RNF38

Functionⁱ

Acts as an E3 ubiquitin-protein ligase able to ubiquitinate p53/TP53 which promotes its relocalization to discrete foci associated with PML nuclear bodies. Exhibits preference for UBE2D2 as a E2 enzyme.1 Publication

Catalytic activityⁱ

S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆-ubiquitinyl-[acceptor protein]-L-lysine.

Pathwayⁱ: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	463 – 504	RING-typePROSITE-ProRule annotationAdd BLAST		42

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
ubiquitin-protein transferase activity
Source: FlyBase
Inferred from direct assayⁱ
- 23973461

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

male gonad development Source: Ensembl
protein ubiquitination
Source: FlyBase
Inferred from direct assayⁱ
- 23973461

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Transferase
Biological process	Ubl conjugation pathway
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: E3 ubiquitin-protein ligase RNF38 (EC:2.3.2.27) Alternative name(s): RING finger protein 38 RING-type E3 ubiquitin transferase RNF38Curated
Gene namesⁱ	Name:RNF38
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000137075.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:18052 RNF38
MIMⁱ	612488 gene
neXtProtⁱ	NX_Q9H0F5

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000137075
PharmGKBⁱ	PA34438

Polymorphism and mutation databases

BioMutaⁱ	RNF38
DMDMⁱ	56749664

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000056078	1 – 515	E3 ubiquitin-protein ligase RNF38Add BLAST		515

Proteomic databases

PaxDbⁱ	Q9H0F5
PeptideAtlas More...PeptideAtlasⁱ	Q9H0F5
PRIDEⁱ	Q9H0F5
ProteomicsDBⁱ	80269 80270 [Q9H0F5-2] 80271 [Q9H0F5-3]

PTM databases

iPTMnetⁱ	Q9H0F5
PhosphoSitePlusⁱ	Q9H0F5

Expressionⁱ

Tissue specificityⁱ

Widely expressed with highest levels in testis.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000137075 Expressed in 223 organ(s), highest expression level in sperm
CleanExⁱ	HS_RNF38
Genevisibleⁱ	Q9H0F5 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA015853

HPAⁱ

HPA015853

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	127416, 17 interactors
IntActⁱ	Q9H0F5, 20 interactors
STRINGⁱ	9606.ENSP00000259605

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	441 – 445	Combined sources	5
Beta strandⁱ	448 – 450	Combined sources	3
Beta strandⁱ	453 – 455	Combined sources	3
Beta strandⁱ	457 – 459	Combined sources	3
Turnⁱ	464 – 467	Combined sources	4
Beta strandⁱ	475 – 478	Combined sources	4
Turnⁱ	480 – 482	Combined sources	3
Beta strandⁱ	484 – 486	Combined sources	3
Helixⁱ	487 – 496	Combined sources	10
Turnⁱ	501 – 503	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q9H0F5
SMRⁱ	Q9H0F5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q9H0F5

EvolutionaryTraceⁱ

Q9H0F5

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	57 – 71	Bipartite nuclear localization signal 1Add BLAST		15
Motifⁱ	115 – 131	Bipartite nuclear localization signal 2Add BLAST		17

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	239 – 404	Pro-richAdd BLAST		166

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	463 – 504	RING-typePROSITE-ProRule annotationAdd BLAST		42

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG0800 Eukaryota ENOG41121N2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110459
HOGENOMⁱ	HOG000231638
HOVERGENⁱ	HBG059283
InParanoidⁱ	Q9H0F5
KEGG Orthology (KO) More...KOⁱ	K19041
OMAⁱ	RSSQHHF
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09VT
PhylomeDBⁱ	Q9H0F5
TreeFamⁱ	TF325756

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit

Sequences (5)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q9H0F5-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MACKISPGAN SASLPGHPNK VICERVRLQS LFPLLPSDQN TTVQEDAHFK 
        60         70         80         90        100
AFFQSEDSPS PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP 
       110        120        130        140        150
SQHHFSGERC NTPARNRRSP PVRRQRGRRD RLSRHNSISQ DENYHHLPYA 
       160        170        180        190        200
QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ NAVMVDIHDQ LHQGTVPVSY 
       210        220        230        240        250
TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV CSVPPPMLQA 
       260        270        280        290        300
CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ 
       310        320        330        340        350
SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH 
       360        370        380        390        400
QEVSFGVPYP PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP 
       410        420        430        440        450
AVGPTFSFEL DVEDGEVENY EALLNLAERL GEAKPRGLTK ADIEQLPSYR 
       460        470        480        490        500
FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP CNHEFHAKCV DKWLKANRTC 
       510 
PICRADASEV HRDSE

Length:515

Mass (Da):57,595

Last modified:December 21, 2004 - v4

Checksum:ⁱABFE9486CA732AFA

GO

Isoform 2 (identifier: Q9H0F5-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
5-54: Missing.

