Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q9H0B8 (CRLD2_HUMAN)

Protein

Cysteine-rich secretory protein LCCL domain-containing 2

Gene

CRISPLD2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes matrix assembly.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glycosaminoglycan binding Source: GO_Central
  • heparin binding Source: Ensembl
View the complete GO annotation on QuickGO ...

GO - Biological processi

  • extracellular matrix organization Source: Ensembl
  • face morphogenesis Source: UniProtKB
  • lung development Source: Ensembl
  • neutrophil degranulation Source: Reactome
View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6798695 Neutrophil degranulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine-rich secretory protein LCCL domain-containing 2
Alternative name(s):
Cysteine-rich secretory protein 11
Short name:
CRISP-11
LCCL domain-containing cysteine-rich secretory protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CRISPLD2
Synonyms:CRISP11, LCRISP2
ORF Names:UNQ2914/PRO1156/PRO9783
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000103196.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:25248 CRISPLD2

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		612434 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q9H0B8

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		83716

Open Targets

More...OpenTargetsi		ENSG00000103196

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA142672077

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CRISPLD2

Domain mapping of disease mutations (DMDM)

More...DMDMi		74717972

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000024814923 – 497Cysteine-rich secretory protein LCCL domain-containing 2Add BLAST475

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi290 ↔ 308PROSITE-ProRule annotation
Disulfide bondi312 ↔ 332PROSITE-ProRule annotation
Disulfide bondi391 ↔ 413PROSITE-ProRule annotation
Disulfide bondi417 ↔ 440PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q9H0B8

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q9H0B8

PeptideAtlas

More...PeptideAtlasi		Q9H0B8

PRoteomics IDEntifications database

More...PRIDEi		Q9H0B8

ProteomicsDB human proteome resource

More...ProteomicsDBi		80245
80246 [Q9H0B8-2]
80247 [Q9H0B8-3]
80248 [Q9H0B8-4]
80249 [Q9H0B8-5]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q9H0B8

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q9H0B8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000103196 Expressed in 225 organ(s), highest expression level in tibia

CleanEx database of gene expression profiles

More...CleanExi		HS_CRISPLD2

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q9H0B8 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q9H0B8 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA030054
HPA030055

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to heparin, dermatan sulfate and chondroitin sulfate.By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		123739, 3 interactors

Protein interaction database and analysis system

More...IntActi		Q9H0B8, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000262424

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q9H0B8

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini62 – 200SCPAdd BLAST139
Domaini284 – 379LCCL 1PROSITE-ProRule annotationAdd BLAST96
Domaini385 – 488LCCL 2PROSITE-ProRule annotationAdd BLAST104

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3017 Eukaryota
COG2340 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157410

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG062505

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q9H0B8

Identification of Orthologs from Complete Genome Data

More...OMAi		RCSGAMC

Database of Orthologous Groups

More...OrthoDBi		EOG091G048D

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q9H0B8

TreeFam database of animal gene trees

More...TreeFami		TF316148

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.170.130.20, 2 hits
3.40.33.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR004043 LCCL
IPR036609 LCCL_sf

The PANTHER Classification System

More...PANTHERi		PTHR10334 PTHR10334, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00188 CAP, 1 hit
PF03815 LCCL, 2 hits

