UniProtKB - Q9H0H0 (INT2_HUMAN)
Protein
Integrator complex subunit 2
Gene
INTS2
Organism
Homo sapiens (Human)
Status
Functioni
Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).1 Publication1 Publication
Caution
It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus.Curated
GO - Biological processi
- snRNA 3'-end processing Source: GO_Central
- snRNA processing Source: HGNC-UCL
- snRNA transcription by RNA polymerase II Source: Reactome
Enzyme and pathway databases
PathwayCommonsi | Q9H0H0 |
Reactomei | R-HSA-6807505, RNA polymerase II transcribes snRNA genes |
SIGNORi | Q9H0H0 |
Names & Taxonomyi
Protein namesi | Recommended name: Integrator complex subunit 2Short name: Int2 |
Gene namesi | Name:INTS2 Synonyms:KIAA1287 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:29241, INTS2 |
MIMi | 611346, gene |
neXtProti | NX_Q9H0H0 |
VEuPathDBi | HostDB:ENSG00000108506.11 |
Subcellular locationi
Nucleus
- Nucleus membrane 1 Publication; Single-pass membrane protein Curated
Other locations
- Cytoplasm 1 Publication
Nucleus
- integrator complex Source: HGNC-UCL
- nuclear membrane Source: UniProtKB-SubCell
- nucleoplasm Source: Reactome
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- integral component of membrane Source: UniProtKB-KW
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 428 – 444 | HelicalSequence analysisAdd BLAST | 17 |
Keywords - Cellular componenti
Cytoplasm, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 57508 |
OpenTargetsi | ENSG00000108506 |
PharmGKBi | PA142671605 |
Miscellaneous databases
Pharosi | Q9H0H0, Tdark |
Genetic variation databases
BioMutai | INTS2 |
DMDMi | 296434542 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000236099 | 1 – 1204 | Integrator complex subunit 2Add BLAST | 1204 |
Proteomic databases
EPDi | Q9H0H0 |
jPOSTi | Q9H0H0 |
MassIVEi | Q9H0H0 |
MaxQBi | Q9H0H0 |
PaxDbi | Q9H0H0 |
PeptideAtlasi | Q9H0H0 |
PRIDEi | Q9H0H0 |
ProteomicsDBi | 80277 |
PTM databases
iPTMneti | Q9H0H0 |
PhosphoSitePlusi | Q9H0H0 |
Expressioni
Gene expression databases
Bgeei | ENSG00000108506, Expressed in brain and 211 other tissues |
ExpressionAtlasi | Q9H0H0, baseline and differential |
Genevisiblei | Q9H0H0, HS |
Organism-specific databases
HPAi | ENSG00000108506, Low tissue specificity |
Interactioni
Subunit structurei
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.
1 PublicationBinary interactionsi
Hide detailsQ9H0H0
With | #Exp. | IntAct |
---|---|---|
CCDC57 - isoform 2 [Q2TAC2-2] | 3 | EBI-8471507,EBI-10961624 |
DEF6 [Q9H4E7] | 3 | EBI-8471507,EBI-745369 |
NCK2 [O43639] | 3 | EBI-8471507,EBI-713635 |
Protein-protein interaction databases
BioGRIDi | 121572, 58 interactors |
CORUMi | Q9H0H0 |
DIPi | DIP-48477N |
IntActi | Q9H0H0, 23 interactors |
MINTi | Q9H0H0 |
STRINGi | 9606.ENSP00000414237 |
Miscellaneous databases
RNActi | Q9H0H0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the Integrator subunit 2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSP2, Eukaryota |
GeneTreei | ENSGT00390000011888 |
InParanoidi | Q9H0H0 |
OMAi | VANFPDC |
OrthoDBi | 173270at2759 |