« Hide

        10         20         30         40         50
MACKSEDSPS PKRQRLSHSV FDYTSASPAP SPPMRPWEMT SNRQPPSVRP 
        60         70         80         90        100
SQHHFSGERC NTPARNRRSP PVRRQRGRRD RLSRHNSISQ DENYHHLPYA 
       110        120        130        140        150
QQQAIEEPRA FHPPNVSPRL LHPAAHPPQQ NAVMVDIHDQ LHQGTVPVSY 
       160        170        180        190        200
TVTTVAPHGI PLCTGQHIPA CSTQQVPGCS VVFSGQHLPV CSVPPPMLQA 
       210        220        230        240        250
CSVQHLPVPY AAFPPLISSD PFLIHPPHLS PHHPPHLPPP GQFVPFQTQQ 
       260        270        280        290        300
SRSPLQRIEN EVELLGEHLP VGGFTYPPSA HPPTLPPSAP LQFLTHDPLH 
       310        320        330        340        350
QEVSFGVPYP PFMPRRLTGR SRYRSQQPIP PPPYHPSLLP YVLSMLPVPP 
       360        370        380        390        400
AVGPTFSFEL DVEDGEVENY EALLNLAERL GEAKPRGLTK ADIEQLPSYR 
       410        420        430        440        450
FNPNNHQSEQ TLCVVCMCDF ESRQLLRVLP CNHEFHAKCV DKWLKANRTC 
       460 
PICRADASEV HRDSE

Note: No experimental confirmation available.

Show »

Length:465

Mass (Da):52,106

Checksum:ⁱ18A919182C967BA6

GO

Isoform 3 (identifier: Q9H0F5-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-83: Missing.

« Hide

        10         20         30         40         50
MRPWEMTSNR QPPSVRPSQH HFSGERCNTP ARNRRSPPVR RQRGRRDRLS 
        60         70         80         90        100
RHNSISQDEN YHHLPYAQQQ AIEEPRAFHP PNVSPRLLHP AAHPPQQNAV 
       110        120        130        140        150
MVDIHDQLHQ GTVPVSYTVT TVAPHGIPLC TGQHIPACST QQVPGCSVVF 
       160        170        180        190        200
SGQHLPVCSV PPPMLQACSV QHLPVPYAAF PPLISSDPFL IHPPHLSPHH 
       210        220        230        240        250
PPHLPPPGQF VPFQTQQSRS PLQRIENEVE LLGEHLPVGG FTYPPSAHPP 
       260        270        280        290        300
TLPPSAPLQF LTHDPLHQEV SFGVPYPPFM PRRLTGRSRY RSQQPIPPPP 
       310        320        330        340        350
YHPSLLPYVL SMLPVPPAVG PTFSFELDVE DGEVENYEAL LNLAERLGEA 
       360        370        380        390        400
KPRGLTKADI EQLPSYRFNP NNHQSEQTLC VVCMCDFESR QLLRVLPCNH 
       410        420        430 
EFHAKCVDKW LKANRTCPIC RADASEVHRD SE

Show »

Length:432

Mass (Da):48,562

Checksum:ⁱCCC2D1396DB31D2C

GO

Isoform 4 (identifier: Q9H0F5-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-44: MACKISPGAN...LPSDQNTTVQ → MQHTCTQQKK...NLAGFQLQSP
45-120: Missing.

« Hide

        10         20         30         40         50
MQHTCTQQKK VTYKHIARFS PRNRLCQADA VFNNNLAGFQ LQSPPVRRQR 
        60         70         80         90        100
GRRDRLSRHN SISQDENYHH LPYAQQQAIE EPRAFHPPNV SPRLLHPAAH 
       110        120        130        140        150
PPQQNAVMVD IHDQLHQGTV PVSYTVTTVA PHGIPLCTGQ HIPACSTQQV 
       160        170        180        190        200
PGCSVVFSGQ HLPVCSVPPP MLQACSVQHL PVPYAAFPPL ISSDPFLIHP 
       210        220        230        240        250
PHLSPHHPPH LPPPGQFVPF QTQQSRSPLQ RIENEVELLG EHLPVGGFTY 
       260        270        280        290        300
PPSAHPPTLP PSAPLQFLTH DPLHQEVSFG VPYPPFMPRR LTGRSRYRSQ 
       310        320        330        340        350
QPIPPPPYHP SLLPYVLSML PVPPAVGPTF SFELDVEDGE VENYEALLNL 
       360        370        380        390        400
AERLGEAKPR GLTKADIEQL PSYRFNPNNH QSEQTLCVVC MCDFESRQLL 
       410        420        430 
RVLPCNHEFH AKCVDKWLKA NRTCPICRAD ASEVHRDSE

