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Protein

NUAK family SNF1-like kinase 2

Gene

NUAK2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.4 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.2 Publications

Cofactori

Mg2+2 Publications

Activity regulationi

Activated by phosphorylation on Thr-208.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei81ATPPROSITE-ProRule annotation1 Publication1
Active sitei175Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi59 – 67ATPPROSITE-ProRule annotationBy similarity9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processApoptosis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ9H093
SIGNORiQ9H093

Names & Taxonomyi

Protein namesi
Recommended name:
NUAK family SNF1-like kinase 2 (EC:2.7.11.1)
Alternative name(s):
Omphalocele kinase 2
SNF1/AMP kinase-related kinase
Short name:
SNARK
Gene namesi
Name:NUAK2Imported
Synonyms:OMPHK2, SNARK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163545.8
HGNCiHGNC:29558 NUAK2
MIMi608131 gene
neXtProtiNX_Q9H093

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi81K → R: Loss of autophosphorylation, kinase activity and of anti-apoptotic activity. 1 Publication1
Mutagenesisi208T → A: Prevents phosphorylation and activation by STK11/LKB1 complex. 1 Publication1

Organism-specific databases

DisGeNETi81788
PharmGKBiPA142671243

Chemistry databases

ChEMBLiCHEMBL5698
GuidetoPHARMACOLOGYi2130

Polymorphism and mutation databases

BioMutaiNUAK2
DMDMi74761376

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002477561 – 628NUAK family SNF1-like kinase 2Add BLAST628

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei208Phosphothreonine; by LKB11 Publication1
Modified residuei435PhosphoserineCombined sources1
Modified residuei523PhosphoserineCombined sources1
Modified residuei544PhosphoserineCombined sources1
Modified residuei547PhosphoserineCombined sources1
Modified residuei573PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated at Thr-208 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Autophosphorylated in vitro.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9H093
MaxQBiQ9H093
PaxDbiQ9H093
PeptideAtlasiQ9H093
PRIDEiQ9H093
ProteomicsDBi80220

PTM databases

iPTMnetiQ9H093
PhosphoSitePlusiQ9H093

Expressioni

Gene expression databases

BgeeiENSG00000163545 Expressed in 163 organ(s), highest expression level in ectocervix
CleanExiHS_NUAK2
ExpressionAtlasiQ9H093 baseline and differential
GenevisibleiQ9H093 HS

Organism-specific databases

HPAiHPA008958

Interactioni

Protein-protein interaction databases

BioGridi123581, 17 interactors
IntActiQ9H093, 4 interactors
STRINGi9606.ENSP00000356125

Chemistry databases

BindingDBiQ9H093

Structurei

3D structure databases

ProteinModelPortaliQ9H093
SMRiQ9H093
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 303Protein kinasePROSITE-ProRule annotationAdd BLAST251

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0611 Eukaryota
ENOG410XPDM LUCA
HOGENOMiHOG000004864
HOVERGENiHBG007160
InParanoidiQ9H093
KOiK08800
OrthoDBiEOG091G033W
PhylomeDBiQ9H093
TreeFamiTF324572