PhylomeDBi | Q9H0H0 |
TreeFami | TF324737 |
Family and domain databases
InterProi | View protein in InterPro IPR026236, Int2_metazoa IPR029321, INTS2 |
PANTHERi | PTHR28608, PTHR28608, 1 hit |
Pfami | View protein in Pfam PF14750, INTS2, 1 hit |
PRINTSi | PR02105, INTSUBUNIT2 |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
Q9H0H0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKDQQTVIMT ECTSLQFVSP FAFEAMQKVD VVCLASLSDP ELRLLLPCLV
60 70 80 90 100
RMALCAPADQ SQSWAQDKKL ILRLLSGVEA VNSIVALLSV DFHALEQDAS
110 120 130 140 150
KEQQLRHKLG GGSGESILVS QLQHGLTLEF EHSDSPRRLR LVLSELLAIM
160 170 180 190 200
NKVSESNGEF FFKSSELFES PVYLEEAADV LCILQAELPS LLPIVDVAEA
210 220 230 240 250
LLHVRNGAWF LCLLVANVPD SFNEVCRGLI KNGERQDEES LGGRRRTDAL
260 270 280 290 300
RFLCKMNPSQ ALKVRGMVVE ECHLPGLGVA LTLDHTKNEA CEDGVSDLVC
310 320 330 340 350
FVSGLLLGTN AKVRTWFGTF IRNGQQRKRE TSSSVLWQMR RQLLLELMGI
360 370 380 390 400
LPTVRSTRIV EEADVDMEPN VSVYSGLKEE HVVKASALLR LYCALMGIAG
410 420 430 440 450
LKPTEEEAEQ LLQLMTSRPP ATPAGVRFVS LSFCMLLAFS TLVSTPEQEQ
460 470 480 490 500
LMVVWLSWMI KEEAYFESTS GVSASFGEML LLVAMYFHSN QLSAIIDLVC
510 520 530 540 550
STLGMKIVIK PSSLSRMKTI FTQEIFTEQV VTAHAVRVPV TSNLSANITG
560 570 580 590 600
FLPIHCIYQL LRSRSFTKHK VSIKDWIYRQ LCETSTPLHP QLLPLIDVYI
610 620 630 640 650
NSILTPASKS NPEATNQPVT EQEILNIFQG VIGGDNIRLN QRFSITAQLL
660 670 680 690 700
VLYYILSYEE ALLANTKTLA AMQRKPKSYS SSLMDQIPIK FLIRQAQGLQ
710 720 730 740 750
QELGGLHSAL LRLLATNYPH LCIVDDWICE EEITGTDALL RRMLLTNNAK
760 770 780 790 800
NHSPKQLQEA FSAVPVNNTQ VMQIIEHLTL LSASELIPYA EVLTSNMSQL
810 820 830 840 850
LNSGVPRRIL QTVNKLWMVL NTVMPRRLWV MTVNALQPSI KFVRQQKYTQ
860 870 880 890 900
NDLMIDPLIV LRCDQRVHRC PPLMDITLHM LNGYLLASKA YLSAHLKETE
910 920 930 940 950
QDRPSQNNTI GLVGQTDAPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE
960 970 980 990 1000
EEKANGVNPD SLLRNVQSVI TTSAPNKGME EGEDNLLCNL REVQCLICCL
1010 1020 1030 1040 1050
LHQMYIADPN IAKLVHFQGY PCELLPLTVA GIPSMHICLD FIPELIAQPE
1060 1070 1080 1090 1100
LEKQIFAIQL LSHLCIQYAL PKSLSVARLA VNVMGTLLTV LTQAKRYAFF
1110 1120 1130 1140 1150
MPTLPSLVSF CRAFPPLYED IMSLLIQIGQ VCASDVATQT RDIDPIITRL
1160 1170 1180 1190 1200
QQIKEKPSGW SQICKDSSYK NGSRDTGSMD PDVQLCHCIE RTVIEIINMS
VSGI
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketJ3KMZ7 | J3KMZ7_HUMAN | Integrator complex subunit 2 | INTS2 | 1,196 | Annotation score: | ||
A0A2R8Y4Z6 | A0A2R8Y4Z6_HUMAN | Integrator complex subunit 2 | INTS2 | 332 | Annotation score: | ||
A0A2R8Y7F8 | A0A2R8Y7F8_HUMAN | Integrator complex subunit 2 | INTS2 | 199 | Annotation score: | ||
J3KRH0 | J3KRH0_HUMAN | Integrator complex subunit 2 | INTS2 | 79 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1 | M → GWRVDL in BAA86601 (PubMed:10574462).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_049628 | 768 | N → H4 PublicationsCorresponds to variant dbSNP:rs606072Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033113 mRNA Translation: BAA86601.1 AL136800 mRNA Translation: CAB66734.1 CR533582 mRNA Translation: CAG38656.1 AC060798 Genomic DNA No translation available. BK005721 mRNA Translation: DAA05721.1 |
