UniProtKB - Q9H0K1 (SIK2_HUMAN)
Protein
Serine/threonine-protein kinase SIK2
Gene
SIK2
Organism
Homo sapiens (Human)
Status
Functioni
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators.1 Publication
Catalytic activityi
Cofactori
Mg2+1 Publication
Activity regulationi
Activated by phosphorylation on Thr-175.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 49 | ATPPROSITE-ProRule annotationBy similarity | 1 | |
Active sitei | 142 | Proton acceptorPROSITE-ProRule annotationBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 26 – 34 | ATPPROSITE-ProRule annotationBy similarity | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB
- magnesium ion binding Source: UniProtKB
- protein serine/threonine kinase activity Source: UniProtKB
- protein serine kinase activity Source: UniProtKB-EC
- protein threonine kinase activity Source: UniProtKB-EC
GO - Biological processi
- cellular response to glucose starvation Source: GO_Central
- intracellular signal transduction Source: UniProtKB
- protein autophosphorylation Source: UniProtKB
- protein phosphorylation Source: UniProtKB
- regulation of insulin receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | Q9H0K1 |
SignaLinki | Q9H0K1 |
SIGNORi | Q9H0K1 |
Names & Taxonomyi
Protein namesi | Recommended name: Serine/threonine-protein kinase SIK2 (EC:2.7.11.1)Alternative name(s): Qin-induced kinase Salt-inducible kinase 2 Short name: SIK-2 Serine/threonine-protein kinase SNF1-like kinase 2 |
Gene namesi | Name:SIK2 Synonyms:KIAA0781Imported, QIK, SNF1LK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:21680, SIK2 |
MIMi | 608973, gene |
neXtProti | NX_Q9H0K1 |
VEuPathDBi | HostDB:ENSG00000170145.4 |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 175 | T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication | 1 | |
Mutagenesisi | 175 | T → E: Constitutively active. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 23235 |
OpenTargetsi | ENSG00000170145 |
PharmGKBi | PA164725750 |
Miscellaneous databases
Pharosi | Q9H0K1, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5699 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9H0K1 |
GuidetoPHARMACOLOGYi | 2198 |
Genetic variation databases
BioMutai | SIK2 |
DMDMi | 59798973 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086662 | 1 – 926 | Serine/threonine-protein kinase SIK2Add BLAST | 926 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 25 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 53 | N6-acetyllysine; by EP3001 Publication | 1 | |
Modified residuei | 175 | Phosphothreonine; by LKB11 Publication | 1 | |
Modified residuei | 534 | PhosphoserineBy similarity | 1 | |
Modified residuei | 587 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated at Thr-175 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39.1 Publication
Acetylation at Lys-53 inhibits kinase activity. Deacetylated by HDAC6.1 Publication
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q9H0K1 |
jPOSTi | Q9H0K1 |
MassIVEi | Q9H0K1 |
MaxQBi | Q9H0K1 |
PaxDbi | Q9H0K1 |
PeptideAtlasi | Q9H0K1 |
PRIDEi | Q9H0K1 |
ProteomicsDBi | 80290 |
PTM databases
iPTMneti | Q9H0K1 |
PhosphoSitePlusi | Q9H0K1 |
Expressioni
Gene expression databases
Bgeei | ENSG00000170145, Expressed in adipose tissue and 244 other tissues |
ExpressionAtlasi | Q9H0K1, baseline and differential |
Genevisiblei | Q9H0K1, HS |
Organism-specific databases
HPAi | ENSG00000170145, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with and phosphorylates TORC2/CRTC2.
1 PublicationBinary interactionsi
Hide detailsQ9H0K1
With | #Exp. | IntAct |
---|---|---|
CEP250 [Q9BV73] | 5 | EBI-1181664,EBI-1053100 |
GABARAPL2 [P60520] | 3 | EBI-1181664,EBI-720116 |
PIK3R1 [P27986] | 7 | EBI-1181664,EBI-79464 |
VCP [P55072] | 4 | EBI-1181664,EBI-355164 |
Protein-protein interaction databases
BioGRIDi | 116840, 39 interactors |
IntActi | Q9H0K1, 30 interactors |
STRINGi | 9606.ENSP00000305976 |
Chemistry databases
BindingDBi | Q9H0K1 |
Miscellaneous databases
RNActi | Q9H0K1, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 20 – 271 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 295 – 335 | UBAPROSITE-ProRule annotationAdd BLAST | 41 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.Curated
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000156445 |
HOGENOMi | CLU_000288_87_0_1 |
InParanoidi | Q9H0K1 |
OMAi | METVDPQ |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q9H0K1 |
TreeFami | TF315213 |
Family and domain databases
CDDi | cd14071, STKc_SIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR017090, Ser/Thr_kinase_SIK1/2 IPR034672, SIK IPR015940, UBA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037014, Ser/Thr_PK_SNF1-like, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
i Sequence
Sequence statusi: Complete.