Note: No experimental confirmation available.

Show »

Length:439

Mass (Da):49,265

Checksum:ⁱ76E2EFFA9FDFA02D

GO

Isoform 5 (identifier: Q9H0F5-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-183: Missing.

« Hide

        10         20         30         40         50
MVDIHDQLHQ GTVPVSYTVT TVAPHGIPLC TGQHIPACST QQVPGCSVVF 
        60         70         80         90        100
SGQHLPVCSV PPPMLQACSV QHLPVPYAAF PPLISSDPFL IHPPHLSPHH 
       110        120        130        140        150
PPHLPPPGQF VPFQTQQSRS PLQRIENEVE LLGEHLPVGG FTYPPSAHPP 
       160        170        180        190        200
TLPPSAPLQF LTHDPLHQEV SFGVPYPPFM PRRLTGRSRY RSQQPIPPPP 
       210        220        230        240        250
YHPSLLPYVL SMLPVPPAVG PTFSFELDVE DGEVENYEAL LNLAERLGEA 
       260        270        280        290        300
KPRGLTKADI EQLPSYRFNP NNHQSEQTLC VVCMCDFESR QLLRVLPCNH 
       310        320        330 
EFHAKCVDKW LKANRTCPIC RADASEVHRD SE

Note: No experimental confirmation available.

Show »

Length:332

Mass (Da):36,836

Checksum:ⁱ4A2E365DA4A094A0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	308	I → K in CAB66751 (PubMed:11230166).Curated		1
Sequence conflictⁱ	421	E → G in BAG52726 (PubMed:14702039).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_055400	206	A → T1 PublicationCorresponds to variant dbSNP:rs183475137Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_053845	1 – 183	Missing in isoform 5. 1 PublicationAdd BLAST	183
Alternative sequenceⁱVSP_037337	1 – 83	Missing in isoform 3. 1 PublicationAdd BLAST	83
Alternative sequenceⁱVSP_053846	1 – 44	MACKI…NTTVQ → MQHTCTQQKKVTYKHIARFS PRNRLCQADAVFNNNLAGFQ LQSP in isoform 4. 1 PublicationAdd BLAST	44
Alternative sequenceⁱVSP_012243	5 – 54	Missing in isoform 2. 1 PublicationAdd BLAST	50
Alternative sequenceⁱVSP_053847	45 – 120	Missing in isoform 4. 1 PublicationAdd BLAST	76

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF394047 mRNA Translation: AAM73697.1 AL136817 mRNA Translation: CAB66751.3 AK024996 mRNA Translation: BAB15050.1 AK093480 mRNA Translation: BAG52726.1 AL161792 Genomic DNA No translation available. AL354935 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58305.1 BC033786 mRNA Translation: AAH33786.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6603.1 [Q9H0F5-1] CCDS6604.1 [Q9H0F5-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_073618.3, NM_022781.4 [Q9H0F5-1] NP_919309.1, NM_194328.2 [Q9H0F5-3] NP_919310.1, NM_194329.2 [Q9H0F5-2] NP_919311.1, NM_194330.2 [Q9H0F5-3] NP_919313.1, NM_194332.2 [Q9H0F5-3] XP_005251423.1, XM_005251366.3 [Q9H0F5-3] XP_005251424.1, XM_005251367.3 [Q9H0F5-3] XP_005251425.1, XM_005251368.3 XP_006716784.1, XM_006716721.3 [Q9H0F5-3] XP_011516014.1, XM_011517712.2 [Q9H0F5-3] XP_011516015.1, XM_011517713.2 [Q9H0F5-3] XP_016869784.1, XM_017014295.1
UniGeneⁱ	Hs.333503

