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Protein

Speriolin-like protein

Gene

SPATC1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.

Names & Taxonomyi

Protein namesi
Recommended name:
Speriolin-like protein
Alternative name(s):
Spermatogenesis and centriole-associated protein 1-like protein
Gene namesi
Name:SPATC1L
Synonyms:C21orf56
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 21

Organism-specific databases

EuPathDBiHostDB:ENSG00000160284.14
HGNCiHGNC:1298 SPATC1L
MIMi612412 gene
neXtProtiNX_Q9H0A9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000160284
PharmGKBiPA25851

Polymorphism and mutation databases

BioMutaiSPATC1L
DMDMi296439382

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000795191 – 340Speriolin-like proteinAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9H0A9
PaxDbiQ9H0A9
PeptideAtlasiQ9H0A9
PRIDEiQ9H0A9
ProteomicsDBi80238
80239 [Q9H0A9-2]

PTM databases

iPTMnetiQ9H0A9
PhosphoSitePlusiQ9H0A9

Expressioni

Gene expression databases

BgeeiENSG00000160284 Expressed in 163 organ(s), highest expression level in right testis
CleanExiHS_C21orf56
GenevisibleiQ9H0A9 HS

Organism-specific databases

HPAiHPA018979
HPA019165
HPA029394

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi123955, 15 interactors
IntActiQ9H0A9, 41 interactors
STRINGi9606.ENSP00000291672

Structurei

3D structure databases

ProteinModelPortaliQ9H0A9
SMRiQ9H0A9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi320 – 323Poly-Leu4

Sequence similaritiesi

Belongs to the speriolin family.Curated

Phylogenomic databases

eggNOGiENOG410IIK2 Eukaryota
ENOG410Y05H LUCA
GeneTreeiENSGT00520000055666
HOGENOMiHOG000060272
HOVERGENiHBG051233
InParanoidiQ9H0A9
OMAiKKQVRLM
OrthoDBiEOG091G0DLF
PhylomeDBiQ9H0A9
TreeFamiTF329273

Family and domain databases

InterProiView protein in InterPro
IPR026715 SPATC1
IPR029384 Speriolin_C
IPR029385 Speriolin_N
PANTHERiPTHR22192 PTHR22192, 1 hit
PfamiView protein in Pfam
PF15059 Speriolin_C, 1 hit
PF15058 Speriolin_N, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H0A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGGELMSR LLSENADLKK QVRLLKENQM LRRLLSQSCQ EGGGHDLLPP
60 70 80 90 100
RAHAYPEAGS PGSGVPDFGR FTSVADTPSQ LQTSSLEDLL CSHAPLSSED
110 120 130 140 150
DTSPGCAAPS QAPFKAFLSP PEPHSHRGTD RKLSPLLSPL QDSLVDKTLL
160 170 180 190 200
EPREMVRPKK VCFSESSLPT GDRTRRSYYL NEIQSFAGAE KDARVVGEIA
210 220 230 240 250
FQLDRRILAY VFPGVTRLYG FTVANIPEKI EQTSTKSLDG SVDERKLREL
260 270 280 290 300
TQRYLALSAR LEKLGYSRDV HPAFSEFLIN TYGILKQRPD LRANPLHSSP
310 320 330 340
AALRKLVIDV VPPKFLGDSL LLLNCLCELS KEDGKPLFAW
Length:340
Mass (Da):37,613
Last modified:May 18, 2010 - v3
Checksum:iAE8E79F7E5B50644
GO
Isoform 2 (identifier: Q9H0A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Show »
Length:186
Mass (Da):21,049
Checksum:i56342795E99552E8
GO

Sequence cautioni

The sequence BAA95497 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059639113P → L. Corresponds to variant dbSNP:rs884134Ensembl.1
Natural variantiVAR_059640298S → N. Corresponds to variant dbSNP:rs14378EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0391511 – 154Missing in isoform 2. 3 PublicationsAdd BLAST154

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136871 mRNA Translation: CAB66805.1
CR533451 mRNA Translation: CAG38482.1
AK304535 mRNA Translation: BAG65335.1
AP001468 Genomic DNA No translation available.
AP001759 Genomic DNA Translation: BAA95497.1 Sequence problems.
CH471079 Genomic DNA Translation: EAX09307.1
BC009497 mRNA Translation: AAH09497.3
BC065570 mRNA Translation: AAH65570.2
BC084577 mRNA Translation: AAH84577.1
BC093804 mRNA Translation: AAH93804.2
BC112293 mRNA Translation: AAI12294.2
CCDSiCCDS13732.1 [Q9H0A9-2]
CCDS46653.1 [Q9H0A9-1]
RefSeqiNP_001136326.1, NM_001142854.1 [Q9H0A9-1]
NP_115637.3, NM_032261.4 [Q9H0A9-2]
XP_005261245.1, XM_005261188.4 [Q9H0A9-1]
XP_016883969.1, XM_017028480.1 [Q9H0A9-1]
UniGeneiHs.381214