CCDSi | CCDS45750.1 |
RefSeqi | NP_001317346.1, NM_001330417.1 NP_065799.1, NM_020748.2 |
Genome annotation databases
Ensembli | ENST00000444766; ENSP00000414237; ENSG00000108506 ENST00000617492; ENSP00000482710; ENSG00000108506 |
GeneIDi | 57508 |
KEGGi | hsa:57508 |
UCSCi | uc002izn.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB033113 mRNA Translation: BAA86601.1 AL136800 mRNA Translation: CAB66734.1 CR533582 mRNA Translation: CAG38656.1 AC060798 Genomic DNA No translation available. BK005721 mRNA Translation: DAA05721.1 |
CCDSi | CCDS45750.1 |
RefSeqi | NP_001317346.1, NM_001330417.1 NP_065799.1, NM_020748.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 121572, 58 interactors |
CORUMi | Q9H0H0 |
DIPi | DIP-48477N |
IntActi | Q9H0H0, 23 interactors |
MINTi | Q9H0H0 |
STRINGi | 9606.ENSP00000414237 |
PTM databases
iPTMneti | Q9H0H0 |
PhosphoSitePlusi | Q9H0H0 |
Genetic variation databases
BioMutai | INTS2 |
DMDMi | 296434542 |
Proteomic databases
EPDi | Q9H0H0 |
jPOSTi | Q9H0H0 |
MassIVEi | Q9H0H0 |
MaxQBi | Q9H0H0 |
PaxDbi | Q9H0H0 |
PeptideAtlasi | Q9H0H0 |
PRIDEi | Q9H0H0 |
ProteomicsDBi | 80277 |
Protocols and materials databases
Antibodypediai | 57004, 67 antibodies |
DNASUi | 57508 |
Genome annotation databases
Ensembli | ENST00000444766; ENSP00000414237; ENSG00000108506 ENST00000617492; ENSP00000482710; ENSG00000108506 |
GeneIDi | 57508 |
KEGGi | hsa:57508 |
UCSCi | uc002izn.4, human |
Organism-specific databases
CTDi | 57508 |
DisGeNETi | 57508 |
GeneCardsi | INTS2 |
HGNCi | HGNC:29241, INTS2 |
HPAi | ENSG00000108506, Low tissue specificity |
MIMi | 611346, gene |
neXtProti | NX_Q9H0H0 |
OpenTargetsi | ENSG00000108506 |
PharmGKBi | PA142671605 |
VEuPathDBi | HostDB:ENSG00000108506.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QSP2, Eukaryota |
GeneTreei | ENSGT00390000011888 |
InParanoidi | Q9H0H0 |
OMAi | VANFPDC |
OrthoDBi | 173270at2759 |
PhylomeDBi | Q9H0H0 |
TreeFami | TF324737 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0H0 |
Reactomei | R-HSA-6807505, RNA polymerase II transcribes snRNA genes |
SIGNORi | Q9H0H0 |
Miscellaneous databases
BioGRID-ORCSi | 57508, 626 hits in 876 CRISPR screens |
ChiTaRSi | INTS2, human |
GenomeRNAii | 57508 |
Pharosi | Q9H0H0, Tdark |
PROi | PR:Q9H0H0 |
RNActi | Q9H0H0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000108506, Expressed in brain and 211 other tissues |
ExpressionAtlasi | Q9H0H0, baseline and differential |
Genevisiblei | Q9H0H0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR026236, Int2_metazoa IPR029321, INTS2 |
PANTHERi | PTHR28608, PTHR28608, 1 hit |
Pfami | View protein in Pfam PF14750, INTS2, 1 hit |
PRINTSi | PR02105, INTSUBUNIT2 |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | INT2_HUMAN | |
Accessioni | Q9H0H0Primary (citable) accession number: Q9H0H0 Secondary accession number(s): Q9ULD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 16, 2006 |
Last sequence update: | May 18, 2010 | |
Last modified: | February 10, 2021 | |
This is version 141 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families