SIK2

Functionⁱ

Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Cofactorⁱ

Mg²⁺1 Publication

Activity regulationⁱ

Activated by phosphorylation on Thr-175.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	49	ATPPROSITE-ProRule annotationBy similarity		1
Active siteⁱ	142	Proton acceptorPROSITE-ProRule annotationBy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	26 – 34	ATPPROSITE-ProRule annotationBy similarity		9

GO - Molecular functionⁱ

ATP binding
Source: UniProtKB
Inferred from direct assayⁱ
- 14976552
magnesium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 14976552
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 14976552
- 18348280

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular response to hormone stimulus Source: GO_Central
intracellular signal transduction
Source: UniProtKB
Inferred from direct assayⁱ
- 14976552
protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 18348280
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 14976552
regulation of insulin receptor signaling pathway Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkⁱ	Q9H0K1
SIGNORⁱ	Q9H0K1

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase SIK2 (EC:2.7.11.1) Alternative name(s): Qin-induced kinase Salt-inducible kinase 2 Short name: SIK-2 Serine/threonine-protein kinase SNF1-like kinase 2
Gene namesⁱ	Name:SIK2 Synonyms:KIAA0781Imported, QIK, SNF1LK2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000170145.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:21680 SIK2
MIMⁱ	608973 gene
neXtProtⁱ	NX_Q9H0K1

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	175	T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication		1
Mutagenesisⁱ	175	T → E: Constitutively active. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	23235
Open Targets More...OpenTargetsⁱ	ENSG00000170145
PharmGKBⁱ	PA164725750

Chemistry databases

ChEMBLⁱ	CHEMBL5699
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2198

Polymorphism and mutation databases

BioMutaⁱ	SIK2
DMDMⁱ	59798973

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086662	1 – 926	Serine/threonine-protein kinase SIK2Add BLAST		926

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	25	PhosphothreonineCombined sources	1
Modified residueⁱ	53	N6-acetyllysine; by EP3001 Publication	1
Modified residueⁱ	175	Phosphothreonine; by LKB11 Publication	1
Modified residueⁱ	534	PhosphoserineBy similarity	1
Modified residueⁱ	587	PhosphoserineCombined sources	1

Post-translational modificationⁱ

Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.1 Publication

Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.1 Publication

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	Q9H0K1
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q9H0K1
PaxDbⁱ	Q9H0K1
PeptideAtlas More...PeptideAtlasⁱ	Q9H0K1
PRIDEⁱ	Q9H0K1
ProteomicsDBⁱ	80290

PTM databases

iPTMnetⁱ	Q9H0K1
PhosphoSitePlusⁱ	Q9H0K1

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000170145 Expressed in 230 organ(s), highest expression level in adipose tissue
ExpressionAtlasⁱ	Q9H0K1 baseline and differential
Genevisibleⁱ	Q9H0K1 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA016026

HPAⁱ

HPA016026

Interactionⁱ

Subunit structureⁱ

Interacts with and phosphorylates TORC2/CRTC2.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
CEP250	Q9BV73	5	EBI-1181664,EBI-1053100
GABARAPL2	P60520	3	EBI-1181664,EBI-720116
PIK3R1	P27986	7	EBI-1181664,EBI-79464

Protein-protein interaction databases

BioGridⁱ	116840, 35 interactors
IntActⁱ	Q9H0K1, 24 interactors
STRINGⁱ	9606.ENSP00000305976

Chemistry databases

BindingDBⁱ

Q9H0K1

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q9H0K1
SMRⁱ	Q9H0K1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	20 – 271	Protein kinasePROSITE-ProRule annotationAdd BLAST		252
Domainⁱ	295 – 335	UBAPROSITE-ProRule annotationAdd BLAST		41

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0586 Eukaryota ENOG410XNQ0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140806
HOVERGENⁱ	HBG079197
InParanoidⁱ	Q9H0K1
KEGG Orthology (KO) More...KOⁱ	K16311
OMAⁱ	DCPRSSG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03A4
PhylomeDBⁱ	Q9H0K1
TreeFamⁱ	TF315213

