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Protein

Dynein regulatory complex protein 9

Gene

IQCG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Binds calmodulin when cellular Ca2+ levels are low and thereby contributes to the regulation of calcium and calmodulin-dependent protein kinase IV (CAMK4) activity; contributes to the regulation of CAMK4 signaling cascades. Required for normal axoneme assembly in sperm flagella, normal sperm tail formation and for male fertility.By similarity

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • Hsp70 protein binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCalmodulin-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein regulatory complex protein 9By similarity
Alternative name(s):
IQ domain-containing protein G
Gene namesi
Name:IQCG
Synonyms:DRC9By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000114473.13
HGNCiHGNC:25251 IQCG
MIMi612477 gene
neXtProtiNX_Q9H095

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton, Flagellum

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi401Q → A: Loss of calmodulin binding. 1 Publication1

Organism-specific databases

DisGeNETi84223
OpenTargetsiENSG00000114473
PharmGKBiPA134919040

Polymorphism and mutation databases

BioMutaiIQCG
DMDMi74752551

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002825611 – 443Dynein regulatory complex protein 9Add BLAST443

Proteomic databases

EPDiQ9H095
PaxDbiQ9H095
PeptideAtlasiQ9H095
PRIDEiQ9H095
ProteomicsDBi80225
80226 [Q9H095-2]

PTM databases

iPTMnetiQ9H095
PhosphoSitePlusiQ9H095

Expressioni

Gene expression databases

BgeeiENSG00000114473
CleanExiHS_IQCG
ExpressionAtlasiQ9H095 baseline and differential
GenevisibleiQ9H095 HS

Organism-specific databases

HPAiHPA042787
HPA051981

Interactioni

Subunit structurei

Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts (via IQ domain) with CALM when calcium levels are low. Does not interact with CALM in the presence of Ca2+. Interacts with the HSP70 proteins HSPA1L and HSPA8 (PubMed:24787902). May form a complex with CAMK4 and HSP70 (By similarity).By similarity1 Publication

GO - Molecular functioni

  • calmodulin binding Source: UniProtKB
  • Hsp70 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi123957, 2 interactors
IntActiQ9H095, 2 interactors
MINTiQ9H095
STRINGi9606.ENSP00000265239

Structurei

Secondary structure

1443
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi389 – 410Combined sources22

3D structure databases

ProteinModelPortaliQ9H095
SMRiQ9H095
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini393 – 422IQPROSITE-ProRule annotationAdd BLAST30

Domaini

The IQ domain mediates interaction with calmodulin when cellular Ca2+ levels are low.1 Publication

Sequence similaritiesi

Belongs to the DRC9 family.Curated

Phylogenomic databases

eggNOGiENOG410IFH5 Eukaryota
ENOG410ZKIR LUCA
GeneTreeiENSGT00730000111263
HOGENOMiHOG000007509
HOVERGENiHBG083921
InParanoidiQ9H095
OMAiFDKDTEM
OrthoDBiEOG091G0DH2
PhylomeDBiQ9H095
TreeFamiTF326203

Family and domain databases

InterProiView protein in InterPro
IPR000048 IQ_motif_EF-hand-BS
PfamiView protein in Pfam
PF00612 IQ, 1 hit
PROSITEiView protein in PROSITE
PS50096 IQ, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9H095-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEEDSLEDSN LPPKVWHSEM TVSVTGEPPS TVEEEGIPKE TDIEIIPEIP
60 70 80 90 100
ETLEPLSLPD VLRISAVLED TTDQLSILNY IMPVQYEGRQ SICVKSREMN
110 120 130 140 150
LEGTNLDKLP MASTITKIPS PLITEEGPNL PEIRHRGRFA VEFNKMQDLV
160 170 180 190 200
FKKPTRQTIM TTETLKKIQI DRQFFSDVIA DTIKELQDSA TYNSLLQALS
210 220 230 240 250
KERENKMHFY DIIAREEKGR KQIISLQKQL INVKKEWQFE VQSQNEYIAN
260 270 280 290 300
LKDQLQEMKA KSNLENRYMK TNTELQIAQT QKKCNRTEEL LVEEIEKLRM
310 320 330 340 350
KTEEEARTHT EIEMFLRKEQ QKLEERLEFW MEKYDKDTEM KQNELNALKA
360 370 380 390 400
TKASDLAHLQ DLAKMIREYE QVIIEDRIEK ERSKKKVKQD LLELKSVIKL
410 420 430 440
QAWWRGTMIR REIGGFKMPK DKVDSKDSKG KGKGKDKRRG KKK
Length:443
Mass (Da):51,918
Last modified:March 1, 2001 - v1
Checksum:iF4816EFF3F3386E7
GO
Isoform 2 (identifier: Q9H095-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-98: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):40,927
Checksum:i3287633A2F81EFF1
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti177D → H in AAH04816 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_031415112A → D1 PublicationCorresponds to variant dbSNP:rs9880989Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0241871 – 98Missing in isoform 2. 1 PublicationAdd BLAST98

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136889 mRNA Translation: CAB66823.1
CR533515 mRNA Translation: CAG38546.1
AK021729 mRNA Translation: BAB13881.1
BC004816 mRNA Translation: AAH04816.2
CCDSiCCDS3331.1 [Q9H095-1]
RefSeqiNP_001127907.1, NM_001134435.2 [Q9H095-1]
NP_001309956.1, NM_001323027.1 [Q9H095-1]
NP_001309957.1, NM_001323028.1
NP_001309958.1, NM_001323029.1 [Q9H095-2]
NP_115639.1, NM_032263.4 [Q9H095-1]
UniGeneiHs.591675

Genome annotation databases

EnsembliENST00000265239; ENSP00000265239; ENSG00000114473 [Q9H095-1]
ENST00000455191; ENSP00000407736; ENSG00000114473 [Q9H095-1]
GeneIDi84223
KEGGihsa:84223
UCSCiuc003fyo.4 human [Q9H095-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDRC9_HUMAN
AccessioniPrimary (citable) accession number: Q9H095
Secondary accession number(s): Q9BST2, Q9HAG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2001
Last modified: July 18, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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