Integrator complex subunit 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• snRNA 3'-end processing Source: GO_Central
• snRNA processing Source: HGNC <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 16239144
• snRNA transcription by RNA polymerase II Source: Reactome

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MKDQQTVIMT ECTSLQFVSP FAFEAMQKVD VVCLASLSDP ELRLLLPCLV 
        60         70         80         90        100
RMALCAPADQ SQSWAQDKKL ILRLLSGVEA VNSIVALLSV DFHALEQDAS 
       110        120        130        140        150
KEQQLRHKLG GGSGESILVS QLQHGLTLEF EHSDSPRRLR LVLSELLAIM 
       160        170        180        190        200
NKVSESNGEF FFKSSELFES PVYLEEAADV LCILQAELPS LLPIVDVAEA 
       210        220        230        240        250
LLHVRNGAWF LCLLVANVPD SFNEVCRGLI KNGERQDEES LGGRRRTDAL 
       260        270        280        290        300
RFLCKMNPSQ ALKVRGMVVE ECHLPGLGVA LTLDHTKNEA CEDGVSDLVC 
       310        320        330        340        350
FVSGLLLGTN AKVRTWFGTF IRNGQQRKRE TSSSVLWQMR RQLLLELMGI 
       360        370        380        390        400
LPTVRSTRIV EEADVDMEPN VSVYSGLKEE HVVKASALLR LYCALMGIAG 
       410        420        430        440        450
LKPTEEEAEQ LLQLMTSRPP ATPAGVRFVS LSFCMLLAFS TLVSTPEQEQ 
       460        470        480        490        500
LMVVWLSWMI KEEAYFESTS GVSASFGEML LLVAMYFHSN QLSAIIDLVC 
       510        520        530        540        550
STLGMKIVIK PSSLSRMKTI FTQEIFTEQV VTAHAVRVPV TSNLSANITG 
       560        570        580        590        600
FLPIHCIYQL LRSRSFTKHK VSIKDWIYRQ LCETSTPLHP QLLPLIDVYI 
       610        620        630        640        650
NSILTPASKS NPEATNQPVT EQEILNIFQG VIGGDNIRLN QRFSITAQLL 
       660        670        680        690        700
VLYYILSYEE ALLANTKTLA AMQRKPKSYS SSLMDQIPIK FLIRQAQGLQ 
       710        720        730        740        750
QELGGLHSAL LRLLATNYPH LCIVDDWICE EEITGTDALL RRMLLTNNAK 
       760        770        780        790        800
NHSPKQLQEA FSAVPVNNTQ VMQIIEHLTL LSASELIPYA EVLTSNMSQL 
       810        820        830        840        850
LNSGVPRRIL QTVNKLWMVL NTVMPRRLWV MTVNALQPSI KFVRQQKYTQ 
       860        870        880        890        900
NDLMIDPLIV LRCDQRVHRC PPLMDITLHM LNGYLLASKA YLSAHLKETE 
       910        920        930        940        950
QDRPSQNNTI GLVGQTDAPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE 
       960        970        980        990       1000
EEKANGVNPD SLLRNVQSVI TTSAPNKGME EGEDNLLCNL REVQCLICCL 
      1010       1020       1030       1040       1050
LHQMYIADPN IAKLVHFQGY PCELLPLTVA GIPSMHICLD FIPELIAQPE 
      1060       1070       1080       1090       1100
LEKQIFAIQL LSHLCIQYAL PKSLSVARLA VNVMGTLLTV LTQAKRYAFF 
      1110       1120       1130       1140       1150
MPTLPSLVSF CRAFPPLYED IMSLLIQIGQ VCASDVATQT RDIDPIITRL 
      1160       1170       1180       1190       1200
QQIKEKPSGW SQICKDSSYK NGSRDTGSMD PDVQLCHCIE RTVIEIINMS 

VSGI                                                   

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. SIMILARITY comments
   Index of protein domains and families