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UniProtKB - Q9H0B8 (CRLD2_HUMAN)
Protein
Cysteine-rich secretory protein LCCL domain-containing 2
Gene
CRISPLD2
Organism
Homo sapiens (Human)
Status
Functioni
Promotes matrix assembly.
By similarityGO - Molecular functioni
- glycosaminoglycan binding Source: GO_Central
- heparin binding Source: Ensembl
GO - Biological processi
- extracellular matrix organization Source: Ensembl
- face morphogenesis Source: UniProtKB
- lung development Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | Q9H0B8 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9H0B8 |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine-rich secretory protein LCCL domain-containing 2Alternative name(s): Cysteine-rich secretory protein 11 Short name: CRISP-11 LCCL domain-containing cysteine-rich secretory protein 2 |
Gene namesi | Name:CRISPLD2 Synonyms:CRISP11, LCRISP2 ORF Names:UNQ2914/PRO1156/PRO9783 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:25248, CRISPLD2 |
MIMi | 612434, gene |
neXtProti | NX_Q9H0B8 |
VEuPathDBi | HostDB:ENSG00000103196 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
- extracellular space Source: GO_Central
Other locations
- extracellular matrix Source: Ensembl
- ficolin-1-rich granule lumen Source: Reactome
- secretory granule lumen Source: Reactome
- transport vesicle Source: LIFEdb
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 83716 |
OpenTargetsi | ENSG00000103196 |
PharmGKBi | PA142672077 |
Miscellaneous databases
Pharosi | Q9H0B8, Tbio |
Genetic variation databases
BioMutai | CRISPLD2 |
DMDMi | 74717972 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | Sequence analysisAdd BLAST | 22 | |
ChainiPRO_0000248149 | 23 – 497 | Cysteine-rich secretory protein LCCL domain-containing 2Add BLAST | 475 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 27 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 290 ↔ 308 | PROSITE-ProRule annotation | ||
Disulfide bondi | 312 ↔ 332 | PROSITE-ProRule annotation | ||
Disulfide bondi | 391 ↔ 413 | PROSITE-ProRule annotation | ||
Disulfide bondi | 417 ↔ 440 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
jPOSTi | Q9H0B8 |
MassIVEi | Q9H0B8 |
MaxQBi | Q9H0B8 |
PaxDbi | Q9H0B8 |
PeptideAtlasi | Q9H0B8 |
PRIDEi | Q9H0B8 |
ProteomicsDBi | 80245 [Q9H0B8-1] 80246 [Q9H0B8-2] 80247 [Q9H0B8-3] 80248 [Q9H0B8-4] 80249 [Q9H0B8-5] |
PTM databases
GlyGeni | Q9H0B8, 5 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q9H0B8 |
PhosphoSitePlusi | Q9H0B8 |
Expressioni
Gene expression databases
Bgeei | ENSG00000103196, Expressed in tibia and 236 other tissues |
ExpressionAtlasi | Q9H0B8, baseline and differential |
Genevisiblei | Q9H0B8, HS |
Organism-specific databases
HPAi | ENSG00000103196, Low tissue specificity |
Interactioni
Subunit structurei
Binds to heparin, dermatan sulfate and chondroitin sulfate.
By similarityProtein-protein interaction databases
BioGRIDi | 123739, 2 interactors |
IntActi | Q9H0B8, 1 interactor |
STRINGi | 9606.ENSP00000262424 |
Miscellaneous databases
RNActi | Q9H0B8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 62 – 200 | SCPAdd BLAST | 139 | |
Domaini | 284 – 379 | LCCL 1PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 385 – 488 | LCCL 2PROSITE-ProRule annotationAdd BLAST | 104 |
Sequence similaritiesi
Belongs to the CRISP family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG3017, Eukaryota |
GeneTreei | ENSGT00940000157410 |
HOGENOMi | CLU_138283_0_0_1 |
InParanoidi | Q9H0B8 |
OMAi | VNTCQRM |
PhylomeDBi | Q9H0B8 |
TreeFami | TF316148 |
Family and domain databases
Gene3Di | 2.170.130.20, 2 hits 3.40.33.10, 1 hit |
