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Protein

RING finger protein 32

Gene

RNF32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in sperm formation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 169RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST43
Zinc fingeri293 – 352RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

Keywordsi

LigandMetal-binding, Zinc

Protein family/group databases

MoonDBiQ9H0A6 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
RING finger protein 32
Gene namesi
Name:RNF32
ORF Names:FKSG33, HSD15
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105982.16
HGNCiHGNC:17118 RNF32
MIMi610241 gene
neXtProtiNX_Q9H0A6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000105982
PharmGKBiPA34435

Polymorphism and mutation databases

BioMutaiRNF32
DMDMi74717970

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002455321 – 362RING finger protein 32Add BLAST362

Proteomic databases

PaxDbiQ9H0A6
PRIDEiQ9H0A6
ProteomicsDBi80231
80232 [Q9H0A6-2]
80233 [Q9H0A6-4]
80234 [Q9H0A6-5]
80235 [Q9H0A6-6]

PTM databases

PhosphoSitePlusiQ9H0A6

Expressioni

Tissue specificityi

Highly expressed in testis, less abundant in ovary.1 Publication

Gene expression databases

BgeeiENSG00000105982 Expressed in 123 organ(s), highest expression level in testis
CleanExiHS_RNF32
ExpressionAtlasiQ9H0A6 baseline and differential
GenevisibleiQ9H0A6 HS

Organism-specific databases

HPAiHPA073560

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi126622, 42 interactors
IntActiQ9H0A6, 30 interactors
STRINGi9606.ENSP00000315950

Structurei

3D structure databases

ProteinModelPortaliQ9H0A6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini186 – 215IQPROSITE-ProRule annotationAdd BLAST30

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri127 – 169RING-type 1; atypicalPROSITE-ProRule annotationAdd BLAST43
Zinc fingeri293 – 352RING-type 2; atypicalPROSITE-ProRule annotationAdd BLAST60

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00390000003759
HOVERGENiHBG082459
InParanoidiQ9H0A6
OMAiYETRVIH
OrthoDBiEOG091G0AGY
PhylomeDBiQ9H0A6
TreeFamiTF329796

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF13639 zf-RING_2, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00184 RING, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50089 ZF_RING_2, 2 hits

Sequences (5+)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Other isoforms seem to exist.

This entry has 5 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q9H0A6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLKNKGHSSK KDNLAVNAVA LQDHILHDLQ LRNLSVADHS KTQVQKKENK
60 70 80 90 100
SLKRDTKAII DTGLKKTTQC PKLEDSEKEY VLDPKPPPLT LAQKLGLIGP
110 120 130 140 150
PPPPLSSDEW EKVKQRSLLQ GDSVQPCPIC KEEFELRPQV LLSCSHVFHK
160 170 180 190 200
ACLQAFEKFT NKKTCPLCRK NQYQTRVIHD GARLFRIKCV TRIQAYWRGC
210 220 230 240 250
VVRKWYRNLR KTVPPTDAKL RKKFFEKKFT EISHRILCSY NTNIEELFAE
260 270 280 290 300
IDQCLAINRS VLQQLEEKCG HEITEEEWEK IQVQALRRET HECSICLAPL
310 320 330 340 350
SAAGGQRVGA GRRSREMALL SCSHVFHHAC LLALEEFSVG DRPPFHACPL
360
CRSCYQKKIL EC
Length:362
Mass (Da):41,516
Last modified:March 1, 2001 - v1
Checksum:i5C6AF6908FCCA456
GO
Isoform 2 (identifier: Q9H0A6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     141-169: LLSCSHVFHKACLQAFEKFTNKKTCPLCR → FSIRG

Note: Derived from EST data.
Show »
Length:338
Mass (Da):38,741
Checksum:iCC5A54DB27C34AF3
GO
Isoform 3 (identifier: Q9H0A6-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     229-235: FTEISHR → TQDWKPA
     236-362: Missing.

Show »
Length:235
Mass (Da):27,131
Checksum:i2D51EBF78FCCDC65
GO
Isoform 4 (identifier: Q9H0A6-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     170-352: Missing.