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd14071 STKc_SIK, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR017090 Ser/Thr_kinase_SIK1/2 IPR034672 SIK IPR015940 UBA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF037014 Ser/Thr_PK_SNF1-like, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS50030 UBA, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q9H0K1-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI 
        60         70         80         90        100
IDKSQLDAVN LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK 
       110        120        130        140        150
NGEIFDYLAN HGRLNESEAR RKFWQILSAV DYCHGRKIVH RDLKAENLLL 
       160        170        180        190        200
DNNMNIKIAD FGFGNFFKSG ELLATWCGSP PYAAPEVFEG QQYEGPQLDI 
       210        220        230        240        250
WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM SEDCEHLIRR 
       260        270        280        290        300
MLVLDPSKRL TIAQIKEHKW MLIEVPVQRP VLYPQEQENE PSIGEFNEQV 
       310        320        330        340        350
LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL 
       360        370        380        390        400
DGRQRRPSTI AEQTVAKAQT VGLPVTMHSP NMRLLRSALL PQASNVEAFS 
       410        420        430        440        450
FPASGCQAEA AFMEEECVDT PKVNGCLLDP VPPVLVRKGC QSLPSNMMET 
       460        470        480        490        500
SIDEGLETEG EAEEDPAHAF EAFQSTRSGQ RRHTLSEVTN QLVVMPGAGK 
       510        520        530        540        550
IFSMNDSPSL DSVDSEYDMG SVQRDLNFLE DNPSLKDIML ANQPSPRMTS 
       560        570        580        590        600
PFISLRPTNP AMQALSSQKR EVHNRSPVSF REGRRASDTS LTQGIVAFRQ 
       610        620        630        640        650
HLQNLARTKG ILELNKVQLL YEQIGPEADP NLAPAAPQLQ DLASSCPQEE 
       660        670        680        690        700
VSQQQESVST LPASVHPQLS PRQSLETQYL QHRLQKPSLL SKAQNTCQLY 
       710        720        730        740        750
CKEPPRSLEQ QLQEHRLQQK RLFLQKQSQL QAYFNQMQIA ESSYPQPSQQ 
       760        770        780        790        800
LPLPRQETPP PSQQAPPFSL TQPLSPVLEP SSEQMQYSPF LSQYQEMQLQ 
       810        820        830        840        850
PLPSTSGPRA APPLPTQLQQ QQPPPPPPPP PPRQPGAAPA PLQFSYQTCE 
       860        870        880        890        900
LPSAASPAPD YPTPCQYPVD GAQQSDLTGP DCPRSPGLQE APSSYDPLAL 
       910        920 
SELPGLFDCE MLDAVDPQHN GYVLVN

Length:926

Mass (Da):103,915

Last modified:March 1, 2001 - v1

Checksum:ⁱ9D7F9BF81FD65CCF

GO

Sequence cautionⁱ

The sequence BAA34501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	192	Q → H in BAF83922 (PubMed:14702039).Curated		1
Sequence conflictⁱ	463	E → V in BAF83922 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_041093	458	T → I1 PublicationCorresponds to variant dbSNP:rs35789057Ensembl.	1
Natural variantⁱVAR_041094	809	R → Q1 PublicationCorresponds to variant dbSNP:rs34223841Ensembl.	1
Natural variantⁱVAR_041095	825	P → L1 PublicationCorresponds to variant dbSNP:rs55889697Ensembl.	1
Natural variantⁱVAR_051667	828	P → L. Corresponds to variant dbSNP:rs45520245Ensembl.	1
Natural variantⁱVAR_051668	829	P → S. Corresponds to variant dbSNP:rs45586732Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018324 mRNA Translation: BAA34501.3 Different initiation. AL136764 mRNA Translation: CAB66698.1 AK291233 mRNA Translation: BAF83922.1 EF445030 Genomic DNA Translation: ACA06072.1 CH471065 Genomic DNA Translation: EAW67148.1 BC013612 mRNA Translation: AAH13612.1 BC078150 mRNA Translation: AAH78150.1 BC113459 mRNA Translation: AAI13460.1 BC117183 mRNA Translation: AAI17184.1 AB084424 mRNA Translation: BAB91442.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS8347.1
NCBI Reference Sequences More...RefSeqⁱ	NP_056006.1, NM_015191.2
UniGeneⁱ	Hs.269128

Genome annotation databases

Ensemblⁱ	ENST00000304987; ENSP00000305976; ENSG00000170145
GeneIDⁱ	23235
KEGGⁱ	hsa:23235
UCSC genome browser More...UCSCⁱ	uc001plt.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H0K1	SNF1-like kinase 2, isoform CRA_c		HUMAN		926	UniRef100_Q9H0K1
Salt inducible kinase 2		GORGO		926
UPI0007DC713C		HUMAN		856
UPI0000EE3928		HUMAN		773

Protein	Similar proteins		Species	Score	Length	Source
Q9H0K1	Serine/threonine-protein kinase SIK2		MOUSE		931	UniRef90_Q9H0K1
SNF1-like kinase 2, isoform CRA_c		HUMAN		926
Salt inducible kinase 2		GORGO		926
Serine/threonine-protein kinase SIK2		CASCN		927
Uncharacterized protein		NOMLE		926
+25

