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Entry version 124 (12 Aug 2020)
Sequence version 1 (01 Mar 2001)
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Protein

Transmembrane protein 117

Gene

TMEM117

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in endoplasmic reticulum (ER) stress-induced cell death pathway.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q9H0C3

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.B.366.1.1, the tmem117 (tmem117) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transmembrane protein 117
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM117
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139173.9

Human Gene Nomenclature Database

More...
HGNCi
HGNC:25308, TMEM117

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0C3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 15Cytoplasmic1 PublicationAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Topological domaini37 – 65Extracellular1 PublicationAdd BLAST29
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 110Cytoplasmic1 PublicationAdd BLAST24
Transmembranei111 – 131HelicalSequence analysisAdd BLAST21
Topological domaini132 – 154Extracellular1 PublicationAdd BLAST23
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Topological domaini176 – 198Cytoplasmic1 PublicationAdd BLAST23
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 239Extracellular1 PublicationAdd BLAST20
Transmembranei240 – 260HelicalSequence analysisAdd BLAST21
Topological domaini261 – 295Cytoplasmic1 PublicationAdd BLAST35
Transmembranei296 – 316HelicalSequence analysisAdd BLAST21
Topological domaini317 – 394Extracellular1 PublicationAdd BLAST78
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Topological domaini416 – 514Cytoplasmic1 PublicationAdd BLAST99

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi353N → A: Reduced N-glycosylation. Loss of N-glycosylation; when associated with A-371. 1 Publication1
Mutagenesisi371N → A: Reduced N-glycosylation. Loss of N-glycosylation; when associated with A-353. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
84216

Open Targets

More...
OpenTargetsi
ENSG00000139173

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA143485638

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q9H0C3, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
TMEM117

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74733520

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002512041 – 514Transmembrane protein 117Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi353N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi371N-linked (GlcNAc...) asparagine1 Publication1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei453PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q9H0C3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q9H0C3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0C3

PeptideAtlas

More...
PeptideAtlasi
Q9H0C3

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0C3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
80252

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q9H0C3, 2 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0C3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0C3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139173, Expressed in pigmented layer of retina and 199 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q9H0C3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0C3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000139173, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123950, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266534

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q9H0C3, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TMEM117 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QXR1, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000013052

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_047657_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H0C3

Identification of Orthologs from Complete Genome Data

More...
OMAi
YVERDMF

Database of Orthologous Groups

More...
OrthoDBi
801372at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0C3

TreeFam database of animal gene trees

More...
TreeFami
TF336012

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029370, TMEM117

The PANTHER Classification System

More...
PANTHERi
PTHR31226, PTHR31226, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15113, TMEM117, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q9H0C3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKDFRYYFQ HPWSRMIVAY LVIFFNFLIF AEDPVSHSQT EANVIVVGNC
60 70 80 90 100
FSFVTNKYPR GVGWRILKVL LWLLAILTGL IAGKFLFHQR LFGQLLRLKM
110 120 130 140 150
FREDHGSWMT MFFSTILFLF IFSHIYNTIL LMDGNMGAYI ITDYMGIRNE
160 170 180 190 200
SFMKLAAVGT WMGDFVTAWM VTDMMLQDKP YPDWGKSARA FWKKGNVRIT
210 220 230 240 250
LFWTVLFTLT SVVVLVITTD WISWDKLNRG FLPSDEVSRA FLASFILVFD
260 270 280 290 300
LLIVMQDWEF PHFMGDVDVN LPGLHTPHMQ FKIPFFQKIF KEEYRIHITG
310 320 330 340 350
KWFNYGIIFL VLILDLNMWK NQIFYKPHEY GQYIGPGQKI YTVKDSESLK
360 370 380 390 400
DLNRTKLSWE WRSNHTNPRT NKTYVEGDMF LHSRFIGASL DVKCLAFVPS
410 420 430 440 450
LIAFVWFGFF IWFFGRFLKN EPRMENQDKT YTRMKRKSPS EHSKDMGITR
460 470 480 490 500
ENTQASVEDP LNDPSLVCIR SDFNEIVYKS SHLTSENLSS QLNESTSATE
510
ADQDPTTSKS TPTN
Length:514
Mass (Da):60,185
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9DBBF7980AAC2246
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VS00F8VS00_HUMAN
Transmembrane protein 117
TMEM117
268Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8W1J2F8W1J2_HUMAN
Transmembrane protein 117
TMEM117
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YI63H0YI63_HUMAN
Transmembrane protein 117
TMEM117
158Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02766090R → H. Corresponds to variant dbSNP:rs1948516Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136855 mRNA Translation: CAB66789.1
AK057287 mRNA Translation: BAB71411.1
BC060798 mRNA Translation: AAH60798.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8745.1

