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Entry version 177 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Toll-interacting protein

Gene

TOLLIP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity (PubMed:11751856). Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (PubMed:25042851).2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAutophagy, Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q9H0E2

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-6798695, Neutrophil degranulation
R-HSA-9020702, Interleukin-1 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q9H0E2

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q9H0E2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Toll-interacting protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOLLIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000078902.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:16476, TOLLIP

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606277, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0E2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
54472

Open Targets

More...
OpenTargetsi
ENSG00000078902

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134876213

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0E2, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TOLLIP

Domain mapping of disease mutations (DMDM)

More...
DMDMi
20140803

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000726252 – 274Toll-interacting proteinAdd BLAST273

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by IRAK1 upon stimulation by IL-1 or microbial products.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H0E2

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q9H0E2

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H0E2

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H0E2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0E2

PeptideAtlas

More...
PeptideAtlasi
Q9H0E2

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0E2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
3808
80260 [Q9H0E2-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0E2

MetOSite database of methionine sulfoxide sites

More...
MetOSitei
Q9H0E2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0E2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000078902, Expressed in anterior cingulate cortex and 222 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H0E2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0E2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000078902, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Oligomerizes. Binds to TLR2 and the TLR4-MD2 complex via its C-terminus. Exists as complex with IRAK1 in unstimulated cells. Upon IL-1 signaling, Tollip binds to the activated IL-1 receptor complex containing IL-1RI, IL-1RacP and the adapter protein MyD88, where it interacts with the TIR domain of IL-1RacP. MyD88 then triggers IRAK1 autophosphorylation, which in turn leads to the dissociation of IRAK1 from Tollip and IL-1RAcP.

Interacts with TOM1L2.

Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain).

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details
Q9H0E2
With#Exp.IntAct
ACTN2 [P35609]3EBI-74615,EBI-77797
ARRDC3 [Q96B67]3EBI-74615,EBI-2875665
C16orf70 [Q9BSU1]5EBI-74615,EBI-946080
C19orf54 - isoform 3 [Q5BKX5-3]3EBI-74615,EBI-11976299
CDIP1 [Q9H305]3EBI-74615,EBI-2876678
CSTF1 [Q05048]2EBI-74615,EBI-1789619
DAB1 [O75553]3EBI-74615,EBI-7875264
DAZAP2 [Q15038]11EBI-74615,EBI-724310
DCDC2 [Q9UHG0]3EBI-74615,EBI-10303987
DDIT4L [Q96D03]3EBI-74615,EBI-742054
DZIP3 [Q86Y13]2EBI-74615,EBI-948630
EIF2AK2 [P19525]2EBI-74615,EBI-640775
FAM166B - isoform 2 [A8MTA8-2]3EBI-74615,EBI-12160437
FAM168A - isoform 2 [Q92567-2]3EBI-74615,EBI-11978259
GUCD1 - isoform 2 [Q96NT3-2]3EBI-74615,EBI-11978177
IRAK2 [O43187]2EBI-74615,EBI-447733
KRTAP13-3 [Q3SY46]5EBI-74615,EBI-10241252
KRTAP15-1 [Q3LI76]3EBI-74615,EBI-11992140
KRTAP19-7 [Q3SYF9]3EBI-74615,EBI-10241353
KRTAP6-1 [Q3LI64]5EBI-74615,EBI-12111050
KRTAP6-2 [Q3LI66]5EBI-74615,EBI-11962084
KRTAP7-1 [Q8IUC3]3EBI-74615,EBI-18394498
MAP1LC3A [Q9H492]3EBI-74615,EBI-720768
MEDAG [Q5VYS4]3EBI-74615,EBI-1050881
MSS51 [Q4VC12]3EBI-74615,EBI-11599933
MSX2 [P35548]3EBI-74615,EBI-6447480
MVP [Q14764]3EBI-74615,EBI-2816254
NRF1 - isoform 4 [Q16656-4]3EBI-74615,EBI-11742836
PEG10 [Q86TG7]2EBI-74615,EBI-2858265
PRPF39 [Q86UA1]3EBI-74615,EBI-2803203
PRR20D [P86480]3EBI-74615,EBI-12754095
PSMB1 [P20618]3EBI-74615,EBI-372273
RBFOX1 - isoform 5 [Q9NWB1-5]3EBI-74615,EBI-12123390
RBPMS [Q93062]4EBI-74615,EBI-740322
RHOXF2 [Q9BQY4]6EBI-74615,EBI-372094
STN1 [Q9H668]3EBI-74615,EBI-746930
TOM1 [O60784]5EBI-74615,EBI-74634
TOM1 - isoform 2 [O60784-2]5EBI-74615,EBI-12117154
TOM1L1 [O75674]3EBI-74615,EBI-712991
TOM1L1 - isoform 2 [O75674-2]5EBI-74615,EBI-12011552
TOM1L2 - isoform 2 [Q6ZVM7-2]7EBI-74615,EBI-12147805
TTC9C [Q8N5M4]3EBI-74615,EBI-2851213
USP54 - isoform 6 [Q70EL1-9]3EBI-74615,EBI-11975223
WDYHV1 [Q96HA8]4EBI-74615,EBI-741158
WRNIP1 [Q96S55]2EBI-74615,EBI-2513471
ZMYND19 [Q96E35]3EBI-74615,EBI-746595
ZRANB1 [Q9UGI0]3EBI-74615,EBI-527853
Isoform 1 [Q9H0E2-1]
With#Exp.IntAct
TOM1 [O60784]4EBI-16173683,EBI-74634

