Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

5'-3' exoribonuclease 2

Gene

XRN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites (PubMed:21700224).By similarity3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri262 – 278CCHC-typeAdd BLAST17

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding, Exonuclease, Hydrolase, Nuclease
Biological processmRNA processing, Transcription, Transcription regulation, Transcription termination
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5'-3' exoribonuclease 2 (EC:3.1.13.-)
Alternative name(s):
DHM1-like protein
Short name:
DHP protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XRN2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 20

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000088930.7

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12836 XRN2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
608851 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0D6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
22803

Open Targets

More...
OpenTargetsi
ENSG00000088930

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37427

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XRN2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
30173484

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000713961 – 9505'-3' exoribonuclease 2Add BLAST950

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei286N6-acetyllysineBy similarity1
Modified residuei439PhosphothreonineCombined sources1
Modified residuei448PhosphoserineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei473PhosphoserineCombined sources1
Modified residuei475PhosphoserineCombined sources1
Modified residuei482PhosphoserineBy similarity1
Modified residuei487PhosphoserineCombined sources1
Modified residuei499PhosphoserineCombined sources1
Modified residuei501PhosphoserineCombined sources1
Modified residuei678PhosphoserineCombined sources1
Modified residuei824Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei824Omega-N-methylarginine; alternateCombined sources1
Modified residuei847Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei847Omega-N-methylarginine; alternateCombined sources1
Modified residuei851Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei851Omega-N-methylarginine; alternateCombined sources1
Modified residuei880Asymmetric dimethylarginineBy similarity1
Modified residuei883Asymmetric dimethylarginine; alternateBy similarity1
Modified residuei883Omega-N-methylarginine; alternateCombined sources1
Modified residuei895Omega-N-methylarginineCombined sources1
Modified residuei946Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei946Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H0D6

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H0D6

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0D6

PeptideAtlas

More...
PeptideAtlasi
Q9H0D6

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0D6

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80258
80259 [Q9H0D6-2]

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...
SWISS-2DPAGEi
Q9H0D6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0D6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0D6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q9H0D6

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
Q9H0D6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the spleen, thymus, prostate, testis, ovary, small intestine, colon, peripheral blood leukocytes, heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas. Isoform 2 is expressed predominantly in peripheral blood leukocytes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000088930 Expressed in 192 organ(s), highest expression level in kidney

CleanEx database of gene expression profiles

More...
CleanExi
HS_XRN2

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0D6 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA047118
HPA050485

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POLR2A and SMN1/SMN2 (PubMed:26700805). Interacts with CDKN2AIP and NKRF (PubMed:24462208). Interacts with CDKN2AIPNL; the interaction is direct (PubMed:26779609). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361).4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
CDKN2AIPNLQ96HQ22EBI-372110,EBI-10038935

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
116483, 127 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H0D6

Database of interacting proteins

More...
DIPi
DIP-31166N

Protein interaction database and analysis system

More...
IntActi
Q9H0D6, 50 interactors

Molecular INTeraction database

More...
MINTi
Q9H0D6

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000366396

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q9H0D6

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H0D6

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri262 – 278CCHC-typeAdd BLAST17

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2044 Eukaryota
COG5049 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00670000098098

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG036677

KEGG Orthology (KO)

More...
KOi
K12619

Identification of Orthologs from Complete Genome Data

More...
OMAi
GEHFDSN

Database of Orthologous Groups

More...
OrthoDBi
EOG091G00A4

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0D6

TreeFam database of animal gene trees

More...
TreeFami
TF105977

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027073 5_3_exoribonuclease
IPR004859 Put_53exo
IPR017151 Xrn2/3/4

The PANTHER Classification System

More...
PANTHERi
PTHR12341 PTHR12341, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03159 XRN_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037239 Exonuclease_Xrn2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H0D6-1) [UniParc]FASTAAdd to basket
Also known as: XRN2a

