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Protein

Nuclear speckle splicing regulatory protein 1

Gene

NSRP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that mediates pre-mRNA alternative splicing regulation.1 Publication

GO - Molecular functioni

  • mRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • developmental process Source: UniProtKB
  • mRNA processing Source: UniProtKB-KW
  • regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
  • RNA splicing Source: UniProtKB-KW

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear speckle splicing regulatory protein 1
Alternative name(s):
Coiled-coil domain-containing protein 55
Nuclear speckle-related protein 70
Short name:
NSrp70
Gene namesi
Name:NSRP1
Synonyms:CCDC55, NSRP70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000126653.15
HGNCiHGNC:25305 NSRP1
MIMi616173 gene
neXtProtiNX_Q9H0G5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi536 – 537RD → AA: Inhibits nuclear localization and alternative splicing activity. 1 Publication2

Organism-specific databases

DisGeNETi84081
OpenTargetsiENSG00000126653
PharmGKBiPA142672171

Polymorphism and mutation databases

BioMutaiNSRP1
DMDMi74733524

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002404341 – 558Nuclear speckle splicing regulatory protein 1Add BLAST558

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphoserineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Cross-linki199Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki210Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei248PhosphoserineCombined sources1
Modified residuei254PhosphoserineCombined sources1
Modified residuei255PhosphoserineCombined sources1
Modified residuei275PhosphothreonineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei457PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9H0G5
MaxQBiQ9H0G5
PaxDbiQ9H0G5
PeptideAtlasiQ9H0G5
PRIDEiQ9H0G5
ProteomicsDBi80276

PTM databases

iPTMnetiQ9H0G5
PhosphoSitePlusiQ9H0G5

Expressioni

Tissue specificityi

Expressed in dendritic cells, T-cells, B-cells and natural killer cells. Expressed in secondary lymphoid organs such as spleen and mesenteric, axillary and brachial lymph nodes.1 Publication

Inductioni

Up-regulated in motile T-cells.1 Publication

Gene expression databases

BgeeiENSG00000126653 Expressed in 199 organ(s), highest expression level in tibia
CleanExiHS_CCDC55
ExpressionAtlasiQ9H0G5 baseline and differential
GenevisibleiQ9H0G5 HS

Organism-specific databases

HPAiHPA015593
HPA015603

Interactioni

Subunit structurei

Interacts (via C-terminus) with SRSF1. Interacts (via C-terminus) with SRSF2.1 Publication

Protein-protein interaction databases

BioGridi123876, 19 interactors
IntActiQ9H0G5, 12 interactors
MINTiQ9H0G5
STRINGi9606.ENSP00000247026

Structurei

3D structure databases

ProteinModelPortaliQ9H0G5
SMRiQ9H0G5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni106 – 170Necessary for alternative splicing activityAdd BLAST65

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili104 – 170Sequence analysisAdd BLAST67
Coiled coili379 – 427Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 37Poly-Asp6
Compositional biasi282 – 359His-richAdd BLAST78

Sequence similaritiesi

Belongs to the NSRP1 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2117 Eukaryota
ENOG410Z5A1 LUCA
GeneTreeiENSGT00730000111127
HOVERGENiHBG081043
InParanoidiQ9H0G5
KOiK13206
OMAiWKREKDR
OrthoDBiEOG091G0KUG
PhylomeDBiQ9H0G5
TreeFamiTF319359

Family and domain databases

InterProiView protein in InterPro
IPR018612 DUF2040
PfamiView protein in Pfam
PF09745 DUF2040, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All

Q9H0G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIPGRQYGL ILPKKTQQLH PVLQKPSVFG NDSDDDDETS VSESLQREAA
60 70 80 90 100
KKQAMKQTKL EIQKALAEDA TVYEYDSIYD EMQKKKEENN PKLLLGKDRK
110 120 130 140 150
PKYIHNLLKA VEIRKKEQEK RMEKKIQRER EMEKGEFDDK EAFVTSAYKK
160 170 180 190 200
KLQERAEEEE REKRAAALEA CLDVTKQKDL SGFYRHLLNQ AVGEEEVPKC
210 220 230 240 250
SFREARSGIK EEKSRGFSNE VSSKNRIPQE KCILQTDVKV EENPDADSDF
260 270 280 290 300
DAKSSADDEI EETRVNCRRE KVIETPENDF KHHRSQNHSR SPSEERGHST
310 320 330 340 350
RHHTKGSRTS RGHEKREDQH QQKQSRDQEN HYTDRDYRKE RDSHRHREAS
360 370 380 390 400
HRDSHWKRHE QEDKPRARDQ RERSDRVWKR EKDREKYSQR EQERDRQQND
410 420 430 440 450
QNRPSEKGEK EEKSKAKEEH MKVRKERYEN NDKYRDREKR EVGVQSSERN
460 470 480 490 500
QDRKESSPNS RAKDKFLDQE RSNKMRNMAK DKERNQEKPS NSESSLGAKH
510 520 530 540 550
RLTEEGQEKG KEQERPPEAV SKFAKRNNEE TVMSARDRYL ARQMARVNAK

