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Entry version 140 (08 May 2019)
Sequence version 3 (18 May 2010)
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Protein

Speriolin-like protein

Gene

SPATC1L

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Miscellaneous

Highly variable expression among individuals is associated with differential sensitivity to the DNA alkylating agent N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), decreased expression being associated with increased sensitivity.

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Speriolin-like protein
Alternative name(s):
Spermatogenesis and centriole-associated protein 1-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SPATC1L
Synonyms:C21orf56
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 21

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1298 SPATC1L

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
612412 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q9H0A9

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
84221

Open Targets

More...
OpenTargetsi
ENSG00000160284

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25851

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SPATC1L

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296439382

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000795191 – 340Speriolin-like proteinAdd BLAST340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei60PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q9H0A9

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q9H0A9

PeptideAtlas

More...
PeptideAtlasi
Q9H0A9

PRoteomics IDEntifications database

More...
PRIDEi
Q9H0A9

ProteomicsDB human proteome resource

More...
ProteomicsDBi
80238
80239 [Q9H0A9-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q9H0A9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q9H0A9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160284 Expressed in 163 organ(s), highest expression level in right testis

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q9H0A9 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA018979
HPA019165
HPA029394

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123955, 15 interactors

Protein interaction database and analysis system

More...
IntActi
Q9H0A9, 41 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291672

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q9H0A9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi320 – 323Poly-Leu4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the speriolin family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IIK2 Eukaryota
ENOG410Y05H LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055666

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000060272

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q9H0A9

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKQVRLM

Database of Orthologous Groups

More...
OrthoDBi
827195at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q9H0A9

TreeFam database of animal gene trees

More...
TreeFami
TF329273

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026715 SPATC1
IPR029384 Speriolin_C
IPR029385 Speriolin_N

The PANTHER Classification System

More...
PANTHERi
PTHR22192 PTHR22192, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15059 Speriolin_C, 1 hit
PF15058 Speriolin_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9H0A9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAEGGELMSR LLSENADLKK QVRLLKENQM LRRLLSQSCQ EGGGHDLLPP
60 70 80 90 100
RAHAYPEAGS PGSGVPDFGR FTSVADTPSQ LQTSSLEDLL CSHAPLSSED
110 120 130 140 150
DTSPGCAAPS QAPFKAFLSP PEPHSHRGTD RKLSPLLSPL QDSLVDKTLL
160 170 180 190 200
EPREMVRPKK VCFSESSLPT GDRTRRSYYL NEIQSFAGAE KDARVVGEIA
210 220 230 240 250
FQLDRRILAY VFPGVTRLYG FTVANIPEKI EQTSTKSLDG SVDERKLREL
260 270 280 290 300
TQRYLALSAR LEKLGYSRDV HPAFSEFLIN TYGILKQRPD LRANPLHSSP
310 320 330 340
AALRKLVIDV VPPKFLGDSL LLLNCLCELS KEDGKPLFAW
Length:340
Mass (Da):37,613
Last modified:May 18, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAE8E79F7E5B50644
GO
Isoform 2 (identifier: Q9H0A9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-154: Missing.

Show »
Length:186
Mass (Da):21,049
Checksum:i56342795E99552E8
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA95497 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059639113P → L. Corresponds to variant dbSNP:rs884134Ensembl.1
Natural variantiVAR_059640298S → N. Corresponds to variant dbSNP:rs14378EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0391511 – 154Missing in isoform 2. 3 PublicationsAdd BLAST154

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL136871 mRNA Translation: CAB66805.1
CR533451 mRNA Translation: CAG38482.1
AK304535 mRNA Translation: BAG65335.1
AP001468 Genomic DNA No translation available.
AP001759 Genomic DNA Translation: BAA95497.1 Sequence problems.
CH471079 Genomic DNA Translation: EAX09307.1
BC009497 mRNA Translation: AAH09497.3
BC065570 mRNA Translation: AAH65570.2
BC084577 mRNA Translation: AAH84577.1
BC093804 mRNA Translation: AAH93804.2
BC112293 mRNA Translation: AAI12294.2