NCBI Reference Sequences

More...
RefSeqi
NP_001273142.1, NM_001286213.1
NP_115632.1, NM_032256.2
XP_011537133.1, XM_011538831.2
XP_011537134.1, XM_011538832.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000266534; ENSP00000266534; ENSG00000139173

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84216

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84216

UCSC genome browser

More...
UCSCi
uc001rod.5, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136855 mRNA Translation: CAB66789.1
AK057287 mRNA Translation: BAB71411.1
BC060798 mRNA Translation: AAH60798.1
CCDSiCCDS8745.1
RefSeqiNP_001273142.1, NM_001286213.1
NP_115632.1, NM_032256.2
XP_011537133.1, XM_011538831.2
XP_011537134.1, XM_011538832.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi123950, 1 interactor
STRINGi9606.ENSP00000266534

Protein family/group databases

TCDBi9.B.366.1.1, the tmem117 (tmem117) family

PTM databases

GlyGeniQ9H0C3, 2 sites
iPTMnetiQ9H0C3
PhosphoSitePlusiQ9H0C3

Polymorphism and mutation databases

BioMutaiTMEM117
DMDMi74733520

Proteomic databases

MassIVEiQ9H0C3
MaxQBiQ9H0C3
PaxDbiQ9H0C3
PeptideAtlasiQ9H0C3
PRIDEiQ9H0C3
ProteomicsDBi80252

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25193, 90 antibodies

The DNASU plasmid repository

More...
DNASUi
84216

Genome annotation databases

EnsembliENST00000266534; ENSP00000266534; ENSG00000139173
GeneIDi84216
KEGGihsa:84216
UCSCiuc001rod.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84216
DisGeNETi84216
EuPathDBiHostDB:ENSG00000139173.9

GeneCards: human genes, protein and diseases

More...
GeneCardsi
TMEM117
HGNCiHGNC:25308, TMEM117
HPAiENSG00000139173, Low tissue specificity
neXtProtiNX_Q9H0C3
OpenTargetsiENSG00000139173
PharmGKBiPA143485638

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QXR1, Eukaryota
GeneTreeiENSGT00390000013052
HOGENOMiCLU_047657_0_0_1
InParanoidiQ9H0C3
OMAiYVERDMF
OrthoDBi801372at2759
PhylomeDBiQ9H0C3
TreeFamiTF336012

Enzyme and pathway databases

PathwayCommonsiQ9H0C3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
84216, 2 hits in 875 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
TMEM117, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
TMEM117

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84216
PharosiQ9H0C3, Tbio

Protein Ontology

More...
PROi
PR:Q9H0C3
RNActiQ9H0C3, protein

Gene expression databases

BgeeiENSG00000139173, Expressed in pigmented layer of retina and 199 other tissues
ExpressionAtlasiQ9H0C3, baseline and differential
GenevisibleiQ9H0C3, HS

Family and domain databases

InterProiView protein in InterPro
IPR029370, TMEM117
PANTHERiPTHR31226, PTHR31226, 1 hit
PfamiView protein in Pfam
PF15113, TMEM117, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTM117_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0C3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: March 1, 2001
Last modified: August 12, 2020
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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