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00837 V5TPXLIKE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00603 LCCL, 2 hits
SM00198 SCP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55797 SSF55797, 1 hit
SSF69848 SSF69848, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01010 CRISP_2, 1 hit
PS50820 LCCL, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0B8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSCVLGGVIP LGLLFLVCGS QGYLLPNVTL LEELLSKYQH NESHSRVRRA 
        60         70         80         90        100
IPREDKEEIL MLHNKLRGQV QPQASNMEYM TWDDELEKSA AAWASQCIWE 
       110        120        130        140        150
HGPTSLLVSI GQNLGAHWGR YRSPGFHVQS WYDEVKDYTY PYPSECNPWC 
       160        170        180        190        200
PERCSGPMCT HYTQIVWATT NKIGCAVNTC RKMTVWGEVW ENAVYFVCNY 
       210        220        230        240        250
SPKGNWIGEA PYKNGRPCSE CPPSYGGSCR NNLCYREETY TPKPETDEMN 
       260        270        280        290        300
EVETAPIPEE NHVWLQPRVM RPTKPKKTSA VNYMTQVVRC DTKMKDRCKG 
       310        320        330        340        350
STCNRYQCPA GCLNHKAKIF GTLFYESSSS ICRAAIHYGI LDDKGGLVDI 
       360        370        380        390        400
TRNGKVPFFV KSERHGVQSL SKYKPSSSFM VSKVKVQDLD CYTTVAQLCP 
       410        420        430        440        450
FEKPATHCPR IHCPAHCKDE PSYWAPVFGT NIYADTSSIC KTAVHAGVIS 
       460        470        480        490 
NESGGDVDVM PVDKKKTYVG SLRNGVQSES LGTPRDGKAF RIFAVRQ
Length:497
Mass (Da):55,920
Last modified:March 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E7ADDCAB37CA4ED
GO
Isoform 2 (identifier: Q9H0B8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     436-497: TSSICKTAVH...KAFRIFAVRQ → VSRMHFQQLSRKAC

Note: No experimental confirmation available.
Show »
Length:449
Mass (Da):51,044
Checksum:i1E597E5C8CA8CD66
GO
Isoform 3 (identifier: Q9H0B8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     371-371: S → R
     372-497: Missing.

Show »
Length:371
Mass (Da):42,207
Checksum:i8D23FBE14F53E85C
GO
Isoform 4 (identifier: Q9H0B8-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     81-159: TWDDELEKSA...CPERCSGPMC → VSAGSGRRGW...QWHNRHALKP
     160-497: Missing.

Note: No experimental confirmation available.
Show »
Length:159
Mass (Da):17,476
Checksum:iCE3BAAB490465049
GO
Isoform 5 (identifier: Q9H0B8-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     121-497: Missing.

Show »
Length:120
Mass (Da):13,497
Checksum:iD0B40A3149B1099C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BTI0H3BTI0_HUMAN
Cysteine-rich secretory protein LCC...
CRISPLD2
496Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BSZ9H3BSZ9_HUMAN
Cysteine-rich secretory protein LCC...
CRISPLD2
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BTP0H3BTP0_HUMAN
Cysteine-rich secretory protein LCC...
CRISPLD2
111Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKP2J3QKP2_HUMAN
Cysteine-rich secretory protein LCC...
CRISPLD2
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BS62H3BS62_HUMAN
Cysteine-rich secretory protein LCC...
CRISPLD2
18Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_027256105S → G2 PublicationsCorresponds to variant dbSNP:rs12051468Ensembl.1
Natural variantiVAR_074672137D → G1 PublicationCorresponds to variant dbSNP:rs1297496215Ensembl.1
Natural variantiVAR_027257322T → S2 PublicationsCorresponds to variant dbSNP:rs721005Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_02017881 – 159TWDDE…SGPMC → VSAGSGRRGWHRGWGLGHQP ALFPSQLCSPASACDGWLRV SSGRGGSRLCSVLFVCFETG SHSATDAGVQWHNRHALKP in isoform 4. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_020179121 – 497Missing in isoform 5. 1 PublicationAdd BLAST377
Alternative sequenceiVSP_020180160 – 497Missing in isoform 4. 1 PublicationAdd BLAST338
Alternative sequenceiVSP_020181371S → R in isoform 3. 1 Publication1
Alternative sequenceiVSP_020182372 – 497Missing in isoform 3. 1 PublicationAdd BLAST126
Alternative sequenceiVSP_020183436 – 497TSSIC…FAVRQ → VSRMHFQQLSRKAC in isoform 2. 1 PublicationAdd BLAST62

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL136861 mRNA Translation: CAB66795.1
AY358413 mRNA Translation: AAQ88779.1
AY358790 mRNA Translation: AAQ89150.1
AK027395 mRNA Translation: BAB55081.1
CH471114 Genomic DNA Translation: EAW95468.1
CH471114 Genomic DNA Translation: EAW95469.1
BC007689 mRNA Translation: AAH07689.1
BC063012 mRNA Translation: AAH63012.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10949.1 [Q9H0B8-1]