Note: No experimental confirmation available.
Show »
Length:179
Mass (Da):20,222
Checksum:iF1F7344CCBF8B636
GO
Isoform 5 (identifier: Q9H0A6-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     92-95: AQKL → GYHS
     96-362: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:95
Mass (Da):10,682
Checksum:i33AD8ABF2FB5FE29
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E940G5E940_HUMAN
RING finger protein 32
RNF32 hCG_18857
310Annotation score:
E9PES2E9PES2_HUMAN
RING finger protein 32
RNF32
221Annotation score:
C9JXI4C9JXI4_HUMAN
RING finger protein 32
RNF32
18Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti97L → P in CAG38544 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_026982288R → Q. Corresponds to variant dbSNP:rs2302148Ensembl.1
Natural variantiVAR_026983291H → Q. Corresponds to variant dbSNP:rs2302147Ensembl.1
Natural variantiVAR_026984307R → C. Corresponds to variant dbSNP:rs2302146Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01973892 – 95AQKL → GYHS in isoform 5. 1 Publication4
Alternative sequenceiVSP_01973996 – 362Missing in isoform 5. 1 PublicationAdd BLAST267
Alternative sequenceiVSP_019740141 – 169LLSCS…CPLCR → FSIRG in isoform 2. CuratedAdd BLAST29
Alternative sequenceiVSP_019741170 – 352Missing in isoform 4. 1 PublicationAdd BLAST183
Alternative sequenceiVSP_019743229 – 235FTEISHR → TQDWKPA in isoform 3. 2 Publications7
Alternative sequenceiVSP_019744236 – 362Missing in isoform 3. 2 PublicationsAdd BLAST127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441222 mRNA Translation: AAM18664.1
AF441224 mRNA Translation: AAM18666.1
AF325690 mRNA Translation: AAG50281.1
AL136874 mRNA Translation: CAB66808.1
AY251165 mRNA Translation: AAP20062.1
BT007037 mRNA Translation: AAP35686.1
CR533513 mRNA Translation: CAG38544.1
AC005534 Genomic DNA Translation: AAD43189.1
BC015416 mRNA Translation: AAH15416.1
CCDSiCCDS5944.1 [Q9H0A6-1]
CCDS78292.1 [Q9H0A6-4]
RefSeqiNP_001171925.1, NM_001184996.1 [Q9H0A6-1]
NP_001171926.1, NM_001184997.1 [Q9H0A6-1]
NP_001295202.1, NM_001308273.1
NP_001295203.1, NM_001308274.1 [Q9H0A6-4]
NP_112198.1, NM_030936.3 [Q9H0A6-1]
XP_005249579.1, XM_005249522.4 [Q9H0A6-1]
XP_011514106.1, XM_011515804.2 [Q9H0A6-1]
XP_011514107.1, XM_011515805.2 [Q9H0A6-1]
XP_011514108.1, XM_011515806.2 [Q9H0A6-1]
XP_011514109.1, XM_011515807.2 [Q9H0A6-1]
XP_011514110.1, XM_011515808.2 [Q9H0A6-1]
XP_011514111.1, XM_011515809.2 [Q9H0A6-1]
XP_011514112.1, XM_011515810.2 [Q9H0A6-1]
XP_011514113.1, XM_011515811.2 [Q9H0A6-1]
XP_011514114.1, XM_011515812.2 [Q9H0A6-1]
XP_016867244.1, XM_017011755.1 [Q9H0A6-4]
UniGeneiHs.446194