Q9H0K1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVMADGPRHL QRGPVRVGFY DIEGTLGKGN FAVVKLGRHR ITKTEVAIKI
60 70 80 90 100
IDKSQLDAVN LEKIYREVQI MKMLDHPHII KLYQVMETKS MLYLVTEYAK
110 120 130 140 150
NGEIFDYLAN HGRLNESEAR RKFWQILSAV DYCHGRKIVH RDLKAENLLL
160 170 180 190 200
DNNMNIKIAD FGFGNFFKSG ELLATWCGSP PYAAPEVFEG QQYEGPQLDI
210 220 230 240 250
WSMGVVLYVL VCGALPFDGP TLPILRQRVL EGRFRIPYFM SEDCEHLIRR
260 270 280 290 300
MLVLDPSKRL TIAQIKEHKW MLIEVPVQRP VLYPQEQENE PSIGEFNEQV
310 320 330 340 350
LRLMHSLGID QQKTIESLQN KSYNHFAAIY FLLVERLKSH RSSFPVEQRL
360 370 380 390 400
DGRQRRPSTI AEQTVAKAQT VGLPVTMHSP NMRLLRSALL PQASNVEAFS
410 420 430 440 450
FPASGCQAEA AFMEEECVDT PKVNGCLLDP VPPVLVRKGC QSLPSNMMET
460 470 480 490 500
SIDEGLETEG EAEEDPAHAF EAFQSTRSGQ RRHTLSEVTN QLVVMPGAGK
510 520 530 540 550
IFSMNDSPSL DSVDSEYDMG SVQRDLNFLE DNPSLKDIML ANQPSPRMTS
560 570 580 590 600
PFISLRPTNP AMQALSSQKR EVHNRSPVSF REGRRASDTS LTQGIVAFRQ
610 620 630 640 650
HLQNLARTKG ILELNKVQLL YEQIGPEADP NLAPAAPQLQ DLASSCPQEE
660 670 680 690 700
VSQQQESVST LPASVHPQLS PRQSLETQYL QHRLQKPSLL SKAQNTCQLY
710 720 730 740 750
CKEPPRSLEQ QLQEHRLQQK RLFLQKQSQL QAYFNQMQIA ESSYPQPSQQ
760 770 780 790 800
LPLPRQETPP PSQQAPPFSL TQPLSPVLEP SSEQMQYSPF LSQYQEMQLQ
810 820 830 840 850
PLPSTSGPRA APPLPTQLQQ QQPPPPPPPP PPRQPGAAPA PLQFSYQTCE
860 870 880 890 900
LPSAASPAPD YPTPCQYPVD GAQQSDLTGP DCPRSPGLQE APSSYDPLAL
910 920
SELPGLFDCE MLDAVDPQHN GYVLVN
Sequence cautioni
The sequence BAA34501 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 192 | Q → H in BAF83922 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 463 | E → V in BAF83922 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_041093 | 458 | T → I1 PublicationCorresponds to variant dbSNP:rs35789057Ensembl. | 1 | |
Natural variantiVAR_041094 | 809 | R → Q1 PublicationCorresponds to variant dbSNP:rs34223841Ensembl. | 1 | |
Natural variantiVAR_041095 | 825 | P → L1 PublicationCorresponds to variant dbSNP:rs55889697Ensembl. | 1 | |
Natural variantiVAR_051667 | 828 | P → L. Corresponds to variant dbSNP:rs45520245Ensembl. | 1 | |
Natural variantiVAR_051668 | 829 | P → S. Corresponds to variant dbSNP:rs45586732Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018324 mRNA Translation: BAA34501.3 Different initiation. AL136764 mRNA Translation: CAB66698.1 AK291233 mRNA Translation: BAF83922.1 EF445030 Genomic DNA Translation: ACA06072.1 CH471065 Genomic DNA Translation: EAW67148.1 BC013612 mRNA Translation: AAH13612.1 BC078150 mRNA Translation: AAH78150.1 BC113459 mRNA Translation: AAI13460.1 BC117183 mRNA Translation: AAI17184.1 AB084424 mRNA Translation: BAB91442.1 |
CCDSi | CCDS8347.1 |
RefSeqi | NP_056006.1, NM_015191.2 |
Genome annotation databases
Ensembli | ENST00000304987; ENSP00000305976; ENSG00000170145 |
GeneIDi | 23235 |
KEGGi | hsa:23235 |
