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Protein

Integrator complex subunit 2

Gene

INTS2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).1 Publication1 Publication

Caution

It is uncertain whether Met-1 or Met-9 is the initiator. Orthologous sequences (mouse and chicken) have shorter N-terminus.Curated

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 2
Short name:
Int2
Gene namesi
Name:INTS2
Synonyms:KIAA1287
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108506.11
HGNCiHGNC:29241 INTS2
MIMi611346 gene
neXtProtiNX_Q9H0H0

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei428 – 444HelicalSequence analysisAdd BLAST17

Keywords - Cellular componenti

Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi57508
OpenTargetsiENSG00000108506
PharmGKBiPA142671605

Polymorphism and mutation databases

BioMutaiINTS2
DMDMi296434542

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002360991 – 1204Integrator complex subunit 2Add BLAST1204

Proteomic databases

EPDiQ9H0H0
MaxQBiQ9H0H0
PaxDbiQ9H0H0
PeptideAtlasiQ9H0H0
PRIDEiQ9H0H0
ProteomicsDBi80277

PTM databases

iPTMnetiQ9H0H0
PhosphoSitePlusiQ9H0H0

Expressioni

Gene expression databases

BgeeiENSG00000108506
CleanExiHS_INTS2
ExpressionAtlasiQ9H0H0 baseline and differential
GenevisibleiQ9H0H0 HS

Organism-specific databases

HPAiHPA049524

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12.1 Publication

Protein-protein interaction databases

BioGridi121572, 44 interactors
CORUMiQ9H0H0
DIPiDIP-48477N
IntActiQ9H0H0, 8 interactors
MINTiQ9H0H0
STRINGi9606.ENSP00000414237

Structurei

3D structure databases

ProteinModelPortaliQ9H0H0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Integrator subunit 2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH4R Eukaryota
ENOG410XYV2 LUCA
GeneTreeiENSGT00390000011888
HOGENOMiHOG000047505
HOVERGENiHBG059904
InParanoidiQ9H0H0
KOiK13139
OMAiLCMLIAC
OrthoDBiEOG091G025T
PhylomeDBiQ9H0H0
TreeFamiTF324737

Family and domain databases

InterProiView protein in InterPro
IPR026236 Int2_metazoa
IPR029321 INTS2
PANTHERiPTHR28608 PTHR28608, 1 hit
PfamiView protein in Pfam
PF14750 INTS2, 1 hit
PRINTSiPR02105 INTSUBUNIT2

Sequencei

Sequence statusi: Complete.

Q9H0H0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDQQTVIMT ECTSLQFVSP FAFEAMQKVD VVCLASLSDP ELRLLLPCLV
60 70 80 90 100
RMALCAPADQ SQSWAQDKKL ILRLLSGVEA VNSIVALLSV DFHALEQDAS
110 120 130 140 150
KEQQLRHKLG GGSGESILVS QLQHGLTLEF EHSDSPRRLR LVLSELLAIM
160 170 180 190 200
NKVSESNGEF FFKSSELFES PVYLEEAADV LCILQAELPS LLPIVDVAEA
210 220 230 240 250
LLHVRNGAWF LCLLVANVPD SFNEVCRGLI KNGERQDEES LGGRRRTDAL
260 270 280 290 300
RFLCKMNPSQ ALKVRGMVVE ECHLPGLGVA LTLDHTKNEA CEDGVSDLVC
310 320 330 340 350
FVSGLLLGTN AKVRTWFGTF IRNGQQRKRE TSSSVLWQMR RQLLLELMGI
360 370 380 390 400
LPTVRSTRIV EEADVDMEPN VSVYSGLKEE HVVKASALLR LYCALMGIAG
410 420 430 440 450
LKPTEEEAEQ LLQLMTSRPP ATPAGVRFVS LSFCMLLAFS TLVSTPEQEQ
460 470 480 490 500
LMVVWLSWMI KEEAYFESTS GVSASFGEML LLVAMYFHSN QLSAIIDLVC
510 520 530 540 550
STLGMKIVIK PSSLSRMKTI FTQEIFTEQV VTAHAVRVPV TSNLSANITG
560 570 580 590 600
FLPIHCIYQL LRSRSFTKHK VSIKDWIYRQ LCETSTPLHP QLLPLIDVYI
610 620 630 640 650
NSILTPASKS NPEATNQPVT EQEILNIFQG VIGGDNIRLN QRFSITAQLL
660 670 680 690 700
VLYYILSYEE ALLANTKTLA AMQRKPKSYS SSLMDQIPIK FLIRQAQGLQ
710 720 730 740 750
QELGGLHSAL LRLLATNYPH LCIVDDWICE EEITGTDALL RRMLLTNNAK
760 770 780 790 800
NHSPKQLQEA FSAVPVNNTQ VMQIIEHLTL LSASELIPYA EVLTSNMSQL
810 820 830 840 850
LNSGVPRRIL QTVNKLWMVL NTVMPRRLWV MTVNALQPSI KFVRQQKYTQ
860 870 880 890 900
NDLMIDPLIV LRCDQRVHRC PPLMDITLHM LNGYLLASKA YLSAHLKETE
910 920 930 940 950
QDRPSQNNTI GLVGQTDAPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE
960 970 980 990 1000
EEKANGVNPD SLLRNVQSVI TTSAPNKGME EGEDNLLCNL REVQCLICCL
1010 1020 1030 1040 1050
LHQMYIADPN IAKLVHFQGY PCELLPLTVA GIPSMHICLD FIPELIAQPE
1060 1070 1080 1090 1100
LEKQIFAIQL LSHLCIQYAL PKSLSVARLA VNVMGTLLTV LTQAKRYAFF
1110 1120 1130 1140 1150
MPTLPSLVSF CRAFPPLYED IMSLLIQIGQ VCASDVATQT RDIDPIITRL
1160 1170 1180 1190 1200
QQIKEKPSGW SQICKDSSYK NGSRDTGSMD PDVQLCHCIE RTVIEIINMS

VSGI
Length:1,204
Mass (Da):134,323
Last modified:May 18, 2010 - v2
Checksum:iE4E160F25E1ACB4B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1M → GWRVDL in BAA86601 (PubMed:10574462).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049628768N → H4 PublicationsCorresponds to variant dbSNP:rs606072Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB033113 mRNA Translation: BAA86601.1
AL136800 mRNA Translation: CAB66734.1
CR533582 mRNA Translation: CAG38656.1
AC060798 Genomic DNA No translation available.
BK005721 mRNA Translation: DAA05721.1
CCDSiCCDS45750.1
RefSeqiNP_001317346.1, NM_001330417.1
NP_065799.1, NM_020748.2
UniGeneiHs.279646

Genome annotation databases

EnsembliENST00000444766; ENSP00000414237; ENSG00000108506
ENST00000617492; ENSP00000482710; ENSG00000108506
GeneIDi57508
KEGGihsa:57508
UCSCiuc002izn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiINT2_HUMAN
AccessioniPrimary (citable) accession number: Q9H0H0
Secondary accession number(s): Q9ULD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 18, 2010
Last modified: July 18, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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