Genome annotation databases

EnsembliENST00000317955; ENSP00000315950; ENSG00000105982 [Q9H0A6-1]
ENST00000392741; ENSP00000376497; ENSG00000105982 [Q9H0A6-4]
ENST00000392743; ENSP00000376499; ENSG00000105982 [Q9H0A6-1]
ENST00000392747; ENSP00000376503; ENSG00000105982 [Q9H0A6-6]
ENST00000405335; ENSP00000385285; ENSG00000105982 [Q9H0A6-1]
ENST00000432459; ENSP00000405588; ENSG00000105982 [Q9H0A6-1]
GeneIDi140545
KEGGihsa:140545
UCSCiuc003wmo.4 human [Q9H0A6-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF441222 mRNA Translation: AAM18664.1
AF441224 mRNA Translation: AAM18666.1
AF325690 mRNA Translation: AAG50281.1
AL136874 mRNA Translation: CAB66808.1
AY251165 mRNA Translation: AAP20062.1
BT007037 mRNA Translation: AAP35686.1
CR533513 mRNA Translation: CAG38544.1
AC005534 Genomic DNA Translation: AAD43189.1
BC015416 mRNA Translation: AAH15416.1
CCDSiCCDS5944.1 [Q9H0A6-1]
CCDS78292.1 [Q9H0A6-4]
RefSeqiNP_001171925.1, NM_001184996.1 [Q9H0A6-1]
NP_001171926.1, NM_001184997.1 [Q9H0A6-1]
NP_001295202.1, NM_001308273.1
NP_001295203.1, NM_001308274.1 [Q9H0A6-4]
NP_112198.1, NM_030936.3 [Q9H0A6-1]
XP_005249579.1, XM_005249522.4 [Q9H0A6-1]
XP_011514106.1, XM_011515804.2 [Q9H0A6-1]
XP_011514107.1, XM_011515805.2 [Q9H0A6-1]
XP_011514108.1, XM_011515806.2 [Q9H0A6-1]
XP_011514109.1, XM_011515807.2 [Q9H0A6-1]
XP_011514110.1, XM_011515808.2 [Q9H0A6-1]
XP_011514111.1, XM_011515809.2 [Q9H0A6-1]
XP_011514112.1, XM_011515810.2 [Q9H0A6-1]
XP_011514113.1, XM_011515811.2 [Q9H0A6-1]
XP_011514114.1, XM_011515812.2 [Q9H0A6-1]
XP_016867244.1, XM_017011755.1 [Q9H0A6-4]
UniGeneiHs.446194

3D structure databases

ProteinModelPortaliQ9H0A6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126622, 42 interactors
IntActiQ9H0A6, 30 interactors
STRINGi9606.ENSP00000315950

Protein family/group databases

MoonDBiQ9H0A6 Predicted

PTM databases

PhosphoSitePlusiQ9H0A6

Polymorphism and mutation databases

BioMutaiRNF32
DMDMi74717970

Proteomic databases

PaxDbiQ9H0A6
PRIDEiQ9H0A6
ProteomicsDBi80231
80232 [Q9H0A6-2]
80233 [Q9H0A6-4]
80234 [Q9H0A6-5]
80235 [Q9H0A6-6]

Protocols and materials databases

DNASUi140545
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317955; ENSP00000315950; ENSG00000105982 [Q9H0A6-1]
ENST00000392741; ENSP00000376497; ENSG00000105982 [Q9H0A6-4]
ENST00000392743; ENSP00000376499; ENSG00000105982 [Q9H0A6-1]
ENST00000392747; ENSP00000376503; ENSG00000105982 [Q9H0A6-6]
ENST00000405335; ENSP00000385285; ENSG00000105982 [Q9H0A6-1]
ENST00000432459; ENSP00000405588; ENSG00000105982 [Q9H0A6-1]
GeneIDi140545
KEGGihsa:140545
UCSCiuc003wmo.4 human [Q9H0A6-1]

Organism-specific databases

CTDi140545
EuPathDBiHostDB:ENSG00000105982.16
GeneCardsiRNF32
HGNCiHGNC:17118 RNF32
HPAiHPA073560
MIMi610241 gene
neXtProtiNX_Q9H0A6
OpenTargetsiENSG00000105982
PharmGKBiPA34435
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0800 Eukaryota
ENOG41121N2 LUCA
GeneTreeiENSGT00390000003759
HOVERGENiHBG082459
InParanoidiQ9H0A6
OMAiYETRVIH
OrthoDBiEOG091G0AGY
PhylomeDBiQ9H0A6
TreeFamiTF329796

Miscellaneous databases

GeneWikiiRNF32
GenomeRNAii140545
PROiPR:Q9H0A6
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105982 Expressed in 123 organ(s), highest expression level in testis
CleanExiHS_RNF32
ExpressionAtlasiQ9H0A6 baseline and differential
GenevisibleiQ9H0A6 HS

Family and domain databases

Gene3Di3.30.40.10, 2 hits
InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
IPR027370 Znf-RING_LisH
IPR001841 Znf_RING
IPR013083 Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PF13639 zf-RING_2, 1 hit
PF13445 zf-RING_UBOX, 1 hit
SMARTiView protein in SMART
SM00184 RING, 2 hits
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit
PS50089 ZF_RING_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiRNF32_HUMAN
AccessioniPrimary (citable) accession number: Q9H0A6
Secondary accession number(s): Q6FIB3
, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9Y6U1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: March 1, 2001
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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