InterProi | View protein in InterPro IPR018244, Allrgn_V5/Tpx1_CS IPR014044, CAP_domain IPR035940, CAP_sf IPR001283, CRISP-related IPR004043, LCCL IPR036609, LCCL_sf |
PANTHERi | PTHR10334, PTHR10334, 1 hit |
Pfami | View protein in Pfam PF00188, CAP, 1 hit PF03815, LCCL, 2 hits |
PRINTSi | PR00837, V5TPXLIKE |
SMARTi | View protein in SMART SM00603, LCCL, 2 hits SM00198, SCP, 1 hit |
SUPFAMi | SSF55797, SSF55797, 1 hit SSF69848, SSF69848, 2 hits |
PROSITEi | View protein in PROSITE PS01010, CRISP_2, 1 hit PS50820, LCCL, 2 hits |
s (5+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q9H0B8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSCVLGGVIP LGLLFLVCGS QGYLLPNVTL LEELLSKYQH NESHSRVRRA
60 70 80 90 100
IPREDKEEIL MLHNKLRGQV QPQASNMEYM TWDDELEKSA AAWASQCIWE
110 120 130 140 150
HGPTSLLVSI GQNLGAHWGR YRSPGFHVQS WYDEVKDYTY PYPSECNPWC
160 170 180 190 200
PERCSGPMCT HYTQIVWATT NKIGCAVNTC RKMTVWGEVW ENAVYFVCNY
210 220 230 240 250
SPKGNWIGEA PYKNGRPCSE CPPSYGGSCR NNLCYREETY TPKPETDEMN
260 270 280 290 300
EVETAPIPEE NHVWLQPRVM RPTKPKKTSA VNYMTQVVRC DTKMKDRCKG
310 320 330 340 350
STCNRYQCPA GCLNHKAKIF GTLFYESSSS ICRAAIHYGI LDDKGGLVDI
360 370 380 390 400
TRNGKVPFFV KSERHGVQSL SKYKPSSSFM VSKVKVQDLD CYTTVAQLCP
410 420 430 440 450
FEKPATHCPR IHCPAHCKDE PSYWAPVFGT NIYADTSSIC KTAVHAGVIS
460 470 480 490
NESGGDVDVM PVDKKKTYVG SLRNGVQSES LGTPRDGKAF RIFAVRQ
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BTI0 | H3BTI0_HUMAN | Cysteine-rich secretory protein LCC... | CRISPLD2 | 496 | Annotation score: | ||
H3BTP0 | H3BTP0_HUMAN | Cysteine-rich secretory protein LCC... | CRISPLD2 | 111 | Annotation score: | ||
H3BSZ9 | H3BSZ9_HUMAN | Cysteine-rich secretory protein LCC... | CRISPLD2 | 209 | Annotation score: | ||
J3QKP2 | J3QKP2_HUMAN | Cysteine-rich secretory protein LCC... | CRISPLD2 | 43 | Annotation score: | ||
H3BS62 | H3BS62_HUMAN | Cysteine-rich secretory protein LCC... | CRISPLD2 | 18 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_027256 | 105 | S → G2 PublicationsCorresponds to variant dbSNP:rs12051468Ensembl. | 1 | |
Natural variantiVAR_074672 | 137 | D → G1 PublicationCorresponds to variant dbSNP:rs1297496215Ensembl. | 1 | |
Natural variantiVAR_027257 | 322 | T → S2 PublicationsCorresponds to variant dbSNP:rs721005Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020178 | 81 – 159 | TWDDE…SGPMC → VSAGSGRRGWHRGWGLGHQP ALFPSQLCSPASACDGWLRV SSGRGGSRLCSVLFVCFETG SHSATDAGVQWHNRHALKP in isoform 4. 1 PublicationAdd BLAST | 79 | |
Alternative sequenceiVSP_020179 | 121 – 497 | Missing in isoform 5. 1 PublicationAdd BLAST | 377 | |
Alternative sequenceiVSP_020180 | 160 – 497 | Missing in isoform 4. 1 PublicationAdd BLAST | 338 | |
Alternative sequenceiVSP_020181 | 371 | S → R in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_020182 | 372 – 497 | Missing in isoform 3. 1 PublicationAdd BLAST | 126 | |
Alternative sequenceiVSP_020183 | 436 – 497 | TSSIC…FAVRQ → VSRMHFQQLSRKAC in isoform 2. 1 PublicationAdd BLAST | 62 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136861 mRNA Translation: CAB66795.1 AY358413 mRNA Translation: AAQ88779.1 AY358790 mRNA Translation: AAQ89150.1 AK027395 mRNA Translation: BAB55081.1 CH471114 Genomic DNA Translation: EAW95468.1 CH471114 Genomic DNA Translation: EAW95469.1 BC007689 mRNA Translation: AAH07689.1 BC063012 mRNA Translation: AAH63012.1 |
CCDSi | CCDS10949.1 [Q9H0B8-1] |
RefSeqi | NP_113664.1, NM_031476.3 [Q9H0B8-1] XP_005256247.1, XM_005256190.1 [Q9H0B8-1] |
Genome annotation databases
Ensembli | ENST00000262424; ENSP00000262424; ENSG00000103196 ENST00000564567; ENSP00000457655; ENSG00000103196 [Q9H0B8-2] ENST00000569090; ENSP00000454858; ENSG00000103196 [Q9H0B8-5] |
GeneIDi | 83716 |
KEGGi | hsa:83716 |
MANE-Selecti | ENST00000262424.10; ENSP00000262424.5; NM_031476.4; NP_113664.1 |
