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UniProtKB - Q9H0H0 (INT2_HUMAN)

Entry version 141 (10 Feb 2021)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

Integrator complex subunit 2

Gene

INTS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).1 Publication1 Publication

Caution

It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H0H0

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6807505, RNA polymerase II transcribes snRNA genes

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q9H0H0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrator complex subunit 2
Short name:
Int2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:INTS2
Synonyms:KIAA1287
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:29241, INTS2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611346, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H0H0

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000108506.11

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei428 – 444HelicalSequence analysisAdd BLAST17

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		57508

Open Targets

More...OpenTargetsi		ENSG00000108506

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142671605

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H0H0, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		INTS2

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434542

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002360991 – 1204Integrator complex subunit 2Add BLAST1204

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q9H0H0

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q9H0H0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q9H0H0

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H0H0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H0H0

PeptideAtlas

More...PeptideAtlasi		Q9H0H0

PRoteomics IDEntifications database

More...PRIDEi		Q9H0H0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		80277

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H0H0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H0H0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000108506, Expressed in brain and 211 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H0H0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H0H0, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000108506, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		121572, 58 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q9H0H0

Database of interacting proteins

More...DIPi		DIP-48477N

Protein interaction database and analysis system

More...IntActi		Q9H0H0, 23 interactors

Molecular INTeraction database

More...MINTi		Q9H0H0

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000414237

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H0H0, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Integrator subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QSP2, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000011888

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H0H0

Identification of Orthologs from Complete Genome Data

More...OMAi		VANFPDC

Database of Orthologous Groups

More...OrthoDBi		173270at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H0H0

TreeFam database of animal gene trees

More...TreeFami		TF324737

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR026236, Int2_metazoa
IPR029321, INTS2

The PANTHER Classification System

More...PANTHERi		PTHR28608, PTHR28608, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14750, INTS2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02105, INTSUBUNIT2

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q9H0H0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKDQQTVIMT ECTSLQFVSP FAFEAMQKVD VVCLASLSDP ELRLLLPCLV 
        60         70         80         90        100
RMALCAPADQ SQSWAQDKKL ILRLLSGVEA VNSIVALLSV DFHALEQDAS 
       110        120        130        140        150
KEQQLRHKLG GGSGESILVS QLQHGLTLEF EHSDSPRRLR LVLSELLAIM 
       160        170        180        190        200
NKVSESNGEF FFKSSELFES PVYLEEAADV LCILQAELPS LLPIVDVAEA 
       210        220        230        240        250
LLHVRNGAWF LCLLVANVPD SFNEVCRGLI KNGERQDEES LGGRRRTDAL 
       260        270        280        290        300
RFLCKMNPSQ ALKVRGMVVE ECHLPGLGVA LTLDHTKNEA CEDGVSDLVC 
       310        320        330        340        350
FVSGLLLGTN AKVRTWFGTF IRNGQQRKRE TSSSVLWQMR RQLLLELMGI 
       360        370        380        390        400
LPTVRSTRIV EEADVDMEPN VSVYSGLKEE HVVKASALLR LYCALMGIAG 
       410        420        430        440        450
LKPTEEEAEQ LLQLMTSRPP ATPAGVRFVS LSFCMLLAFS TLVSTPEQEQ 
       460        470        480        490        500
LMVVWLSWMI KEEAYFESTS GVSASFGEML LLVAMYFHSN QLSAIIDLVC 
       510        520        530        540        550
STLGMKIVIK PSSLSRMKTI FTQEIFTEQV VTAHAVRVPV TSNLSANITG 
       560        570        580        590        600
FLPIHCIYQL LRSRSFTKHK VSIKDWIYRQ LCETSTPLHP QLLPLIDVYI 
       610        620        630        640        650
NSILTPASKS NPEATNQPVT EQEILNIFQG VIGGDNIRLN QRFSITAQLL 
       660        670        680        690        700
VLYYILSYEE ALLANTKTLA AMQRKPKSYS SSLMDQIPIK FLIRQAQGLQ 
       710        720        730        740        750
QELGGLHSAL LRLLATNYPH LCIVDDWICE EEITGTDALL RRMLLTNNAK 
       760        770        780        790        800
NHSPKQLQEA FSAVPVNNTQ VMQIIEHLTL LSASELIPYA EVLTSNMSQL 
       810        820        830        840        850
LNSGVPRRIL QTVNKLWMVL NTVMPRRLWV MTVNALQPSI KFVRQQKYTQ 
       860        870        880        890        900
NDLMIDPLIV LRCDQRVHRC PPLMDITLHM LNGYLLASKA YLSAHLKETE 
       910        920        930        940        950
QDRPSQNNTI GLVGQTDAPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE 
       960        970        980        990       1000
EEKANGVNPD SLLRNVQSVI TTSAPNKGME EGEDNLLCNL REVQCLICCL 
      1010       1020       1030       1040       1050
LHQMYIADPN IAKLVHFQGY PCELLPLTVA GIPSMHICLD FIPELIAQPE 
      1060       1070       1080       1090       1100
LEKQIFAIQL LSHLCIQYAL PKSLSVARLA VNVMGTLLTV LTQAKRYAFF 
      1110       1120       1130       1140       1150
MPTLPSLVSF CRAFPPLYED IMSLLIQIGQ VCASDVATQT RDIDPIITRL 
      1160       1170       1180       1190       1200
QQIKEKPSGW SQICKDSSYK NGSRDTGSMD PDVQLCHCIE RTVIEIINMS 