Genome annotation databases

EnsembliENST00000291672; ENSP00000291672; ENSG00000160284 [Q9H0A9-1]
ENST00000330205; ENSP00000333869; ENSG00000160284 [Q9H0A9-2]
ENST00000618495; ENSP00000478124; ENSG00000274679 [Q9H0A9-2]
ENST00000621926; ENSP00000483544; ENSG00000274679 [Q9H0A9-1]
GeneIDi84221
KEGGihsa:84221
UCSCiuc002zii.4 human [Q9H0A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136871 mRNA Translation: CAB66805.1
CR533451 mRNA Translation: CAG38482.1
AK304535 mRNA Translation: BAG65335.1
AP001468 Genomic DNA No translation available.
AP001759 Genomic DNA Translation: BAA95497.1 Sequence problems.
CH471079 Genomic DNA Translation: EAX09307.1
BC009497 mRNA Translation: AAH09497.3
BC065570 mRNA Translation: AAH65570.2
BC084577 mRNA Translation: AAH84577.1
BC093804 mRNA Translation: AAH93804.2
BC112293 mRNA Translation: AAI12294.2
CCDSiCCDS13732.1 [Q9H0A9-2]
CCDS46653.1 [Q9H0A9-1]
RefSeqiNP_001136326.1, NM_001142854.1 [Q9H0A9-1]
NP_115637.3, NM_032261.4 [Q9H0A9-2]
XP_005261245.1, XM_005261188.4 [Q9H0A9-1]
XP_016883969.1, XM_017028480.1 [Q9H0A9-1]
UniGeneiHs.381214

3D structure databases

ProteinModelPortaliQ9H0A9
SMRiQ9H0A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123955, 15 interactors
IntActiQ9H0A9, 41 interactors
STRINGi9606.ENSP00000291672

PTM databases

iPTMnetiQ9H0A9
PhosphoSitePlusiQ9H0A9

Polymorphism and mutation databases

BioMutaiSPATC1L
DMDMi296439382

Proteomic databases

EPDiQ9H0A9
PaxDbiQ9H0A9
PeptideAtlasiQ9H0A9
PRIDEiQ9H0A9
ProteomicsDBi80238
80239 [Q9H0A9-2]

Protocols and materials databases

DNASUi84221
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291672; ENSP00000291672; ENSG00000160284 [Q9H0A9-1]
ENST00000330205; ENSP00000333869; ENSG00000160284 [Q9H0A9-2]
ENST00000618495; ENSP00000478124; ENSG00000274679 [Q9H0A9-2]
ENST00000621926; ENSP00000483544; ENSG00000274679 [Q9H0A9-1]
GeneIDi84221
KEGGihsa:84221
UCSCiuc002zii.4 human [Q9H0A9-1]

Organism-specific databases

CTDi84221
EuPathDBiHostDB:ENSG00000160284.14
GeneCardsiSPATC1L
H-InvDBiHIX0203124
HGNCiHGNC:1298 SPATC1L
HPAiHPA018979
HPA019165
HPA029394
MIMi612412 gene
neXtProtiNX_Q9H0A9
OpenTargetsiENSG00000160284
PharmGKBiPA25851
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIK2 Eukaryota
ENOG410Y05H LUCA
GeneTreeiENSGT00520000055666
HOGENOMiHOG000060272
HOVERGENiHBG051233
InParanoidiQ9H0A9
OMAiKKQVRLM
OrthoDBiEOG091G0DLF
PhylomeDBiQ9H0A9
TreeFamiTF329273

Miscellaneous databases

GeneWikiiC21orf56
GenomeRNAii84221
PROiPR:Q9H0A9
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160284 Expressed in 163 organ(s), highest expression level in right testis
CleanExiHS_C21orf56
GenevisibleiQ9H0A9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026715 SPATC1
IPR029384 Speriolin_C
IPR029385 Speriolin_N
PANTHERiPTHR22192 PTHR22192, 1 hit
PfamiView protein in Pfam
PF15059 Speriolin_C, 1 hit
PF15058 Speriolin_N, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSPC1L_HUMAN
AccessioniPrimary (citable) accession number: Q9H0A9
Secondary accession number(s): B4E323
, Q52LS9, Q6FIH5, Q6P0L3, Q9NSE5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 137 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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