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Entry version 169 (07 Oct 2020)
Sequence version 3 (03 Sep 2014)
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Protein

Zinc finger protein 541

Gene

ZNF541

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of some chromatin remodeling multiprotein complex that plays a role during spermatogenesis.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri838 – 860C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1289 – 1311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Repressor
Biological processDifferentiation, Spermatogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H0D2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 541
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF541
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000118156.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25294, ZNF541

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0D2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84215

Open Targets

More...
OpenTargetsi
ENSG00000118156

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134941115

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0D2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF541

Domain mapping of disease mutations (DMDM)

More...
DMDMi
221222508

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001971361 – 1346Zinc finger protein 541Add BLAST1346

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H0D2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0D2

PeptideAtlas

More...
PeptideAtlasi
Q9H0D2

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0D2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80255 [Q9H0D2-3]
80256 [Q9H0D2-2]
80257 [Q9H0D2-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0D2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0D2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000118156, Expressed in testis and 98 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H0D2, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0D2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000118156, Tissue enriched (testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with DNTTIP1 (PubMed:21573134).

Identified in a complex with KCDT19, HDAC1 and HSPA2 (By similarity).

Component of a histone deacetylase complex containing DNTTIP1, ZNF541, HDAC1 and HDAC2 (PubMed:21573134).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
123949, 2 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q9H0D2

Protein interaction database and analysis system

More...
IntActi
Q9H0D2, 3 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000375770

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H0D2, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q9H0D2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1053 – 1145ELM2PROSITE-ProRule annotationAdd BLAST93
Domaini1160 – 1211SANTPROSITE-ProRule annotationAdd BLAST52

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri140 – 162C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri168 – 190C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri196 – 220C2H2-type 3PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri838 – 860C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1289 – 1311C2H2-type 5PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota
KOG4167, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160330

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_006052_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H0D2