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGVPAFFRWL SRKYPSIIVN CVEEKPKECN GVKIPVDASK PNPNDVEFDN
60 70 80 90 100
LYLDMNGIIH PCTHPEDKPA PKNEDEMMVA IFEYIDRLFS IVRPRRLLYM
110 120 130 140 150
AIDGVAPRAK MNQQRSRRFR ASKEGMEAAV EKQRVREEIL AKGGFLPPEE
160 170 180 190 200
IKERFDSNCI TPGTEFMDNL AKCLRYYIAD RLNNDPGWKN LTVILSDASA
210 220 230 240 250
PGEGEHKIMD YIRRQRAQPN HDPNTHHCLC GADADLIMLG LATHEPNFTI
260 270 280 290 300
IREEFKPNKP KPCGLCNQFG HEVKDCEGLP REKKGKHDEL ADSLPCAEGE
310 320 330 340 350
FIFLRLNVLR EYLERELTMA SLPFTFDVER SIDDWVFMCF FVGNDFLPHL
360 370 380 390 400
PSLEIRENAI DRLVNIYKNV VHKTGGYLTE SGYVNLQRVQ MIMLAVGEVE
410 420 430 440 450
DSIFKKRKDD EDSFRRRQKE KRKRMKRDQP AFTPSGILTP HALGSRNSPG
460 470 480 490 500
SQVASNPRQA AYEMRMQNNS SPSISPNTSF TSDGSPSPLG GIKRKAEDSD
510 520 530 540 550
SEPEPEDNVR LWEAGWKQRY YKNKFDVDAA DEKFRRKVVQ SYVEGLCWVL
560 570 580 590 600
RYYYQGCASW KWYYPFHYAP FASDFEGIAD MPSDFEKGTK PFKPLEQLMG
610 620 630 640 650
VFPAASGNFL PPSWRKLMSD PDSSIIDFYP EDFAIDLNGK KYAWQGVALL
660 670 680 690 700
PFVDERRLRA ALEEVYPDLT PEETRRNSLG GDVLFVGKHH PLHDFILELY
710 720 730 740 750
QTGSTEPVEV PPELCHGIQG KFSLDEEAIL PDQIVCSPVP MLRDLTQNTV
760 770 780 790 800
VSINFKDPQF AEDYIFKAVM LPGARKPAAV LKPSDWEKSS NGRQWKPQLG
810 820 830 840 850
FNRDRRPVHL DQAAFRTLGH VMPRGSGTGI YSNAAPPPVT YQGNLYRPLL
860 870 880 890 900
RGQAQIPKLM SNMRPQDSWR GPPPLFQQQR FDRGVGAEPL LPWNRMLQTQ
910 920 930 940 950
NAAFQPNQYQ MLAGPGGYPP RRDDRGGRQG YPREGRKYPL PPPSGRYNWN
Length:950
Mass (Da):108,582
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i763B5E0E628F97A8
GO
Isoform 2 (identifier: Q9H0D6-2) [UniParc]FASTAAdd to basket
Also known as: XRN2b

The sequence of this isoform differs from the canonical sequence as follows:
     1-76: Missing.

Note: No experimental confirmation available.
Show »
Length:874
Mass (Da):99,962
Checksum:i85DBF4213F810AEC
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAR24369 differs from that shown. Reason: Frameshift at position 73.Curated
The sequence BAA90934 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti14Y → C in AAQ13577 (PubMed:10409438).Curated1
Sequence conflicti109A → V in AAD55138 (PubMed:10409438).Curated1
Sequence conflicti109A → V in AAQ13577 (PubMed:10409438).Curated1
Sequence conflicti122 – 124SKE → IKR in AAD55138 (PubMed:10409438).Curated3
Sequence conflicti240 – 245GLATHE → AFPHMN in AAQ13577 (PubMed:10409438).Curated6
Sequence conflicti259K → R in AAD55138 (PubMed:10409438).Curated1
Sequence conflicti259K → R in AAQ13577 (PubMed:10409438).Curated1
Sequence conflicti280P → S in AAD55138 (PubMed:10409438).Curated1
Sequence conflicti280P → S in AAQ13577 (PubMed:10409438).Curated1
Sequence conflicti313L → V in AAQ13577 (PubMed:10409438).Curated1
Sequence conflicti463E → D in AAD55138 (PubMed:10409438).Curated1
Sequence conflicti582P → S in AAQ13577 (PubMed:10409438).Curated1
Sequence conflicti584D → E in AAD55138 (PubMed:10409438).Curated1
Sequence conflicti737S → A in AAD55138 (PubMed:10409438).Curated1
Sequence conflicti760F → L in AAR24369 (PubMed:16147866).Curated1
Sequence conflicti787E → G in AAD55138 (PubMed:10409438).Curated1
Sequence conflicti874P → L in AAR24369 (PubMed:16147866).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027516743R → M. Corresponds to variant dbSNP:rs6137324Ensembl.1
Natural variantiVAR_053002925R → C. Corresponds to variant dbSNP:rs6047420Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0205961 – 76Missing in isoform 2. 1 PublicationAdd BLAST76