Genome annotation databases

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q9H0F5	Uncharacterized protein		MACMU		515	UniRef100_Q9H0F5
Uncharacterized protein		COLAP		515
RNF38 isoform 10		PONAB		515
Uncharacterized protein		RHIRO		515
Uncharacterized protein		PAPAN		515
+4
Q9H0F5-2	Uncharacterized protein		MACMU		465	UniRef100_F6TXS5
Uncharacterized protein		COLAP		465
RNF38 isoform 8		PONAB		465
Uncharacterized protein		RHIRO		465
Uncharacterized protein		PAPAN		465
+6
Q9H0F5-3	Uncharacterized protein		NOMLE		515	UniRef100_G1QUL9
Ring finger protein 38 (Fragment)		NEOVI		142
RING finger protein 38 isoform 1		MACMU		432
Ring finger protein 38		MACNE		432
Ring finger protein 38		RHIRO		432
+10
Q9H0F5-4	Uncharacterized protein		PANPA		439	UniRef100_A0A2R9BJH2
Ring finger protein 38		GORGO		439
Q9H0F5-5	Uncharacterized protein		NOMLE		515	UniRef100_G1QUL9
Ring finger protein 38 (Fragment)		NEOVI		142
RING finger protein 38 isoform 1		MACMU		432
Ring finger protein 38		MACNE		432
Ring finger protein 38		RHIRO		432
+10

Protein	Similar proteins		Species	Score	Length	Source
Q9H0F5	E3 ubiquitin-protein ligase RNF38		MOUSE		518	UniRef90_Q9H0F5
Uncharacterized protein		MACMU		515
Uncharacterized protein		COLAP		515
RNF38 isoform 10		PONAB		515
Uncharacterized protein		RHIRO		515
+149
Q9H0F5-2	Uncharacterized protein		MACMU		465	UniRef90_F6TXS5
Uncharacterized protein		COLAP		465
RNF38 isoform 8		PONAB		465
Uncharacterized protein		RHIRO		465
Uncharacterized protein		PAPAN		465
+7
Q9H0F5-3	Uncharacterized protein		NOMLE		515	UniRef90_G1QUL9
Ring finger protein 38 (Fragment)		NEOVI		142
RING finger protein 38 isoform 1		MACMU		432
Ring finger protein 38		MACNE		432
Ring finger protein 38		RHIRO		432
+10
Q9H0F5-4	RNF38 isoform 7		PANTR		439	UniRef90_A0A2J8QRP8
RNF38 isoform 7		PONAB		454
Uncharacterized protein		NOMLE		439
Uncharacterized protein		PANPA		439
Ring finger protein 38		GORGO		439
+4
Q9H0F5-5	Uncharacterized protein		NOMLE		515	UniRef90_G1QUL9
Ring finger protein 38 (Fragment)		NEOVI		142
RING finger protein 38 isoform 1		MACMU		432
Ring finger protein 38		MACNE		432
Ring finger protein 38		RHIRO		432
+10

Protein	Similar proteins		Species	Score	Length	Source
Q9H0F5	E3 ubiquitin-protein ligase RNF38		MOUSE		518	UniRef50_Q9H0F5
Uncharacterized protein		MACMU		515
Uncharacterized protein		COLAP		515
RNF38 isoform 10		PONAB		515
Uncharacterized protein		RHIRO		515
+316
Q9H0F5-4	Isoform 2 of E3 ubiquitin-protein ligase RNF38		MOUSE		464	UniRef50_Q8BI21-2
RING finger protein 44		HUMAN		432
RING finger protein 44		RAT		350
Putative ring finger protein 38 (Fragment)		DESRO		467
Ring finger protein 38		CALJA		465
+488

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF394047 mRNA Translation: AAM73697.1 AL136817 mRNA Translation: CAB66751.3 AK024996 mRNA Translation: BAB15050.1 AK093480 mRNA Translation: BAG52726.1 AL161792 Genomic DNA No translation available. AL354935 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58305.1 BC033786 mRNA Translation: AAH33786.2
CCDSⁱ	CCDS6603.1 [Q9H0F5-1] CCDS6604.1 [Q9H0F5-2]
RefSeqⁱ	NP_073618.3, NM_022781.4 [Q9H0F5-1] NP_919309.1, NM_194328.2 [Q9H0F5-3] NP_919310.1, NM_194329.2 [Q9H0F5-2] NP_919311.1, NM_194330.2 [Q9H0F5-3] NP_919313.1, NM_194332.2 [Q9H0F5-3] XP_005251423.1, XM_005251366.3 [Q9H0F5-3] XP_005251424.1, XM_005251367.3 [Q9H0F5-3] XP_005251425.1, XM_005251368.3 XP_006716784.1, XM_006716721.3 [Q9H0F5-3] XP_011516014.1, XM_011517712.2 [Q9H0F5-3] XP_011516015.1, XM_011517713.2 [Q9H0F5-3] XP_016869784.1, XM_017014295.1
UniGeneⁱ	Hs.333503