TYIEKEDD
Length:558
Mass (Da):66,390
Last modified:March 1, 2001 - v1
Checksum:i99B7BDBCFD06F98D
GO

Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A024QZ33A0A024QZ33_HUMAN
Coiled-coil domain containing 55, i...
NSRP1 CCDC55, hCG_1646942
504Annotation score:
K7ERM9K7ERM9_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
157Annotation score:
K7EMD8K7EMD8_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
104Annotation score:
K7EK40K7EK40_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
64Annotation score:
J3QLV5J3QLV5_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
74Annotation score:
J3QRI6J3QRI6_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
92Annotation score:
K7EQJ6K7EQJ6_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
68Annotation score:
J3KT62J3KT62_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
42Annotation score:
J3QS82J3QS82_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
41Annotation score:
H7BYM1H7BYM1_HUMAN
Nuclear speckle-splicing regulatory...
NSRP1
50Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti270E → G in CAG38586 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05410486K → T. Corresponds to variant dbSNP:rs11544945Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136806 mRNA Translation: CAB66740.1
CR533555 mRNA Translation: CAG38586.1
AC104984 Genomic DNA No translation available.
BC040118 mRNA Translation: AAH40118.1
BC105044 mRNA Translation: AAI05045.1
BC105046 mRNA Translation: AAI05047.1
CCDSiCCDS11255.1
RefSeqiNP_001248396.1, NM_001261467.1
NP_115517.1, NM_032141.3
UniGeneiHs.462663

Genome annotation databases

EnsembliENST00000247026; ENSP00000247026; ENSG00000126653
GeneIDi84081
KEGGihsa:84081
UCSCiuc002heu.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136806 mRNA Translation: CAB66740.1
CR533555 mRNA Translation: CAG38586.1
AC104984 Genomic DNA No translation available.
BC040118 mRNA Translation: AAH40118.1
BC105044 mRNA Translation: AAI05045.1
BC105046 mRNA Translation: AAI05047.1
CCDSiCCDS11255.1
RefSeqiNP_001248396.1, NM_001261467.1
NP_115517.1, NM_032141.3
UniGeneiHs.462663

3D structure databases

ProteinModelPortaliQ9H0G5
SMRiQ9H0G5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123876, 19 interactors
IntActiQ9H0G5, 12 interactors
MINTiQ9H0G5
STRINGi9606.ENSP00000247026

PTM databases

iPTMnetiQ9H0G5
PhosphoSitePlusiQ9H0G5

Polymorphism and mutation databases

BioMutaiNSRP1
DMDMi74733524

Proteomic databases

EPDiQ9H0G5
MaxQBiQ9H0G5
PaxDbiQ9H0G5
PeptideAtlasiQ9H0G5
PRIDEiQ9H0G5
ProteomicsDBi80276

Protocols and materials databases

DNASUi84081
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000247026; ENSP00000247026; ENSG00000126653
GeneIDi84081
KEGGihsa:84081
UCSCiuc002heu.5 human

Organism-specific databases

CTDi84081
DisGeNETi84081
EuPathDBiHostDB:ENSG00000126653.15
GeneCardsiNSRP1
HGNCiHGNC:25305 NSRP1
HPAiHPA015593
HPA015603
MIMi616173 gene
neXtProtiNX_Q9H0G5
OpenTargetsiENSG00000126653
PharmGKBiPA142672171
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2117 Eukaryota
ENOG410Z5A1 LUCA
GeneTreeiENSGT00730000111127
HOVERGENiHBG081043
InParanoidiQ9H0G5
KOiK13206
OMAiWKREKDR
OrthoDBiEOG091G0KUG
PhylomeDBiQ9H0G5
TreeFamiTF319359

Miscellaneous databases

ChiTaRSiNSRP1 human
GeneWikiiCCDC55_(gene)
GenomeRNAii84081
PROiPR:Q9H0G5
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000126653 Expressed in 199 organ(s), highest expression level in tibia
CleanExiHS_CCDC55
ExpressionAtlasiQ9H0G5 baseline and differential
GenevisibleiQ9H0G5 HS

Family and domain databases

InterProiView protein in InterPro
IPR018612 DUF2040
PfamiView protein in Pfam
PF09745 DUF2040, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNSRP1_HUMAN
AccessioniPrimary (citable) accession number: Q9H0G5
Secondary accession number(s): Q6FI71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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