Database of Orthologous Groups

More...
OrthoDBi
165439at2759

TreeFam database of animal gene trees

More...
TreeFami
TF106431

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01448, ELM2, 1 hit
PF00096, zf-C2H2, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00355, ZnF_C2H2, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 3 (identifier: Q9H0D2-3) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDQYSLGDEG ALPSEMHLPS FSESQGLNCS DTLNRDLGPN TRGFLYAGLS
60 70 80 90 100
GLDPDPSLPT PDMSSEVLED NLDTLSLYSG KDSDSVKLLE EYADSESQAS
110 120 130 140 150
LQDLGLGVLK AKEADEGGRA TSGSARKGKR QHSSPQNPLL DCSLCGKVFS
160 170 180 190 200
SASSLSKHYL THSQERKHVC KICSKAFKRQ DHLTGHMLTH QKTKPFVCIE
210 220 230 240 250
QGCSKSYCDY RSLRRHYEVH HGLCILKEAP PEEEACGDSP HAHESAGQPP
260 270 280 290 300
PSSLRSLVPP EARSPGSLLP HRDLLRRIVS SIVHQKTPSP GPAPAGASDS
310 320 330 340 350
EGRNTACPCP ASSGSSSCTP AGPHAAPAAL DTELPEEPCL PQKEPATDVF
360 370 380 390 400
TAPNSRAAEN GAPDPPEPEP DTALLQARST AECWPEGGSV PACLPLFRGQ
410 420 430 440 450
TVPASSQPSS HSFQWLRNLP GCPKSKGNNV FVVHKPSAVP SREGSESGPG
460 470 480 490 500
PSSGSPSEES PPGPGGGLED ALPFPAALLR VPAEAPSDPR SASGEDDPCA
510 520 530 540 550
PKKVKVDCDS FLCQNPGEPG LQEAQKAGGL PADASPLFRQ LFLKSQEPLV
560 570 580 590 600
SHEQMQVFQM ITKSQRIFSH AQVAAVSSQL PAPEGKPAAL RPLQGPWPQQ
610 620 630 640 650
PPPLAPAVDS LHAGPGNPEA EGSPARRRKT TPGVPREASP GSTRRDAKGG
660 670 680 690 700
LKVAAVPTPL AAPSLDPSRN PDISSLAKQL RSSKGTLDLE DIFPSTGQRQ
710 720 730 740 750
TQLGGEEPPG ASLPGKQAPA ENGAASRITK GEKGPACSRG GGYRLLGNPR
760 770 780 790 800
APRFSGFRKE KAKMDMCCAA SPSQVAMASF SSAGPPADPS KSKLTIFSRI
810 820 830 840 850
QGGNIYRLPH PVKEENVAGR GNQQNGSPTD WTKPRSTFVC KNCSQMFYTE
860 870 880 890 900
KGLSSHMCFH SDQWPSPRGK QEPQVFGTEF CKPLRQVLRP EGDRHSPPGT
910 920 930 940 950
KKPLDPTAAA PLVVPQSIPV VPVTRHIGSM AMGQEKDGEE RDSKESSQQR
960 970 980 990 1000
KRKKRPPPST AGEPGPAGCH QSRLRSPMFL VDCLLKGLFQ CSPYTPPPML
1010 1020 1030 1040 1050
SPIREGSGVY FNTLCSTSTQ ASPDQLISSM LDQVDGSFGI CVVKDDTKIS
1060 1070 1080 1090 1100
IEPHINIGSR FQAEIPELQE RSLAGTDEHV ASLVWKPWGD MMISSETQDR
1110 1120 1130 1140 1150
VTELCNVACS SVMPGGGTNL ELALHCLHEA QGNVQVALET LLLRGPHKPR
1160 1170 1180 1190 1200
THLLADYRYT GSDVWTPIEK RLFKKAFYAH KKDFYLIHKM IQTKTVAQCV
1210 1220 1230 1240 1250
EYYYIWKKMI KFDCGRAPGL EKRVKREPEE VERTEEKVPC SPRERPSHHP
1260 1270 1280 1290 1300
TPKLKTKSYR RESILSSSPN AGSKRTPELL GSAESQGIFP CRECERVFDK
1310 1320 1330 1340
IKSRNAHMKR HRLQDHVEPI IRVKWPVKPF QLKEEELGAD IGPLQW
Length:1,346
Mass (Da):145,587
Last modified:September 3, 2014 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC9FEB46072EED963
GO
Isoform 2 (identifier: Q9H0D2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     932-1189: Missing.

Show »
Length:1,088
Mass (Da):116,894
Checksum:iD85DFC8CC72661D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M0R167M0R167_HUMAN
Zinc finger protein 541
ZNF541
866Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A075B6F0A0A075B6F0_HUMAN
Zinc finger protein 541
ZNF541
1,365Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7BXG6H7BXG6_HUMAN
Zinc finger protein 541
ZNF541
679Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI01051 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI01052 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI01053 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI01054 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAB66780 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAD38720 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti473P → A in CAD38720 (PubMed:11230166).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_054220486P → S. Corresponds to variant dbSNP:rs3810320Ensembl.1
Natural variantiVAR_035717712S → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_054221791K → E. Corresponds to variant dbSNP:rs34984302Ensembl.1
Natural variantiVAR_054222795T → S. Corresponds to variant dbSNP:rs3826835Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_016024932 – 1189Missing in isoform 2. 1 PublicationAdd BLAST258

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC010331 Genomic DNA No translation available.
AC016589 Genomic DNA No translation available.
AC073548 Genomic DNA No translation available.
AL136846 mRNA Translation: CAB66780.1 Different initiation.
AL833862 mRNA Translation: CAD38720.2 Frameshift.
BC101050 mRNA Translation: AAI01051.1 Different initiation.
BC101051 mRNA Translation: AAI01052.1 Different initiation.
BC101052 mRNA Translation: AAI01053.1 Different initiation.
BC101053 mRNA Translation: AAI01054.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS46133.2 [Q9H0D2-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001264004.1, NM_001277075.1 [Q9H0D2-3]
XP_005259368.1, XM_005259311.4 [Q9H0D2-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000391901; ENSP00000375770; ENSG00000118156 [Q9H0D2-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84215