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
119978, 97 interactors

Database of interacting proteins

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DIPi
DIP-30845N

Protein interaction database and analysis system

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IntActi
Q9H0E2, 85 interactors

Molecular INTeraction database

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MINTi
Q9H0E2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000314733

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H0E2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1274
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H0E2

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q9H0E2

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini35 – 152C2PROSITE-ProRule annotationAdd BLAST118
Domaini229 – 272CUEPROSITE-ProRule annotationAdd BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi133 – 136AIM14
Motifi151 – 154AIM24

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 44Gln-richAdd BLAST17

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tollip family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QWQA, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000013104

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_067725_2_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q9H0E2

KEGG Orthology (KO)

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KOi
K05402

Identification of Orthologs from Complete Genome Data

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OMAi
YNQGMVP

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0E2

TreeFam database of animal gene trees

More...
TreeFami
TF324180

Family and domain databases

Conserved Domains Database

More...
CDDi
cd04016, C2_Tollip, 1 hit
cd14363, CUE_TOLIP, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR003892, CUE
IPR041799, TOLIP_CUE
IPR037301, Tollip_C2
IPR009060, UBA-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF02845, CUE, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00239, C2, 1 hit
SM00546, CUE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50004, C2, 1 hit
PS51140, CUE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0E2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATTVSTQRG PVYIGELPQD FLRITPTQQQ RQVQLDAQAA QQLQYGGAVG
60 70 80 90 100
TVGRLNITVV QAKLAKNYGM TRMDPYCRLR LGYAVYETPT AHNGAKNPRW
110 120 130 140 150
NKVIHCTVPP GVDSFYLEIF DERAFSMDDR IAWTHITIPE SLRQGKVEDK
160 170 180 190 200
WYSLSGRQGD DKEGMINLVM SYALLPAAMV MPPQPVVLMP TVYQQGVGYV
210 220 230 240 250
PITGMPAVCS PGMVPVALPP AAVNAQPRCS EEDLKAIQDM FPNMDQEVIR
260 270
SVLEAQRGNK DAAINSLLQM GEEP
Length:274
Mass (Da):30,282
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i386E0F284D3837DA
GO
Isoform 2 (identifier: Q9H0E2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-69: Missing.

Show »
Length:205
Mass (Da):22,812
Checksum:iDED391C6A30BAE56
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EN89E7EN89_HUMAN
Toll interacting protein, isoform C...
TOLLIP hCG_40380
246Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F2Z2Y8F2Z2Y8_HUMAN
Toll-interacting protein
TOLLIP
213Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNS3E9PNS3_HUMAN
Toll-interacting protein
TOLLIP
80Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ25E9PQ25_HUMAN
Toll-interacting protein
TOLLIP
186Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PP67E9PP67_HUMAN
Toll-interacting protein
TOLLIP
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB14283 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti40Missing in CAB58118 (PubMed:10854325).Curated1
Sequence conflicti150K → E in BAB14283 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079499161D → N1 PublicationCorresponds to variant dbSNP:rs1037270334Ensembl.1
Natural variantiVAR_034557222A → S. Corresponds to variant dbSNP:rs5744015Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0563011 – 69Missing in isoform 2. 1 PublicationAdd BLAST69

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ242972 mRNA Translation: CAB58118.1
AL136835 mRNA Translation: CAB66769.1
AK022871 mRNA Translation: BAB14283.1 Different initiation.
AK127123 mRNA Translation: BAG54438.1
AC136297 Genomic DNA No translation available.
BC004420 mRNA Translation: AAH04420.1
BC012057 mRNA Translation: AAH12057.1
BC018272 mRNA Translation: AAH18272.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS7723.1 [Q9H0E2-1]
CCDS81532.1 [Q9H0E2-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001305441.1, NM_001318512.1
NP_001305443.1, NM_001318514.1 [Q9H0E2-2]
NP_001305444.1, NM_001318515.1
NP_001305445.1, NM_001318516.1
NP_061882.2, NM_019009.3 [Q9H0E2-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000317204; ENSP00000314733; ENSG00000078902 [Q9H0E2-1]
ENST00000527886; ENSP00000434035; ENSG00000078902 [Q9H0E2-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
54472