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF064257 mRNA Translation: AAD55138.1
AF152169 mRNA Translation: AAQ13577.1
AY382900 mRNA Translation: AAR24369.1 Frameshift.
AL136841 mRNA Translation: CAB66775.1
AL117332 Genomic DNA No translation available.
AL158013 Genomic DNA No translation available.
AK000084 mRNA Translation: BAA90934.1 Different initiation.
BC006417 mRNA Translation: AAH06417.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13144.1 [Q9H0D6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001304889.1, NM_001317960.1
NP_036387.2, NM_012255.4 [Q9H0D6-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.255932

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000377191; ENSP00000366396; ENSG00000088930 [Q9H0D6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
22803

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:22803

UCSC genome browser

More...
UCSCi
uc002wsf.2 human [Q9H0D6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064257 mRNA Translation: AAD55138.1
AF152169 mRNA Translation: AAQ13577.1
AY382900 mRNA Translation: AAR24369.1 Frameshift.
AL136841 mRNA Translation: CAB66775.1
AL117332 Genomic DNA No translation available.
AL158013 Genomic DNA No translation available.
AK000084 mRNA Translation: BAA90934.1 Different initiation.
BC006417 mRNA Translation: AAH06417.2
CCDSiCCDS13144.1 [Q9H0D6-1]
RefSeqiNP_001304889.1, NM_001317960.1
NP_036387.2, NM_012255.4 [Q9H0D6-1]
UniGeneiHs.255932

3D structure databases

ProteinModelPortaliQ9H0D6
SMRiQ9H0D6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116483, 127 interactors
CORUMiQ9H0D6
DIPiDIP-31166N
IntActiQ9H0D6, 50 interactors
MINTiQ9H0D6
STRINGi9606.ENSP00000366396

PTM databases

iPTMnetiQ9H0D6
PhosphoSitePlusiQ9H0D6
SwissPalmiQ9H0D6

Polymorphism and mutation databases

BioMutaiXRN2
DMDMi30173484

2D gel databases

SWISS-2DPAGEiQ9H0D6

Proteomic databases

EPDiQ9H0D6
MaxQBiQ9H0D6
PaxDbiQ9H0D6
PeptideAtlasiQ9H0D6
PRIDEiQ9H0D6
ProteomicsDBi80258
80259 [Q9H0D6-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
22803
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000377191; ENSP00000366396; ENSG00000088930 [Q9H0D6-1]
GeneIDi22803
KEGGihsa:22803
UCSCiuc002wsf.2 human [Q9H0D6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
22803
DisGeNETi22803
EuPathDBiHostDB:ENSG00000088930.7

GeneCards: human genes, protein and diseases

More...
GeneCardsi
XRN2
HGNCiHGNC:12836 XRN2
HPAiHPA047118
HPA050485
MIMi608851 gene
neXtProtiNX_Q9H0D6
OpenTargetsiENSG00000088930
PharmGKBiPA37427

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2044 Eukaryota
COG5049 LUCA
GeneTreeiENSGT00670000098098
HOVERGENiHBG036677
KOiK12619
OMAiGEHFDSN
OrthoDBiEOG091G00A4
PhylomeDBiQ9H0D6
TreeFamiTF105977

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
XRN2 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
5%27-3%27_exoribonuclease_2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
22803
PMAP-CutDBiQ9H0D6

Protein Ontology

More...
PROi
PR:Q9H0D6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000088930 Expressed in 192 organ(s), highest expression level in kidney
CleanExiHS_XRN2
GenevisibleiQ9H0D6 HS

Family and domain databases

InterProiView protein in InterPro
IPR027073 5_3_exoribonuclease
IPR004859 Put_53exo
IPR017151 Xrn2/3/4
PANTHERiPTHR12341 PTHR12341, 1 hit
PfamiView protein in Pfam
PF03159 XRN_N, 1 hit
PIRSFiPIRSF037239 Exonuclease_Xrn2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXRN2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0D6
Secondary accession number(s): Q3L8N4
, Q6KGZ9, Q9BQL1, Q9NTW0, Q9NXS6, Q9UL53
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again