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS13732.1 [Q9H0A9-2]
CCDS46653.1 [Q9H0A9-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001136326.1, NM_001142854.1 [Q9H0A9-1]
NP_115637.3, NM_032261.4 [Q9H0A9-2]
XP_005261245.1, XM_005261188.4 [Q9H0A9-1]
XP_016883969.1, XM_017028480.1 [Q9H0A9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291672; ENSP00000291672; ENSG00000160284 [Q9H0A9-1]
ENST00000330205; ENSP00000333869; ENSG00000160284 [Q9H0A9-2]
ENST00000618495; ENSP00000478124; ENSG00000274679 [Q9H0A9-2]
ENST00000621926; ENSP00000483544; ENSG00000274679 [Q9H0A9-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
84221

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:84221

UCSC genome browser

More...
UCSCi
uc002zii.4 human [Q9H0A9-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136871 mRNA Translation: CAB66805.1
CR533451 mRNA Translation: CAG38482.1
AK304535 mRNA Translation: BAG65335.1
AP001468 Genomic DNA No translation available.
AP001759 Genomic DNA Translation: BAA95497.1 Sequence problems.
CH471079 Genomic DNA Translation: EAX09307.1
BC009497 mRNA Translation: AAH09497.3
BC065570 mRNA Translation: AAH65570.2
BC084577 mRNA Translation: AAH84577.1
BC093804 mRNA Translation: AAH93804.2
BC112293 mRNA Translation: AAI12294.2
CCDSiCCDS13732.1 [Q9H0A9-2]
CCDS46653.1 [Q9H0A9-1]
RefSeqiNP_001136326.1, NM_001142854.1 [Q9H0A9-1]
NP_115637.3, NM_032261.4 [Q9H0A9-2]
XP_005261245.1, XM_005261188.4 [Q9H0A9-1]
XP_016883969.1, XM_017028480.1 [Q9H0A9-1]

3D structure databases

SMRiQ9H0A9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123955, 15 interactors
IntActiQ9H0A9, 41 interactors
STRINGi9606.ENSP00000291672

PTM databases

iPTMnetiQ9H0A9
PhosphoSitePlusiQ9H0A9

Polymorphism and mutation databases

BioMutaiSPATC1L
DMDMi296439382

Proteomic databases

EPDiQ9H0A9
PaxDbiQ9H0A9
PeptideAtlasiQ9H0A9
PRIDEiQ9H0A9
ProteomicsDBi80238
80239 [Q9H0A9-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
84221
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291672; ENSP00000291672; ENSG00000160284 [Q9H0A9-1]
ENST00000330205; ENSP00000333869; ENSG00000160284 [Q9H0A9-2]
ENST00000618495; ENSP00000478124; ENSG00000274679 [Q9H0A9-2]
ENST00000621926; ENSP00000483544; ENSG00000274679 [Q9H0A9-1]
GeneIDi84221
KEGGihsa:84221
UCSCiuc002zii.4 human [Q9H0A9-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84221
DisGeNETi84221

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SPATC1L

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0203124
HGNCiHGNC:1298 SPATC1L
HPAiHPA018979
HPA019165
HPA029394
MIMi612412 gene
neXtProtiNX_Q9H0A9
OpenTargetsiENSG00000160284
PharmGKBiPA25851

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IIK2 Eukaryota
ENOG410Y05H LUCA
GeneTreeiENSGT00520000055666
HOGENOMiHOG000060272
InParanoidiQ9H0A9
OMAiKKQVRLM
OrthoDBi827195at2759
PhylomeDBiQ9H0A9
TreeFamiTF329273

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
C21orf56

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
84221

Protein Ontology

More...
PROi
PR:Q9H0A9

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000160284 Expressed in 163 organ(s), highest expression level in right testis
GenevisibleiQ9H0A9 HS

Family and domain databases

InterProiView protein in InterPro
IPR026715 SPATC1
IPR029384 Speriolin_C
IPR029385 Speriolin_N
PANTHERiPTHR22192 PTHR22192, 1 hit
PfamiView protein in Pfam
PF15059 Speriolin_C, 1 hit
PF15058 Speriolin_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPC1L_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q9H0A9
Secondary accession number(s): B4E323
, Q52LS9, Q6FIH5, Q6P0L3, Q9NSE5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: May 18, 2010
Last modified: May 8, 2019
This is version 140 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 21
    Human chromosome 21: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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