NCBI Reference Sequences

More...RefSeqi		NP_113664.1, NM_031476.3 [Q9H0B8-1]
XP_005256247.1, XM_005256190.1 [Q9H0B8-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.513779
Hs.617091

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000262424; ENSP00000262424; ENSG00000103196 [Q9H0B8-1]
ENST00000564567; ENSP00000457655; ENSG00000103196 [Q9H0B8-2]
ENST00000569090; ENSP00000454858; ENSG00000103196 [Q9H0B8-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		83716

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:83716

UCSC genome browser

More...UCSCi		uc002fil.3 human [Q9H0B8-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136861 mRNA Translation: CAB66795.1
AY358413 mRNA Translation: AAQ88779.1
AY358790 mRNA Translation: AAQ89150.1
AK027395 mRNA Translation: BAB55081.1
CH471114 Genomic DNA Translation: EAW95468.1
CH471114 Genomic DNA Translation: EAW95469.1
BC007689 mRNA Translation: AAH07689.1
BC063012 mRNA Translation: AAH63012.1
CCDSiCCDS10949.1 [Q9H0B8-1]
RefSeqiNP_113664.1, NM_031476.3 [Q9H0B8-1]
XP_005256247.1, XM_005256190.1 [Q9H0B8-1]
UniGeneiHs.513779
Hs.617091

3D structure databases

ProteinModelPortaliQ9H0B8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123739, 3 interactors
IntActiQ9H0B8, 1 interactor
STRINGi9606.ENSP00000262424

PTM databases

iPTMnetiQ9H0B8
PhosphoSitePlusiQ9H0B8

Polymorphism and mutation databases

BioMutaiCRISPLD2
DMDMi74717972

Proteomic databases

MaxQBiQ9H0B8
PaxDbiQ9H0B8
PeptideAtlasiQ9H0B8
PRIDEiQ9H0B8
ProteomicsDBi80245
80246 [Q9H0B8-2]
80247 [Q9H0B8-3]
80248 [Q9H0B8-4]
80249 [Q9H0B8-5]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		83716
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262424; ENSP00000262424; ENSG00000103196 [Q9H0B8-1]
ENST00000564567; ENSP00000457655; ENSG00000103196 [Q9H0B8-2]
ENST00000569090; ENSP00000454858; ENSG00000103196 [Q9H0B8-5]
GeneIDi83716
KEGGihsa:83716
UCSCiuc002fil.3 human [Q9H0B8-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		83716
DisGeNETi83716
EuPathDBiHostDB:ENSG00000103196.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		CRISPLD2
HGNCiHGNC:25248 CRISPLD2
HPAiHPA030054
HPA030055
MIMi612434 gene
neXtProtiNX_Q9H0B8
OpenTargetsiENSG00000103196
PharmGKBiPA142672077

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00940000157410
HOVERGENiHBG062505
InParanoidiQ9H0B8
OMAiRCSGAMC
OrthoDBiEOG091G048D
PhylomeDBiQ9H0B8
TreeFamiTF316148

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CRISPLD2 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CRISPLD2

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		83716

Protein Ontology

More...PROi		PR:Q9H0B8

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000103196 Expressed in 225 organ(s), highest expression level in tibia
CleanExiHS_CRISPLD2
ExpressionAtlasiQ9H0B8 baseline and differential
GenevisibleiQ9H0B8 HS

Family and domain databases

Gene3Di2.170.130.20, 2 hits
3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR004043 LCCL
IPR036609 LCCL_sf
PANTHERiPTHR10334 PTHR10334, 2 hits
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PF03815 LCCL, 2 hits
PRINTSiPR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00603 LCCL, 2 hits
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
SSF69848 SSF69848, 2 hits
PROSITEiView protein in PROSITE
PS01010 CRISP_2, 1 hit
PS50820 LCCL, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCRLD2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0B8
Secondary accession number(s): D3DUM0
, Q6P590, Q6UWH0, Q6UXC6, Q96IB1, Q96K61
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: March 1, 2001
Last modified: December 5, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again