiENSG00000170145
PharmGKBiPA164725750
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0586 Eukaryota
ENOG410XNQ0 LUCA
GeneTreeiENSGT00900000140806
HOVERGENiHBG079197
InParanoidiQ9H0K1
KOiK16311
OMAiDCPRSSG
OrthoDBiEOG091G03A4
PhylomeDBiQ9H0K1
TreeFamiTF315213

Enzyme and pathway databases

SignaLinkiQ9H0K1
SIGNORiQ9H0K1

Miscellaneous databases

ChiTaRSiSIK2 human
GeneWikiiSNF1LK2
GenomeRNAii23235
PROiPR:Q9H0K1
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000170145 Expressed in 230 organ(s), highest expression level in adipose tissue
ExpressionAtlasiQ9H0K1 baseline and differential
GenevisibleiQ9H0K1 HS

Family and domain databases

CDDicd14071 STKc_SIK, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
IPR017090 Ser/Thr_kinase_SIK1/2
IPR034672 SIK
IPR015940 UBA
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
PIRSFiPIRSF037014 Ser/Thr_PK_SNF1-like, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 2 hits
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
PS50030 UBA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSIK2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0K1
Secondary accession number(s): A8K5B8
, B0YJ94, O94878, Q17RV0, Q6AZE2, Q76N03, Q8NCV7, Q96CZ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: March 1, 2001
Last modified: October 10, 2018
This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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