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:54472

UCSC genome browser

More...
UCSCi
uc001ltd.4, human [Q9H0E2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ242972 mRNA Translation: CAB58118.1
AL136835 mRNA Translation: CAB66769.1
AK022871 mRNA Translation: BAB14283.1 Different initiation.
AK127123 mRNA Translation: BAG54438.1
AC136297 Genomic DNA No translation available.
BC004420 mRNA Translation: AAH04420.1
BC012057 mRNA Translation: AAH12057.1
BC018272 mRNA Translation: AAH18272.1
CCDSiCCDS7723.1 [Q9H0E2-1]
CCDS81532.1 [Q9H0E2-2]
RefSeqiNP_001305441.1, NM_001318512.1
NP_001305443.1, NM_001318514.1 [Q9H0E2-2]
NP_001305444.1, NM_001318515.1
NP_001305445.1, NM_001318516.1
NP_061882.2, NM_019009.3 [Q9H0E2-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1WGLNMR-A229-274[»]
2N31NMR-A1-53[»]
SMRiQ9H0E2
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi119978, 97 interactors
DIPiDIP-30845N
IntActiQ9H0E2, 85 interactors
MINTiQ9H0E2
STRINGi9606.ENSP00000314733

PTM databases

iPTMnetiQ9H0E2
MetOSiteiQ9H0E2
PhosphoSitePlusiQ9H0E2

Polymorphism and mutation databases

BioMutaiTOLLIP
DMDMi20140803

Proteomic databases

EPDiQ9H0E2
jPOSTiQ9H0E2
MassIVEiQ9H0E2
MaxQBiQ9H0E2
PaxDbiQ9H0E2
PeptideAtlasiQ9H0E2
PRIDEiQ9H0E2
ProteomicsDBi3808
80260 [Q9H0E2-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
10168, 553 antibodies

The DNASU plasmid repository

More...
DNASUi
54472

Genome annotation databases

EnsembliENST00000317204; ENSP00000314733; ENSG00000078902 [Q9H0E2-1]
ENST00000527886; ENSP00000434035; ENSG00000078902 [Q9H0E2-2]
GeneIDi54472
KEGGihsa:54472
UCSCiuc001ltd.4, human [Q9H0E2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
54472
DisGeNETi54472
EuPathDBiHostDB:ENSG00000078902.15

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TOLLIP
HGNCiHGNC:16476, TOLLIP
HPAiENSG00000078902, Low tissue specificity
MIMi606277, gene
neXtProtiNX_Q9H0E2
OpenTargetsiENSG00000078902
PharmGKBiPA134876213

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QWQA, Eukaryota
GeneTreeiENSGT00390000013104
HOGENOMiCLU_067725_2_0_1
InParanoidiQ9H0E2
KOiK05402
OMAiYNQGMVP
PhylomeDBiQ9H0E2
TreeFamiTF324180

Enzyme and pathway databases

PathwayCommonsiQ9H0E2
ReactomeiR-HSA-6798695, Neutrophil degranulation
R-HSA-9020702, Interleukin-1 signaling
SignaLinkiQ9H0E2
SIGNORiQ9H0E2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
54472, 5 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TOLLIP, human
EvolutionaryTraceiQ9H0E2

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TOLLIP

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
54472
PharosiQ9H0E2, Tbio

Protein Ontology

More...
PROi
PR:Q9H0E2
RNActiQ9H0E2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000078902, Expressed in anterior cingulate cortex and 222 other tissues
ExpressionAtlasiQ9H0E2, baseline and differential
GenevisibleiQ9H0E2, HS

Family and domain databases

CDDicd04016, C2_Tollip, 1 hit
cd14363, CUE_TOLIP, 1 hit
Gene3Di2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR003892, CUE
IPR041799, TOLIP_CUE
IPR037301, Tollip_C2
IPR009060, UBA-like_sf
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF02845, CUE, 1 hit
SMARTiView protein in SMART
SM00239, C2, 1 hit
SM00546, CUE, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
PROSITEiView protein in PROSITE
PS50004, C2, 1 hit
PS51140, CUE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOLIP_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0E2
Secondary accession number(s): B3KXC6, Q9H9E6, Q9UJ69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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