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UniProtKB - Q9H0F5 (RNF38_HUMAN)

Entry version 163 (07 Apr 2021)
Sequence version 4 (21 Dec 2004)
Previous versions | rss
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Protein

E3 ubiquitin-protein ligase RNF38

Gene

RNF38

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. EC:2.3.2.27

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri463 – 504RING-typePROSITE-ProRule annotationAdd BLAST42

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processUbl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q9H0F5

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase RNF38 (EC:2.3.2.27)
Alternative name(s):
RING finger protein 38
RING-type E3 ubiquitin transferase RNF38Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RNF38
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:18052, RNF38

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612488, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H0F5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000137075.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		152006

Open Targets

More...OpenTargetsi		ENSG00000137075

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA34438

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q9H0F5, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		RNF38

Domain mapping of disease mutations (DMDM)

More...DMDMi		56749664

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000560781 – 515E3 ubiquitin-protein ligase RNF38Add BLAST515

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H0F5

PeptideAtlas

More...PeptideAtlasi		Q9H0F5

PRoteomics IDEntifications database

More...PRIDEi		Q9H0F5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		3188
80269 [Q9H0F5-1]
80270 [Q9H0F5-2]
80271 [Q9H0F5-3]
81080

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H0F5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H0F5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with highest levels in testis.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000137075, Expressed in sperm and 237 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H0F5, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000137075, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		127416, 39 interactors

Protein interaction database and analysis system

More...IntActi		Q9H0F5, 28 interactors

Molecular INTeraction database

More...MINTi		Q9H0F5

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000259605

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q9H0F5, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1515
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q9H0F5

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q9H0F5

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi57 – 71Bipartite nuclear localization signal 1Add BLAST15
Motifi115 – 131Bipartite nuclear localization signal 2Add BLAST17

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi239 – 404Pro-richAdd BLAST166

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri463 – 504RING-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0800, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156228

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_024578_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H0F5

Identification of Orthologs from Complete Genome Data

More...OMAi		RSGYYQQ

Database of Orthologous Groups

More...OrthoDBi		1570520at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H0F5

TreeFam database of animal gene trees

More...TreeFami		TF325756

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13639, zf-RING_2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00184, RING, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H0F5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK 
        60         70         80         90        100
AFFQSEDSPS PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP 
       110        120        130        140        150
SQHHFSGERC NTPARNRRSP PVRRQRGRRD RLSRHNSISQ DENYHHLPYA 
       160        170        180        190        200
QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ NAVMVDIHDQ LHQGTVPVSY 
       210        220        230        240        250
TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV CSVPPPMLQA 
       260        270        280        290        300
CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ 
       310        320        330        340        350
SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH 
       360        370        380        390        400
QEVSFGVPYP PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP 
       410        420        430        440        450
AVGPTFSFEL DVEDGEVENY EALLNLAERL GEAKPRGLTK ADIEQLPSYR 
       460        470        480        490        500
FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP CNHEFHAKCV DKWLKANRTC 
       510 
PICRADASEV HRDSE
Length:515
Mass (Da):57,595
Last modified:December 21, 2004 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iABFE9486CA732AFA
GO
Isoform 2 (identifier: Q9H0F5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-54: Missing.

Show »
Length:465
Mass (Da):52,106
Checksum:i18A919182C967BA6
GO
Isoform 3 (identifier: Q9H0F5-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: Missing.

Show »
Length:432
Mass (Da):48,562
Checksum:iCCC2D1396DB31D2C
GO
Isoform 4 (identifier: Q9H0F5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: MACKISPGAN...LPSDQNTTVQ → MQHTCTQQKK...NLAGFQLQSP
     45-120: Missing.

Show »
Length:439
Mass (Da):49,265
Checksum:i76E2EFFA9FDFA02D
GO
Isoform 5 (identifier: Q9H0F5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-183: Missing.

Show »
Length:332
Mass (Da):36,836
Checksum:i4A2E365DA4A094A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti308I → K in CAB66751 (PubMed:11230166).Curated1
Sequence conflicti421E → G in BAG52726 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_055400206A → T1 PublicationCorresponds to variant dbSNP:rs183475137Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0538451 – 183Missing in isoform 5. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_0373371 – 83Missing in isoform 3. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_0538461 – 44MACKI…NTTVQ → MQHTCTQQKKVTYKHIARFS PRNRLCQADAVFNNNLAGFQ LQSP in isoform 4. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0122435 – 54Missing in isoform 2. 1 PublicationAdd BLAST50
Alternative sequenceiVSP_05384745 – 120Missing in isoform 4. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF394047 mRNA Translation: AAM73697.1
AL136817 mRNA Translation: CAB66751.3
AK024996 mRNA Translation: BAB15050.1
AK093480 mRNA Translation: BAG52726.1
AL161792 Genomic DNA No translation available.
AL354935 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58305.1
BC033786 mRNA Translation: AAH33786.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS6603.1 [Q9H0F5-1]
CCDS6604.1 [Q9H0F5-2]