Protein	Similar proteins		Species	Score	Length	Source
Q9H0K1	Serine/threonine-protein kinase SIK2		MOUSE		931	UniRef50_Q9H0K1
Serine/threonine-protein kinase SIK2		PONAB		925
SNF1-like kinase 2, isoform CRA_c		HUMAN		926
Salt inducible kinase 2		GORGO		926
Serine/threonine-protein kinase SIK2		CASCN		927
+239

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB018324 mRNA Translation: BAA34501.3 Different initiation. AL136764 mRNA Translation: CAB66698.1 AK291233 mRNA Translation: BAF83922.1 EF445030 Genomic DNA Translation: ACA06072.1 CH471065 Genomic DNA Translation: EAW67148.1 BC013612 mRNA Translation: AAH13612.1 BC078150 mRNA Translation: AAH78150.1 BC113459 mRNA Translation: AAI13460.1 BC117183 mRNA Translation: AAI17184.1 AB084424 mRNA Translation: BAB91442.1
CCDSⁱ	CCDS8347.1
RefSeqⁱ	NP_056006.1, NM_015191.2
UniGeneⁱ	Hs.269128

3D structure databases

ProteinModelPortalⁱ	Q9H0K1
SMRⁱ	Q9H0K1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	116840, 35 interactors
IntActⁱ	Q9H0K1, 24 interactors
STRINGⁱ	9606.ENSP00000305976

Chemistry databases

BindingDBⁱ	Q9H0K1
ChEMBLⁱ	CHEMBL5699
GuidetoPHARMACOLOGYⁱ	2198

PTM databases

iPTMnetⁱ	Q9H0K1
PhosphoSitePlusⁱ	Q9H0K1

Polymorphism and mutation databases

BioMutaⁱ	SIK2
DMDMⁱ	59798973

Proteomic databases

EPDⁱ	Q9H0K1
MaxQBⁱ	Q9H0K1
PaxDbⁱ	Q9H0K1
PeptideAtlasⁱ	Q9H0K1
PRIDEⁱ	Q9H0K1
ProteomicsDBⁱ	80290

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	23235
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000304987; ENSP00000305976; ENSG00000170145
GeneIDⁱ	23235
KEGGⁱ	hsa:23235
UCSCⁱ	uc001plt.4 human

Organism-specific databases

CTDⁱ	23235
DisGeNETⁱ	23235
EuPathDBⁱ	HostDB:ENSG00000170145.4
GeneCardsⁱ	SIK2
HGNCⁱ	HGNC:21680 SIK2
HPAⁱ	HPA016026
MIMⁱ	608973 gene
neXtProtⁱ	NX_Q9H0K1
OpenTargetsⁱ	ENSG00000170145
PharmGKBⁱ	PA164725750
HUGEⁱ	Search...
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0586 Eukaryota ENOG410XNQ0 LUCA
GeneTreeⁱ	ENSGT00900000140806
HOVERGENⁱ	HBG079197
InParanoidⁱ	Q9H0K1
KOⁱ	K16311
OMAⁱ	DCPRSSG
OrthoDBⁱ	EOG091G03A4
PhylomeDBⁱ	Q9H0K1
TreeFamⁱ	TF315213

Enzyme and pathway databases

SignaLinkⁱ	Q9H0K1
SIGNORⁱ	Q9H0K1

Miscellaneous databases

ChiTaRSⁱ	SIK2 human
GeneWikiⁱ	SNF1LK2
GenomeRNAiⁱ	23235
Protein Ontology More...PROⁱ	PR:Q9H0K1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000170145 Expressed in 230 organ(s), highest expression level in adipose tissue
ExpressionAtlasⁱ	Q9H0K1 baseline and differential
Genevisibleⁱ	Q9H0K1 HS

Family and domain databases

CDDⁱ	cd14071 STKc_SIK, 1 hit
InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS IPR017090 Ser/Thr_kinase_SIK1/2 IPR034672 SIK IPR015940 UBA
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF037014 Ser/Thr_PK_SNF1-like, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 2 hits
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit PS50030 UBA, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SIK2_HUMAN
Accessionⁱ	Q9H0K1Primary (citable) accession number: Q9H0K1 Secondary accession number(s): A8K5B8 Q96CZ8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 15, 2005
	Last sequence update:	March 1, 2001
	Last modified:	October 10, 2018
	This is version 163 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q9H0K1 (SIK2_HUMAN)

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Serine/threonine-protein kinase SIK2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