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q9H093-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MESLVFARRS GPTPSAAELA RPLAEGLIKS PKPLMKKQAV KRHHHKHNLR
60 70 80 90 100
HRYEFLETLG KGTYGKVKKA RESSGRLVAI KSIRKDKIKD EQDLMHIRRE
110 120 130 140 150
IEIMSSLNHP HIIAIHEVFE NSSKIVIVME YASRGDLYDY ISERQQLSER
160 170 180 190 200
EARHFFRQIV SAVHYCHQNR VVHRDLKLEN ILLDANGNIK IADFGLSNLY
210 220 230 240 250
HQGKFLQTFC GSPLYASPEI VNGKPYTGPE VDSWSLGVLL YILVHGTMPF
260 270 280 290 300
DGHDHKILVK QISNGAYREP PKPSDACGLI RWLLMVNPTR RATLEDVASH
310 320 330 340 350
WWVNWGYATR VGEQEAPHEG GHPGSDSARA SMADWLRRSS RPLLENGAKV
360 370 380 390 400
CSFFKQHAPG GGSTTPGLER QHSLKKSRKE NDMAQSLHSD TADDTAHRPG
410 420 430 440 450
KSNLKLPKGI LKKKVSASAE GVQEDPPELS PIPASPGQAA PLLPKKGILK
460 470 480 490 500
KPRQRESGYY SSPEPSESGE LLDAGDVFVS GDPKEQKPPQ ASGLLLHRKG
510 520 530 540 550
ILKLNGKFSQ TALELAAPTT FGSLDELAPP RPLARASRPS GAVSEDSILS
560 570 580 590 600
SESFDQLDLP ERLPEPPLRG CVSVDNLTGL EEPPSEGPGS CLRRWRQDPL
610 620
GDSCFSLTDC QEVTATYRQA LRVCSKLT
Length:628
Mass (Da):69,612
Last modified:March 1, 2001 - v1
Checksum:iF76F8B1BF94F4C87
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_040964309T → S1 PublicationCorresponds to variant dbSNP:rs55745939Ensembl.1
Natural variantiVAR_040965341R → L1 PublicationCorresponds to variant dbSNP:rs35208615Ensembl.1
Natural variantiVAR_040966503K → R in an ovarian Endometrioid carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040967516A → V1 PublicationCorresponds to variant dbSNP:rs35070935Ensembl.1
Natural variantiVAR_040968541G → E in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136891 mRNA Translation: CAB66825.1
AK074830 mRNA Translation: BAC11234.1
BC017306 mRNA Translation: AAH17306.1
RefSeqiNP_112214.2, NM_030952.2
UniGeneiHs.497512

Genome annotation databases

EnsembliENST00000367157; ENSP00000356125; ENSG00000163545
GeneIDi81788
KEGGihsa:81788
UCSCiuc001hce.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136891 mRNA Translation: CAB66825.1
AK074830 mRNA Translation: BAC11234.1
BC017306 mRNA Translation: AAH17306.1
RefSeqiNP_112214.2, NM_030952.2
UniGeneiHs.497512

3D structure databases

ProteinModelPortaliQ9H093
SMRiQ9H093
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123581, 17 interactors
IntActiQ9H093, 4 interactors
STRINGi9606.ENSP00000356125

Chemistry databases

BindingDBiQ9H093
ChEMBLiCHEMBL5698
GuidetoPHARMACOLOGYi2130

PTM databases

iPTMnetiQ9H093
PhosphoSitePlusiQ9H093

Polymorphism and mutation databases

BioMutaiNUAK2
DMDMi74761376

Proteomic databases

EPDiQ9H093
MaxQBiQ9H093
PaxDbiQ9H093
PeptideAtlasiQ9H093
PRIDEiQ9H093
ProteomicsDBi80220

Protocols and materials databases

DNASUi81788
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367157; ENSP00000356125; ENSG00000163545
GeneIDi81788
KEGGihsa:81788
UCSCiuc001hce.4 human

Organism-specific databases

CTDi81788
DisGeNETi81788
EuPathDBiHostDB:ENSG00000163545.8
GeneCardsiNUAK2
HGNCiHGNC:29558 NUAK2
HPAiHPA008958
MIMi608131 gene
neXtProtiNX_Q9H093
PharmGKBiPA142671243
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0611 Eukaryota
ENOG410XPDM LUCA
HOGENOMiHOG000004864
HOVERGENiHBG007160
InParanoidiQ9H093
KOiK08800
OrthoDBiEOG091G033W
PhylomeDBiQ9H093
TreeFamiTF324572

Enzyme and pathway databases

SignaLinkiQ9H093
SIGNORiQ9H093

Miscellaneous databases

GeneWikiiNUAK2
GenomeRNAii81788
PROiPR:Q9H093
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000163545 Expressed in 163 organ(s), highest expression level in ectocervix
CleanExiHS_NUAK2
ExpressionAtlasiQ9H093 baseline and differential
GenevisibleiQ9H093 HS

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNUAK2_HUMAN
AccessioniPrimary (citable) accession number: Q9H093
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: March 1, 2001
Last modified: September 12, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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