UCSCi | uc002fil.3, human [Q9H0B8-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL136861 mRNA Translation: CAB66795.1 AY358413 mRNA Translation: AAQ88779.1 AY358790 mRNA Translation: AAQ89150.1 AK027395 mRNA Translation: BAB55081.1 CH471114 Genomic DNA Translation: EAW95468.1 CH471114 Genomic DNA Translation: EAW95469.1 BC007689 mRNA Translation: AAH07689.1 BC063012 mRNA Translation: AAH63012.1 |
CCDSi | CCDS10949.1 [Q9H0B8-1] |
RefSeqi | NP_113664.1, NM_031476.3 [Q9H0B8-1] XP_005256247.1, XM_005256190.1 [Q9H0B8-1] |
3D structure databases
SMRi | Q9H0B8 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 123739, 2 interactors |
IntActi | Q9H0B8, 1 interactor |
STRINGi | 9606.ENSP00000262424 |
PTM databases
GlyGeni | Q9H0B8, 5 sites, 2 O-linked glycans (3 sites) |
iPTMneti | Q9H0B8 |
PhosphoSitePlusi | Q9H0B8 |
Genetic variation databases
BioMutai | CRISPLD2 |
DMDMi | 74717972 |
Proteomic databases
jPOSTi | Q9H0B8 |
MassIVEi | Q9H0B8 |
MaxQBi | Q9H0B8 |
PaxDbi | Q9H0B8 |
PeptideAtlasi | Q9H0B8 |
PRIDEi | Q9H0B8 |
ProteomicsDBi | 80245 [Q9H0B8-1] 80246 [Q9H0B8-2] 80247 [Q9H0B8-3] 80248 [Q9H0B8-4] 80249 [Q9H0B8-5] |
Protocols and materials databases
Antibodypediai | 30609, 137 antibodies from 22 providers |
DNASUi | 83716 |
Genome annotation databases
Ensembli | ENST00000262424; ENSP00000262424; ENSG00000103196 ENST00000564567; ENSP00000457655; ENSG00000103196 [Q9H0B8-2] ENST00000569090; ENSP00000454858; ENSG00000103196 [Q9H0B8-5] |
GeneIDi | 83716 |
KEGGi | hsa:83716 |
MANE-Selecti | ENST00000262424.10; ENSP00000262424.5; NM_031476.4; NP_113664.1 |
UCSCi | uc002fil.3, human [Q9H0B8-1] |
Organism-specific databases
CTDi | 83716 |
DisGeNETi | 83716 |
GeneCardsi | CRISPLD2 |
HGNCi | HGNC:25248, CRISPLD2 |
HPAi | ENSG00000103196, Low tissue specificity |
MIMi | 612434, gene |
neXtProti | NX_Q9H0B8 |
OpenTargetsi | ENSG00000103196 |
PharmGKBi | PA142672077 |
VEuPathDBi | HostDB:ENSG00000103196 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3017, Eukaryota |
GeneTreei | ENSGT00940000157410 |
HOGENOMi | CLU_138283_0_0_1 |
InParanoidi | Q9H0B8 |
OMAi | VNTCQRM |
PhylomeDBi | Q9H0B8 |
TreeFami | TF316148 |
Enzyme and pathway databases
PathwayCommonsi | Q9H0B8 |
Reactomei | R-HSA-6798695, Neutrophil degranulation |
SignaLinki | Q9H0B8 |
Miscellaneous databases
BioGRID-ORCSi | 83716, 11 hits in 1040 CRISPR screens |
ChiTaRSi | CRISPLD2, human |
GeneWikii | CRISPLD2 |
GenomeRNAii | 83716 |
Pharosi | Q9H0B8, Tbio |
PROi | PR:Q9H0B8 |
RNActi | Q9H0B8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000103196, Expressed in tibia and 236 other tissues |
ExpressionAtlasi | Q9H0B8, baseline and differential |
Genevisiblei | Q9H0B8, HS |
Family and domain databases
Gene3Di | 2.170.130.20, 2 hits 3.40.33.10, 1 hit |
InterProi | View protein in InterPro IPR018244, Allrgn_V5/Tpx1_CS IPR014044, CAP_domain IPR035940, CAP_sf IPR001283, CRISP-related IPR004043, LCCL IPR036609, LCCL_sf |
PANTHERi | PTHR10334, PTHR10334, 1 hit |
Pfami | View protein in Pfam PF00188, CAP, 1 hit PF03815, LCCL, 2 hits |
PRINTSi | PR00837, V5TPXLIKE |
SMARTi | View protein in SMART SM00603, LCCL, 2 hits SM00198, SCP, 1 hit |
SUPFAMi | SSF55797, SSF55797, 1 hit SSF69848, SSF69848, 2 hits |
PROSITEi | View protein in PROSITE PS01010, CRISP_2, 1 hit PS50820, LCCL, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CRLD2_HUMAN | |
Accessioni | Q9H0B8Primary (citable) accession number: Q9H0B8 Secondary accession number(s): D3DUM0 Q96K61 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 5, 2006 |
Last sequence update: | March 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 146 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families