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84215

UCSC genome browser

More...
UCSCi
uc002phg.5, human [Q9H0D2-3]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010331 Genomic DNA No translation available.
AC016589 Genomic DNA No translation available.
AC073548 Genomic DNA No translation available.
AL136846 mRNA Translation: CAB66780.1 Different initiation.
AL833862 mRNA Translation: CAD38720.2 Frameshift.
BC101050 mRNA Translation: AAI01051.1 Different initiation.
BC101051 mRNA Translation: AAI01052.1 Different initiation.
BC101052 mRNA Translation: AAI01053.1 Different initiation.
BC101053 mRNA Translation: AAI01054.1 Different initiation.
CCDSiCCDS46133.2 [Q9H0D2-3]
RefSeqiNP_001264004.1, NM_001277075.1 [Q9H0D2-3]
XP_005259368.1, XM_005259311.4 [Q9H0D2-3]

3D structure databases

SMRiQ9H0D2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123949, 2 interactors
CORUMiQ9H0D2
IntActiQ9H0D2, 3 interactors
STRINGi9606.ENSP00000375770

PTM databases

iPTMnetiQ9H0D2
PhosphoSitePlusiQ9H0D2

Polymorphism and mutation databases

BioMutaiZNF541
DMDMi221222508

Proteomic databases

MassIVEiQ9H0D2
PaxDbiQ9H0D2
PeptideAtlasiQ9H0D2
PRIDEiQ9H0D2
ProteomicsDBi80255 [Q9H0D2-3]
80256 [Q9H0D2-2]
80257 [Q9H0D2-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
18215, 117 antibodies

Genome annotation databases

EnsembliENST00000391901; ENSP00000375770; ENSG00000118156 [Q9H0D2-3]
GeneIDi84215
KEGGihsa:84215
UCSCiuc002phg.5, human [Q9H0D2-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84215
DisGeNETi84215
EuPathDBiHostDB:ENSG00000118156.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF541
HGNCiHGNC:25294, ZNF541
HPAiENSG00000118156, Tissue enriched (testis)
neXtProtiNX_Q9H0D2
OpenTargetsiENSG00000118156
PharmGKBiPA134941115

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG1721, Eukaryota
KOG4167, Eukaryota
GeneTreeiENSGT00940000160330
HOGENOMiCLU_006052_0_0_1
InParanoidiQ9H0D2
OrthoDBi165439at2759
TreeFamiTF106431

Enzyme and pathway databases

PathwayCommonsiQ9H0D2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
84215, 18 hits in 894 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ZNF541, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
84215
PharosiQ9H0D2, Tdark

Protein Ontology

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PROi
PR:Q9H0D2
RNActiQ9H0D2, protein

Gene expression databases

BgeeiENSG00000118156, Expressed in testis and 98 other tissues
ExpressionAtlasiQ9H0D2, baseline and differential
GenevisibleiQ9H0D2, HS

Family and domain databases

InterProiView protein in InterPro
IPR000949, ELM2_dom
IPR009057, Homeobox-like_sf
IPR001005, SANT/Myb
IPR017884, SANT_dom
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF01448, ELM2, 1 hit
PF00096, zf-C2H2, 1 hit
SMARTiView protein in SMART
SM01189, ELM2, 1 hit
SM00717, SANT, 1 hit
SM00355, ZnF_C2H2, 5 hits
SUPFAMiSSF46689, SSF46689, 1 hit
SSF57667, SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS51156, ELM2, 1 hit
PS51293, SANT, 1 hit
PS00028, ZINC_FINGER_C2H2_1, 5 hits
PS50157, ZINC_FINGER_C2H2_2, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZN541_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0D2
Secondary accession number(s): Q8NDK8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: September 3, 2014
Last modified: October 7, 2020
This is version 169 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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