NCBI Reference Sequences

More...RefSeqi		NP_073618.3, NM_022781.4 [Q9H0F5-1]
NP_919309.1, NM_194328.2 [Q9H0F5-3]
NP_919310.1, NM_194329.2 [Q9H0F5-2]
NP_919311.1, NM_194330.2 [Q9H0F5-3]
NP_919313.1, NM_194332.2 [Q9H0F5-3]
XP_005251423.1, XM_005251366.3 [Q9H0F5-3]
XP_005251424.1, XM_005251367.3 [Q9H0F5-3]
XP_005251425.1, XM_005251368.3
XP_006716784.1, XM_006716721.3 [Q9H0F5-3]
XP_011516014.1, XM_011517712.2 [Q9H0F5-3]
XP_011516015.1, XM_011517713.2 [Q9H0F5-3]
XP_016869784.1, XM_017014295.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000259605; ENSP00000259605; ENSG00000137075 [Q9H0F5-1]
ENST00000350199; ENSP00000343947; ENSG00000137075 [Q9H0F5-3]
ENST00000353739; ENSP00000335239; ENSG00000137075 [Q9H0F5-2]
ENST00000357058; ENSP00000349566; ENSG00000137075 [Q9H0F5-3]
ENST00000377877; ENSP00000367109; ENSG00000137075 [Q9H0F5-4]
ENST00000377885; ENSP00000367117; ENSG00000137075 [Q9H0F5-3]
ENST00000611646; ENSP00000483536; ENSG00000137075 [Q9H0F5-4]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		152006

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:152006

UCSC genome browser

More...UCSCi		uc003zzh.5, human [Q9H0F5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF394047 mRNA Translation: AAM73697.1
AL136817 mRNA Translation: CAB66751.3
AK024996 mRNA Translation: BAB15050.1
AK093480 mRNA Translation: BAG52726.1
AL161792 Genomic DNA No translation available.
AL354935 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58305.1
BC033786 mRNA Translation: AAH33786.2
CCDSiCCDS6603.1 [Q9H0F5-1]
CCDS6604.1 [Q9H0F5-2]
RefSeqiNP_073618.3, NM_022781.4 [Q9H0F5-1]
NP_919309.1, NM_194328.2 [Q9H0F5-3]
NP_919310.1, NM_194329.2 [Q9H0F5-2]
NP_919311.1, NM_194330.2 [Q9H0F5-3]
NP_919313.1, NM_194332.2 [Q9H0F5-3]
XP_005251423.1, XM_005251366.3 [Q9H0F5-3]
XP_005251424.1, XM_005251367.3 [Q9H0F5-3]
XP_005251425.1, XM_005251368.3
XP_006716784.1, XM_006716721.3 [Q9H0F5-3]
XP_011516014.1, XM_011517712.2 [Q9H0F5-3]
XP_011516015.1, XM_011517713.2 [Q9H0F5-3]
XP_016869784.1, XM_017014295.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1X4JNMR-A445-506[»]
4V3KX-ray2.04C/F439-515[»]
4V3LX-ray1.53C439-515[»]
SMRiQ9H0F5
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127416, 39 interactors
IntActiQ9H0F5, 28 interactors
MINTiQ9H0F5
STRINGi9606.ENSP00000259605

PTM databases

iPTMnetiQ9H0F5
PhosphoSitePlusiQ9H0F5

Genetic variation databases

BioMutaiRNF38
DMDMi56749664

Proteomic databases

PaxDbiQ9H0F5
PeptideAtlasiQ9H0F5
PRIDEiQ9H0F5
ProteomicsDBi3188
80269 [Q9H0F5-1]
80270 [Q9H0F5-2]
80271 [Q9H0F5-3]
81080

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2887, 87 antibodies

The DNASU plasmid repository

More...DNASUi		152006

Genome annotation databases

EnsembliENST00000259605; ENSP00000259605; ENSG00000137075 [Q9H0F5-1]
ENST00000350199; ENSP00000343947; ENSG00000137075 [Q9H0F5-3]
ENST00000353739; ENSP00000335239; ENSG00000137075 [Q9H0F5-2]
ENST00000357058; ENSP00000349566; ENSG00000137075 [Q9H0F5-3]
ENST00000377877; ENSP00000367109; ENSG00000137075 [Q9H0F5-4]
ENST00000377885; ENSP00000367117; ENSG00000137075 [Q9H0F5-3]
ENST00000611646; ENSP00000483536; ENSG00000137075 [Q9H0F5-4]
GeneIDi152006
KEGGihsa:152006
UCSCiuc003zzh.5, human [Q9H0F5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		152006
DisGeNETi152006

GeneCards: human genes, protein and diseases

More...GeneCardsi		RNF38
HGNCiHGNC:18052, RNF38
HPAiENSG00000137075, Low tissue specificity
MIMi612488, gene
neXtProtiNX_Q9H0F5
OpenTargetsiENSG00000137075
PharmGKBiPA34438
VEuPathDBiHostDB:ENSG00000137075.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG0800, Eukaryota
GeneTreeiENSGT00940000156228
HOGENOMiCLU_024578_0_0_1
InParanoidiQ9H0F5
OMAiRSGYYQQ
OrthoDBi1570520at2759
PhylomeDBiQ9H0F5
TreeFamiTF325756

Enzyme and pathway databases

UniPathwayiUPA00143
PathwayCommonsiQ9H0F5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		152006, 2 hits in 992 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		RNF38, human
EvolutionaryTraceiQ9H0F5

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		RNF38

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		152006
PharosiQ9H0F5, Tdark

Protein Ontology

More...PROi		PR:Q9H0F5
RNActiQ9H0F5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000137075, Expressed in sperm and 237 other tissues
GenevisibleiQ9H0F5, HS

Family and domain databases

Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF13639, zf-RING_2, 1 hit
SMARTiView protein in SMART
SM00184, RING, 1 hit
PROSITEiView protein in PROSITE
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRNF38_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0F5
Secondary accession number(s): A6PVP9
, B1AM81, B1AM82, B3KSG4, E7EVL3, Q7LB33, Q8N0Y0, Q9H748
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: April 7, 2021
This is version 163 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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