UCSCi | uc001plt.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB018324 mRNA Translation: BAA34501.3 Different initiation. AL136764 mRNA Translation: CAB66698.1 AK291233 mRNA Translation: BAF83922.1 EF445030 Genomic DNA Translation: ACA06072.1 CH471065 Genomic DNA Translation: EAW67148.1 BC013612 mRNA Translation: AAH13612.1 BC078150 mRNA Translation: AAH78150.1 BC113459 mRNA Translation: AAI13460.1 BC117183 mRNA Translation: AAI17184.1 AB084424 mRNA Translation: BAB91442.1 |
CCDSi | CCDS8347.1 |
RefSeqi | NP_056006.1, NM_015191.2 |
3D structure databases
SMRi | Q9H0K1 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 116840, 39 interactors |
IntActi | Q9H0K1, 30 interactors |
STRINGi | 9606.ENSP00000305976 |
Chemistry databases
BindingDBi | Q9H0K1 |
ChEMBLi | CHEMBL5699 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | Q9H0K1 |
GuidetoPHARMACOLOGYi | 2198 |
PTM databases
iPTMneti | Q9H0K1 |
PhosphoSitePlusi | Q9H0K1 |
Genetic variation databases
BioMutai | SIK2 |
DMDMi | 59798973 |
Proteomic databases
EPDi | Q9H0K1 |
jPOSTi | Q9H0K1 |
MassIVEi | Q9H0K1 |
MaxQBi | Q9H0K1 |
PaxDbi | Q9H0K1 |
PeptideAtlasi | Q9H0K1 |
PRIDEi | Q9H0K1 |
ProteomicsDBi | 80290 |
Protocols and materials databases
Antibodypediai | 18251, 296 antibodies |
DNASUi | 23235 |
Genome annotation databases
Ensembli | ENST00000304987; ENSP00000305976; ENSG00000170145 |
GeneIDi | 23235 |
KEGGi | hsa:23235 |
UCSCi | uc001plt.4, human |
Organism-specific databases
CTDi | 23235 |
DisGeNETi | 23235 |
GeneCardsi | SIK2 |
HGNCi | HGNC:21680, SIK2 |
HPAi | ENSG00000170145, Low tissue specificity |
MIMi | 608973, gene |
neXtProti | NX_Q9H0K1 |
OpenTargetsi | ENSG00000170145 |
PharmGKBi | PA164725750 |
VEuPathDBi | HostDB:ENSG00000170145.4 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0586, Eukaryota |
GeneTreei | ENSGT00940000156445 |
HOGENOMi | CLU_000288_87_0_1 |
InParanoidi | Q9H0K1 |
OMAi | METVDPQ |
OrthoDBi | 1127668at2759 |
PhylomeDBi | Q9H0K1 |
TreeFami | TF315213 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0K1 |
SignaLinki | Q9H0K1 |
SIGNORi | Q9H0K1 |
Miscellaneous databases
BioGRID-ORCSi | 23235, 5 hits in 900 CRISPR screens |
ChiTaRSi | SIK2, human |
GeneWikii | SNF1LK2 |
GenomeRNAii | 23235 |
Pharosi | Q9H0K1, Tchem |
PROi | PR:Q9H0K1 |
RNActi | Q9H0K1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000170145, Expressed in adipose tissue and 244 other tissues |
ExpressionAtlasi | Q9H0K1, baseline and differential |
Genevisiblei | Q9H0K1, HS |
Family and domain databases
CDDi | cd14071, STKc_SIK, 1 hit |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR017090, Ser/Thr_kinase_SIK1/2 IPR034672, SIK IPR015940, UBA |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
PIRSFi | PIRSF037014, Ser/Thr_PK_SNF1-like, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit PS50030, UBA, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SIK2_HUMAN | |
Accessioni | Q9H0K1Primary (citable) accession number: Q9H0K1 Secondary accession number(s): A8K5B8 Q96CZ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 15, 2005 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families