VSGI
Length:1,204
Mass (Da):134,323
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4E160F25E1ACB4B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KMZ7J3KMZ7_HUMAN
Integrator complex subunit 2
INTS2
1,196Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y4Z6A0A2R8Y4Z6_HUMAN
Integrator complex subunit 2
INTS2
332Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7F8A0A2R8Y7F8_HUMAN
Integrator complex subunit 2
INTS2
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KRH0J3KRH0_HUMAN
Integrator complex subunit 2
INTS2
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → GWRVDL in BAA86601 (PubMed:10574462).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_049628768N → H4 PublicationsCorresponds to variant dbSNP:rs606072Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AB033113 mRNA Translation: BAA86601.1
AL136800 mRNA Translation: CAB66734.1
CR533582 mRNA Translation: CAG38656.1
AC060798 Genomic DNA No translation available.
BK005721 mRNA Translation: DAA05721.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS45750.1

NCBI Reference Sequences

More...RefSeqi		NP_001317346.1, NM_001330417.1
NP_065799.1, NM_020748.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000444766; ENSP00000414237; ENSG00000108506
ENST00000617492; ENSP00000482710; ENSG00000108506

Database of genes from NCBI RefSeq genomes

More...GeneIDi		57508

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:57508

UCSC genome browser

More...UCSCi		uc002izn.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033113 mRNA Translation: BAA86601.1
AL136800 mRNA Translation: CAB66734.1
CR533582 mRNA Translation: CAG38656.1
AC060798 Genomic DNA No translation available.
BK005721 mRNA Translation: DAA05721.1
CCDSiCCDS45750.1
RefSeqiNP_001317346.1, NM_001330417.1
NP_065799.1, NM_020748.2

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi121572, 58 interactors
CORUMiQ9H0H0
DIPiDIP-48477N
IntActiQ9H0H0, 23 interactors
MINTiQ9H0H0
STRINGi9606.ENSP00000414237

PTM databases

iPTMnetiQ9H0H0
PhosphoSitePlusiQ9H0H0

Genetic variation databases

BioMutaiINTS2
DMDMi296434542

Proteomic databases

EPDiQ9H0H0
jPOSTiQ9H0H0
MassIVEiQ9H0H0
MaxQBiQ9H0H0
PaxDbiQ9H0H0
PeptideAtlasiQ9H0H0
PRIDEiQ9H0H0
ProteomicsDBi80277

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		57004, 67 antibodies

The DNASU plasmid repository

More...DNASUi		57508

Genome annotation databases

EnsembliENST00000444766; ENSP00000414237; ENSG00000108506
ENST00000617492; ENSP00000482710; ENSG00000108506
GeneIDi57508
KEGGihsa:57508
UCSCiuc002izn.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		57508
DisGeNETi57508

GeneCards: human genes, protein and diseases

More...GeneCardsi		INTS2
HGNCiHGNC:29241, INTS2
HPAiENSG00000108506, Low tissue specificity
MIMi611346, gene
neXtProtiNX_Q9H0H0
OpenTargetsiENSG00000108506
PharmGKBiPA142671605
VEuPathDBiHostDB:ENSG00000108506.11

Human Unidentified Gene-Encoded large proteins database

More...HUGEi		Search...

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502QSP2, Eukaryota
GeneTreeiENSGT00390000011888
InParanoidiQ9H0H0
OMAiVANFPDC
OrthoDBi173270at2759
PhylomeDBiQ9H0H0
TreeFamiTF324737

Enzyme and pathway databases

PathwayCommonsiQ9H0H0
ReactomeiR-HSA-6807505, RNA polymerase II transcribes snRNA genes
SIGNORiQ9H0H0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		57508, 626 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		INTS2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		57508
PharosiQ9H0H0, Tdark

Protein Ontology

More...PROi		PR:Q9H0H0
RNActiQ9H0H0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000108506, Expressed in brain and 211 other tissues
ExpressionAtlasiQ9H0H0, baseline and differential
GenevisibleiQ9H0H0, HS

Family and domain databases

InterProiView protein in InterPro
IPR026236, Int2_metazoa
IPR029321, INTS2
PANTHERiPTHR28608, PTHR28608, 1 hit
PfamiView protein in Pfam
PF14750, INTS2, 1 hit
PRINTSiPR02105, INTSUBUNIT2

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiINT2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0H0
Secondary accession number(s): Q9ULD3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: February 10, 2021
This is version 141 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families
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