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1X4J	NMR	-	A	445-506	[»]
	4V3K	X-ray	2.04	C/F	439-515	[»]
	4V3L	X-ray	1.53	C	439-515	[»]
ProteinModelPortalⁱ	Q9H0F5
SMRⁱ	Q9H0F5
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	127416, 17 interactors
IntActⁱ	Q9H0F5, 20 interactors
STRINGⁱ	9606.ENSP00000259605

PTM databases

iPTMnetⁱ	Q9H0F5
PhosphoSitePlusⁱ	Q9H0F5

Polymorphism and mutation databases

BioMutaⁱ	RNF38
DMDMⁱ	56749664

Proteomic databases

PaxDbⁱ	Q9H0F5
PeptideAtlasⁱ	Q9H0F5
PRIDEⁱ	Q9H0F5
ProteomicsDBⁱ	80269 80270 [Q9H0F5-2] 80271 [Q9H0F5-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	152006
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000259605; ENSP00000259605; ENSG00000137075 [Q9H0F5-1] ENST00000350199; ENSP00000343947; ENSG00000137075 [Q9H0F5-3] ENST00000353739; ENSP00000335239; ENSG00000137075 [Q9H0F5-2] ENST00000357058; ENSP00000349566; ENSG00000137075 [Q9H0F5-3] ENST00000377877; ENSP00000367109; ENSG00000137075 [Q9H0F5-4] ENST00000377885; ENSP00000367117; ENSG00000137075 [Q9H0F5-3] ENST00000611646; ENSP00000483536; ENSG00000137075 [Q9H0F5-4]
GeneIDⁱ	152006
KEGGⁱ	hsa:152006
UCSCⁱ	uc003zzh.5 human [Q9H0F5-1]

Organism-specific databases

CTDⁱ	152006
EuPathDBⁱ	HostDB:ENSG00000137075.17
GeneCardsⁱ	RNF38
HGNCⁱ	HGNC:18052 RNF38
HPAⁱ	HPA015853
MIMⁱ	612488 gene
neXtProtⁱ	NX_Q9H0F5
OpenTargetsⁱ	ENSG00000137075
PharmGKBⁱ	PA34438
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0800 Eukaryota ENOG41121N2 LUCA
GeneTreeⁱ	ENSGT00730000110459
HOGENOMⁱ	HOG000231638
HOVERGENⁱ	HBG059283
InParanoidⁱ	Q9H0F5
KOⁱ	K19041
OMAⁱ	RSSQHHF
OrthoDBⁱ	EOG091G09VT
PhylomeDBⁱ	Q9H0F5
TreeFamⁱ	TF325756

Enzyme and pathway databases

UniPathwayⁱ	UPA00143

UniPathwayⁱ

UPA00143

Miscellaneous databases

ChiTaRSⁱ	RNF38 human
EvolutionaryTraceⁱ	Q9H0F5
GeneWikiⁱ	RNF38
GenomeRNAiⁱ	152006
Protein Ontology More...PROⁱ	PR:Q9H0F5
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000137075 Expressed in 223 organ(s), highest expression level in sperm
CleanExⁱ	HS_RNF38
Genevisibleⁱ	Q9H0F5 HS

Family and domain databases

Gene3Dⁱ	3.30.40.10, 1 hit
InterProⁱ	View protein in InterPro IPR001841 Znf_RING IPR013083 Znf_RING/FYVE/PHD
Pfamⁱ	View protein in Pfam PF13639 zf-RING_2, 1 hit
SMARTⁱ	View protein in SMART SM00184 RING, 1 hit
PROSITEⁱ	View protein in PROSITE PS50089 ZF_RING_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	RNF38_HUMAN
Accessionⁱ	Q9H0F5Primary (citable) accession number: Q9H0F5 Secondary accession number(s): A6PVP9 Q9H748
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 21, 2004
	Last sequence update:	December 21, 2004
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PATHWAY comments
Index of metabolic and biosynthesis pathways
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q9H0F5 (RNF38_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

E3 ubiquitin-protein ligase RNF38

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Compositional bias

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

Pathwayⁱ: protein ubiquitination

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